{"id":55887,"date":"2024-03-26T10:27:21","date_gmt":"2024-03-26T17:27:21","guid":{"rendered":"https:\/\/www.chronobiology.com\/melatonin-chronobiologia\/indikacie\/"},"modified":"2024-03-26T10:27:23","modified_gmt":"2024-03-26T17:27:23","slug":"indikacie","status":"publish","type":"page","link":"https:\/\/dev.chronobiology.com\/sk\/melatonin-chronobiologia\/indikacie\/","title":{"rendered":"Indik\u00e1cie"},"content":{"rendered":"

[vc_row full_width=“stretch_row“ el_class=“banner-top“][vc_column][vc_custom_heading source=“post_title“ font_container=“tag:h1|text_align:center“ use_theme_fonts=“yes“][\/vc_column][\/vc_row][vc_row el_class=“melatoninfacts2″][vc_column][vc_column_text]<\/p>\n

Indik\u00e1cie<\/h2>\n

Nov\u00fd v\u00fdskum v oblasti cirkadi\u00e1nnej biol\u00f3gie dok\u00e1zal, \u017ee zdrav\u00fd cirkadi\u00e1nny rytmus, a najm\u00e4 zdrav\u00e1 hladina melaton\u00ednu, m\u00e1 pozit\u00edvny vplyv na zdravie. Za posledn\u00fdch 20 rokov sa v mnoh\u00fdch klinick\u00fdch \u0161t\u00fadi\u00e1ch testovalo a preuk\u00e1zalo terapeutick\u00e9 vyu\u017eitie melaton\u00ednu v r\u00f4znych oblastiach medic\u00edny a to, \u017ee u\u017e\u00edvanie tohto horm\u00f3nu m\u00f4\u017ee by\u0165 \u00fa\u010dinnou lie\u010dbou r\u00f4znych ochoren\u00ed. V bud\u00facnosti sa uskuto\u010dn\u00ed e\u0161te viac v\u00fdskumov o r\u00f4znych mo\u017enostiach vyu\u017eitia melaton\u00ednu, najm\u00e4 v spojen\u00ed s in\u00fdmi tradi\u010dn\u00fdmi lie\u010debn\u00fdmi postupmi, a to bu\u010f na zv\u00fd\u0161enie ich terapeutickej \u00fa\u010dinnosti, alebo na zn\u00ed\u017eenie ich toxicity. Melaton\u00edn sa tak m\u00f4\u017ee pou\u017e\u00edva\u0165 bu\u010f ako \u00fa\u010dinn\u00e1 l\u00e1tka, alebo ako indik\u00e1tor \u010dasu, ktor\u00fd pom\u00e1ha riadi\u0165 cirkadi\u00e1nny rytmus.[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_tta_accordion color=“turquoise“ c_icon=“chevron“ c_position=“right“ active_section=“99″ no_fill=“true“ collapsible_all=“true“][vc_tta_section title=“Tr\u00e1viaci syst\u00e9m“ tab_id=“1479159301199-fd863768-f6af00cc-ae91″][vc_row_inner css=“.vc_custom_1479392036356{background-image: url(https:\/\/www.chronobiology.com\/wp-content\/uploads\/2016\/11\/indications_1.jpg?id=11701) !important;}“][vc_column_inner][vc_column_text]Enterochromaf\u00ednov\u00e9 bunky (neuroendokrinn\u00e9 bunky, ktor\u00e9 sa nach\u00e1dzaj\u00fa v epitelovom tkanive tr\u00e1viaceho traktu) tr\u00e1viaceho syst\u00e9mu produkuj\u00fa 400-kr\u00e1t viac melaton\u00ednu ako epif\u00fdza. V\u00e4\u010d\u0161ina tu vyprodukovan\u00e9ho melaton\u00ednu sa v\u0161ak neuvo\u013e\u0148uje do krvi, ale vyu\u017e\u00edva sa predov\u0161etk\u00fdm priamo na mieste.<\/p>\n

Aj ke\u010f presn\u00e1 funkcia melaton\u00ednu v tr\u00e1viacej s\u00fastave zatia\u013e nie je zn\u00e1ma, horm\u00f3n m\u00e1 v\u010faka svojim antioxida\u010dn\u00fdm vlastnostiam ochrann\u00fa funkciu pred vznikom vredov v sliznici \u017eal\u00fadka. V s\u00fa\u010dasnosti sa e\u0161te st\u00e1le d\u00f4kladne sk\u00fama, \u010di v tom zohr\u00e1vaj\u00fa \u00falohu mechanizmy \u00fa\u010dinku pren\u00e1\u0161an\u00e9 receptormi.<\/p>\n

Gastroezofage\u00e1lna refluxn\u00e1 choroba<\/h3>\n

Mnoh\u00e9 horm\u00f3ny, ktor\u00e9 s\u00favisia s jeden\u00edm a tr\u00e1ven\u00edm, ako napr\u00edklad ghrelin, inzul\u00edn a lept\u00edn, sa pravidelne uvo\u013e\u0148uj\u00fa vo ve\u013emi \u0161pecifickom \u010dase cyklicky po\u010das 24 hod\u00edn. Ak po\u010das dlh\u0161ieho \u010dasov\u00e9ho obdobia nie je k dispoz\u00edcii svetlo, tieto hormon\u00e1lne cykly sa preru\u0161ia. Namiesto cyklick\u00e9ho uvo\u013e\u0148ovania horm\u00f3nov, napr\u00edklad ke\u010f je \u010dlovek hore a mus\u00ed jes\u0165, sa teraz horm\u00f3ny uvo\u013e\u0148uj\u00fa n\u00e1hodne. Ke\u010f\u017ee tieto horm\u00f3ny m\u00f4\u017eu by\u0165 bez pr\u00edtomnosti potravy v tr\u00e1viacom trakte \u0161kodliv\u00e9, preto\u017ee sp\u00f4sobuj\u00fa dodato\u010dn\u00fa produkciu \u017eal\u00fado\u010dnej kyseliny. Z toho mo\u017eno vyvodi\u0165, \u017ee to m\u00f4\u017ee by\u0165 hlavnou pr\u00ed\u010dinou mnoh\u00fdch ochoren\u00ed tr\u00e1viaceho traktu a por\u00fach pr\u00edjmu potravy.<\/p>\n

Nedostato\u010dn\u00e1 hormon\u00e1lna regul\u00e1cia spolu s meniacimi sa cyklami auton\u00f3mnych \u010dinnost\u00ed m\u00f4\u017ee vies\u0165 k poruch\u00e1m tr\u00e1venia. V pr\u00edpade gastroezofage\u00e1lnej refluxnej choroby, pri ktorej sa nespr\u00e1vne zv\u00fd\u0161en\u00e9 mno\u017estvo \u017eal\u00fado\u010dnej kyseliny tla\u010d\u00ed do pa\u017eer\u00e1ka, m\u00f4\u017ee melaton\u00edn skuto\u010dne zn\u00ed\u017ei\u0165 po\u0161kodenie oxidovanej DNA sliznice. Okrem toho m\u00f4\u017ee horm\u00f3n sl\u00fa\u017ei\u0165 ako ochrana \u017eal\u00fado\u010dnej sliznice pred zdraviu \u0161kodliv\u00fdmi l\u00e1tkami, ako s\u00fa salicyl\u00e1ty (nach\u00e1dzaj\u00face sa v potravin\u00e1ch a liekoch proti bolesti) a\/alebo vrtu\u013en\u00edkov\u00e9 bakt\u00e9rie.<\/p>\n

Syndr\u00f3m dr\u00e1\u017ediv\u00e9ho \u010dreva<\/h3>\n

Syndr\u00f3m dr\u00e1\u017ediv\u00e9ho \u010dreva (IBS) je charakterizovan\u00fd nevysvetlite\u013enou boles\u0165ou \u017eal\u00fadka, plynatos\u0165ou spojenou so zmenami v pohybe \u010driev, ako je z\u00e1pcha alebo hna\u010dka, ako aj celkov\u00fdm nepohodl\u00edm. V tomto pr\u00edpade m\u00f4\u017ee melaton\u00edn pom\u00f4c\u0165 prostredn\u00edctvom regul\u00e1cie motility a citlivosti tr\u00e1viaceho traktu. R\u00f4zne \u0161t\u00fadie preuk\u00e1zali, \u017ee melaton\u00edn m\u00e1 pozit\u00edvny \u00fa\u010dinok pri lie\u010dbe syndr\u00f3mu dr\u00e1\u017ediv\u00e9ho \u010dreva okrem in\u00e9ho t\u00fdm, \u017ee zni\u017euje bolesti \u017eal\u00fadka a kone\u010dn\u00edka a zni\u017euje s\u00favisiace poruchy sp\u00e1nku. Okrem toho nov\u00e9 \u0161t\u00fadie preuk\u00e1zali, \u017ee tento horm\u00f3n by mohol zohr\u00e1va\u0165 d\u00f4le\u017eit\u00fa \u00falohu aj pri zdrav\u00ed \u010drevnej fl\u00f3ry a jej cirkadi\u00e1nnom rytme. Tr\u00e1viace bakt\u00e9rie maj\u00fa svoj vlastn\u00fd cirkadi\u00e1nny rytmus, ktor\u00fd ovplyv\u0148uje aj na\u0161u funk\u010dnos\u0165. \u010coraz viac \u0161t\u00fadi\u00ed poukazuje na to, \u017ee tieto mikr\u00f3by s\u00fa pre \u013eudsk\u00e9 zdravie mimoriadne d\u00f4le\u017eit\u00e9 a \u017ee aj mal\u00e1 nerovnov\u00e1ha m\u00f4\u017ee sp\u00f4sobi\u0165 poruchu. Pr\u00e1ve tento rytmus tr\u00e1viacich bakt\u00e9ri\u00ed je synchronizovan\u00fd s cirkadi\u00e1nnymi procesmi n\u00e1\u0161ho tela pomocou melaton\u00ednu.<\/p>\n

Z\u00e1palov\u00e9 ochorenia \u010driev<\/h3>\n

Patr\u00ed sem mno\u017estvo chronick\u00fdch z\u00e1palov\u00fdch ochoren\u00ed, ako je ulcer\u00f3zna kolit\u00edda (chronick\u00fd z\u00e1pal hrub\u00e9ho \u010dreva) a Crohnova choroba. R\u00f4zne \u0161t\u00fadie preuk\u00e1zali, \u017ee melaton\u00edn je d\u00f4le\u017eit\u00fdm regul\u00e1torom z\u00e1palu, ako aj pohyblivosti tr\u00e1viaceho traktu, \u010do poukazuje na skuto\u010dnos\u0165, \u017ee doplnkov\u00fd melaton\u00edn m\u00f4\u017ee ma\u0165 pozit\u00edvny vplyv na z\u00e1pal hrub\u00e9ho \u010dreva.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_tta_section][\/vc_tta_accordion][vc_tta_accordion color=“turquoise“ c_icon=“chevron“ c_position=“right“ active_section=“99″ no_fill=“true“ collapsible_all=“true“][vc_tta_section title=“Kardiovaskul\u00e1rne ochorenia“ tab_id=“1481054223339-720930fd-7ae7″][vc_row_inner css=“.vc_custom_1479392221643{background-image: url(https:\/\/www.chronobiology.com\/wp-content\/uploads\/2016\/11\/indications_2.jpg?id=11702) !important;}“][vc_column_inner][vc_column_text]V\u010faka svojmu antioxida\u010dn\u00e9mu \u00fa\u010dinku proti \u0161kodliv\u00fdm cholesterolov\u00fdm usadenin\u00e1m m\u00f4\u017ee melaton\u00edn chr\u00e1ni\u0165 srdce aj cievy. Tento horm\u00f3n zni\u017euje ostatn\u00e9 stresov\u00e9 horm\u00f3ny, zni\u017euje krvn\u00fd tlak a dosahuje pozit\u00edvny vplyv na kardiovaskul\u00e1rny syst\u00e9m. Melaton\u00edn m\u00f4\u017ee by\u0165 u\u017eito\u010dn\u00fd pri zni\u017eovan\u00ed hypertrofie srdca a zni\u017eovan\u00ed frekvencie srdcov\u00fdch infarktov. Horm\u00f3n p\u00f4sob\u00ed aj ako odporca vo\u013en\u00fdch radik\u00e1lov, ktor\u00e9 nap\u00e1daj\u00fa srdcov\u00fd sval. Ke\u010f\u017ee melaton\u00edn m\u00e1 protiz\u00e1palov\u00e9 vlastnosti, m\u00f4\u017ee sa \u00fa\u010dinne vyu\u017e\u00edva\u0165 aj pri lie\u010dbe arterioskler\u00f3zy. Viacer\u00e9 \u0161t\u00fadie invitro uk\u00e1zali, \u017ee melaton\u00edn \u00fa\u010dinne inhibuje oxid\u00e1ciu LDL, ktor\u00e1 je jednou z hlavn\u00fdch pr\u00ed\u010din vzniku arterioskler\u00f3zy.<\/p>\n

Vysok\u00fd krvn\u00fd tlak<\/h3>\n

Vysok\u00fd krvn\u00fd tlak patr\u00ed k ochoreniam roz\u0161\u00edren\u00fdm v z\u00e1padn\u00fdch priemyseln\u00fdch krajin\u00e1ch. Pri hypertenzii sa zvy\u0161uje tlak v cievach, aby sa zabezpe\u010dilo, \u017ee cez obmedzen\u00e9 cievy m\u00f4\u017ee st\u00e1le pr\u00fadi\u0165 dostato\u010dn\u00e9 mno\u017estvo krvi. Tento vysok\u00fd tlak v\u0161ak podporuje v\u00e4\u010d\u0161ie obmedzenie ciev a\/alebo rozpad existuj\u00facich krvn\u00fdch zrazen\u00edn, \u010do m\u00f4\u017ee vies\u0165 k m\u0155tvici, infarktu a in\u00fdm ochoreniam ciev. Melaton\u00edn sa uk\u00e1zal ako u\u017eito\u010dn\u00fd pri regul\u00e1cii krvn\u00e9ho tlaku. \u0160t\u00fadiami sa podarilo dok\u00e1za\u0165, \u017ee peror\u00e1lne u\u017e\u00edvanie melaton\u00ednu m\u00f4\u017ee zn\u00ed\u017ei\u0165 vysok\u00fd krvn\u00fd tlak, ako aj reaktivitu ciev. Je to d\u00f4sledok toho, \u017ee melaton\u00edn m\u00e1 uvo\u013e\u0148uj\u00faci \u00fa\u010dinok na cievy a p\u00f4sob\u00ed ako siln\u00fd lapa\u010d radik\u00e1lov, ke\u010f\u017ee vo\u013en\u00e9 radik\u00e1ly maj\u00fa negat\u00edvny vplyv na krvn\u00fd tlak. Napriek tomu presn\u00e9 mechanizmy p\u00f4sobenia melaton\u00ednu v s\u00favislosti s krvn\u00fdm tlakom dodnes nie s\u00fa zn\u00e1me.<\/p>\n

Infarkt a m\u0155tvica<\/h3>\n

Infarkt aj mozgov\u00e1 pr\u00edhoda sa t\u00fdkaj\u00fa ak\u00fatneho uz\u00e1veru cievy, tak\u017ee tkaniv\u00e1, ktor\u00e9 s\u00fa z\u00e1sobovan\u00e9 touto cievou, nemaj\u00fa dostatok kysl\u00edka a s\u00fa po\u0161koden\u00e9. Hlavn\u00fdm cie\u013eom lie\u010dby je \u010do najr\u00fdchlej\u0161ie obnovi\u0165 z\u00e1sobovanie krvou a kysl\u00edkom. Len \u010do sa obnov\u00ed \u017eivotodarn\u00fd pr\u00edsun kysl\u00edka, u\u017e po\u0161koden\u00e9 tkanivo je n\u00e1chyln\u00e9 na \u010fal\u0161ie oxida\u010dn\u00e9 po\u0161kodenie v d\u00f4sledku pr\u00edlevu kysl\u00edka, ktor\u00fd prich\u00e1dza. Presnej\u0161ie povedan\u00e9, tieto sekund\u00e1rne po\u0161kodenia mo\u017eno zn\u00ed\u017ei\u0165 alebo im dokonca \u00faplne zabr\u00e1ni\u0165 s\u00fa\u010dasn\u00fdm pod\u00e1van\u00edm vy\u0161\u0161ej d\u00e1vky melaton\u00ednu. Predbe\u017en\u00e9 \u0161t\u00fadie dokazuj\u00fa, \u017ee melaton\u00edn m\u00f4\u017ee v t\u00fdchto situ\u00e1ci\u00e1ch v\u00fdrazne zn\u00ed\u017ei\u0165 rozsah po\u0161kodenia buniek.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_tta_section][\/vc_tta_accordion][vc_tta_accordion color=“turquoise“ c_icon=“chevron“ c_position=“right“ active_section=“99″ no_fill=“true“ collapsible_all=“true“][vc_tta_section title=“Diabetes“ tab_id=“1481054247663-4337e241-bd12″][vc_row_inner css=“.vc_custom_1479392377806{background-image: url(https:\/\/www.chronobiology.com\/wp-content\/uploads\/2016\/11\/indications_3.jpg?id=11703) !important;}“][vc_column_inner][vc_column_text]Cukrovka je roz\u0161\u00edren\u00e9 ochorenie, ktor\u00e9 sa t\u00fdka najm\u00e4 star\u0161\u00edch \u013eud\u00ed. Vedci predpokladaj\u00fa, \u017ee mut\u00e1cia v g\u00e9ne pre melaton\u00ednov\u00fd receptor MT2 nar\u00fa\u0161a spojenie medzi vn\u00fatorn\u00fdmi hodinami a uvo\u013e\u0148ovan\u00edm inzul\u00ednu. To m\u00f4\u017ee vies\u0165 k abnorm\u00e1lnym hodnot\u00e1m cukru v krvi a nakoniec k cukrovke. Pribli\u017ene tretina \u013eud\u00ed m\u00e1 trochu zmenen\u00fa verziu tohto melaton\u00ednov\u00e9ho receptora, ktor\u00fd sa nach\u00e1dza na bunkov\u00fdch membr\u00e1nach beta buniek v pankrease. Beta bunky v pankrease s\u00fa zodpovedn\u00e9 za uvo\u013e\u0148ovanie inzul\u00ednu. Ak sa melaton\u00edn navia\u017ee na receptory t\u00fdchto buniek, uvo\u013e\u0148ovanie sa spomal\u00ed. Mierne mutovan\u00e1 verzia beta buniek v\u0161ak reaguje na melaton\u00edn zv\u00fd\u0161en\u00edm po\u010dtu receptorov. T\u00fdm sa zosiln\u00ed \u00fa\u010dinok, ktor\u00fd melaton\u00edn na bunky m\u00e1, \u010do sp\u00f4sobuje hypoglyk\u00e9miu a \u010fal\u0161ie prediabetick\u00e9 stavy. Ke\u010f \u013eudia s touto g\u00e9novou vari\u00e1ciou pracuj\u00fa a jedia v noci, ke\u010f je ich hladina melaton\u00ednu vysok\u00e1, potom maj\u00fa vy\u0161\u0161iu hladinu cukru v krvi, ktor\u00e1 zvy\u0161uje riziko vzniku cukrovky a in\u00fdch endokrinn\u00fdch ochoren\u00ed.<\/p>\n

R\u00f4zne \u0161t\u00fadie uk\u00e1zali, \u017ee melaton\u00edn m\u00f4\u017ee ovplyv\u0148ova\u0165 vylu\u010dovanie inzul\u00ednu a homeost\u00e1zu gluk\u00f3zy. Pokusy na bunk\u00e1ch viedli k zisteniu, \u017ee horm\u00f3n potl\u00e1\u010da uvo\u013e\u0148ovanie inzul\u00ednu v beta bunk\u00e1ch pankreasu. Potkany, ktor\u00e9 mali sklon k cukrovke 2. typu, boli u\u017e\u00edvan\u00edm melaton\u00ednu chr\u00e1nen\u00e9 pred hyperlipid\u00e9miou a hyperglyk\u00e9miou. U my\u0161\u00ed do\u0161lo k zlep\u0161eniu inzul\u00ednovej rezistencie, ako aj metabolizmu gluk\u00f3zy. V n\u00e1hodnej dvojito zaslepenej \u0161t\u00fadii s 22 \u017eenami po menopauze sa zistilo, \u017ee melaton\u00edn zlep\u0161uje toleranciu gluk\u00f3zy a citlivos\u0165 na inzul\u00edn u star\u0161\u00edch \u017eien. V inej \u0161t\u00fadii sa zistilo, \u017ee melaton\u00edn je \u00fa\u010dinn\u00fd antioxidant na zlep\u0161enie \u00fa\u010dinnosti peror\u00e1lnych antidiabet\u00edk. Ak si uvedom\u00edme, \u017ee no\u010dn\u00e1 hladina melaton\u00ednu je u star\u0161\u00edch \u013eud\u00ed obzvl\u00e1\u0161\u0165 n\u00edzka, potom je jasn\u00e9, pre\u010do pr\u00e1ve t\u00e1to skupina \u013eud\u00ed m\u00e1 zv\u00fd\u0161en\u00e9 riziko cukrovky, preto\u017ee melaton\u00edn u\u017e nie je schopn\u00fd spr\u00e1vne riadi\u0165 no\u010dn\u00e9 uvo\u013e\u0148ovanie inzul\u00ednu.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_tta_section][\/vc_tta_accordion][vc_tta_accordion color=“turquoise“ c_icon=“chevron“ c_position=“right“ active_section=“99″ no_fill=“true“ collapsible_all=“true“][vc_tta_section title=“Fibromyalgia“ tab_id=“1481321243325-21232dbc-d1b5″][vc_row_inner css=“.vc_custom_1479392377806{background-image: url(https:\/\/www.chronobiology.com\/wp-content\/uploads\/2016\/11\/indications_3.jpg?id=11703) !important;}“][vc_column_inner][vc_column_text]Fibromyalgia je chronick\u00e9 bolestiv\u00e9 ochorenie a postihuje pribli\u017ene \u0161tyri percent\u00e1 popul\u00e1cie. Nov\u00e1 \u0161t\u00fadia zistila, \u017ee k tomuto ochoreniu m\u00f4\u017ee prispieva\u0165 n\u00edzka hladina melaton\u00ednu.<\/p>\n

Slovo „fibromyalgia“ poch\u00e1dza z troch r\u00f4znych slov: latinsk\u00e9ho slova „fibra“, \u010do znamen\u00e1 vl\u00e1knit\u00e9 tkanivo, gr\u00e9ckych slov „myos“, \u010do znamen\u00e1 sval, a „algos“, \u010do znamen\u00e1 boles\u0165. V skuto\u010dnosti s\u00fa hlavn\u00fdmi pr\u00edznakmi tohto ochorenia bolesti svalov, \u0161liach a v\u00e4zov. Boles\u0165 svalov v\u0161ak nie je jedin\u00fdm pr\u00edznakom. U \u013eud\u00ed postihnut\u00fdch t\u00fdmto ochoren\u00edm sa \u010dasto vyskytuj\u00fa aj zmeny, ktor\u00e9 sp\u00f4sobuj\u00fa, \u017ee nervov\u00fd syst\u00e9m na\u010falej pren\u00e1\u0161a a spracov\u00e1va boles\u0165, aj ke\u010f podnety nie s\u00fa pr\u00edtomn\u00e9. Medzi \u010fal\u0161ie pr\u00edznaky patr\u00ed \u00fanava, depresia a nespavos\u0165.<\/p>\n

Existuje viacero \u0161t\u00fadi\u00ed regraduj\u00facich melaton\u00edn a boles\u0165. Melaton\u00edn je nielen horm\u00f3n, ktor\u00fd pom\u00e1ha riadi\u0165 n\u00e1\u0161 vroden\u00fd cirkadi\u00e1nny rytmus alebo biologick\u00e9 24-hodinov\u00e9 hodiny, ale sl\u00fa\u017ei aj ako regul\u00e1tor bolesti. Horm\u00f3n p\u00f4sob\u00ed nepriamo na opioidn\u00e9 receptory, \u010do s\u00fa tie ist\u00e9 receptory, na ktor\u00e9 sa zameriavaj\u00fa lieky proti bolesti. Hoci sa dlho predpokladalo, \u017ee nespavos\u0165 a \u00fanavu spojen\u00fa s ochoren\u00edm mo\u017eno prip\u00edsa\u0165 neust\u00e1lemu pre\u017e\u00edvaniu bolesti, v s\u00fa\u010dasnosti sa predpoklad\u00e1, \u017ee nedostatok melaton\u00ednu k tomu prispieva aj nasleduj\u00facimi dvoma sp\u00f4sobmi: Jeho vplyv na cirkadi\u00e1nny rytmus, napr\u00edklad na sp\u00e1nkov\u00e9 spr\u00e1vanie, a jeho vplyv na boles\u0165 prostredn\u00edctvom opioidn\u00fdch receptorov. Ned\u00e1vno uskuto\u010dnen\u00e1 skupina experimentov toti\u017e zistila, \u017ee u\u017e\u00edvanie doplnkov melaton\u00ednu m\u00f4\u017ee v\u00fdrazne zlep\u0161i\u0165 viacer\u00e9 pr\u00edznaky FMS.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_tta_section][\/vc_tta_accordion][vc_tta_accordion color=“turquoise“ c_icon=“chevron“ c_position=“right“ active_section=“99″ no_fill=“true“ collapsible_all=“true“][vc_tta_section title=“Neuropsychiatrick\u00e9 poruchy“ tab_id=“1481054287060-61d9c82c-ade3″][vc_row_inner css=“.vc_custom_1479392649001{background-image: url(https:\/\/www.chronobiology.com\/wp-content\/uploads\/2016\/11\/indications_4.jpg?id=11704) !important;}“][vc_column_inner][vc_column_text]<\/p>\n

Alzheimerova choroba<\/h3>\n

Alzheimerova choroba je progres\u00edvne neurodegenerat\u00edvne ochorenie, ktor\u00e9 sp\u00f4sobuje stratu pam\u00e4ti a zmeny myslenia a spr\u00e1vania, ktor\u00e9 sa \u010dasom zhor\u0161uj\u00fa. Pacienti s Alzheimerovou chorobou maj\u00fa v porovnan\u00ed s kontroln\u00fdmi skupinami ove\u013ea ni\u017e\u0161ie hladiny melaton\u00ednu, \u010do vedie k predpokladu, \u017ee tento horm\u00f3n by mohol zohr\u00e1va\u0165 pozit\u00edvnu \u00falohu pri lie\u010dbe tohto ochorenia.<\/p>\n

Nieko\u013eko klinick\u00fdch \u0161t\u00fadi\u00ed sa zameralo na u\u017e\u00edvanie melaton\u00ednu a na to, ako sa prostredn\u00edctvom neho daj\u00fa zmierni\u0165 viacer\u00e9 pr\u00edznaky Alzheimerovej choroby vr\u00e1tane por\u00fach sp\u00e1nku a kognit\u00edvnych por\u00fach. SCN (suprachiasmaticus nucleus), z\u00e1kladn\u00e1 oblas\u0165 v hypotalame, ur\u010duje cirkadi\u00e1nny rytmus najm\u00e4 prostredn\u00edctvom stimul\u00e1cie produkcie melaton\u00ednu a prostredn\u00edctvom melaton\u00ednu je aj protiregulovan\u00e1. Ak SCN u pacientov s Alzheimerovou chorobou reaguje na svetlo len neochotne, m\u00f4\u017ee by\u0165 u\u017eito\u010dn\u00e9 priame pod\u00e1vanie doplnkov melaton\u00ednu. V \u0161t\u00fadii uskuto\u010dnenej v roku 2012 sa melaton\u00edn pou\u017e\u00edval v s\u00favislosti s fyzick\u00fdm pohybom. T\u00e1to lie\u010dba zn\u00ed\u017eila kognit\u00edvne po\u0161kodenia a oxida\u010dn\u00fd stres v mozgu, \u010do s\u00fa faktory, ktor\u00e9 prispievaj\u00fa k Alzheimerovej chorobe.<\/p>\n

\u010eal\u0161ia terapia, ktor\u00e1 kombinuje jasn\u00e9 svetlo r\u00e1no s peror\u00e1lnym pod\u00e1van\u00edm melaton\u00ednu ve\u010der, sa ukazuje ako prospe\u0161n\u00e1 pre zlep\u0161enie \u010dasu bdenia a aktivity pacientov s Alzheimerovou chorobou, ktor\u00ed s\u00fa umiestnen\u00ed v zdravotn\u00edckych zariadeniach. Viacer\u00ed v\u00fdskumn\u00edci tie\u017e uviedli, \u017ee hudobn\u00e1 terapia zvy\u0161uje vylu\u010dovanie melaton\u00ednu, \u010do je tie\u017e terapia pou\u017e\u00edvan\u00e1 u pacientov s Alzheimerovou chorobou.<\/p>\n

Parkinsonova choroba<\/h3>\n

Parkinsonova choroba je roz\u0161\u00edren\u00e9 neurodegenerat\u00edvne ochorenie, ktor\u00e9 sa ned\u00e1 lie\u010di\u0165. Parkinsonovu chorobu sp\u00f4sobuje degener\u00e1cia ur\u010dit\u00fdch neur\u00f3nov v mozgu, ktor\u00e9 str\u00e1caj\u00fa schopnos\u0165 produkova\u0165 dopam\u00edn, neurotransmiter, ktor\u00fd podporuje kognit\u00edvne funkcie, kontrolu em\u00f3ci\u00ed, koordin\u00e1ciu pohybov a mno\u017estvo \u010fal\u0161\u00edch d\u00f4le\u017eit\u00fdch funkci\u00ed. Pr\u00edznaky sa za\u010d\u00ednaj\u00fa pomaly, roky predt\u00fdm, ako sa prejavia motorick\u00e9 pr\u00edznaky, ktor\u00e9 ved\u00fa k diagn\u00f3ze, a zvy\u010dajne zah\u0155\u0148aj\u00fa probl\u00e9my so sp\u00e1nkom a stratu \u010duchu (anosmiu). Hoci Parkinsonova choroba s\u00favis\u00ed najm\u00e4 s blok\u00e1dou dopam\u00ednu mozgu, zd\u00e1 sa, \u017ee \u00falohu zohr\u00e1va aj melaton\u00edn. To by mohlo vysvet\u013eova\u0165, pre\u010do poruchy sp\u00e1nku id\u00fa ruka v ruke s t\u00fdmto ochoren\u00edm. V priebehu progresie Parkinsonovej choroby kles\u00e1 po\u010det melaton\u00ednov\u00fdch receptorov v mozgu. V\u010dasn\u00e9 pod\u00e1vanie melaton\u00ednu m\u00f4\u017ee osob\u00e1m trpiacim Parkinsonovou chorobou pom\u00f4c\u0165 dobre spa\u0165 a tie\u017e chr\u00e1ni\u0165 ich mozog pred \u010fal\u0161\u00edmi degenerat\u00edvnymi zmenami. Po\u010detn\u00e9 \u0161t\u00fadie nazna\u010duj\u00fa, \u017ee stabiliz\u00e1cia sp\u00e1nkov\u00fdch cyklov prostredn\u00edctvom po\u017eitia melaton\u00ednu by mala by\u0165 \u0161tandardnou s\u00fa\u010das\u0165ou lie\u010dby tohto ochorenia.<\/p>\n

\u013dudia s Parkinsonovou chorobou, ktor\u00ed u\u017e\u00edvaj\u00fa melaton\u00edn, vykazuj\u00fa menej a slab\u0161ie pr\u00edznaky ako t\u00ed, ktor\u00ed ho neu\u017e\u00edvaj\u00fa. Dlho sa to pripisovalo lie\u010divej povahe dostato\u010dn\u00e9ho sp\u00e1nku, ale dnes u\u017e vieme, \u017ee melaton\u00edn nie je len horm\u00f3nom navodzuj\u00facim sp\u00e1nok, ale aj neuroprotekt\u00edvnou l\u00e1tkou, ktor\u00e1 dok\u00e1\u017ee zastavi\u0165 alebo zn\u00ed\u017ei\u0165 po\u0161kodenie, ako aj podpori\u0165 regener\u00e1ciu nervov\u00fdch buniek v mozgu a kostnej dreni. Hoci sa to intenz\u00edvne nesk\u00fama, predpoklad\u00e1 sa, \u017ee neuroprotekt\u00edvne vlastnosti melaton\u00ednu m\u00f4\u017eu spomali\u0165 postup Parkinsonovej choroby, najm\u00e4 prostredn\u00edctvom spomalenia neurologick\u00fdch po\u0161koden\u00ed, ktor\u00e9 sp\u00f4sobuj\u00fa postupn\u00fa stratu nervovosvalov\u00fdch funkci\u00ed.<\/p>\n

Epilepsia<\/h3>\n

Epilepsia je porucha elektricky veden\u00fdch nervov\u00fdch buniek v mozgu, ktor\u00e1 sp\u00f4sobuje postihnut\u00fdm \u013eu\u010fom z\u00e1chvaty a\/alebo do\u010dasn\u00fa stratu vedomia. In\u00e9 formy epilepsie a z\u00e1chvatov s\u00fa sp\u00f4soben\u00e9 oxida\u010dn\u00fdm stresom a vo\u013en\u00fdmi radik\u00e1lmi. Nov\u00e1 \u0161t\u00fadia zistila, \u017ee existuje s\u00favislos\u0165 medzi poruchami sp\u00e1nku a epilepsiou, \u010do op\u00e4\u0165 poukazuje na skuto\u010dnos\u0165, \u017ee cirkadi\u00e1nny rytmus m\u00e1 vplyv na v\u00fdskyt z\u00e1chvatov. U\u017e pred rokmi vedci zistili, \u017ee tieto z\u00e1chvaty sa \u010dasto riadia 24-hodinov\u00fdm rytmom. To znamen\u00e1, \u017ee sa vyskytuj\u00fa ka\u017ed\u00fd de\u0148 pribli\u017ene v rovnakom \u010dase. Vedci sa domnievaj\u00fa, \u017ee to mo\u017eno \u010diasto\u010dne prip\u00edsa\u0165 cirkadi\u00e1nnemu rytmu n\u00e1\u0161ho mozgu.<\/p>\n

R\u00f4zne \u0161t\u00fadie medzi de\u0165mi uk\u00e1zali, \u017ee pod\u00e1vanie melaton\u00ednu dok\u00e1zalo zn\u00ed\u017ei\u0165 z\u00e1va\u017enos\u0165 epileptick\u00fdch z\u00e1chvatov. V\u010faka svojim antioxida\u010dn\u00fdm vlastnostiam v centr\u00e1lnom nervovom syst\u00e9me dok\u00e1\u017ee tento horm\u00f3n p\u00f4sobi\u0165 ako neuroprotektor proti oxida\u010dn\u00e9mu stresu, ktor\u00fd sa prejavuje u pacientov s epilepsiou. Okrem toho sa podarilo zdokumentova\u0165 \u0161pecifick\u00e9 melaton\u00ednov\u00e9 receptory v mozgovej k\u00f4re a to, \u017ee stimul\u00e1cia t\u00fdchto receptorov melaton\u00ednom potl\u00e1\u010da za\u010diatok z\u00e1chvatov. Takto sa zd\u00e1, \u017ee melaton\u00edn m\u00e1 pozit\u00edvny vplyv prostredn\u00edctvom r\u00f4znych mechanizmov \u00fa\u010dinku na mno\u017estvo r\u00f4znych typov epilepsie<\/p>\n

Porucha pozornosti\/hyperaktivita<\/h3>\n

Poruchy sp\u00e1nku s\u00fa ve\u013emi \u010dast\u00e9 u det\u00ed, ktor\u00e9 trpia poruchou pozornosti\/hyperaktivitou (ADHD). Aktu\u00e1lna \u0161t\u00fadia sk\u00fama dlhodob\u00fa konzum\u00e1ciu melaton\u00ednu a jeho \u00fa\u010dinnos\u0165 pri pomoci de\u0165om s ADHD. Pod\u013ea vyjadren\u00ed rodi\u010dov sa u 88 % lie\u010den\u00fdch det\u00ed prejavilo zlep\u0161enie por\u00fach sp\u00e1nku. Okrem toho 71 percent uviedlo zlep\u0161enie spr\u00e1vania a 61 percent uviedlo zlep\u0161enie n\u00e1lady.<\/p>\n

Schizofr\u00e9nia<\/h3>\n

Schizofr\u00e9nia je \u010fal\u0161ou neuro-psychiatrickou poruchou, pri ktorej sa zistilo, \u017ee ju sprev\u00e1dzaj\u00fa naru\u0161en\u00e9 cirkadi\u00e1nne rytmy a klesaj\u00faca hladina melaton\u00ednu. Vzh\u013eadom na tieto anom\u00e1lie sa predpoklad\u00e1, \u017ee melaton\u00edn by mohol pom\u00f4c\u0165 pri lie\u010dbe tohto ochorenia. Zistilo sa tie\u017e, \u017ee horm\u00f3n zvy\u0161uje \u00fa\u010dinnos\u0165 antipsychotick\u00fdch liekov a m\u00f4\u017ee zn\u00ed\u017ei\u0165 ich ved\u013eaj\u0161ie \u00fa\u010dinky. V \u0161t\u00fadii s pacientmi trpiacimi schizofr\u00e9niou sa melaton\u00edn pou\u017e\u00edval v kombin\u00e1cii s popul\u00e1rnym antipsychotikom. In\u00e1 skupina pacientov, ktor\u00e1 sa z\u00fa\u010dastnila na tej istej \u0161t\u00fadii, tie\u017e dost\u00e1vala toto antipsychotikum, ale namiesto melaton\u00ednu dost\u00e1vala len sprievodn\u00e9 placebo. U \u00fa\u010dastn\u00edkov, ktor\u00ed dost\u00e1vali melaton\u00edn, sa prejavilo menej ved\u013eaj\u0161\u00edch \u00fa\u010dinkov, ako napr\u00edklad priberanie na v\u00e1he, ako aj ni\u017e\u0161ia hodnota PANSS, ktor\u00e1 meria z\u00e1va\u017enos\u0165 schizofrenick\u00fdch pr\u00edznakov.<\/p>\n

Depresia<\/h3>\n

Depresia je ochorenie, ktor\u00e9 treba bra\u0165 v\u00e1\u017ene a ktor\u00e9 sprev\u00e1dzaj\u00fa pr\u00edznaky ako nedostatok energie, bezn\u00e1dej, negat\u00edvne my\u0161lienky, poruchy sp\u00e1nku a v najhor\u0161\u00edch pr\u00edpadoch my\u0161lienky na samovra\u017edu. Medzi fyzick\u00e9 pr\u00edznaky patr\u00ed denn\u00e1 ospalos\u0165, nespavos\u0165, bolesti svalov, gastrointestin\u00e1lne \u0165a\u017ekosti, bolesti hlavy a in\u00e9 ne\u0161pecifick\u00e9 zmyslov\u00e9 poruchy. U \u013eud\u00ed trpiacich depresiou sa takmer v\u017edy prejavuje funk\u010dn\u00e1 porucha seroton\u00ednov\u00e9ho syst\u00e9mu. Seroton\u00edn je jedn\u00fdm z najd\u00f4le\u017eitej\u0161\u00edch neurotransmiterov\/posielac\u00edch l\u00e1tok v \u013eudskom tele a \u010dasto sa ozna\u010duje aj ako horm\u00f3n \u0161\u0165astia, preto\u017ee hladina seroton\u00ednu v\u00fdrazne ovplyv\u0148uje na\u0161u emocion\u00e1lnu pohodu. Nedostatok seroton\u00ednu, najm\u00e4 v mozgu, umo\u017e\u0148uje zhor\u0161enie na\u0161ej n\u00e1lady a zabezpe\u010duje zl\u00fd stav mysle. Skuto\u010dnos\u0165, \u017ee seroton\u00edn sa ve\u010der vyu\u017e\u00edva na produkciu no\u010dn\u00e9ho horm\u00f3nu melaton\u00ednu, vysvet\u013euje, pre\u010do nedostatok seroton\u00ednu m\u00f4\u017ee vies\u0165 aj k zl\u00e9mu sp\u00e1nku.<\/p>\n

Existuj\u00fa \u0161t\u00fadie, ktor\u00e9 dokazuj\u00fa, \u017ee melaton\u00edn m\u00f4\u017ee prinajmen\u0161om zlep\u0161i\u0165 viacer\u00e9 pr\u00edznaky depresie, najm\u00e4 tie, ktor\u00e9 s\u00favisia s poruchami sp\u00e1nku. V\u00fdsledkom bolo, \u017ee pacienti s \u0165a\u017ekou depresiou boli lie\u010den\u00ed melaton\u00ednom. Melaton\u00edn bol \u00fa\u010dinn\u00fd pri zlep\u0161ovan\u00ed kvality sp\u00e1nku postihnut\u00fdch os\u00f4b. Okrem toho mo\u017eno pozit\u00edvne v\u00fdsledky pozorova\u0165 u pacientov, ktor\u00ed trpia sez\u00f3nnou depresiou. In\u00e1 \u0161t\u00fadia uv\u00e1dza ni\u017e\u0161iu \u00farove\u0148 depresie u pacientov so zimnou depresiou, ktor\u00ed boli lie\u010den\u00ed n\u00edzkou d\u00e1vkou melaton\u00ednu v popolud\u0148aj\u0161\u00edch hodin\u00e1ch. Aj mal\u00e9 d\u00e1vky melaton\u00ednu m\u00f4\u017eu zlep\u0161i\u0165 synchroniz\u00e1ciu vn\u00fatorn\u00fdch hod\u00edn a biologick\u00e9ho denn\u00e9ho rytmu so zmenen\u00fdm pomerom svetla po\u010das zimy, \u010do umo\u017e\u0148uje v\u00fdrazn\u00e9 zlep\u0161enie n\u00e1lady.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_tta_section][\/vc_tta_accordion][vc_tta_accordion color=“turquoise“ c_icon=“chevron“ c_position=“right“ active_section=“99″ no_fill=“true“ collapsible_all=“true“][vc_tta_section title=“Rakovina“ tab_id=“1481054316572-f240aafe-4074″][vc_row_inner css=“.vc_custom_1479393247359{background-image: url(https:\/\/www.chronobiology.com\/wp-content\/uploads\/2016\/11\/indications_5.jpg?id=11708) !important;}“][vc_column_inner][vc_column_text]Hoci sa melaton\u00edn u\u017e desa\u0165ro\u010dia pou\u017e\u00edva na lie\u010dbu nespavosti a in\u00fdch por\u00fach sp\u00e1nku, m\u00f4\u017ee by\u0165 cenn\u00fd aj pri lie\u010dbe rakoviny. V mnoh\u00fdch oh\u013eadoch sa rakovina zaober\u00e1 spr\u00e1vnym na\u010dasovan\u00edm. Norm\u00e1lne bunky rast\u00fa a umieraj\u00fa v\u010faka extr\u00e9mne regulovan\u00fdm procesom, ktor\u00e9 s\u00fa predur\u010den\u00e9 na\u0161imi hodinov\u00fdmi g\u00e9nmi. Ak tieto g\u00e9ny vykazuj\u00fa nejak\u00e9 mut\u00e1cie alebo inak nefunguj\u00fa spr\u00e1vne, potom m\u00f4\u017eu bunky za\u010da\u0165 nekontrolovate\u013ene r\u00e1s\u0165 a zab\u00edja\u0165 ostatn\u00e9 zdrav\u00e9 bunky v okol\u00ed.<\/p>\n

Nov\u00fd v\u00fdskum nazna\u010duje, \u017ee melaton\u00edn podkop\u00e1va rast n\u00e1dorov a z\u00e1rove\u0148 zmier\u0148uje ved\u013eaj\u0161ie \u00fa\u010dinky in\u00fdch lie\u010debn\u00fdch postupov proti rakovine. Aby sme boli konkr\u00e9tnej\u0161\u00ed, t\u00ed \u013eudia, ktor\u00ed v noci nem\u00f4\u017eu spa\u0165, vykazuj\u00fa vy\u0161\u0161ie riziko vzniku rakoviny, a preto Svetov\u00e1 zdravotn\u00edcka organiz\u00e1cia klasifikovala pr\u00e1cu na zmeny ako karcinog\u00e9nnu (podporuj\u00facu vznik rakoviny).<\/p>\n

Hoci s\u00favislos\u0165 medzi naru\u0161en\u00fdm cirkadi\u00e1nnym rytmom a rakovinou je jasn\u00e1, mechanizmus zv\u00fd\u0161en\u00e9ho rizika vzniku rakoviny nebol doteraz objasnen\u00fd. Nov\u00e1 metaanal\u00fdza chronobiologick\u00fdch \u0161t\u00fadi\u00ed nazna\u010duje, \u017ee melaton\u00edn \u00fato\u010d\u00ed na rakovinu v jej z\u00e1kladoch t\u00fdm, \u017ee preru\u0161uje biochemick\u00e9 procesy, ktor\u00e9 n\u00e1dory vyu\u017e\u00edvaj\u00fa na svoj rast. Melaton\u00edn dok\u00e1\u017ee zabr\u00e1ni\u0165 rakovinov\u00fdm bunk\u00e1m mno\u017ei\u0165 sa t\u00fdm, \u017ee sp\u00f4sobuje apopt\u00f3zu (programovan\u00fa bunkov\u00fa smr\u0165) a preru\u0161uje pr\u00edvod krvi do n\u00e1dorov. Je tie\u017e zn\u00e1me, \u017ee tento horm\u00f3n p\u00f4sob\u00ed ako antioxida\u010dn\u00e1 l\u00e1tka, ktor\u00e1 zlep\u0161uje imunitn\u00fd syst\u00e9m, \u010do tie\u017e br\u00e1ni vzniku rakoviny. A napokon, pr\u00edli\u0161 m\u00e1lo melaton\u00ednu m\u00f4\u017ee vies\u0165 k vysokej hladine cytok\u00ednov (prirodzen\u00e1 molekula, ktor\u00e1 s\u00favis\u00ed s rakovinou).<\/p>\n

Pri pod\u00e1van\u00ed melaton\u00ednu laborat\u00f3rnym zvierat\u00e1m, ktor\u00e9 trpeli n\u00e1dormi, sa potom rast n\u00e1doru v\u00fdrazne spomalil. \u0160t\u00fadie tie\u017e ukazuj\u00fa, \u017ee \u013eudsk\u00ed pacienti s rakovinou pri u\u017e\u00edvan\u00ed doplnku melaton\u00ednu \u013eah\u0161ie zn\u00e1\u0161aj\u00fa in\u00fa lie\u010dbu. V bl\u00edzkej bud\u00facnosti by sa tento z\u00e1zra\u010dn\u00fd horm\u00f3n mohol sta\u0165 s\u00fa\u010das\u0165ou \u0161tandardnej lie\u010dby rakoviny.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_tta_section][\/vc_tta_accordion][vc_tta_accordion color=“turquoise“ c_icon=“chevron“ c_position=“right“ active_section=“99″ no_fill=“true“ collapsible_all=“true“][vc_tta_section title=“Bolesti hlavy“ tab_id=“1481054421918-d560abc5-f17a“][vc_row_inner css=“.vc_custom_1481067315830{background-image: url(https:\/\/www.chronobiology.com\/wp-content\/uploads\/2016\/11\/indications-4.jpg?id=18360) !important;}“][vc_column_inner][vc_column_text]Melaton\u00edn by mohol by\u0165 u\u017eito\u010dn\u00fd aj proti r\u00f4znym typom bolest\u00ed hlavy a migr\u00e9ny. Medzi vlastnosti melaton\u00ednu, ktor\u00e9 pom\u00e1haj\u00fa v boji proti bolestiam hlavy, patria tieto: protiz\u00e1palov\u00fd \u00fa\u010dinok, inhib\u00edcia nadmern\u00e9ho uvo\u013e\u0148ovania dopam\u00ednu, stabiliz\u00e1cia membr\u00e1n a zv\u00fd\u0161enie hladiny GABA (najd\u00f4le\u017eitej\u0161\u00ed inhibi\u010dn\u00fd neurotransmiter v mozgu). Okrem toho p\u00f4sob\u00ed ako ochrana proti vo\u013en\u00fdm radik\u00e1lom.<\/p>\n

Pod\u013ea \u0161t\u00fadi\u00ed m\u00f4\u017ee tento horm\u00f3n dokonca zabr\u00e1ni\u0165 migr\u00e9ne. Presn\u00fd mechanizmus nie je v s\u00fa\u010dasnosti zn\u00e1my, ale existuje mnoho s\u00favislost\u00ed medzi cirkadi\u00e1nnym rytmom a t\u00fdmto typom bolesti hlavy. V\u00e4\u010d\u0161ina \u013eud\u00ed, ktor\u00ed trpia migr\u00e9nami, ich dost\u00e1va takmer ka\u017ed\u00fd de\u0148 v rovnakom \u010dase, \u010do vedie k z\u00e1veru, \u017ee cirkadi\u00e1nne zlo\u017eky zohr\u00e1vaj\u00fa ur\u010dit\u00fa \u00falohu. Okrem toho m\u00f4\u017ee by\u0165 jednou z hlavn\u00fdch pr\u00ed\u010din tohto typu bolesti hlavy aj g\u00e9n, ktor\u00fd s\u00favis\u00ed s poruchami cirkadi\u00e1nneho rytmu. Je mo\u017en\u00e9, \u017ee u\u017e\u00edvanie melaton\u00ednu m\u00f4\u017ee zabi\u0165 dve muchy jednou ranou, preto\u017ee potl\u00e1\u010da migr\u00e9ny a z\u00e1rove\u0148 podporuje zdrav\u00fd cyklus sp\u00e1nku a bdenia. Zlep\u0161enie by sa mohlo dosiahnu\u0165 aj prostredn\u00edctvom melaton\u00ednu pri lie\u010dbe klastrov\u00fdch bolest\u00ed hlavy a idiopatick\u00fdch bodav\u00fdch bolest\u00ed hlavy. Klastrov\u00e9 bolesti hlavy s\u00fa charakterizovan\u00e9 siln\u00fdmi jednostrann\u00fdmi boles\u0165ami hlavy. Sprievodn\u00fdmi pr\u00edznakmi s\u00fa slzenie o\u010d\u00ed alebo te\u010d\u00faci nos. Nedostato\u010dn\u00e9 vylu\u010dovanie melaton\u00ednu m\u00f4\u017ee vies\u0165 k v\u00fdskytu z\u00e1chvatov bolesti v noci alebo dokonca po\u010das d\u0148a. Frekvencia bolest\u00ed hlavy by sa u niektor\u00fdch pacientov mohla pomocou melaton\u00ednu v\u00fdrazne zn\u00ed\u017ei\u0165. Melaton\u00edn sa uk\u00e1zal ako \u00fa\u010dinnej\u0161\u00ed ako in\u00e9 lieky proti bolesti pri idiopatick\u00fdch bodav\u00fdch bolestiach hlavy (spont\u00e1nne sa vyskytuj\u00faca bodav\u00e1 boles\u0165, ktor\u00e1 trv\u00e1 nieko\u013eko sek\u00fand) a vykazoval aj menej ved\u013eaj\u0161\u00edch \u00fa\u010dinkov.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_tta_section][\/vc_tta_accordion][vc_tta_accordion color=“turquoise“ c_icon=“chevron“ c_position=“right“ active_section=“99″ no_fill=“true“ collapsible_all=“true“][vc_tta_section title=“O\u010di“ tab_id=“1481054457945-508ecd0b-50c9″][vc_row_inner css=“.vc_custom_1481067398768{background-image: url(https:\/\/www.chronobiology.com\/wp-content\/uploads\/2016\/11\/indications-2.jpg?id=18358) !important;}“][vc_column_inner][vc_column_text]Melaton\u00edn sa produkuje nielen v epif\u00fdze, ale aj v sietnici. Tento horm\u00f3n, ktor\u00e9ho mno\u017estvo u star\u0161\u00edch \u013eud\u00ed kles\u00e1, sa podie\u013ea na kontrole pigment\u00e1cie o\u010d\u00ed. Okrem in\u00e9ho pom\u00e1ha regulova\u0165 mno\u017estvo svetla, ktor\u00e9 sa dostane k fotoreceptorom oka. Pigmentov\u00fd epitel sietnice (vonkaj\u0161ia vrstva sietnice) je tie\u017e nez\u00e1visle chr\u00e1nen\u00fd pred oxida\u010dn\u00fdm po\u0161koden\u00edm.<\/p>\n

Degener\u00e1cia makuly<\/h3>\n

Toto o\u010dn\u00e9 ochorenie, ktor\u00e9 ni\u010d\u00ed najd\u00f4le\u017eitej\u0161iu, centr\u00e1lnu \u010das\u0165 sietnice, patr\u00ed medzi naj\u010dastej\u0161ie pr\u00ed\u010diny slepoty u dospel\u00fdch. Pod\u013ea \u0161t\u00fadi\u00ed m\u00f4\u017ee u\u017e\u00edvanie melaton\u00ednu oddiali\u0165 progresiu ochorenia a chr\u00e1ni\u0165 sietnicu. V s\u00fa\u010dasnosti sa e\u0161te st\u00e1le sk\u00fama, \u010di melaton\u00edn p\u00f4sob\u00ed len ako lapa\u010d radik\u00e1lov, alebo \u010di m\u00e1 aj vplyv na receptory.<\/p>\n

Glauk\u00f3m<\/h3>\n

Glauk\u00f3mom oka sa rozumie nieko\u013eko r\u00f4znych o\u010dn\u00fdch ochoren\u00ed, ktor\u00e9 m\u00f4\u017eu vies\u0165 k strate optick\u00fdch nervov\u00fdch vl\u00e1kien. Hlavnou pr\u00ed\u010dinou tohto ochorenia je zv\u00fd\u0161en\u00fd tlak v o\u010dnej komore, ktor\u00fd \u010dasto s\u00favis\u00ed s n\u00edzkym tlakom v cievach z\u00e1sobuj\u00facich sietnicu. Ak je ochorenie pokro\u010dil\u00e9, m\u00f4\u017ee vies\u0165 k er\u00f3zii zreni\u010dky, pri\u010dom najprv s\u00fa po\u0161koden\u00e9 vonkaj\u0161ie nervy sietnice a postupne nasleduj\u00fa vn\u00fatorn\u00e9 nervy. V\u00fdsledkom je v\u00fdpadok zorn\u00e9ho po\u013ea – od okraja smerom dovn\u00fatra -, ktor\u00fd m\u00f4\u017ee nakoniec sp\u00f4sobi\u0165 \u00fapln\u00fa slepotu. V\u00fdskum uk\u00e1zal, \u017ee oxida\u010dn\u00fd stres pri glauk\u00f3me m\u00f4\u017ee sp\u00f4sobi\u0165 aj stratu fotoreceptorov. V tomto pr\u00edpade m\u00f4\u017ee by\u0165 melaton\u00edn \u00fa\u010dinn\u00fd t\u00fdm, \u017ee zni\u017euje tlak v oku a navy\u0161e chr\u00e1ni fotoreceptory pred vo\u013en\u00fdmi radik\u00e1lmi.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_tta_section][\/vc_tta_accordion][vc_tta_accordion color=“turquoise“ c_icon=“chevron“ c_position=“right“ active_section=“99″ no_fill=“true“ collapsible_all=“true“][vc_tta_section title=“Plodnos\u0165 a tehotenstvo“ tab_id=“1481054489011-c3c7f4d0-5362″][vc_row_inner css=“.vc_custom_1481067422458{background-image: url(https:\/\/www.chronobiology.com\/wp-content\/uploads\/2016\/11\/indications-3.jpg?id=18359) !important;}“][vc_column_inner][vc_column_text]Ned\u00e1vno publikovan\u00e1 \u0161t\u00fadia z Texaskej univerzity nazna\u010duje, \u017ee pre optim\u00e1lnu plodnos\u0165 je potrebn\u00e1 zdrav\u00e1 hladina melaton\u00ednu. Tak ako v\u0161etky ostatn\u00e9 bunky v tele, aj vaj\u00ed\u010dka s\u00fa n\u00e1chyln\u00e9 na vo\u013en\u00e9 radik\u00e1ly, ktor\u00e9 m\u00f4\u017eu sp\u00f4sobi\u0165 po\u0161kodenie DNA. V tomto pr\u00edpade melaton\u00edn p\u00f4sob\u00ed vo vaje\u010dn\u00edkoch ako antioxidant t\u00fdm, \u017ee odstra\u0148uje vo\u013en\u00e9 radik\u00e1ly a zabra\u0148uje po\u0161kodeniu buniek. V \u010fal\u0161ej chronobiologickej \u0161t\u00fadii uverejnenej v \u010dasopise Journal of Medicine and Life sa zistilo, \u017ee melaton\u00edn m\u00e1 ve\u013ek\u00fd v\u00fdznam pre v\u00fdvoj embrya a plodu. Hladina melaton\u00ednu sa po\u010das tehotenstva zvy\u0161uje kon\u0161tantnou r\u00fdchlos\u0165ou. Ke\u010f\u017ee sa tento horm\u00f3n pren\u00e1\u0161a placentou v nezmenenej podobe, mo\u017eno ho zisti\u0165 v plodovej vode aj vo vyv\u00edjaj\u00facom sa plode. Plod m\u00e1 v mozgu receptory pre melaton\u00edn u\u017e d\u00e1vno predt\u00fdm, ako sa \u00faplne sformuje.<\/p>\n

Melaton\u00edn od matky m\u00e1 pre plod r\u00f4zne funkcie. Na jednej strane sprostredk\u00fava inform\u00e1cie o cykloch svetla a tmy do mozgu plodu, \u010do pom\u00e1ha die\u0165a\u0165u vybudova\u0165 si vlastn\u00fd cirkadi\u00e1nny rytmus. Na druhej strane sa predpoklad\u00e1, \u017ee melaton\u00edn zohr\u00e1va d\u00f4le\u017eit\u00fa \u00falohu aj pri aktiv\u00e1cii ur\u010dit\u00fdch g\u00e9nov, ktor\u00e9 s\u00fa d\u00f4le\u017eit\u00e9 pre spr\u00e1vny v\u00fdvoj od po\u010datia a\u017e po narodenie. Z tohto d\u00f4vodu mnoh\u00ed r\u00f4zni vedci odpor\u00fa\u010daj\u00fa pod\u00e1vanie melaton\u00ednu tehotn\u00fdm \u017een\u00e1m, najm\u00e4 pri pr\u00edtomnosti por\u00fach sp\u00e1nku, preto\u017ee sa preuk\u00e1zali len pozit\u00edvne \u00fa\u010dinky pre die\u0165a.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_tta_section][\/vc_tta_accordion][vc_tta_accordion color=“turquoise“ c_icon=“chevron“ c_position=“right“ active_section=“99″ no_fill=“true“ collapsible_all=“true“][vc_tta_section title=“Sp\u00e1nok“ tab_id=“1481054511245-6cd0663b-bbaf“][vc_row_inner css=“.vc_custom_1479393081118{background-image: url(https:\/\/www.chronobiology.com\/wp-content\/uploads\/2016\/11\/indications_9.jpg?id=11706) !important;}“][vc_column_inner][vc_column_text]Najd\u00f4kladnej\u0161ie presk\u00faman\u00fdm a zdokumentovan\u00fdm \u00fa\u010dinkom melaton\u00ednu je jeho vplyv na rytmus sp\u00e1nku a bdenia. Melaton\u00edn je vhodn\u00fd na zasp\u00e1vanie aj na udr\u017eanie sp\u00e1nku. Tento horm\u00f3n sa osved\u010dil pri viacer\u00fdch poruch\u00e1ch sp\u00e1nku, ako je napr\u00edklad jetlag, pr\u00e1ca na zmeny, syndr\u00f3m oneskoren\u00e9ho n\u00e1stupu sp\u00e1nku alebo u star\u0161\u00edch \u013eud\u00ed s probl\u00e9mami so sp\u00e1nkom. Prostredn\u00edctvom neho mo\u017eno v\u00fdrazne zlep\u0161i\u0165 efektivitu sp\u00e1nku a celkov\u00fd \u010das sp\u00e1nku.<\/p>\n

Poruchy sp\u00e1nku a ich d\u00f4sledky<\/h3>\n

Chronick\u00e9 poruchy sp\u00e1nku, ktor\u00e9 sa vyskytuj\u00fa v priemere v troch zo siedmich noc\u00ed, zvy\u0161uj\u00fa mo\u017enos\u0165 vzniku srdcov\u00e9ho infarktu, m\u0155tvice, cukrovky, ochoren\u00ed ciev a problematickej obezity.<\/p>\n

T\u00edm z Pensylv\u00e1nskej univerzity po prv\u00fdkr\u00e1t analyzoval zozbieran\u00e9 \u00fadaje od viac ako 130 000 \u013eud\u00ed (priemern\u00fd vek 46 rokov) a dok\u00e1zal vyvodi\u0165 nasleduj\u00face z\u00e1very: Minim\u00e1lne poruchy pri zasp\u00e1van\u00ed alebo po\u010das sp\u00e1nku, ale aj pr\u00edli\u0161 dlh\u00fd sp\u00e1nok m\u00f4\u017eu ma\u0165 obrovsk\u00fd v\u00fdznam. Riziko obezity sa zvy\u0161uje o 35 percent, cukrovky o 54 percent a kardiovaskul\u00e1rnych ochoren\u00ed o 98 percent. Zdvojn\u00e1sobilo sa aj riziko m\u0155tvice.<\/p>\n

Vedci z Harvard Medical School sa s\u00fastre\u010fuj\u00fa na 90 a\u017e 120 min\u00fat ka\u017ed\u00fa noc, ktor\u00e9 zdrav\u00fdm \u013eu\u010fom poskytuj\u00fa hlbok\u00fd sp\u00e1nok. Konzultovali 784 \u013eud\u00ed s norm\u00e1lnym krvn\u00fdm tlakom, ktor\u00ed s\u00fahlasili s t\u00fdm, \u017ee bud\u00fa doma sledova\u0165 svoje sp\u00e1nkov\u00e9 f\u00e1zy pomocou mal\u00e9ho pr\u00edstroja. Experiment prebiehal po\u010das 42 mesiacov.<\/p>\n

Hlbok\u00fd sp\u00e1nok vo v\u0161eobecnosti tvor\u00ed pribli\u017ene 25 percent no\u010dn\u00e9ho sp\u00e1nku. Mozgov\u00e1 aktivita v tejto f\u00e1ze je oslaben\u00e1 a zni\u017euje sa srdcov\u00e1 frekvencia a uvo\u013e\u0148ovanie stresov\u00fdch horm\u00f3nov. Hodnoty krvn\u00e9ho tlaku s\u00fa v tomto obdob\u00ed spravidla o 10 bodov ni\u017e\u0161ie ako norm\u00e1lne. No\u010dn\u00e9 zn\u00ed\u017eenie tlaku sa pova\u017euje za mimoriadne pozit\u00edvne. Av\u0161ak stav, pri ktorom tlak zost\u00e1va zv\u00fd\u0161en\u00fd, sa pova\u017euje za rizikov\u00fd faktor srdcov\u00fdch ochoren\u00ed.<\/p>\n

V\u00fdsledkom bolo, \u017ee mu\u017ei, u ktor\u00fdch sa preuk\u00e1zala krat\u0161ia regenera\u010dn\u00e1 f\u00e1za, reagovali zv\u00fd\u0161en\u00fdm krvn\u00fdm tlakom nebezpe\u010dn\u00fdch rozmerov (viacer\u00ed z pozorovan\u00fdch dosiahli len \u0161tyri percent\u00e1, teda 15 min\u00fat potrebn\u00e9ho hlbok\u00e9ho sp\u00e1nku). Spravidla sa u v\u00e4\u010d\u0161iny z nich prejavil preru\u0161ovan\u00fd a skr\u00e1ten\u00fd sp\u00e1nok. Tejto skupine by mala prospie\u0165 suplement\u00e1cia melaton\u00ednom.<\/p>\n

Doplnky melaton\u00ednu<\/h3>\n

Prv\u00e9 \u0161t\u00fadie v oblasti chronobiol\u00f3gie uk\u00e1zali, \u017ee doplnky melaton\u00ednu m\u00f4\u017eu pom\u00f4c\u0165 pri lie\u010dbe cirkadi\u00e1nnych por\u00fach sp\u00e1nku, ako aj pri rie\u0161en\u00ed mnoh\u00fdch probl\u00e9mov s\u00favisiacich so sp\u00e1nkom. Nie v\u0161etky melaton\u00ednov\u00e9 doplnky s\u00fa v\u0161ak rovnak\u00e9. Sp\u00f4sob, ak\u00fdm sa melaton\u00edn v t\u00fdchto doplnkoch uvo\u013e\u0148uje, m\u00f4\u017ee ma\u0165 neuverite\u013en\u00fd vplyv na fyziologick\u00e9 hodnoty a \u00fa\u010dinky tohto horm\u00f3nu.<\/p>\n

Niektor\u00ed \u013eudia s\u00fa toho n\u00e1zoru, \u017ee melaton\u00edn nefunguje tak dramaticky, ako o\u010dak\u00e1vali. Potom sa \u010dasto mylne domnievaj\u00fa, \u017ee melaton\u00edn nie je u\u017eito\u010dn\u00fd pri lie\u010dbe probl\u00e9mov so sp\u00e1nkom, ale v skuto\u010dnosti si mo\u017eno jednoducho vybrali nespr\u00e1vny druh melaton\u00ednov\u00e9ho doplnku. Okrem toho mo\u017eno zast\u00e1va\u0165 n\u00e1zor, \u017ee melaton\u00edn nefunguje ako klasick\u00e9 hypnotikum, ale sk\u00f4r ako regul\u00e1tor rytmu sp\u00e1nok-bdenie. Z tohto d\u00f4vodu sa \u00fa\u010dinok d\u00e1 vyhodnoti\u0165 a\u017e najsk\u00f4r r\u00e1no, ke\u010f sa m\u00f4\u017eete op\u00fdta\u0165, ako ste fit a \u010di bol sp\u00e1nok pokojn\u00fd, ako dlho v\u00e1m trvalo zaspa\u0165 a ako \u010dasto ste sa budili.<\/p>\n

Pomal\u00e9 alebo r\u00fdchle uvo\u013e\u0148ovanie<\/h3>\n

Najbe\u017enej\u0161\u00ed typ melaton\u00ednov\u00fdch doplnkov disponuje bu\u010f r\u00fdchlym, alebo pomal\u00fdm uvo\u013e\u0148ovan\u00edm horm\u00f3nu. R\u00fdchle uvo\u013e\u0148ovanie melaton\u00ednu vedie k r\u00fdchlemu vzostupu hladiny melaton\u00ednu, ktor\u00e1 po jednej a\u017e dvoch hodin\u00e1ch za\u010dne op\u00e4\u0165 klesa\u0165. \u013dudia, ktor\u00ed u\u017e\u00edvaj\u00fa tento typ doplnku, zistia, \u017ee sa r\u00fdchlo stan\u00fa ospal\u00fdmi, ale maj\u00fa probl\u00e9m prespa\u0165 cel\u00fa noc alebo jednoducho nemaj\u00fa kvalitn\u00fd sp\u00e1nok. Na druhej strane, pomaly sa uvo\u013e\u0148uj\u00faci melaton\u00edn potrebuje hodiny, k\u00fdm navod\u00ed sp\u00e1nok a nepust\u00ed a\u017e do skor\u00fdch rann\u00fdch hod\u00edn. \u013dudia, ktor\u00ed si zvolili pr\u00edpravky umo\u017e\u0148uj\u00face pomal\u00e9 uvo\u013e\u0148ovanie melaton\u00ednu, m\u00f4\u017eu ma\u0165 probl\u00e9my so zasp\u00e1van\u00edm kv\u00f4li po\u010diato\u010dnej n\u00edzkej hladine melaton\u00ednu, po ktorej nasleduj\u00fa \u0165a\u017ekosti so vst\u00e1van\u00edm, preto\u017ee r\u00e1no je jeho hladina e\u0161te neprirodzene vysok\u00e1.<\/p>\n

Dobre na\u010dasovan\u00e9 uvo\u013e\u0148ovanie melaton\u00ednu (chronobiologicky spr\u00e1vne kombinovan\u00fd melaton\u00edn alebo pulzuj\u00faci melaton\u00edn) pon\u00faka lep\u0161iu mo\u017enos\u0165 udr\u017eania prirodzen\u00e9ho cirkadi\u00e1nneho rytmu.<\/p>\n

Dobre na\u010dasovan\u00e9 uvo\u013e\u0148ovanie (chronobiologick\u00fd spr\u00e1vne kombinovan\u00fd melaton\u00edn alebo pulzuj\u00faci melaton\u00edn):<\/strong><\/p>\n

\u010casovo riaden\u00e9 uvo\u013e\u0148ovanie melaton\u00ednu je doplnok, ktor\u00fd je zostaven\u00fd tak, aby sa horm\u00f3n uvo\u013e\u0148oval presne v takom mno\u017estve, ktor\u00e9 napodob\u0148uje zdrav\u00fa, prirodzen\u00fa hladinu melaton\u00ednu. Uvo\u013e\u0148uje sa postupne, tak\u017ee hladina melaton\u00ednu po u\u017eit\u00ed doplnku r\u00fdchlo st\u00fapa a potom zost\u00e1va na tejto vysokej \u00farovni nieko\u013eko hod\u00edn. Hladina potom k r\u00e1nu op\u00e4\u0165 r\u00fdchlo kles\u00e1, aby umo\u017enila prebudenie. T\u00fdm sa napodob\u0148uj\u00fa zdrav\u00e9, norm\u00e1lne cykly cirkadi\u00e1nneho rytmu, ktor\u00e9 s\u00fa spojen\u00e9 s pokojn\u00fdm sp\u00e1nkom.<\/p>\n

V\u00fdskum v oblasti chronobiol\u00f3gie uk\u00e1zal, \u017ee udr\u017eiavanie melaton\u00ednov\u00e9ho cyklu je d\u00f4le\u017eit\u00e9 nielen pre pokojn\u00fd sp\u00e1nok, ale aj pre celkov\u00fa pohodu. Z tohto d\u00f4vodu \u010doraz viac odborn\u00edkov na zdravie odpor\u00fa\u010da spr\u00e1vne na\u010dasovan\u00e9 uvo\u013e\u0148ovanie melaton\u00ednu ako ide\u00e1lny doplnok. Tento typ doplnku sa ove\u013ea viac pribli\u017euje prirodzen\u00e9mu melaton\u00ednu pr\u00edtomn\u00e9mu v zdravom mozgu. Zabezpe\u010denie zdrav\u00e9ho cirkadi\u00e1nneho rytmu je pre zdravie d\u00f4le\u017eit\u00e9, a preto je dobre na\u010dasovan\u00fd melaton\u00ednov\u00fd doplnok spravidla najlep\u0161ou vo\u013ebou. Pri poruch\u00e1ch cirkadi\u00e1nneho rytmu, ako je napr\u00edklad jetlag, pr\u00e1ca na zmeny alebo syndr\u00f3m oneskoren\u00e9ho n\u00e1stupu sp\u00e1nku, sa melaton\u00edn produkuje v dostato\u010dnom mno\u017estve, ale v nespr\u00e1vnom \u010dase. V takom pr\u00edpade prich\u00e1dza do \u00favahy pou\u017eitie pr\u00edpravku s dobre na\u010dasovan\u00fdm melaton\u00ednom alebo pr\u00edpravku s r\u00fdchlo sa uvo\u013e\u0148uj\u00facim melaton\u00ednom, aby sa preprogramoval prirodzen\u00fd cirkadi\u00e1nny rytmus na po\u017eadovan\u00fd no\u010dn\u00fd rytmus. Tento typ lie\u010dby sa naz\u00fdva chronoterapia, preto\u017ee nenahr\u00e1dza melaton\u00edn, ale reguluje jeho endog\u00e9nne uvo\u013e\u0148ovanie.<\/p>\n

Ak je pr\u00ed\u010dinou por\u00fach sp\u00e1nku viac alebo menej v\u00fdrazn\u00fd nedostatok melaton\u00ednu, je potrebn\u00e9 melaton\u00edn doplni\u0165, napr\u00edklad pomocou hormon\u00e1lnej substitu\u010dnej lie\u010dby. Na tento \u00fa\u010del sa mus\u00ed pou\u017ei\u0165 chronobiologicky optimalizovan\u00fd farmaceutick\u00fd pr\u00edpravok, ktor\u00fd uvo\u013e\u0148uje melaton\u00edn po\u010das \u0161iestich hod\u00edn. V tomto pr\u00edpade by sa mala pou\u017ei\u0165 vy\u0161\u0161ie op\u00edsan\u00e1 pulzuj\u00faca forma.<\/p>\n

\"melatonin-chronobiology\"<\/a>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_tta_section][\/vc_tta_accordion][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

[vc_row full_width=“stretch_row“ el_class=“banner-top“][vc_column][vc_custom_heading source=“post_title“ font_container=“tag:h1|text_align:center“ use_theme_fonts=“yes“][\/vc_column][\/vc_row][vc_row el_class=“melatoninfacts2″][vc_column][vc_column_text] Indik\u00e1cie Nov\u00fd v\u00fdskum v oblasti cirkadi\u00e1nnej biol\u00f3gie dok\u00e1zal, \u017ee zdrav\u00fd cirkadi\u00e1nny rytmus, a najm\u00e4 zdrav\u00e1 hladina melaton\u00ednu, m\u00e1 pozit\u00edvny vplyv na zdravie. Za posledn\u00fdch 20 rokov sa v mnoh\u00fdch klinick\u00fdch \u0161t\u00fadi\u00e1ch testovalo a preuk\u00e1zalo terapeutick\u00e9 vyu\u017eitie melaton\u00ednu v r\u00f4znych oblastiach medic\u00edny a to, \u017ee u\u017e\u00edvanie tohto horm\u00f3nu m\u00f4\u017ee […]<\/p>\n","protected":false},"author":15,"featured_media":55888,"parent":55865,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"full-width-content","footnotes":""},"categories":[523,517],"class_list":{"0":"post-55887","1":"page","2":"type-page","3":"status-publish","4":"has-post-thumbnail","6":"category-melatonin-sk","7":"category-spanok","8":"entry"},"acf":[],"yoast_head":"\nIndik\u00e1cie – Chronobiology.com<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/dev.chronobiology.com\/sk\/melatonin-chronobiologia\/indikacie\/\" \/>\n<meta property=\"og:locale\" content=\"sk_SK\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Indik\u00e1cie\" \/>\n<meta property=\"og:description\" content=\"[vc_row full_width=“stretch_row“ el_class=“banner-top“][vc_column][vc_custom_heading source=“post_title“ font_container=“tag:h1|text_align:center“ use_theme_fonts=“yes“][\/vc_column][\/vc_row][vc_row el_class=“melatoninfacts2″][vc_column][vc_column_text] Indik\u00e1cie Nov\u00fd v\u00fdskum v oblasti cirkadi\u00e1nnej biol\u00f3gie dok\u00e1zal, \u017ee zdrav\u00fd cirkadi\u00e1nny rytmus, a najm\u00e4 zdrav\u00e1 hladina melaton\u00ednu, m\u00e1 pozit\u00edvny vplyv na zdravie. 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