{"id":58505,"date":"2017-03-08T13:13:27","date_gmt":"2017-03-08T21:13:27","guid":{"rendered":"https:\/\/www.chronobiology.com\/fighting-cancer-place-24-hour-rhythms\/"},"modified":"2024-07-18T14:52:39","modified_gmt":"2024-07-18T21:52:39","slug":"combattre-le-cancer-la-place-des-rythmes-de-24-heures","status":"publish","type":"post","link":"https:\/\/dev.chronobiology.com\/fr\/combattre-le-cancer-la-place-des-rythmes-de-24-heures\/","title":{"rendered":"Combattre le cancer : La place des rythmes de 24 heures"},"content":{"rendered":"

Les scientifiques sont constamment \u00e0 la recherche de traitements nouveaux et innovants contre le cancer. Des recherches r\u00e9centes sugg\u00e8rent que l’am\u00e9lioration de l’horloge circadienne pourrait ralentir la croissance des tumeurs et contribuer au traitement du cancer.<\/p>\n

Un rythme circadien perturb\u00e9 est une cons\u00e9quence courante de la vie moderne. Les gens constatent souvent qu’ils ne peuvent pas dormir suffisamment en raison d’horaires de travail charg\u00e9s et d’autres obligations. En outre, les voyages et d’autres activit\u00e9s courantes laissent beaucoup d’entre nous en d\u00e9calage horaire et \u00e9puis\u00e9s. Il a \u00e9t\u00e9 constat\u00e9 que cette situation avait divers effets physiques et psychologiques n\u00e9gatifs, mais les liens r\u00e9cents entre la perturbation du rythme circadien et le cancer sugg\u00e8rent que les cons\u00e9quences peuvent m\u00eame \u00eatre mortelles.<\/p>\n

Perturbation du rythme circadien et cancer<\/h2>\n

\"Fighting<\/a>Le d\u00e9r\u00e8glement du rythme circadien a \u00e9t\u00e9 associ\u00e9 \u00e0 divers cancers, notamment le cancer du sein<\/a>, le cancer du c\u00f4lon et le m\u00e9lanome. Des niveaux irr\u00e9guliers de m\u00e9latonine seraient \u00e0 l’origine de ce lien. La m\u00e9latonine<\/a> fait partie int\u00e9grante du cycle cellulaire, indiquant aux cellules \u00e0 quel moment elles doivent effectuer les processus critiques de r\u00e9paration de l’ADN afin de pouvoir se reproduire en toute s\u00e9curit\u00e9. Lorsque les niveaux de m\u00e9latonine sont faibles au mauvais moment, les cellules n’effectuent pas les processus de r\u00e9paration et de reconstruction comme il se doit. On pense que c’est l’une des causes profondes de l’une des maladies les plus mortelles au monde : le cancer : le cancer.<\/p>\n

Est-il possible de traiter le cancer en aidant les cellules tumorales \u00e0 r\u00e9guler leur rythme circadien intrins\u00e8que ? Un groupe de chercheurs s’est pench\u00e9 sur cette question et a apport\u00e9 des r\u00e9ponses surprenantes.<\/p>\n

Une nouvelle \u00e9tude montre que les horloges circadiennes jouent un r\u00f4le essentiel dans le traitement du cancer<\/h2>\n

Les g\u00e8nes de l’horloge, qui r\u00e9gulent le rythme circadien, sont supprim\u00e9s dans un grand nombre des cancers les plus courants. Les chercheurs ont pris des cellules de m\u00e9lanome et ont induit un rythme circadien sain en utilisant la dexam\u00e9thasone, la forskoline ou un choc thermique. Les cellules de m\u00e9lanome qui ont r\u00e9agi \u00e0 ce traitement en adoptant un rythme circadien sain ont connu une croissance beaucoup plus faible apr\u00e8s le traitement<\/a>. En d’autres termes, inciter les g\u00e8nes de l’horloge \u00e0 r\u00e9adopter leur rythme naturel pourrait \u00eatre un moyen potentiel de ralentir ou d’arr\u00eater la croissance des tumeurs.<\/p>\n

Les cellules de m\u00e9lanome ne sont pas les seules cellules canc\u00e9reuses \u00e0 r\u00e9agir \u00e0 ce traitement. Certains g\u00e9notypes de cancer du c\u00f4lon arr\u00eatent ou ralentissent \u00e9galement leur croissance lorsqu’un rythme circadien sain est induit. Cependant, ce traitement ne fonctionne pas lorsque le g\u00e8ne de l’horloge BMAL1 a \u00e9t\u00e9 \u00ab\u00a0neutralis\u00e9\u00a0\u00bb. Les implications sont claires : un rythme circadien fonctionnel peut \u00eatre crucial pour les cellules saines, mais il semble avoir un effet n\u00e9gatif sur la prolif\u00e9ration des cellules canc\u00e9reuses.<\/p>\n

Chronobiologie : Le prochain grand traitement du cancer ?<\/h2>\n

De nombreux traitements contre le cancer sont tr\u00e8s invasifs ou tout simplement inconfortables. La chirurgie pour \u00e9liminer le cancer peut n\u00e9cessiter une longue convalescence ; la chimioth\u00e9rapie peut affecter les cellules saines et, par cons\u00e9quent, donner aux patients une sensation de fatigue et de maladie. Cependant, le r\u00e9tablissement d’un rythme circadien sain n’a que des effets positifs dans le traitement du cancer.<\/p>\n

Bien que cette recherche se concentre sur le rythme circadien intrins\u00e8que des cellules canc\u00e9reuses, si vous \u00eates concern\u00e9 par la pr\u00e9vention du cancer, le maintien d’un rythme circadien sain est essentiel<\/a>. Un rythme circadien fonctionnel peut vous aider \u00e0 vous sentir en meilleure sant\u00e9 aujourd’hui et tout au long de votre vie.<\/p>\n","protected":false},"excerpt":{"rendered":"

Les scientifiques sont constamment \u00e0 la recherche de traitements nouveaux et innovants contre le cancer. Des recherches r\u00e9centes sugg\u00e8rent que l’am\u00e9lioration de l’horloge circadienne pourrait ralentir la croissance des tumeurs et contribuer au traitement du cancer. Un rythme circadien perturb\u00e9 est une cons\u00e9quence courante de la vie moderne. Les gens constatent souvent qu’ils ne peuvent […]<\/p>\n","protected":false},"author":15,"featured_media":25456,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","footnotes":""},"categories":[174,256,241],"tags":[],"class_list":{"0":"post-58505","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-le-rythme-circadien","8":"category-melatonine","9":"category-recherche-sur-le-cancer","10":"entry"},"acf":[],"yoast_head":"\nFighting Cancer: The Place of 24-Hour Rhythms<\/title>\n<meta name=\"description\" content=\"Scientists are constantly searching for new and innovative treatments for cancer. 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Recent research suggests that enhancing circadian clocks may slow tumor growth and assist in cancer treatment.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/dev.chronobiology.com\/fr\/combattre-le-cancer-la-place-des-rythmes-de-24-heures\/\" \/>\n<meta property=\"og:site_name\" content=\"Chronobiology.com\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/chronobiology\" \/>\n<meta property=\"article:published_time\" content=\"2017-03-08T21:13:27+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-07-18T21:52:39+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/dev.chronobiology.com\/wp-content\/uploads\/2017\/02\/fighting-cancer-the-place-of-24-hour-rhythms-2.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1800\" \/>\n\t<meta property=\"og:image:height\" content=\"679\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Edwin Urbina\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@chronobionews\" \/>\n<meta name=\"twitter:site\" content=\"@chronobionews\" \/>\n<meta name=\"twitter:label1\" content=\"\u00c9crit par\" \/>\n\t<meta name=\"twitter:data1\" content=\"Edwin Urbina\" \/>\n\t<meta name=\"twitter:label2\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/dev.chronobiology.com\/fr\/combattre-le-cancer-la-place-des-rythmes-de-24-heures\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/dev.chronobiology.com\/fr\/combattre-le-cancer-la-place-des-rythmes-de-24-heures\/\"},\"author\":{\"name\":\"Edwin Urbina\",\"@id\":\"https:\/\/dev.chronobiology.com\/fr\/#\/schema\/person\/bbdffa2f15784a87635cc2a178677bf9\"},\"headline\":\"Combattre le cancer : La place des rythmes de 24 heures\",\"datePublished\":\"2017-03-08T21:13:27+00:00\",\"dateModified\":\"2024-07-18T21:52:39+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/dev.chronobiology.com\/fr\/combattre-le-cancer-la-place-des-rythmes-de-24-heures\/\"},\"wordCount\":661,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/dev.chronobiology.com\/fr\/#organization\"},\"image\":{\"@id\":\"https:\/\/dev.chronobiology.com\/fr\/combattre-le-cancer-la-place-des-rythmes-de-24-heures\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/dev.chronobiology.com\/wp-content\/uploads\/2017\/02\/fighting-cancer-the-place-of-24-hour-rhythms-2.jpg\",\"articleSection\":[\"Le-rythme circadien\",\"M\u00e9latonine\",\"Recherche sur le cancer\"],\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/dev.chronobiology.com\/fr\/combattre-le-cancer-la-place-des-rythmes-de-24-heures\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/dev.chronobiology.com\/fr\/combattre-le-cancer-la-place-des-rythmes-de-24-heures\/\",\"url\":\"https:\/\/dev.chronobiology.com\/fr\/combattre-le-cancer-la-place-des-rythmes-de-24-heures\/\",\"name\":\"Fighting Cancer: The Place of 24-Hour Rhythms\",\"isPartOf\":{\"@id\":\"https:\/\/dev.chronobiology.com\/fr\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/dev.chronobiology.com\/fr\/combattre-le-cancer-la-place-des-rythmes-de-24-heures\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/dev.chronobiology.com\/fr\/combattre-le-cancer-la-place-des-rythmes-de-24-heures\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/dev.chronobiology.com\/wp-content\/uploads\/2017\/02\/fighting-cancer-the-place-of-24-hour-rhythms-2.jpg\",\"datePublished\":\"2017-03-08T21:13:27+00:00\",\"dateModified\":\"2024-07-18T21:52:39+00:00\",\"description\":\"Scientists are constantly searching for new and innovative treatments for cancer. 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