{"id":59261,"date":"2022-08-10T14:06:17","date_gmt":"2022-08-10T21:06:17","guid":{"rendered":"https:\/\/www.chronobiology.com\/the-role-of-chronopharmacology-in-medicine\/"},"modified":"2024-07-18T15:21:14","modified_gmt":"2024-07-18T22:21:14","slug":"le-r-le-de-la-chronopharmacologie-en-m-decine","status":"publish","type":"post","link":"https:\/\/dev.chronobiology.com\/fr\/le-r-le-de-la-chronopharmacologie-en-m-decine\/","title":{"rendered":"Le r\u00f4le de la chronopharmacologie en m\u00e9decine"},"content":{"rendered":"<p>Bien que les concepts associ\u00e9s \u00e0 la chronobiologie existent <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6120700\/\" target=\"_blank\" rel=\"noopener\">depuis des si\u00e8cles<\/a>, ce n&rsquo;est qu&rsquo;avec la science moderne que nous avons pu r\u00e9ellement voir comment les rythmes biologiques entrent en jeu au niveau mol\u00e9culaire. \u00c0 mesure que la science approfondit l&rsquo;\u00e9tude des rythmes biologiques et l&rsquo;<a href=\"https:\/\/www.chronobiology.com\/your-body-clock-determines-the-worst-times-of-day-for-your-health\/\" target=\"_blank\" rel=\"noopener\">importance de leur synchronisation<\/a>, une multitude de nouvelles connaissances ouvrent des perspectives passionnantes pour le traitement des maladies et la protection de la sant\u00e9. Parmi ces nouvelles possibilit\u00e9s figure le r\u00f4le de la chronopharmacologie et de la chronoth\u00e9rapeutique dans l&rsquo;optimisation des effets b\u00e9n\u00e9fiques des traitements m\u00e9dicamenteux et dans la r\u00e9duction des effets secondaires n\u00e9fastes.<\/p>\n<h2>Le temps et le rythme sont profonds<\/h2>\n<p><a href=\"https:\/\/www.chronobiology.com\/wp-content\/uploads\/2022\/08\/Horizontal-In-Text-Image-35-2.jpg\"><img decoding=\"async\" class=\"size-medium wp-image-43387 alignright\" title=\"Horizontal In Text Image 35 2\" src=\"https:\/\/www.chronobiology.com\/wp-content\/uploads\/2022\/08\/Horizontal-In-Text-Image-35-2-300x206.jpg\" alt=\"Horizontal In Text Image 35 2\" width=\"300\" height=\"206\" srcset=\"https:\/\/dev.chronobiology.com\/wp-content\/uploads\/2022\/08\/Horizontal-In-Text-Image-35-2-300x206.jpg 300w, https:\/\/dev.chronobiology.com\/wp-content\/uploads\/2022\/08\/Horizontal-In-Text-Image-35-2-768x528.jpg 768w, https:\/\/dev.chronobiology.com\/wp-content\/uploads\/2022\/08\/Horizontal-In-Text-Image-35-2.jpg 800w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/a>Le pr\u00e9fixe chrono- vient d&rsquo;un mot grec, khronos, qui signifie temps. Les rythmes sont li\u00e9s au temps et \u00e0 la synchronisation, et ils peuvent \u00eatre profonds. Le rythme le plus profond est peut-\u00eatre celui du jour et de la nuit, le rythme de vie d&rsquo;environ 24 heures auquel l&rsquo;homme a \u00e9volu\u00e9. Ce <a href=\"https:\/\/www.nigms.nih.gov\/education\/fact-sheets\/Pages\/circadian-rhythms.aspx\" target=\"_blank\" rel=\"noopener\">rythme circadien<\/a> et les comportements humains qu&rsquo;il a influenc\u00e9s, comme le fait d&rsquo;\u00eatre actif le jour et de se reposer la nuit, se sont imbriqu\u00e9s dans les m\u00e9canismes de fonctionnement de notre corps, servant de facteur d&rsquo;organisation, m\u00eame pour les activit\u00e9s de chaque <a href=\"https:\/\/kids.frontiersin.org\/articles\/10.3389\/frym.2019.00005\" target=\"_blank\" rel=\"noopener\">cellule<\/a>.<\/p>\n<p>La chronobiologie \u00e9tudie les <a href=\"https:\/\/www.biologyonline.com\/dictionary\/chronobiology\" target=\"_blank\" rel=\"noopener\">rythmes biologiques<\/a>. La <a href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/chronopharmacology\" target=\"_blank\" rel=\"noopener\">chronopharmacologie<\/a> se r\u00e9f\u00e8re donc \u00e0 l&rsquo;interaction entre les rythmes biologiques et les m\u00e9dicaments. La <a href=\"https:\/\/www.merriam-webster.com\/medical\/chronotherapeutics\" target=\"_blank\" rel=\"noopener\">chronoth\u00e9rapeutique<\/a> est l&rsquo;application pratique des principes de la chronopharmacologie dans le but de programmer les m\u00e9dicaments en tenant <a href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/chronotherapeutics\" target=\"_blank\" rel=\"noopener\">compte des rythmes biologiques<\/a> afin d&rsquo;en tirer un maximum de b\u00e9n\u00e9fices tout en r\u00e9duisant les effets secondaires n\u00e9gatifs potentiels.<\/p>\n<h2>Explorer le r\u00f4le de la chronopharmacologie en m\u00e9decine<\/h2>\n<p>Pour comprendre le r\u00f4le de la chronopharmacologie, il faut d&rsquo;abord expliquer ce que sont les rythmes circadiens. Les rythmes circadiens influencent d&rsquo;innombrables processus dans l&rsquo;organisme, <a href=\"https:\/\/www.pharmatutor.org\/articles\/chronopharmacology-overview\" target=\"_blank\" rel=\"noopener\">y compris ceux<\/a> li\u00e9s \u00e0 la fa\u00e7on dont les m\u00e9dicaments sont absorb\u00e9s et m\u00e9tabolis\u00e9s par l&rsquo;organisme et, finalement, \u00e9limin\u00e9s de l&rsquo;organisme. <a href=\"https:\/\/www.annualreviews.org\/doi\/abs\/10.1146\/annurev-pharmtox-011613-135923?journalCode=pharmtox#:~:text=Recent%20research%20shows%20that%20these%20clocks%20can%20respond,that%20considers%20chronointeractions%20among%20different%20clock-regulated%20systems.%20Keywords\" target=\"_blank\" rel=\"noopener\">Par exemple<\/a>, il peut y avoir un moment de la journ\u00e9e o\u00f9 les prot\u00e9ines n\u00e9cessaires \u00e0 l&rsquo;absorption d&rsquo;un m\u00e9dicament par l&rsquo;organisme sont les plus disponibles. Le <a href=\"https:\/\/www.researchgate.net\/publication\/5604529_The_influence_of_circadian_rhythms_on_the_kinetics_of_drugs_in_humans\" target=\"_blank\" rel=\"noopener\">moment de la journ\u00e9e<\/a> peut jouer un r\u00f4le r\u00e9el dans l&rsquo;efficacit\u00e9 d&rsquo;un m\u00e9dicament et peut influencer l&rsquo;\u00e9quilibre entre les b\u00e9n\u00e9fices et la toxicit\u00e9. Ces concepts concernant le choix du <a href=\"https:\/\/www.chronobiology.com\/new-study-backs-chronopharmacology-in-cancer-treatment\/\" target=\"_blank\" rel=\"noopener\">moment de la prise d&rsquo;un m\u00e9dicament pour obtenir un b\u00e9n\u00e9fice optimal et r\u00e9duire les effets secondaires n\u00e9gatifs<\/a> ne sont pas nouveaux. En fait, la science m\u00e9dicale explore les concepts de chronopharmacologie depuis des <a href=\"https:\/\/www.nature.com\/articles\/d41586-018-04600-8\" target=\"_blank\" rel=\"noopener\">d\u00e9cennies<\/a>.<\/p>\n<p>Cependant, les rythmes biologiques humains ne sont pas les seuls \u00e0 prendre en compte dans une situation m\u00e9dicale. Le parasite responsable du paludisme, par exemple, avec ses fi\u00e8vres cycliques, a son <a href=\"https:\/\/www.hhmi.org\/news\/discovery-of-malaria-parasites-clock-could-pave-way-to-new-treatments\" target=\"_blank\" rel=\"noopener\">propre rythme circadien<\/a>, tout comme le parasite responsable de la maladie du sommeil. De nombreux <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7013081\/\" target=\"_blank\" rel=\"noopener\">agents pathog\u00e8nes<\/a> ont leur propre rythme circadien, de m\u00eame que certains types de <a href=\"https:\/\/www.chronobiology.com\/disrupting-the-circadian-rhythm-of-cancer-potential-for-new-treatment\/\" target=\"_blank\" rel=\"noopener\">cellules canc\u00e9reuses<\/a>. La chronopharmacologie et la chronoth\u00e9rapeutique modernes \u00e9voluent afin de mieux prendre en compte la possibilit\u00e9 que plusieurs rythmes soient en jeu lorsqu&rsquo;il s&rsquo;agit de d\u00e9terminer le moment le plus avantageux pour \u00e9laborer un plan de traitement m\u00e9dicamenteux.<\/p>\n<h2>Cancer, recherche sur les maladies cardiovasculaires et chronopharmacologie<\/h2>\n<p>Le cancer et les maladies cardiovasculaires, deux des principales causes de d\u00e9c\u00e8s, ont jou\u00e9 un r\u00f4le important dans le d\u00e9veloppement de la psychopharmacologie moderne. Ces deux maladies ont connu certains des premiers succ\u00e8s de la chronoth\u00e9rapeutique.<\/p>\n<p>Il a \u00e9t\u00e9 d\u00e9montr\u00e9 que le <a href=\"https:\/\/www.nature.com\/articles\/d41586-018-04600-8\" target=\"_blank\" rel=\"noopener\">moment de l&rsquo;<\/a> administration des m\u00e9dicaments anticanc\u00e9reux influen\u00e7ait l&rsquo;efficacit\u00e9 des m\u00e9dicaments et leur <a href=\"https:\/\/www.pharmaceutical-technology.com\/analysis\/featurewatching-the-clock-should-day-and-night-influence-our-drug-regimens-4971648\/\" target=\"_blank\" rel=\"noopener\">toxicit\u00e9<\/a> lors des essais cliniques. Aujourd&rsquo;hui, les chercheurs m\u00e9dicaux sont \u00e9galement en mesure de prendre en <a href=\"https:\/\/www.sciencedaily.com\/releases\/2015\/09\/150917135002.htm\" target=\"_blank\" rel=\"noopener\">consid\u00e9ration et de cibler le<\/a> rythme circadien variable des cellules canc\u00e9reuses afin d&rsquo;obtenir une synchronisation encore plus pr\u00e9cise des m\u00e9dicaments.<\/p>\n<p>En ce qui concerne les <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0002870399703923\" target=\"_blank\" rel=\"noopener\">maladies cardiovasculaires<\/a>, les chercheurs ont d\u00e9couvert que les \u00e9v\u00e9nements cardiaques, tels que les accidents vasculaires c\u00e9r\u00e9braux, l&rsquo;angine de poitrine et les crises cardiaques, semblent \u00eatre influenc\u00e9s par un rythme circadien, \u00e9tant plus susceptibles de se produire le matin. Cela a conduit les chercheurs \u00e0 travailler sur le timing des m\u00e9dicaments dans le but de fournir le soutien m\u00e9dical n\u00e9cessaire au bon moment afin d&rsquo;\u00e9viter les \u00e9v\u00e9nements cardiaques majeurs.<\/p>\n<h2>Le timing des m\u00e9dicaments et d&rsquo;autres maladies et \u00e9tats de sant\u00e9<\/h2>\n<p>La polyarthrite rhumato\u00efde est une maladie auto-immune qui, selon des <a href=\"https:\/\/www.chronobiology.com\/applied-chronobiology-rheumatoid-arthritis-lead-effective-treatments\/\" target=\"_blank\" rel=\"noopener\">recherches r\u00e9centes<\/a>, pourrait b\u00e9n\u00e9ficier d&rsquo;une approche chronoth\u00e9rapeutique. En ajustant le moment de la prise des m\u00e9dicaments, le plus souvent des anti-inflammatoires non st\u00e9ro\u00efdiens (AINS) tels que l&rsquo;aspirine, le naprox\u00e8ne et l&rsquo;ibuprof\u00e8ne, et le m\u00e9thotrexate, un immunosuppresseur, ces m\u00e9dicaments peuvent atteindre leur efficacit\u00e9 maximale le matin, lorsque les sympt\u00f4mes sont g\u00e9n\u00e9ralement les plus marqu\u00e9s.<\/p>\n<p>Il a \u00e9galement \u00e9t\u00e9 d\u00e9montr\u00e9 que l&rsquo;<a href=\"https:\/\/www.dovepress.com\/recent-advances-in-chronotherapy-for-the-management-of-asthma-peer-reviewed-fulltext-article-CPT\" target=\"_blank\" rel=\"noopener\">asthme<\/a>, dont les sympt\u00f4mes sont plus graves la nuit, et les <a href=\"https:\/\/www.chronobiology.com\/rhythm-allergies-chronopharmacology-can-help-breathe-easier\/\" target=\"_blank\" rel=\"noopener\">allergies<\/a> b\u00e9n\u00e9ficiaient de la synchronisation des m\u00e9dicaments. L&rsquo;approche chronoth\u00e9rapeutique est \u00e9galement un outil tr\u00e8s pr\u00e9cieux dans la gestion du <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33092512\/\" target=\"_blank\" rel=\"noopener\">diab\u00e8te<\/a>. Les chercheurs <a href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/chronopharmacology\" target=\"_blank\" rel=\"noopener\">\u00e9tudient \u00e9galement<\/a> l&rsquo;impact potentiel de la chronopharmacologie sur le traitement des troubles du sommeil et de la d\u00e9pression et obtiennent des r\u00e9sultats encourageants.<\/p>\n<h2>Un traitement cibl\u00e9, plus s\u00fbr et plus efficace<\/h2>\n<p><a href=\"https:\/\/www.chronobiology.com\/wp-content\/uploads\/2022\/08\/Vertical-In-Text-Image-2.jpg\"><img decoding=\"async\" class=\"size-medium wp-image-43380 alignright\" title=\"Vertical In Text Image 2\" src=\"https:\/\/www.chronobiology.com\/wp-content\/uploads\/2022\/08\/Vertical-In-Text-Image-2-206x300.jpg\" alt=\"Vertical In Text Image 2\" width=\"206\" height=\"300\" srcset=\"https:\/\/dev.chronobiology.com\/wp-content\/uploads\/2022\/08\/Vertical-In-Text-Image-2-206x300.jpg 206w, https:\/\/dev.chronobiology.com\/wp-content\/uploads\/2022\/08\/Vertical-In-Text-Image-2.jpg 550w\" sizes=\"(max-width: 206px) 100vw, 206px\" \/><\/a>La chronopharmacologie et la chronoth\u00e9rapeutique modernes offrent des avantages consid\u00e9rables en ce qui concerne l&rsquo;utilisation de m\u00e9dicaments dans le traitement des maladies. Nous avons tous vu les publicit\u00e9s pour les m\u00e9dicaments avec la longue liste d&rsquo;effets secondaires potentiels. Aussi n\u00e9cessaires que soient les m\u00e9dicaments dans le traitement des maladies, ils impliquent souvent un compromis. De nombreux produits pharmaceutiques comportent un risque d&rsquo;effets secondaires importants, voire de toxicit\u00e9.<\/p>\n<p>Le r\u00f4le de la chronopharmacologie dans l&rsquo;<a href=\"https:\/\/www.chronobiology.com\/melatonin-sleep-disorders-chronopharmacology\/\" target=\"_blank\" rel=\"noopener\">ouverture de nouvelles possibilit\u00e9s<\/a> contribuera \u00e0 r\u00e9duire le risque d&rsquo;effets n\u00e9fastes tout en maximisant l&rsquo;efficacit\u00e9 des m\u00e9dicaments. Et, comme toujours, les scientifiques vont encore plus loin, cherchant des moyens de cibler les rythmes biologiques des agents pathog\u00e8nes, des parasites et des cellules malades tout en travaillant avec les rythmes circadiens du patient individuel pour produire des plans de traitement m\u00e9dicamenteux plus \u00e9troitement cibl\u00e9s, plus s\u00fbrs et plus efficaces.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Bien que les concepts associ\u00e9s \u00e0 la chronobiologie existent depuis des si\u00e8cles, ce n&rsquo;est qu&rsquo;avec la science moderne que nous avons pu r\u00e9ellement voir comment les rythmes biologiques entrent en jeu au niveau mol\u00e9culaire. \u00c0 mesure que la science approfondit l&rsquo;\u00e9tude des rythmes biologiques et l&rsquo;importance de leur synchronisation, une multitude de nouvelles connaissances ouvrent [&hellip;]<\/p>\n","protected":false},"author":11,"featured_media":43396,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","footnotes":""},"categories":[174,252,258],"tags":[],"class_list":{"0":"post-59261","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-le-rythme-circadien","8":"category-sante-de-lhomme","9":"category-sante-de-la-femme","10":"entry"},"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.4 (Yoast SEO v23.4) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Le r\u00f4le de la chronopharmacologie en m\u00e9decine &#8211; 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