{"id":58471,"date":"2016-12-21T11:31:00","date_gmt":"2016-12-21T19:31:00","guid":{"rendered":"https:\/\/www.chronobiology.com\/new-findings-show-the-liver-has-a-clear-rhythm\/"},"modified":"2024-07-18T14:51:59","modified_gmt":"2024-07-18T21:51:59","slug":"de-nouvelles-d-couvertes-montrent-que-le-foie-a-un-rythme-clair","status":"publish","type":"post","link":"https:\/\/dev.chronobiology.com\/fr\/de-nouvelles-d-couvertes-montrent-que-le-foie-a-un-rythme-clair\/","title":{"rendered":"De nouvelles d\u00e9couvertes montrent que le foie a un rythme clair"},"content":{"rendered":"

Le rythme circadien a fait l’objet de nombreuses \u00e9tudes et \u00e9crits. De nouvelles recherches sugg\u00e8rent que votre foie joue un r\u00f4le complexe dans le maintien de votre horloge interne.<\/p>\n

Le foie est l’un des organes les plus importants de l’organisme. Il maintient la glyc\u00e9mie \u00e0 un niveau s\u00fbr, cr\u00e9e de nombreuses prot\u00e9ines n\u00e9cessaires \u00e0 des activit\u00e9s allant de la coagulation \u00e0 la digestion et joue m\u00eame un r\u00f4le vital en \u00e9liminant les m\u00e9tabolites et les toxines de la circulation sanguine. Le foie produit \u00e9galement de la bile, qui joue un double r\u00f4le en nous aidant \u00e0 dig\u00e9rer les graisses et en \u00e9liminant la bilirubine de notre organisme. De nouvelles recherches sugg\u00e8rent que l’humble foie joue \u00e9galement un r\u00f4le important dans l’horloge interne, avec des cellules qui maintiennent un rythme circadien distinct du reste de l’organisme.<\/p>\n

AMPK et CKII : des prot\u00e9ines cl\u00e9s dans le rythme circadien<\/h2>\n

\u00c0 bien des \u00e9gards, notre corps fonctionne comme une machine dont les diverses prot\u00e9ines jouent le r\u00f4le de m\u00e9canismes de synchronisation, voire de rouages. L’AMPK est l’une de ces prot\u00e9ines<\/a>, qui d\u00e9tecte lorsque les cellules manquent d’\u00e9nergie et \u00a0\u00bb active \u00a0\u00bb le m\u00e9tabolisme en fonction des besoins. La CK2 est une autre prot\u00e9ine r\u00e9gulatrice multifonctionnelle<\/a>, qui aide les cellules \u00e0 d\u00e9cider si et quand elles doivent se diviser et m\u00eame mourir.<\/p>\n

Comme vous pouvez l’imaginer, ces prot\u00e9ines sont particuli\u00e8rement importantes dans les cellules du foie. Le foie joue un r\u00f4le immense dans la r\u00e9gulation du m\u00e9tabolisme et de la croissance cellulaire dans le corps humain. En outre, de nouvelles recherches indiquent que ces prot\u00e9ines aident \u00e9galement le foie \u00e0 fonctionner et \u00e0 maintenir un rythme circadien qui est li\u00e9 au cycle veille-sommeil<\/a> du reste de l’organisme, tout en \u00e9tant ind\u00e9pendant de celui-ci.<\/p>\n

Le rythme quotidien des cellules h\u00e9patiques<\/h2>\n

\"New<\/a>Les chercheurs ont mesur\u00e9 les niveaux de diff\u00e9rentes prot\u00e9ines, dont l’AMPK et la CKII, dans le foie de souris soumises \u00e0 un r\u00e9gime de je\u00fbne et d’alimentation strictement chronom\u00e9tr\u00e9 ou autoris\u00e9es \u00e0 manger normalement. Ils ont constat\u00e9 que les niveaux de ces prot\u00e9ines et d’autres dans le foie changeaient en fonction de l’heure de la journ\u00e9e<\/a>, ce qui montre un lien \u00e9vident avec l’horloge interne principale de l’organisme, r\u00e9gl\u00e9e par le noyau suprachiasmatique<\/a> de l’hypothalamus. En outre, les cellules h\u00e9patiques de souris soumises \u00e0 un programme sp\u00e9cifique d’alimentation et de je\u00fbne pr\u00e9sentaient une horloge interne l\u00e9g\u00e8rement diff\u00e9rente, qui r\u00e9pondait \u00e0 la fois aux signaux du cerveau et \u00e0 ceux de la consommation alimentaire de l’animal.<\/p>\n

Cette recherche sugg\u00e8re que le rythme circadien du foie est maintenu non seulement par l’horloge centrale de l’organisme, mais aussi par son propre m\u00e9canisme interne. Bien que le fonctionnement de cette \u00ab\u00a0horloge digestive\u00a0\u00bb ne soit pas encore connu, il pourrait s’av\u00e9rer important pour comprendre des maladies telles que le diab\u00e8te, dans lesquelles la fonction h\u00e9patique est souvent alt\u00e9r\u00e9e ou d\u00e9r\u00e9gl\u00e9e.<\/p>\n

Biologie circadienne et sant\u00e9<\/h2>\n

Aussi insignifiant que puisse para\u00eetre \u00e0 premi\u00e8re vue le rythme circadien d’un seul organe, ces d\u00e9couvertes pourraient bient\u00f4t avoir des r\u00e9percussions importantes sur la sant\u00e9 humaine. La prot\u00e9ine CKII, l’une des prot\u00e9ines r\u00e9gul\u00e9es en partie par le rythme circadien du foie, a \u00e9t\u00e9 impliqu\u00e9e dans certains types de cancer<\/a> ainsi que dans des maladies m\u00e9taboliques telles que le diab\u00e8te de type 2. Comprendre comment contr\u00f4ler les niveaux de cette prot\u00e9ine pourrait nous permettre de traiter plus efficacement cette grande vari\u00e9t\u00e9 de maladies humaines \u00e0 l’avenir. En outre, la recherche en chronobiologie, qui met en lumi\u00e8re les horloges internes d’organes tels que le foie, pourrait d\u00e9boucher sur des moyens plus efficaces de traiter les troubles du rythme circadien qui affectent des millions de personnes.<\/p>\n

Le foie est l’un des organes les plus importants du corps humain. Il joue un r\u00f4le dans presque tous les aspects de notre sant\u00e9 et souvent aussi dans la maladie. Mieux comprendre comment le foie affecte et est affect\u00e9 par nos horloges internes est la premi\u00e8re \u00e9tape vers de nouvelles th\u00e9rapies qui gu\u00e9rissent les maladies et sauvent des vies.<\/p>\n","protected":false},"excerpt":{"rendered":"

Le rythme circadien a fait l’objet de nombreuses \u00e9tudes et \u00e9crits. De nouvelles recherches sugg\u00e8rent que votre foie joue un r\u00f4le complexe dans le maintien de votre horloge interne. Le foie est l’un des organes les plus importants de l’organisme. Il maintient la glyc\u00e9mie \u00e0 un niveau s\u00fbr, cr\u00e9e de nombreuses prot\u00e9ines n\u00e9cessaires \u00e0 des […]<\/p>\n","protected":false},"author":15,"featured_media":25188,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","footnotes":""},"categories":[174,241],"tags":[],"class_list":{"0":"post-58471","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-le-rythme-circadien","8":"category-recherche-sur-le-cancer","9":"entry"},"acf":[],"yoast_head":"\nNew Findings Show the Liver has a Clear Rhythm<\/title>\n<meta name=\"description\" content=\"A lot has been studied and written about circadian rhythm. 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New research suggests that your liver plays an intricate role in maintaining your internal clocks.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/dev.chronobiology.com\/fr\/de-nouvelles-d-couvertes-montrent-que-le-foie-a-un-rythme-clair\/\" \/>\n<meta property=\"og:site_name\" content=\"Chronobiology.com\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/chronobiology\" \/>\n<meta property=\"article:published_time\" content=\"2016-12-21T19:31:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-07-18T21:51:59+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/dev.chronobiology.com\/wp-content\/uploads\/2016\/12\/new-findings-show-the-liver-has-a-clear-rhythm-2.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1800\" \/>\n\t<meta property=\"og:image:height\" content=\"679\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Edwin Urbina\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@chronobionews\" \/>\n<meta name=\"twitter:site\" content=\"@chronobionews\" \/>\n<meta name=\"twitter:label1\" content=\"\u00c9crit par\" \/>\n\t<meta name=\"twitter:data1\" content=\"Edwin Urbina\" \/>\n\t<meta name=\"twitter:label2\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/dev.chronobiology.com\/fr\/de-nouvelles-d-couvertes-montrent-que-le-foie-a-un-rythme-clair\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/dev.chronobiology.com\/fr\/de-nouvelles-d-couvertes-montrent-que-le-foie-a-un-rythme-clair\/\"},\"author\":{\"name\":\"Edwin Urbina\",\"@id\":\"https:\/\/dev.chronobiology.com\/fr\/#\/schema\/person\/bbdffa2f15784a87635cc2a178677bf9\"},\"headline\":\"De nouvelles d\u00e9couvertes montrent que le foie a un rythme clair\",\"datePublished\":\"2016-12-21T19:31:00+00:00\",\"dateModified\":\"2024-07-18T21:51:59+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/dev.chronobiology.com\/fr\/de-nouvelles-d-couvertes-montrent-que-le-foie-a-un-rythme-clair\/\"},\"wordCount\":760,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/dev.chronobiology.com\/fr\/#organization\"},\"image\":{\"@id\":\"https:\/\/dev.chronobiology.com\/fr\/de-nouvelles-d-couvertes-montrent-que-le-foie-a-un-rythme-clair\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/dev.chronobiology.com\/wp-content\/uploads\/2016\/12\/new-findings-show-the-liver-has-a-clear-rhythm-2.jpg\",\"articleSection\":[\"Le-rythme circadien\",\"Recherche sur le cancer\"],\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/dev.chronobiology.com\/fr\/de-nouvelles-d-couvertes-montrent-que-le-foie-a-un-rythme-clair\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/dev.chronobiology.com\/fr\/de-nouvelles-d-couvertes-montrent-que-le-foie-a-un-rythme-clair\/\",\"url\":\"https:\/\/dev.chronobiology.com\/fr\/de-nouvelles-d-couvertes-montrent-que-le-foie-a-un-rythme-clair\/\",\"name\":\"New Findings Show the Liver has a Clear Rhythm\",\"isPartOf\":{\"@id\":\"https:\/\/dev.chronobiology.com\/fr\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/dev.chronobiology.com\/fr\/de-nouvelles-d-couvertes-montrent-que-le-foie-a-un-rythme-clair\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/dev.chronobiology.com\/fr\/de-nouvelles-d-couvertes-montrent-que-le-foie-a-un-rythme-clair\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/dev.chronobiology.com\/wp-content\/uploads\/2016\/12\/new-findings-show-the-liver-has-a-clear-rhythm-2.jpg\",\"datePublished\":\"2016-12-21T19:31:00+00:00\",\"dateModified\":\"2024-07-18T21:51:59+00:00\",\"description\":\"A lot has been studied and written about circadian rhythm. 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