{"id":63776,"date":"2024-08-09T01:45:41","date_gmt":"2024-08-09T08:45:41","guid":{"rendered":"https:\/\/www.chronobiology.com\/sport-eller-mellanmalhur-var-hjarna-fattar-beslut\/"},"modified":"2024-09-04T03:04:22","modified_gmt":"2024-09-04T10:04:22","slug":"sport-eller-mellanmalhur-var-hjarna-fattar-beslut","status":"publish","type":"post","link":"https:\/\/dev.chronobiology.com\/sv\/sport-eller-mellanmalhur-var-hjarna-fattar-beslut\/","title":{"rendered":"Sport eller mellanm\u00e5l?Hur v\u00e5r hj\u00e4rna fattar beslut"},"content":{"rendered":"

Ska jag sporta eller vill jag hellre g\u00e5 till ett kaf\u00e9 och njuta av en god jordgubbsmilkshake?
\nVad som exakt h\u00e4nder i hj\u00e4rnan n\u00e4r vi fattar detta beslut har hittills varit ett mysterium f\u00f6r vetenskapen, men forskare vid ETH Z\u00fcrich har hittat l\u00f6sningen.
\nDe har dechiffrerat vilken hj\u00e4rnsubstans och vilka nervceller som f\u00f6rmedlar detta beslut: neurotransmittorn orexin och de neuroner som producerar den.
\nDessa neurovetenskapliga principer \u00e4r relevanta eftersom m\u00e5nga m\u00e4nniskor inte f\u00e5r tillr\u00e4ckligt med motion.
\nDe flesta av oss har f\u00f6rmodligen n\u00e5gon g\u00e5ng beslutat att hoppa \u00f6ver motionen<\/a> till f\u00f6rm\u00e5n f\u00f6r n\u00e5gon av de m\u00e5nga alternativa frestelserna i det dagliga livet.
\nEnligt V\u00e4rldsh\u00e4lsoorganisationen f\u00e5r 80 procent av ungdomarna och 27 procent av de vuxna inte tillr\u00e4ckligt med motion.
\nOch fetma \u00f6kar i en alarmerande takt, inte bara bland vuxna utan \u00e4ven bland barn och ungdomar. <\/p>\n

Orexin spelar en nyckelroll f\u00f6r om mat f\u00f6redras framf\u00f6r motion<\/h2>\n

Trots denna statistik lyckas m\u00e5nga m\u00e4nniskor motst\u00e5 de st\u00e4ndigt n\u00e4rvarande frestelserna och f\u00e5 tillr\u00e4ckligt med motion.
\nForskare under ledning av Denis Burdakov, professor i neurovetenskap vid ETH Z\u00fcrich, ville veta vad det \u00e4r i v\u00e5r hj\u00e4rna som hj\u00e4lper oss att fatta dessa beslut.
\nI sina experiment med m\u00f6ss kunde forskarna visa att orexin spelar en nyckelroll i denna process.
\nDet \u00e4r en av \u00f6ver hundra neurotransmittorer<\/a> som \u00e4r aktiva i hj\u00e4rnan.
\nAndra signalsubstanser, som serotonin och dopamin, uppt\u00e4cktes f\u00f6r l\u00e4nge sedan och deras roll har i stort sett klarlagts.
\nSituationen \u00e4r annorlunda med orexin: forskarna uppt\u00e4ckte det relativt sent, f\u00f6r cirka 25 \u00e5r sedan, och h\u00e5ller nu gradvis p\u00e5 att klarg\u00f6ra dess funktioner.
\nBurdakov \u00e4r en av de forskare som har forskat om orexin. \"Ung,Glad,Hungrig,Rolig,Gladlynt,Kvinna,Kl\u00e4d,Vit,Kl\u00e4der,Holding\"<\/a>Enligt forskarna \u00e4r dopamin en popul\u00e4r f\u00f6rklaring inom neurovetenskapen till varf\u00f6r vi v\u00e4ljer vissa saker och undviker andra.
\nDenna budb\u00e4rarsubstans i hj\u00e4rnan \u00e4r avg\u00f6rande f\u00f6r v\u00e5r allm\u00e4nna motivation.
\nV\u00e5r nuvarande kunskap om dopamin f\u00f6rklarar dock inte utan<\/a> vidare varf\u00f6r vi v\u00e4ljer att motionera<\/a> i st\u00e4llet f\u00f6r<\/a> att \u00e4ta.<\/a>
\nV\u00e5r hj\u00e4rna fris\u00e4tter dopamin b\u00e5de n\u00e4r vi \u00e4ter och n\u00e4r vi motionerar, men det f\u00f6rklarar inte varf\u00f6r vi v\u00e4ljer det ena framf\u00f6r det andra.
\nF\u00f6r att ta reda p\u00e5 det<\/a> utvecklade forskarna ett sinnrikt beteendeexperiment med m\u00f6ss som fick v\u00e4lja fritt mellan \u00e5tta olika alternativ under tio minuters f\u00f6rs\u00f6k.
\nDessa inkluderade ett hjul som de kunde springa p\u00e5 och en ”milkshakebar” d\u00e4r de kunde njuta av en vanlig milkshake med jordgubbssmak.
\nI sitt experiment j\u00e4mf\u00f6rde forskarna olika grupper av m\u00f6ss: en grupp med normala m\u00f6ss och en grupp d\u00e4r m\u00f6ssens orexinsystem blockerades, antingen med ett l\u00e4kemedel eller genom att genetiskt modifiera deras celler.
\nM\u00f6ssen med ett intakt orexinsystem tillbringade dubbelt s\u00e5 mycket tid p\u00e5 l\u00f6phjulet och h\u00e4lften s\u00e5 mycket tid vid milkshakebaren som de m\u00f6ss vars orexinsystem var blockerat.
\nIntressant nog skilde sig dock inte de tv\u00e5 gruppernas beteende \u00e5t i experiment d\u00e4r forskarna bara erbj\u00f6d m\u00f6ssen antingen l\u00f6phjulet eller milkshaken.
\nDetta inneb\u00e4r att orexinsystemets huvudsakliga roll inte \u00e4r att kontrollera hur mycket m\u00f6ssen tr\u00e4nar eller hur mycket de \u00e4ter, utan snarare, enligt forskarna, verkar det spela en central roll f\u00f6r att best\u00e4mma mellan det ena och det andra n\u00e4r b\u00e5da alternativen finns tillg\u00e4ngliga.
\nUtan orexin var beslutet tydligt till f\u00f6rm\u00e5n f\u00f6r milkshaken, och m\u00f6ssen avstod fr\u00e5n tr\u00e4ning till f\u00f6rm\u00e5n f\u00f6r mat<\/a>. <\/p>\n

Vad detta inneb\u00e4r f\u00f6r m\u00e4nniskan<\/h2>\n

ETH-forskarna antar att orexin ocks\u00e5 kan vara ansvarigt f\u00f6r detta beslut hos m\u00e4nniskor; de hj\u00e4rnfunktioner som \u00e4r inblandade \u00e4r k\u00e4nda f\u00f6r att vara praktiskt taget desamma hos b\u00e5da arterna.
\nEnligt Daria Peleg-Raibstein, gruppledare vid ETH Z\u00fcrich, som ledde studien tillsammans med Denis Burdakov, blir n\u00e4sta steg att verifiera dessa resultat p\u00e5 m\u00e4nniskor.
\nDetta skulle kunna inneb\u00e4ra att man unders\u00f6ker patienter som av genetiska sk\u00e4l har ett begr\u00e4nsat orexinsystem – detta \u00e4r fallet hos cirka en av tv\u00e5tusen personer.
\nDessa personer lider av narkolepsi (en s\u00f6mnst\u00f6rning).<\/a> En annan m\u00f6jlighet skulle vara att observera personer som f\u00e5r ett l\u00e4kemedel som blockerar orexin.
\nS\u00e5dana l\u00e4kemedel \u00e4r godk\u00e4nda f\u00f6r patienter med s\u00f6mnl\u00f6shet.
\nGenom att f\u00f6rst\u00e5 hur hj\u00e4rnan f\u00f6rmedlar sambandet mellan matintag och fysisk aktivitet kan man enligt forskarna utveckla mer effektiva strategier f\u00f6r att bek\u00e4mpa den globala fetmaepidemin<\/a> och tillh\u00f6rande metabola sjukdomar.
\nI synnerhet kan interventioner utvecklas f\u00f6r att hj\u00e4lpa till att \u00f6vervinna hinder f\u00f6r motion hos friska personer och personer med begr\u00e4nsad fysisk aktivitet.
\nBurdakov p\u00e5pekar dock att detta \u00e4r viktiga fr\u00e5gor f\u00f6r forskare som \u00e4r involverade i klinisk forskning p\u00e5 m\u00e4nniskor.
\nHan och hans grupp \u00e4gnar sig \u00e5t grundl\u00e4ggande neurovetenskaplig forskning.
\nH\u00e4rn\u00e4st vill han ta reda p\u00e5 hur orexinneuronerna interagerar med resten av hj\u00e4rnan n\u00e4r de fattar beslut som det mellan tr\u00e4ning och mellanm\u00e5l. <\/p>\n","protected":false},"excerpt":{"rendered":"

Ska jag sporta eller vill jag hellre g\u00e5 till ett kaf\u00e9 och njuta av en god jordgubbsmilkshake? Vad som exakt h\u00e4nder i hj\u00e4rnan n\u00e4r vi fattar detta beslut har hittills varit ett mysterium f\u00f6r vetenskapen, men forskare vid ETH Z\u00fcrich har hittat l\u00f6sningen. De har dechiffrerat vilken hj\u00e4rnsubstans och vilka nervceller som f\u00f6rmedlar detta beslut: […]<\/p>\n","protected":false},"author":11,"featured_media":63432,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","footnotes":""},"categories":[322],"tags":[],"class_list":{"0":"post-63776","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-metabolism-sv","8":"entry"},"acf":[],"yoast_head":"\nSport eller mellanm\u00e5l?Hur v\u00e5r hj\u00e4rna fattar beslut – Chronobiology.com<\/title>\n<meta name=\"description\" content=\"Ska jag sporta eller vill jag hellre g\u00e5 till ett kaf\u00e9 och njuta av en l\u00e4cker jordgubbsmilkshake? 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