{"id":58441,"date":"2016-09-14T11:06:51","date_gmt":"2016-09-14T18:06:51","guid":{"rendered":"https:\/\/www.chronobiology.com\/circadian-rhythm-skin-disorders-eczema-psoriasis\/"},"modified":"2024-07-18T14:51:25","modified_gmt":"2024-07-18T21:51:25","slug":"le-rythme-circadien-des-troubles-cutan-s-ecz-ma-et-psoriasis","status":"publish","type":"post","link":"https:\/\/dev.chronobiology.com\/fr\/le-rythme-circadien-des-troubles-cutan-s-ecz-ma-et-psoriasis\/","title":{"rendered":"Le rythme circadien des troubles cutan\u00e9s : Ecz\u00e9ma et Psoriasis"},"content":{"rendered":"

La compr\u00e9hension du rythme circadien de la peau et des troubles cutan\u00e9s pourrait permettre de mieux traiter les probl\u00e8mes dermatologiques courants.<\/p>\n

Des dizaines de millions de personnes souffrent d’affections cutan\u00e9es inesth\u00e9tiques, prurigineuses et douloureuses, telles que l’ecz\u00e9ma et le psoriasis. S’il existe de nombreux traitements m\u00e9dicaux qui peuvent contribuer \u00e0 att\u00e9nuer les sympt\u00f4mes, ils ne constituent pas un rem\u00e8de. Pire encore, il y a de nombreuses personnes pour lesquelles les m\u00e9dicaments standard ne fonctionnent pas ou provoquent une vari\u00e9t\u00e9 d’effets secondaires ind\u00e9sirables. Cependant, de nouvelles recherches en chronobiologie sugg\u00e8rent que le choix du moment peut \u00eatre un \u00e9l\u00e9ment tr\u00e8s important dans la gestion des maladies dermatologiques.<\/p>\n

Ecz\u00e9ma et psoriasis : Des maladies courantes sans rem\u00e8de<\/h2>\n

L’ecz\u00e9ma est l’une des affections cutan\u00e9es les plus courantes<\/a>, touchant plus de 30 millions de personnes. Les personnes qui en souffrent pr\u00e9sentent des plaques de peau s\u00e8che et prurigineuse qui peuvent se fissurer et saigner. Le psoriasis est une maladie similaire, bien que moins courante. Les personnes atteintes de psoriasis ont un syst\u00e8me immunitaire hyperactif qui provoque une inflammation et une surproduction de cellules cutan\u00e9es<\/a>. Cette surproduction de cellules entra\u00eene l’apparition de plaques douloureuses et prurigineuses constitu\u00e9es d’une accumulation de cellules cutan\u00e9es enflamm\u00e9es.<\/p>\n

Des recherches ont montr\u00e9 que l’ecz\u00e9ma et le psoriasis ont des cycles nuit-jour distincts. La prise de m\u00e9dicaments aux moments de ces cycles o\u00f9 ils sont le plus susceptibles d’\u00eatre efficaces peut permettre un traitement plus efficace. Mais quel est le meilleur moment pour utiliser un m\u00e9dicament pour la peau ?<\/p>\n

Le rythme circadien de la peau<\/h2>\n

\"The<\/a>La peau, comme tous les organes, a un cycle nuit-jour qui lui est propre<\/a>. Les cellules de la peau se divisent et prolif\u00e8rent davantage la nuit, pour effectuer des r\u00e9parations essentielles. Pendant cette p\u00e9riode, la peau est plus acide, moins hydrat\u00e9e et a m\u00eame une temp\u00e9rature l\u00e9g\u00e8rement plus \u00e9lev\u00e9e que pendant la journ\u00e9e. L’inflammation du psoriasis suit un sch\u00e9ma similaire, avec des niveaux plus \u00e9lev\u00e9s de cellules immunitaires tard dans la nuit et donc une plus grande prolif\u00e9ration de cellules cutan\u00e9es inutiles. L’ecz\u00e9ma semble<\/a> \u00e9galement s’aggraver consid\u00e9rablement la nuit<\/a>, ce qui perturbe le sommeil de nombreuses personnes qui en souffrent.<\/p>\n

Une nouvelle \u00e9tude pourrait avoir identifi\u00e9 les g\u00e8nes \u00e0 l’origine de cette g\u00eane. Des g\u00e8nes tels que les g\u00e8nes CLOCK et PER2, qui sont \u00e9troitement impliqu\u00e9s dans la r\u00e9gulation et le maintien du rythme circadien, semblent \u00e9galement \u00eatre \u00e0 l’origine de nombreuses affections cutan\u00e9es courantes. Les souris qui pr\u00e9sentent des mutations dans le g\u00e8ne CLOCK souffrent moins de maladies cutan\u00e9es telles que le psoriasis<\/a>. Leur peau ne r\u00e9agit pas aussi fortement \u00e0 l’activit\u00e9 auto-immune qui provoque normalement les pouss\u00e9es de psoriasis. Les souris qui pr\u00e9sentaient une mutation du g\u00e8ne PER2, en revanche, ont d\u00e9velopp\u00e9 un psoriasis m\u00eame si elles ne pr\u00e9sentaient pas les autres sympt\u00f4mes auto-immuns habituellement associ\u00e9s \u00e0 cette maladie de la peau.<\/p>\n

La chronoth\u00e9rapie pourrait-elle soulager les maladies de la peau ?<\/h2>\n

Les sympt\u00f4mes des maladies de la peau telles que l’ecz\u00e9ma et le psoriasis semblent \u00eatre \u00e9troitement li\u00e9s au rythme circadien. Des \u00e9tudes ant\u00e9rieures ont montr\u00e9 que les m\u00e9dicaments topiques sont mieux absorb\u00e9s le soir, ce qui en fait le moment id\u00e9al pour les utiliser. En outre, la prise de m\u00e9dicaments contre les troubles \u00e0 pr\u00e9dominance nocturne avant l’heure du coucher peut att\u00e9nuer certains des sympt\u00f4mes les plus graves observ\u00e9s la nuit. Enfin, l’arr\u00eat des l\u00e9sions cellulaires au moment o\u00f9 elles sont le plus susceptibles de se produire r\u00e9duira probablement les sympt\u00f4mes m\u00eame pendant la journ\u00e9e.<\/p>\n

Lachronoth\u00e9rapie<\/a> peut permettre \u00e0 de nombreuses personnes souffrant de ces maladies et d’autres affections cutan\u00e9es de retrouver une peau saine et une bonne nuit de sommeil. Mais ce n’est pas le seul domaine o\u00f9 l’\u00e9tude du rythme circadien peut nous permettre d’am\u00e9liorer notre sant\u00e9. Comprendre le rythme circadien<\/a> des diff\u00e9rentes parties de notre corps est souvent la premi\u00e8re \u00e9tape vers le d\u00e9veloppement de traitements plus efficaces.<\/p>\n","protected":false},"excerpt":{"rendered":"

La compr\u00e9hension du rythme circadien de la peau et des troubles cutan\u00e9s pourrait permettre de mieux traiter les probl\u00e8mes dermatologiques courants. Des dizaines de millions de personnes souffrent d’affections cutan\u00e9es inesth\u00e9tiques, prurigineuses et douloureuses, telles que l’ecz\u00e9ma et le psoriasis. S’il existe de nombreux traitements m\u00e9dicaux qui peuvent contribuer \u00e0 att\u00e9nuer les sympt\u00f4mes, ils ne […]<\/p>\n","protected":false},"author":15,"featured_media":24708,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","footnotes":""},"categories":[174,254],"tags":[],"class_list":{"0":"post-58441","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-le-rythme-circadien","8":"category-peau","9":"entry"},"acf":[],"yoast_head":"\nThe Circadian Rhythm of Skin Disorders: Eczema and Psoriasis<\/title>\n<meta name=\"description\" content=\"Understanding the circadian rhythm of skin and skin disorders may allow people to better 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