{"id":58535,"date":"2017-05-12T10:59:03","date_gmt":"2017-05-12T17:59:03","guid":{"rendered":"https:\/\/www.chronobiology.com\/new-tool-named-cyclops-allows-us-see-daily-rhythms-cells\/"},"modified":"2024-07-18T14:53:13","modified_gmt":"2024-07-18T21:53:13","slug":"le-nouvel-outil-cyclops-nous-permet-de-voir-les-rythmes-quotidiens-des-cellules","status":"publish","type":"post","link":"https:\/\/dev.chronobiology.com\/fr\/le-nouvel-outil-cyclops-nous-permet-de-voir-les-rythmes-quotidiens-des-cellules\/","title":{"rendered":"Le nouvel outil CYCLOPS nous permet de voir les rythmes quotidiens des cellules"},"content":{"rendered":"<p>Un nouvel outil appel\u00e9 CYCLOPS pourrait changer la fa\u00e7on dont nous \u00e9tudions le rythme circadien en permettant aux chercheurs d&rsquo;examiner plus facilement les rythmes circadiens dans des cellules humaines vivantes.<\/p>\n<p>La plupart des recherches sur les m\u00e9canismes mol\u00e9culaires qui sous-tendent le rythme circadien sont effectu\u00e9es sur des souris, des mouches \u00e0 fruits et d&rsquo;autres animaux. Il y a une bonne raison \u00e0 cela : L&rsquo;identification des rythmes dans les cellules humaines peut repr\u00e9senter un \u00e9norme d\u00e9fi \u00e9thique et logistique. Les chercheurs h\u00e9sitent \u00e0 pr\u00e9lever des \u00e9chantillons vivants sur des \u00eatres humains, et encore moins \u00e0 en pr\u00e9lever plusieurs tout au long de la journ\u00e9e. Toutefois, un nouvel outil appel\u00e9 CYCLOPS pourrait faciliter l&rsquo;\u00e9tude approfondie du rythme circadien humain sur des tissus humains vivants.<\/p>\n<h2>Qu&rsquo;est-ce que CYCLOPS ?<\/h2>\n<p>La technologie peut changer la fa\u00e7on dont nous \u00e9tudions la sant\u00e9 humaine et m\u00eame la fa\u00e7on dont nous traitons les affections courantes. CYCLOPS pourrait r\u00e9volutionner non seulement le monde de la chronobiologie, mais aussi la m\u00e9decine dans son ensemble. Quel est ce nouvel outil r\u00e9volutionnaire ? CYCLOPS, abr\u00e9viation de \u00ab\u00a0CYClic Ordering by Periodic Structure\u00a0\u00bb, est un <a href=\"https:\/\/www.pennmedicine.org\/news\/news-releases\/2017\/april\/cyclops-algorithm-spots-daily-rhythms-in-cells\" target=\"_blank\" rel=\"noopener noreferrer\">algorithme informatique capable de compiler les donn\u00e9es existantes<\/a> sur l&rsquo;activit\u00e9 cellulaire afin d&rsquo;identifier les rythmes. Nous disposons actuellement d&rsquo;un grand nombre d&rsquo;informations sur de nombreuses cellules, mais nous n&rsquo;avons aucun moyen de d\u00e9terminer avec certitude si leur activit\u00e9 varie de mani\u00e8re pr\u00e9visible tout au long de la journ\u00e9e. CYCLOPS offre une nouvelle opportunit\u00e9.<\/p>\n<h2>Appliquer l&rsquo;informatique \u00e0 la sant\u00e9 humaine<\/h2>\n<p><a href=\"https:\/\/www.chronobiology.com\/wp-content\/uploads\/2017\/05\/new-tool-named-cyclops-allows-us-to-see-daily-rhythms-in-cells.jpg\"><img decoding=\"async\" class=\"alignright size-medium wp-image-19918\" src=\"https:\/\/www.chronobiology.com\/wp-content\/uploads\/2017\/05\/new-tool-named-cyclops-allows-us-to-see-daily-rhythms-in-cells-300x200.jpg\" alt=\"New Tool Named CYCLOPS Allows Us to See Daily Rhythms in Cells\" width=\"300\" height=\"200\" srcset=\"https:\/\/dev.chronobiology.com\/wp-content\/uploads\/2017\/05\/new-tool-named-cyclops-allows-us-to-see-daily-rhythms-in-cells-300x200.jpg 300w, https:\/\/dev.chronobiology.com\/wp-content\/uploads\/2017\/05\/new-tool-named-cyclops-allows-us-to-see-daily-rhythms-in-cells-768x513.jpg 768w, https:\/\/dev.chronobiology.com\/wp-content\/uploads\/2017\/05\/new-tool-named-cyclops-allows-us-to-see-daily-rhythms-in-cells.jpg 800w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/a>Ce nouvel algorithme n&rsquo;offre pas qu&rsquo;un avantage th\u00e9orique. CYCLOPS offre la possibilit\u00e9 de <a href=\"https:\/\/www.eurekalert.org\/pub_releases\/2017-04\/uops-as042517.php\" target=\"_blank\" rel=\"noopener noreferrer\">traiter plus efficacement toute une s\u00e9rie de pathologies humaines<\/a>. Par exemple, cet algorithme a d\u00e9tect\u00e9 que le g\u00e8ne codant pour le transporteur cellulaire de glucose GLUT2 est extr\u00eamement actif \u00e0 certains moments de la journ\u00e9e, mais presque silencieux \u00e0 d&rsquo;autres. Ceci est important car un m\u00e9dicament couramment utilis\u00e9 pour le traitement du cancer du pancr\u00e9as, la streptozocine, peut avoir des effets mortels lorsqu&rsquo;il se fixe sur ce transporteur. En administrant la streptozocine \u00e0 des moments de la journ\u00e9e o\u00f9 elle est moins susceptible d&rsquo;interagir avec GLUT2, il est probable que l&rsquo;on r\u00e9duira les taux de mortalit\u00e9 \u00e9lev\u00e9s dus \u00e0 ce cancer mortel. La pratique consistant \u00e0 administrer des m\u00e9dicaments \u00e0 des moments strat\u00e9giques pour \u00e9viter les effets secondaires ou renforcer l&rsquo;effet th\u00e9rapeutique, connue sous le nom de <a href=\"https:\/\/www.chronobiology.com\/health-benefits-of-chronopharmacology\/\" target=\"_blank\" rel=\"noopener noreferrer\">chronopharmacologie,<\/a> pourrait devenir courante une fois que nous comprendrons mieux le comportement des cellules tout au long de la journ\u00e9e de 24 heures.<\/p>\n<p>Le cancer du pancr\u00e9as est rare, mais des maladies encore plus courantes pourraient \u00eatre trait\u00e9es plus efficacement gr\u00e2ce \u00e0 cette technologie. Les inhibiteurs de l&rsquo;ECA, une classe de m\u00e9dicaments utilis\u00e9s pour traiter diverses affections, dont l&rsquo;hypertension art\u00e9rielle, se sont r\u00e9v\u00e9l\u00e9s plus efficaces lorsqu&rsquo;ils sont pris la nuit. Gr\u00e2ce \u00e0 ce nouvel algorithme informatique, nous savons maintenant exactement pourquoi cela se produit et nous pouvons planifier le traitement en cons\u00e9quence. Les personnes souffrant d&rsquo;hypertension art\u00e9rielle pourraient \u00eatre en mesure d&rsquo;obtenir de meilleurs r\u00e9sultats avec de plus petites quantit\u00e9s d&rsquo;inhibiteurs de l&rsquo;ECA, tout en \u00e9vitant les complications telles que les accidents vasculaires c\u00e9r\u00e9braux, les crises cardiaques et les an\u00e9vrismes.<\/p>\n<h2>Mieux vivre gr\u00e2ce \u00e0 la science moderne<\/h2>\n<p>Jusqu&rsquo;\u00e0 pr\u00e9sent, il \u00e9tait difficile de mieux comprendre nos rythmes circadiens. Cependant, CYCLOPS offre une nouvelle fa\u00e7on de mener des recherches qui peuvent avoir un b\u00e9n\u00e9fice tangible pour beaucoup d&rsquo;entre nous. Cela ouvre de nouvelles possibilit\u00e9s pour la chronopharmacologie et une vari\u00e9t\u00e9 de traitements bas\u00e9s sur la connaissance de la chronobiologie. Bien qu&rsquo;il semble tir\u00e9 par les cheveux de pr\u00e9tendre qu&rsquo;un programme informatique peut sauver des vies, cette technologie a bel et bien ce potentiel.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Un nouvel outil appel\u00e9 CYCLOPS pourrait changer la fa\u00e7on dont nous \u00e9tudions le rythme circadien en permettant aux chercheurs d&rsquo;examiner plus facilement les rythmes circadiens dans des cellules humaines vivantes. La plupart des recherches sur les m\u00e9canismes mol\u00e9culaires qui sous-tendent le rythme circadien sont effectu\u00e9es sur des souris, des mouches \u00e0 fruits et d&rsquo;autres animaux. [&hellip;]<\/p>\n","protected":false},"author":15,"featured_media":25608,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","footnotes":""},"categories":[174],"tags":[],"class_list":{"0":"post-58535","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-le-rythme-circadien","8":"entry"},"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.4 (Yoast SEO v23.4) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>New Tool Named CYCLOPS Allows Us to See Daily Rhythms in Cells<\/title>\n<meta name=\"description\" content=\"A new tool named CYCLOPS may change the way we study the circadian rhythm by 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