{"id":58449,"date":"2016-09-30T10:07:37","date_gmt":"2016-09-30T17:07:37","guid":{"rendered":"https:\/\/www.chronobiology.com\/new-research-cancer-genes-dictate-circadian-rhythm\/"},"modified":"2024-07-18T14:51:34","modified_gmt":"2024-07-18T21:51:34","slug":"nouvelles-recherches-sur-le-cancer-et-les-g-nes-qui-d-terminent-le-rythme-circadien","status":"publish","type":"post","link":"https:\/\/dev.chronobiology.com\/fr\/nouvelles-recherches-sur-le-cancer-et-les-g-nes-qui-d-terminent-le-rythme-circadien\/","title":{"rendered":"Nouvelles recherches sur le cancer et les g\u00e8nes qui d\u00e9terminent le rythme circadien"},"content":{"rendered":"

De nouvelles recherches permettent d’obtenir de nouvelles informations sur les g\u00e8nes qui dictent le rythme circadien, informations qui pourraient \u00eatre utilis\u00e9es pour traiter et m\u00eame gu\u00e9rir le cancer \u00e0 l’avenir.<\/p>\n

Le cancer est l’une des maladies les plus redoutables que l’on puisse contracter. La lutte contre le cancer est toujours un combat pour la vie, et de nombreux traitements peuvent \u00eatre aussi d\u00e9bilitants que la maladie. Cependant, la compr\u00e9hension des g\u00e8nes qui dictent le rythme circadien peut nous aider \u00e0 traiter le cancer plus efficacement et avec moins d’effets secondaires.<\/p>\n

Traiter le cancer du sein \u00e0 l’aide des g\u00e8nes qui dictent le rythme circadien<\/h2>\n

Dans le traitement du cancer du sein, les r\u00e9cepteurs sont essentiels. L’une des premi\u00e8res \u00e9tapes apr\u00e8s le diagnostic d’un cancer du sein consiste \u00e0 g\u00e9notyper le cancer, c’est-\u00e0-dire \u00e0 d\u00e9terminer les r\u00e9cepteurs et les g\u00e8nes qu’il poss\u00e8de. Cette connaissance est cruciale car ces r\u00e9cepteurs sont essentiels \u00e0 la croissance du cancer et \u00e0 la formation de m\u00e9tastases, ce qui en fait un point faible \u00e0 partir duquel nous pouvons attaquer l’ennemi. Le cancer du sein d\u00e9pourvu de r\u00e9cepteur d’\u0153strog\u00e8ne est l’un des types de cancer les plus difficiles \u00e0 traiter, car il ne poss\u00e8de pas ce talon d’Achille. Toutefois, un g\u00e8ne de l’horloge circadienne appel\u00e9 ARNTL2 pourrait constituer une future piste de traitement.<\/p>\n

Comme de nombreux g\u00e8nes de l’horloge, ARNTL2 est un \u00e9l\u00e9ment essentiel de la croissance et du m\u00e9tabolisme, ce qui le rend indispensable \u00e0 la formation de m\u00e9tastases par le cancer. Les personnes atteintes d’un cancer pr\u00e9sentant des niveaux \u00e9lev\u00e9s d’activit\u00e9 du g\u00e8ne ARNTL2 sont plus susceptibles de voir leur cancer se m\u00e9tastaser<\/a> et de mourir de la maladie. Le fait qu’un g\u00e8ne du rythme circadien soit impliqu\u00e9 dans la croissance du cancer et la formation de m\u00e9tastases pourrait expliquer pourquoi les personnes qui travaillent \u00e0 des heures irr\u00e9guli\u00e8res, en particulier les femmes, sont plus susceptibles de d\u00e9velopper un cancer<\/a>.<\/p>\n

Aider les patients atteints de cancer \u00e0 mieux respirer<\/h2>\n

Le cancer du sein n’est pas la seule tumeur maligne \u00e0 \u00eatre li\u00e9e aux g\u00e8nes du rythme circadien. Le cancer du poumon semble d\u00e9pendre d’un ensemble diff\u00e9rent de g\u00e8nes qui fonctionnent \u00e9galement comme des horloges internes, Per2 et BMAL1. Lorsque des personnes perdent la fonction de ces g\u00e8nes \u00e0 la suite de mutations<\/a>, elles sont plus susceptibles de d\u00e9velopper un cancer du poumon et d’avoir des m\u00e9tastases. La perte de ces g\u00e8nes, qui font partie des \u00ab\u00a0points de contr\u00f4le\u00a0\u00bb de la croissance et du d\u00e9veloppement, entra\u00eene une croissance incontr\u00f4l\u00e9e et, \u00e0 terme, un cancer.<\/p>\n

Le lien entre le travail post\u00e9 et le cancer<\/h2>\n

Le cancer de la prostate est une autre maladie qui fait des ravages chez de nombreuses personnes. Comme le cancer du sein, le cancer de la prostate peut souvent \u00eatre trait\u00e9 en attaquant les r\u00e9cepteurs qui r\u00e9gissent sa croissance. Dans le cas du cancer de la prostate, une multitude d’hormones et de r\u00e9cepteurs diff\u00e9rents sont impliqu\u00e9s. La m\u00e9latonine semble supprimer plusieurs de ces g\u00e8nes de l’horloge<\/a>, ce qui supprime leur activation et donc la croissance du cancer de la prostate. C’est peut-\u00eatre la raison pour laquelle les hommes qui ont un travail post\u00e9 sont plus susceptibles de d\u00e9velopper ce cancer<\/a> et d’en mourir. Des m\u00e9dicaments sont d\u00e9j\u00e0 en cours de d\u00e9veloppement pour supprimer ces r\u00e9cepteurs afin d’emp\u00eacher ces tumeurs de se d\u00e9velopper, de former des m\u00e9tastases et, en fin de compte, de faire d’autres victimes.<\/p>\n

La compr\u00e9hension du rythme circadien humain peut produire des informations qui nous permettent de dormir plus facilement. Mais cette connaissance peut aussi nous aider \u00e0 traiter plus efficacement le cancer et \u00e0 rendre la sant\u00e9 aux personnes qui en ont le plus besoin. Les g\u00e8nes qui d\u00e9terminent le rythme circadien sont \u00e9galement des g\u00e8nes qui contr\u00f4lent une multitude de processus dans l’organisme, de sorte que leur compr\u00e9hension peut avoir un impact consid\u00e9rable sur la sant\u00e9 humaine.<\/p>\n","protected":false},"excerpt":{"rendered":"

De nouvelles recherches permettent d’obtenir de nouvelles informations sur les g\u00e8nes qui dictent le rythme circadien, informations qui pourraient \u00eatre utilis\u00e9es pour traiter et m\u00eame gu\u00e9rir le cancer \u00e0 l’avenir. Le cancer est l’une des maladies les plus redoutables que l’on puisse contracter. La lutte contre le cancer est toujours un combat pour la vie, […]<\/p>\n","protected":false},"author":15,"featured_media":24740,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","footnotes":""},"categories":[174,256,241,257],"tags":[],"class_list":{"0":"post-58449","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-le-rythme-circadien","8":"category-melatonine","9":"category-recherche-sur-le-cancer","10":"category-travail-poste","11":"entry"},"acf":[],"yoast_head":"\nThe New Research on Cancer and the Genes That Dictate the Circadian Rhythm<\/title>\n<meta name=\"description\" content=\"New research is yielding new information about the 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