{"id":63978,"date":"2024-09-04T04:07:54","date_gmt":"2024-09-04T11:07:54","guid":{"rendered":"https:\/\/www.chronobiology.com\/vedci-testuju-novy-liek-urceny-na-zmiernenie-srdcoveho-zlyhavania-a-spankovej-apnoe\/"},"modified":"2024-09-04T04:07:54","modified_gmt":"2024-09-04T11:07:54","slug":"vedci-testuju-novy-liek-urceny-na-zmiernenie-srdcoveho-zlyhavania-a-spankovej-apnoe","status":"publish","type":"post","link":"https:\/\/dev.chronobiology.com\/sk\/vedci-testuju-novy-liek-urceny-na-zmiernenie-srdcoveho-zlyhavania-a-spankovej-apnoe\/","title":{"rendered":"Vedci testuj\u00fa nov\u00fd liek ur\u010den\u00fd na zmiernenie srdcov\u00e9ho zlyh\u00e1vania a sp\u00e1nkovej apnoe"},"content":{"rendered":"

Zlyhanie srdca<\/a> je be\u017en\u00fd stav.
\nV Eur\u00f3pe trp\u00ed srdcovou nedostato\u010dnos\u0165ou viac ako 10 mili\u00f3nov \u013eud\u00ed.
\nZ r\u00f4znych d\u00f4vodov u\u017e srdce nedok\u00e1\u017ee produkova\u0165 dostato\u010dne vysok\u00fd srdcov\u00fd v\u00fddaj, aby z\u00e1sobovalo telo dostato\u010dn\u00fdm mno\u017estvom kysl\u00edka a umo\u017enilo norm\u00e1lny metabolizmus.
\nM\u00f4\u017ee to by\u0165 sp\u00f4soben\u00e9 zn\u00ed\u017een\u00fdm v\u00fdvrhov\u00fdm v\u00fdkonom (systolick\u00e9 zlyhanie srdca) alebo naru\u0161enou schopnos\u0165ou srdcov\u00e9ho svalu relaxova\u0165 (diastolick\u00e9 zlyhanie srdca).
\nNov\u00fd liek v\u0161ak \u00fadajne s\u013eubne zmier\u0148uje srdcov\u00e9 zlyh\u00e1vanie, ktor\u00e9 je spojen\u00e9 so sp\u00e1nkov\u00fdm apnoe a skr\u00e1ten\u00edm \u017eivota<\/a>. <\/p>\n

Nov\u00fd liek je vraj \u00fa\u010dinn\u00fd pri zlyh\u00e1van\u00ed srdca a sp\u00e1nkovej apnoe<\/h2>\n

Tento liek, zn\u00e1my ako AF-130, bol testovan\u00fd na zvieracom modeli na Waipapa Taumata Rau, University of Auckland, kde vedci zistili, \u017ee zlep\u0161uje schopnos\u0165 srdca pumpova\u0165, ale \u010do je rovnako d\u00f4le\u017eit\u00e9, zabra\u0148uje sp\u00e1nkovej apnoe,<\/a> ktor\u00e1 skracuje \u017eivot.
\n\u013dudia trpiaci sp\u00e1nkov\u00fdm apnoe prest\u00e1vaj\u00fa po\u010das sp\u00e1nku d\u00fdcha\u0165.
\nD\u00fdchacie cesty postihnut\u00fdch s\u00fa nato\u013eko z\u00fa\u017een\u00e9, \u017ee d\u00fdchanie je nielen v\u00fdrazne s\u0165a\u017een\u00e9, ale \u00faplne sa zastav\u00ed.
\nNov\u00fd liek je prospe\u0161n\u00fd nielen pri srdcovom zlyh\u00e1van\u00ed, ale m\u00f4\u017ee zmierni\u0165 aj apnoe, na ktor\u00e9 v s\u00fa\u010dasnosti neexistuje \u017eiadny in\u00fd liek okrem CPAP (d\u00fdchacieho pr\u00edstroja), ktor\u00fd sa zle zn\u00e1\u0161a.
\nKe\u010f \u010dlovek utrp\u00ed srdcov\u00fd infarkt<\/a> a n\u00e1sledn\u00e9 zlyhanie srdca, mozog reaguje aktiv\u00e1ciou sympatick\u00e9ho syst\u00e9mu, reakciou „bojuj alebo utekaj“, aby stimuloval srdce k pumpovaniu krvi.
\nMozog v\u0161ak t\u00fato aktiv\u00e1ciu nervov\u00e9ho syst\u00e9mu udr\u017eiava aj vtedy, ke\u010f u\u017e nie je potrebn\u00e1, \u010do spolu s n\u00e1sledn\u00fdm sp\u00e1nkov\u00fdm apnoe prispieva k skr\u00e1teniu d\u013a\u017eky \u017eivota pacienta.
\nV\u00e4\u010d\u0161ina pacientov zomiera do piatich rokov od diagnostikovania srdcov\u00e9ho zlyhania.
\nT\u00e1to \u0161t\u00fadia odhalila prv\u00fd liek, ktor\u00fd tlm\u00ed nervov\u00fa aktivitu z mozgu do srdca, \u010d\u00edm zvr\u00e1ti postupn\u00fd \u00fapadok srdca pri srdcovom zlyhan\u00ed, vysvet\u013euj\u00fa vedci.
\n\u010cas\u0165 mozgu, ktor\u00e1 vysiela nervov\u00e9 impulzy do srdca, riadi aj d\u00fdchanie, tak\u017ee tento liek pln\u00ed dvojit\u00fa \u00falohu – zni\u017euje reakciu „bojuj alebo utekaj“ a z\u00e1rove\u0148 stimuluje d\u00fdchanie, aby zastavil sp\u00e1nkov\u00e9 apnoe.
\nTieto v\u00fdsledky maj\u00fa re\u00e1lny potenci\u00e1l zlep\u0161i\u0165 pohodu a d\u013a\u017eku \u017eivota \u013eud\u00ed s ochoren\u00edm srdca.
\n\u010eal\u0161\u00edm vzru\u0161uj\u00facim faktorom pre vedcov, ktor\u00ed publikovali svoje v\u00fdsledky v \u010dasopise Nature Communications<\/a>, je, \u017ee liek bude \u010doskoro schv\u00e1len\u00fd \u00daradom pre kontrolu potrav\u00edn a lie\u010div (FDA), aj ke\u010f na in\u00fd zdravotn\u00fd probl\u00e9m, \u010do otv\u00e1ra cestu pre \u0161t\u00fadie na \u013eu\u010foch v priebehu nasleduj\u00faceho roka alebo dvoch. <\/p>\n

\n

Ako s\u00favisia sp\u00e1nkov\u00e9 n\u00e1vyky a zlyhanie srdca<\/h2>\n

Pokojn\u00fd sp\u00e1nok<\/a> zohr\u00e1va d\u00f4le\u017eit\u00fa \u00falohu aj pre srdce.
\nV\u00fdskum toti\u017e ukazuje, \u017ee probl\u00e9my so sp\u00e1nkom<\/a> m\u00f4\u017eu zohr\u00e1va\u0165 \u00falohu pri vzniku srdcov\u00fdch ochoren\u00ed, ale zdrav\u00e9 sp\u00e1nkov\u00e9 n\u00e1vyky s\u00fa spojen\u00e9 s ni\u017e\u0161\u00edm rizikom srdcov\u00e9ho zlyhania.
\nT\u00e1to observa\u010dn\u00e1 \u0161t\u00fadia<\/a> sk\u00famala vz\u0165ah medzi zdrav\u00fdmi sp\u00e1nkov\u00fdmi n\u00e1vykmi a srdcov\u00fdm zlyhan\u00edm a zah\u0155\u0148ala \u00fadaje od 408 802 \u00fa\u010dastn\u00edkov britskej biobanky vo veku 37 a\u017e 73 rokov v \u010dase zaradenia do \u0161t\u00fadie (2006 – 2010).
\nV\u00fdskyt srdcov\u00e9ho zlyhania bol zaznamenan\u00fd do 1. apr\u00edla 2019.
\nV\u00fdskumn\u00edci zaznamenali 5 221 pr\u00edpadov srdcov\u00e9ho zlyhania po\u010das medi\u00e1nu sledovania 10 rokov.
\nV\u00fdskumn\u00edci analyzovali kvalitu sp\u00e1nku, ako aj v\u0161eobecn\u00e9 sp\u00e1nkov\u00e9 vzorce.
\nMerania kvality sp\u00e1nku zah\u0155\u0148ali trvanie sp\u00e1nku, nespavos\u0165<\/a> a chr\u00e1panie a \u010fal\u0161ie charakteristiky s\u00favisiace so sp\u00e1nkom, ako napr\u00edklad: \u010di \u00fa\u010dastn\u00edk bol rann\u00e9 vt\u00e1\u010da alebo no\u010dn\u00e1 sova a \u010di bol po\u010das d\u0148a unaven\u00fd (pravdepodobne ne\u00famyselne k\u00fdval hlavou alebo zaspal po\u010das d\u0148a). <\/div>\n

Zn\u00ed\u017eenie rizika srdcov\u00e9ho zlyhania o 42 percent<\/h3>\n

Sk\u00f3re zdrav\u00e9ho sp\u00e1nku, ktor\u00e9 v\u00fdskumn\u00edci vytvorili, bolo zalo\u017een\u00e9 na hodnoten\u00ed t\u00fdchto piatich sp\u00e1nkov\u00fdch vzorcov.
\nSp\u00e1nkov\u00e9 spr\u00e1vanie sa zaznamen\u00e1valo pomocou dotazn\u00edkov s dotykovou obrazovkou. D\u013a\u017eka sp\u00e1nku<\/a> bola rozdelen\u00e1 do troch skup\u00edn: kr\u00e1tky sp\u00e1nok<\/a> alebo menej ako 7 hod\u00edn denne; 7 a\u017e 8 hod\u00edn denne, 9 hod\u00edn a viac denne.
\nPo zoh\u013eadnen\u00ed cukrovky, vysok\u00e9ho krvn\u00e9ho tlaku, u\u017e\u00edvania liekov, genetick\u00fdch zmien a \u010fal\u0161\u00edch kovari\u00e1t sa u dospel\u00fdch s najzdrav\u0161\u00edm sp\u00e1nkov\u00fdm re\u017eimom (skor\u00e9 vst\u00e1vanie, 7 a\u017e 8 hod\u00edn sp\u00e1nku denne, bez \u010dastej nespavosti, chr\u00e1pania alebo nadmernej dennej ospalosti) zn\u00ed\u017eilo riziko srdcov\u00e9ho zlyhania o 42 % v porovnan\u00ed s dospel\u00fdmi s nezdrav\u00fdm sp\u00e1nkov\u00fdm re\u017eimom.
\nZistilo sa tie\u017e, \u017ee riziko srdcov\u00e9ho zlyhania bolo o 8 % ni\u017e\u0161ie u \u013eud\u00ed, ktor\u00ed skoro vst\u00e1vaj\u00fa, o 12 % ni\u017e\u0161ie u \u013eud\u00ed, ktor\u00ed spali 7 a\u017e 8 hod\u00edn denne; o 17 % ni\u017e\u0161ie u t\u00fdch, ktor\u00ed netrpeli \u010dastou nespavos\u0165ou, a o 34 % ni\u017e\u0161ie u t\u00fdch, ktor\u00ed nepoci\u0165ovali denn\u00fa ospalos\u0165.
\nV\u00fdsledky ukazuj\u00fa, \u017ee sp\u00e1nok a srdcov\u00e9 ochorenia<\/a> spolu s\u00favisia, a zd\u00f4raz\u0148uj\u00fa v\u00fdznam zlep\u0161enia celkov\u00e9ho sp\u00e1nkov\u00e9ho re\u017eimu na prevenciu srdcov\u00e9ho zlyhania. <\/p>\n","protected":false},"excerpt":{"rendered":"

Zlyhanie srdca je be\u017en\u00fd stav. V Eur\u00f3pe trp\u00ed srdcovou nedostato\u010dnos\u0165ou viac ako 10 mili\u00f3nov \u013eud\u00ed. Z r\u00f4znych d\u00f4vodov u\u017e srdce nedok\u00e1\u017ee produkova\u0165 dostato\u010dne vysok\u00fd srdcov\u00fd v\u00fddaj, aby z\u00e1sobovalo telo dostato\u010dn\u00fdm mno\u017estvom kysl\u00edka a umo\u017enilo norm\u00e1lny metabolizmus. M\u00f4\u017ee to by\u0165 sp\u00f4soben\u00e9 zn\u00ed\u017een\u00fdm v\u00fdvrhov\u00fdm v\u00fdkonom (systolick\u00e9 zlyhanie srdca) alebo naru\u0161enou schopnos\u0165ou srdcov\u00e9ho svalu relaxova\u0165 (diastolick\u00e9 zlyhanie srdca). […]<\/p>\n","protected":false},"author":11,"featured_media":63982,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","footnotes":""},"categories":[517,512],"tags":[],"class_list":{"0":"post-63978","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-spanok","8":"category-zdravie-srdca","9":"entry"},"acf":[],"yoast_head":"\nVedci testuj\u00fa nov\u00fd liek ur\u010den\u00fd na zmiernenie srdcov\u00e9ho zlyh\u00e1vania a sp\u00e1nkovej apnoe – Chronobiology.com<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/dev.chronobiology.com\/sk\/vedci-testuju-novy-liek-urceny-na-zmiernenie-srdcoveho-zlyhavania-a-spankovej-apnoe\/\" \/>\n<meta property=\"og:locale\" content=\"sk_SK\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Vedci testuj\u00fa nov\u00fd liek ur\u010den\u00fd na zmiernenie srdcov\u00e9ho zlyh\u00e1vania a sp\u00e1nkovej apnoe\" \/>\n<meta property=\"og:description\" content=\"Zlyhanie srdca je be\u017en\u00fd stav. V Eur\u00f3pe trp\u00ed srdcovou nedostato\u010dnos\u0165ou viac ako 10 mili\u00f3nov \u013eud\u00ed. Z r\u00f4znych d\u00f4vodov u\u017e srdce nedok\u00e1\u017ee produkova\u0165 dostato\u010dne vysok\u00fd srdcov\u00fd v\u00fddaj, aby z\u00e1sobovalo telo dostato\u010dn\u00fdm mno\u017estvom kysl\u00edka a umo\u017enilo norm\u00e1lny metabolizmus. M\u00f4\u017ee to by\u0165 sp\u00f4soben\u00e9 zn\u00ed\u017een\u00fdm v\u00fdvrhov\u00fdm v\u00fdkonom (systolick\u00e9 zlyhanie srdca) alebo naru\u0161enou schopnos\u0165ou srdcov\u00e9ho svalu relaxova\u0165 (diastolick\u00e9 zlyhanie srdca). […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/dev.chronobiology.com\/sk\/vedci-testuju-novy-liek-urceny-na-zmiernenie-srdcoveho-zlyhavania-a-spankovej-apnoe\/\" \/>\n<meta property=\"og:site_name\" content=\"Chronobiology.com\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/chronobiology\" \/>\n<meta property=\"article:published_time\" content=\"2024-09-04T11:07:54+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/dev.chronobiology.com\/wp-content\/uploads\/2023\/04\/Shutterstock_1663310782.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1800\" \/>\n\t<meta property=\"og:image:height\" content=\"679\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Denise Abraham\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@chronobionews\" \/>\n<meta name=\"twitter:site\" content=\"@chronobionews\" \/>\n<meta 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