{"id":63535,"date":"2024-08-23T01:01:27","date_gmt":"2024-08-23T08:01:27","guid":{"rendered":"https:\/\/www.chronobiology.com\/crevna-molekula-spomaluje-spalovanie-tukov-pocas-postu\/"},"modified":"2024-09-04T03:02:24","modified_gmt":"2024-09-04T10:02:24","slug":"crevna-molekula-spomaluje-spalovanie-tukov-pocas-postu","status":"publish","type":"post","link":"https:\/\/dev.chronobiology.com\/sk\/crevna-molekula-spomaluje-spalovanie-tukov-pocas-postu\/","title":{"rendered":"\u010crevn\u00e1 molekula spoma\u013euje spa\u013eovanie tukov po\u010das p\u00f4stu"},"content":{"rendered":"

\u010c\u00edm menej \u010derv druhu Caenorhabditis elegans <\/em>(C. elegans<\/em> ) \u017eerie <\/em>, t\u00fdm pomal\u0161ie str\u00e1ca tuk. Vedci zo Scripps Research teraz zistili, pre\u010do je to tak: mal\u00e1 molekula, ktor\u00fa produkuj\u00fa \u010drev\u00e1 \u010dervov po\u010das hladovania, putuje do mozgu a blokuje sign\u00e1l spa\u013eovania tukov<\/a> po\u010das tohto obdobia.Hoci presn\u00e1 molekula, ktor\u00fa identifikovali u \u010dervov, e\u0161te nebola sk\u00faman\u00e1 u \u013eud\u00ed, nov\u00e1 pr\u00e1ca pom\u00e1ha vedcom lep\u0161ie pochopi\u0165 zlo\u017eit\u00fa interakciu medzi \u010drevom a mozgom. Mohla by tie\u017e objasni\u0165, pre\u010do m\u00e1 p\u00f4st – zdr\u017eanie sa jedla na ur\u010dit\u00fd \u010das – v\u00fdhody, ktor\u00e9 nez\u00e1visia od mno\u017estva prijat\u00fdch kal\u00f3ri\u00ed.
\nNov\u00e1 \u0161t\u00fadia<\/a> bola uverejnen\u00e1 v \u010dasopise Nature Communications <\/em> 11.<\/em> augusta<\/em>2024.<\/p>\n

Vedci pod veden\u00edm Supriya Srinivasan, profesorky neurovedy Scripps Research, PhD, hlavnej autorky novej \u0161t\u00fadie, <\/em>po prv\u00fdkr\u00e1t zistili, \u017ee p\u00f4st pren\u00e1\u0161a do mozgu inform\u00e1cie, ktor\u00e9 presahuj\u00fa r\u00e1mec oby\u010dajnej kalorickej depriv\u00e1cie.<\/em> Tieto zistenia ich ved\u00fa k zamysleniu, \u010di v \u010drev\u00e1ch in\u00fdch \u017eivo\u010d\u00edchov vr\u00e1tane cicavcov vznikaj\u00fa molekuly, ktor\u00e9 vysvet\u013euj\u00fa niektor\u00e9 zdravotn\u00e9 \u00fa\u010dinky spojen\u00e9 s p\u00f4stom.<\/p>\n

Molekula inzul\u00ednu produkovan\u00e1 \u010drevn\u00fdmi bunkami ovplyv\u0148uje metabolizmus tukov prostredn\u00edctvom mozgu<\/h2>\n

Vedci u\u017e dlho vedia, \u017ee mozog riadi produkciu a odb\u00faravanie tukov u \u013eud\u00ed, in\u00fdch cicavcov a modelov\u00fdch organizmov, ako je C. elegans<\/em>. V roku 2017 Srinivasanova skupina identifikovala FLP-7, mozgov\u00fd horm\u00f3n, ktor\u00fd stimuluje spa\u013eovanie tukov v \u010drev\u00e1ch nemat\u00f3dy. C. elegans <\/em>v\u0161ak nemaj\u00fa v \u010drev\u00e1ch<\/a> senzorick\u00e9 nervy, tak\u017ee vedci sa sna\u017eili rozl\u00fa\u0161ti\u0165 opa\u010dn\u00fa komunika\u010dn\u00fa cestu: Ako \u010drev\u00e1 signalizuj\u00fa mozgu? Odborn\u00edci vedeli, \u017ee zmena metabolizmu v \u010dreve m\u00f4\u017ee zmeni\u0165 vlastnosti neur\u00f3nov v mozgu, ale bolo ve\u013emi z\u00e1hadn\u00e9, ako sa to vlastne deje. \"480<\/a>V novej pr\u00e1ci Srinivasanov\u00e1 a jej kolegovia postupne odstr\u00e1nili z \u010driev C. elegans<\/em> viac ako 100 sign\u00e1lnych molek\u00fal a merali ich vplyv na produkciu FLP-7 v mozgu.<\/p>\n

Zistili, \u017ee jedna molekula m\u00e1 z\u00e1sadn\u00fd vplyv na FLP-7: forma inzul\u00ednu zn\u00e1ma ako INS-7. U \u013eud\u00ed je inzul\u00edn zn\u00e1my predov\u0161etk\u00fdm ako horm\u00f3n produkovan\u00fd pankreasom, ktor\u00fd kontroluje hladinu cukru v krvi<\/a>. T\u00e1to molekula inzul\u00ednu v\u0161ak bola namiesto toho produkovan\u00e1 \u010drevn\u00fdmi bunkami mala vplyv aj na metabolizmus tukov prostredn\u00edctvom mozgu. Ke\u010f vedci zistili, \u017ee ide o inzul\u00edn, pova\u017eovali to za paradox. Inzul\u00edn je tak dobre presk\u00faman\u00fd u cicavcov a neexistoval \u017eiadny precedens, \u017ee by inzul\u00ednov\u00e1 molekula zohr\u00e1vala tak\u00fato \u00falohu.<\/p>\n

Ke\u010f v\u0161ak skupina sk\u00famala, ako INS-7 p\u00f4sob\u00ed na mozgov\u00e9 bunky produkuj\u00face FLP-7, zistili, \u017ee neaktivuje inzul\u00ednov\u00e9 receptory – ako v\u0161etky predt\u00fdm objaven\u00e9 molekuly inzul\u00ednu – ale blokuje inzul\u00ednov\u00fd receptor. T\u00e1to blok\u00e1da n\u00e1sledne spustila kask\u00e1du \u010fal\u0161\u00edch molekul\u00e1rnych udalost\u00ed, ktor\u00e9 nakoniec sp\u00f4sobili, \u017ee mozgov\u00e9 bunky prestali produkova\u0165 FLP-7. Pod\u013ea Srinivasana je INS-7 v podstate sign\u00e1l z \u010driev, ktor\u00fd mozgu oznamuje, aby moment\u00e1lne nespa\u013eoval \u010fal\u0161ie tukov\u00e9 z\u00e1soby, preto\u017ee mu nie je dod\u00e1van\u00e1 \u017eiadna potrava.<\/p>\n

Sign\u00e1ly medzi \u010drevom a mozgom riadia metabolizmus<\/h2>\n

\u0160t\u00fadie u\u017e uk\u00e1zali, \u017ee obdobie p\u00f4stu<\/a> m\u00f4\u017ee ovplyvni\u0165 organizmus r\u00f4znymi sp\u00f4sobmi, ale mechanizmy t\u00fdchto zmien boli doteraz nejasn\u00e9. Nov\u00e1 \u0161t\u00fadia poukazuje na jeden zo sp\u00f4sobov, ktor\u00fdm m\u00f4\u017ee pr\u00e1zdne \u010drevo vysiela\u0165 sign\u00e1l do mozgu, \u010do m\u00f4\u017ee vies\u0165 k cel\u00e9mu radu zdravotn\u00fdch \u00fa\u010dinkov, ktor\u00e9 sa net\u00fdkaj\u00fa len tuku. Nov\u00e9 zistenia pod\u013ea Srinivasana pom\u00e1haj\u00fa vysvetli\u0165, ako mozog a tr\u00e1viaci syst\u00e9m komunikuj\u00fa oboma smermi pri riaden\u00ed metabolizmu v reakcii na dostupnos\u0165 potravy. Je potrebn\u00fd \u010fal\u0161\u00ed v\u00fdskum, aby sa ur\u010dilo, ktor\u00e9 konkr\u00e9tne cesty u cicavcov sa podie\u013eaj\u00fa na nov\u00fdch sign\u00e1loch medzi \u010drevom a mozgom.<\/p>\n

Zl\u00fa\u010deniny, ktor\u00e9 napodob\u0148uj\u00fa \u010drevn\u00e9 horm\u00f3ny – ako napr\u00edklad semaglutid, zn\u00e1my pod obchodn\u00fdmi n\u00e1zvami Ozempic, Wegovy a Rybelus – sa ned\u00e1vno osved\u010dili v boji proti obezite a cukrovke<\/a>, tak\u017ee nov\u00e9 \u010drevn\u00e9 peptidy by mohli doplni\u0165 t\u00fato skupinu liekov. Srinivasan tie\u017e pl\u00e1nuje experimenty na presk\u00famanie toho, ako s\u00fa \u010drevn\u00e9 bunky C. elegans <\/em>stimulovan\u00e9 k produkcii INS-7 po\u010das hladovania a ak\u00e9 typy mozgov\u00fdch buniek s\u00fa touto molekulou ovplyvnen\u00e9.<\/p>\n","protected":false},"excerpt":{"rendered":"

\u010c\u00edm menej \u010derv druhu Caenorhabditis elegans (C. elegans ) \u017eerie , t\u00fdm pomal\u0161ie str\u00e1ca tuk. Vedci zo Scripps Research teraz zistili, pre\u010do je to tak: mal\u00e1 molekula, ktor\u00fa produkuj\u00fa \u010drev\u00e1 \u010dervov po\u010das hladovania, putuje do mozgu a blokuje sign\u00e1l spa\u013eovania tukov po\u010das tohto obdobia.Hoci presn\u00e1 molekula, ktor\u00fa identifikovali u \u010dervov, e\u0161te nebola sk\u00faman\u00e1 u \u013eud\u00ed, […]<\/p>\n","protected":false},"author":11,"featured_media":63748,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","footnotes":""},"categories":[513,514],"tags":[],"class_list":{"0":"post-63535","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-crevna-flora","8":"category-metabolizmus","9":"entry"},"acf":[],"yoast_head":"\n\u010crevn\u00e1 molekula spoma\u013euje spa\u013eovanie tukov po\u010das p\u00f4stu – Chronobiology.com<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/dev.chronobiology.com\/sk\/crevna-molekula-spomaluje-spalovanie-tukov-pocas-postu\/\" \/>\n<meta property=\"og:locale\" content=\"sk_SK\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u010crevn\u00e1 molekula spoma\u013euje spa\u013eovanie tukov po\u010das p\u00f4stu\" \/>\n<meta property=\"og:description\" content=\"\u010c\u00edm menej \u010derv druhu Caenorhabditis elegans (C. elegans ) \u017eerie , t\u00fdm pomal\u0161ie str\u00e1ca tuk. Vedci zo Scripps Research teraz zistili, pre\u010do je to tak: mal\u00e1 molekula, ktor\u00fa produkuj\u00fa \u010drev\u00e1 \u010dervov po\u010das hladovania, putuje do mozgu a blokuje sign\u00e1l spa\u013eovania tukov po\u010das tohto obdobia.Hoci presn\u00e1 molekula, ktor\u00fa identifikovali u \u010dervov, e\u0161te nebola sk\u00faman\u00e1 u \u013eud\u00ed, […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/dev.chronobiology.com\/sk\/crevna-molekula-spomaluje-spalovanie-tukov-pocas-postu\/\" \/>\n<meta property=\"og:site_name\" content=\"Chronobiology.com\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/chronobiology\" \/>\n<meta property=\"article:published_time\" content=\"2024-08-23T08:01:27+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-09-04T10:02:24+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/dev.chronobiology.com\/wp-content\/uploads\/2024\/08\/yxc-1.png\" \/>\n\t<meta property=\"og:image:width\" 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