{"id":58278,"date":"2015-10-09T18:09:18","date_gmt":"2015-10-09T18:09:18","guid":{"rendered":"https:\/\/www.chronobiology.com\/chronopharmacology-hypertension-and-the-risk-of-diabetes\/"},"modified":"2024-07-18T14:44:18","modified_gmt":"2024-07-18T21:44:18","slug":"chronopharmacologie-hypertension-et-risque-de-diab-te","status":"publish","type":"post","link":"https:\/\/dev.chronobiology.com\/fr\/chronopharmacologie-hypertension-et-risque-de-diab-te\/","title":{"rendered":"Chronopharmacologie, hypertension et risque de diab\u00e8te"},"content":{"rendered":"
\n

Des \u00e9tudes ont montr\u00e9 que l’hypertension art\u00e9rielle et le diab\u00e8te de type 2 \u00e9taient li\u00e9s \u00e0 plusieurs reprises. Bien que les changements de mode de vie qui traitent ces maladies soient les m\u00eames, comme l’am\u00e9lioration du r\u00e9gime alimentaire et l’augmentation de l’exercice physique, il n’y a pas encore eu de perc\u00e9e dans la recherche d’un m\u00e9dicament qui traite les deux maladies. Toutefois, une nouvelle \u00e9tude de chronopharmacologie<\/a> sugg\u00e8re que les m\u00e9dicaments contre l’hypertension administr\u00e9s \u00e0 certains moments de la journ\u00e9e pourraient \u00eatre efficaces pour pr\u00e9venir le diab\u00e8te de type 2.<\/p>\n

Le lien entre l’hypertension et le diab\u00e8te de type 2<\/h2>\n

\"Hypertension,<\/a>Les personnes souffrant d’hypertension sont plus susceptibles de d\u00e9velopper un diab\u00e8te de type 2, et vice-versa. Ces deux maladies font partie d’une maladie que les professionnels de la sant\u00e9 appellent le syndrome m\u00e9tabolique. Lorsqu’une personne souffre de ces deux maladies, elle court un risque beaucoup plus \u00e9lev\u00e9 de d\u00e9velopper de graves probl\u00e8mes cardiaques. L’hypertension art\u00e9rielle peut entra\u00eener des probl\u00e8mes de circulation, tandis que le diab\u00e8te augmente le risque d’ath\u00e9roscl\u00e9rose, c’est-\u00e0-dire de durcissement des art\u00e8res.<\/p>\n

Il est important d’aborder les diff\u00e9rentes maladies impliqu\u00e9es dans le syndrome m\u00e9tabolique comme un tout, en travaillant \u00e0 la sant\u00e9 de l’ensemble du corps. Le diab\u00e8te et l’hypertension affectant un grand nombre de personnes et \u00e9tant tous deux intimement li\u00e9s au rythme circadien<\/a>, ils sont devenus un domaine d’\u00e9tude populaire pour les chercheurs en biologie circadienne.<\/p>\n

Traitement du syndrome m\u00e9tabolique bas\u00e9 sur le rythme circadien<\/h2>\n

Bien que l’hypertension art\u00e9rielle et le diab\u00e8te de type 2 soient clairement li\u00e9s, il n’a pas \u00e9t\u00e9 d\u00e9montr\u00e9 que le traitement de l’hypertension permettait de pr\u00e9venir ou de traiter le diab\u00e8te. C’est regrettable, car la prise en charge de ces deux maladies peut prendre beaucoup de temps, \u00eatre \u00e9puisante et n\u00e9cessiter la prise quotidienne de m\u00e9dicaments co\u00fbteux. La pr\u00e9vention du diab\u00e8te est le meilleur traitement, c’est pourquoi les chercheurs en chronobiologie<\/a> ont eu le plaisir de d\u00e9couvrir que la prise de m\u00e9dicaments contre l’hypertension \u00e0 une certaine heure de la journ\u00e9e r\u00e9duisait consid\u00e9rablement le risque de diab\u00e8te.<\/p>\n

Leschercheurs en chronobiologie ont \u00e9tudi\u00e9 plus de 2000 personnes<\/a> souffrant d’hypertension qui prenaient leurs m\u00e9dicaments \u00e0 diff\u00e9rents moments de la journ\u00e9e. Si l’heure de la journ\u00e9e n’a pas eu d’incidence sur l’efficacit\u00e9 du m\u00e9dicament \u00e0 abaisser la tension art\u00e9rielle, ils ont constat\u00e9 qu’elle semblait avoir un effet sur le risque de diab\u00e8te. Les personnes qui prenaient leurs m\u00e9dicaments antihypertenseurs le soir \u00e9taient beaucoup moins susceptibles de d\u00e9velopper un diab\u00e8te de type 2.<\/p>\n

Moment de la prise des m\u00e9dicaments antihypertenseurs<\/h2>\n

La plupart des m\u00e9decins recommandent aux patients de prendre leur traitement antihypertenseur le matin. En effet, les hormones associ\u00e9es \u00e0 l’\u00e9tat de veille, telles que le cortisol, augmentent la tension art\u00e9rielle et l’hypertension a tendance \u00e0 \u00eatre plus s\u00e9v\u00e8re le matin. Cependant, les personnes qui ont pris leurs m\u00e9dicaments contre l’hypertension le soir ont en fait une tension art\u00e9rielle plus basse tout au long de la journ\u00e9e et une fluctuation plus faible de la tension art\u00e9rielle. En outre, ces personnes ont 65 % de risques en moins de d\u00e9velopper un diab\u00e8te de type 2, ce qui leur permet d’\u00eatre en meilleure sant\u00e9 et de r\u00e9duire les risques de maladies cardiovasculaires graves.<\/p>\n

Personnes qui s’adonnent \u00e0 la di\u00e8te et celles qui ne s’y adonnent pas<\/h2>\n

\"Chronopharmacology,<\/a>En plus de r\u00e9duire le risque de diab\u00e8te et de futures complications cardiaques, la prise de m\u00e9dicaments contre la tension art\u00e9rielle la nuit peut \u00eatre particuli\u00e8rement utile pour les<\/a> personnes dites \u00a0\u00bb non dippers<\/a>\u00ab\u00a0. Les \u00ab\u00a0dippers\u00a0\u00bb sont des personnes souffrant d’hypertension qui voient leur tension art\u00e9rielle baisser la nuit, tout comme les personnes ayant une tension art\u00e9rielle normale. Les \u00ab\u00a0non-dippers\u00a0\u00bb n’ont pas cette baisse de tension art\u00e9rielle. Non seulement les non-dippers ont tendance \u00e0 avoir une tension art\u00e9rielle plus \u00e9lev\u00e9e m\u00eame s’ils prennent des m\u00e9dicaments, mais ils sont \u00e9galement plus expos\u00e9s au diab\u00e8te, aux maladies cardiaques et \u00e0 d’autres complications li\u00e9es \u00e0 l’hypertension.<\/p>\n

Y a-t-il un inconv\u00e9nient \u00e0 prendre des m\u00e9dicaments antihypertenseurs la nuit ? Les chercheurs et les m\u00e9decins n’en ont pas encore trouv\u00e9. Non seulement ce m\u00e9dicament est plus efficace lorsqu’il est pris avant le coucher, mais il a plus de chances d’aider les non-dippers, qui sont les plus difficiles \u00e0 traiter. En outre, il r\u00e9duit le risque de d\u00e9velopper un diab\u00e8te de type 2, avec tous les facteurs de risque qui l’accompagnent. Les patients qui prennent des antihypertenseurs peuvent d\u00e9sormais mener une vie plus saine et plus longue gr\u00e2ce \u00e0 cette nouvelle \u00e9tude passionnante.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Des \u00e9tudes ont montr\u00e9 que l’hypertension art\u00e9rielle et le diab\u00e8te de type 2 \u00e9taient li\u00e9s \u00e0 plusieurs reprises. Bien que les changements de mode de vie qui traitent ces maladies soient les m\u00eames, comme l’am\u00e9lioration du r\u00e9gime alimentaire et l’augmentation de l’exercice physique, il n’y a pas encore eu de perc\u00e9e dans la recherche d’un […]<\/p>\n","protected":false},"author":11,"featured_media":23884,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","footnotes":""},"categories":[249],"tags":[],"class_list":{"0":"post-58278","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-sante-du-coeur","8":"entry"},"acf":[],"yoast_head":"\nChronopharmacologie, hypertension et risque de diab\u00e8te – Chronobiology.com<\/title>\n<meta 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