{"id":58200,"date":"2015-05-08T21:03:19","date_gmt":"2015-05-08T21:03:19","guid":{"rendered":"https:\/\/www.chronobiology.com\/circadian-connection-the-missing-link-in-arthritis-treatment-and-prevention\/"},"modified":"2024-07-18T14:41:49","modified_gmt":"2024-07-18T21:41:49","slug":"la-connexion-circadienne-le-cha-non-manquant-dans-le-traitement-et-la-pr-vention-de-l-arthrite","status":"publish","type":"post","link":"https:\/\/dev.chronobiology.com\/fr\/la-connexion-circadienne-le-cha-non-manquant-dans-le-traitement-et-la-pr-vention-de-l-arthrite\/","title":{"rendered":"La connexion circadienne : Le cha\u00eenon manquant dans le traitement et la pr\u00e9vention de l’arthrite"},"content":{"rendered":"

Dans le monde moderne de la m\u00e9decine, la tentation est grande de se tourner vers les id\u00e9es d\u00e9su\u00e8tes et souvent ridiculis\u00e9es du pass\u00e9 et de supposer que la science a d\u00e9sormais tout compris. Cet \u00e9tat d’esprit n’est pas seulement \u00e9go\u00efste, il peut \u00eatre carr\u00e9ment dangereux. Les nouvelles informations qui surgissent constamment mettent en lumi\u00e8re des croyances modernes solidement ancr\u00e9es qui ne sont pas toujours aussi in\u00e9branlables que beaucoup l’avaient suppos\u00e9.<\/p>\n

\"Circadian<\/a>La chronopharmacologie<\/a>, c’est-\u00e0-dire l’\u00e9tude de l’impact des processus biologiques de l’organisme sur les traitements pharmaceutiques et vice-versa, en est un bon exemple.<\/p>\n

La recherche moderne fait des d\u00e9couvertes \u00e9piques sur l’impact de la biologie circadienne sur le corps humain. La chronobiologie<\/a>, \u00e9galement appel\u00e9e biologie circadienne, est l’\u00e9tude de la mani\u00e8re dont les cycles quotidiens, saisonniers et m\u00eame annuels affectent le corps humain. Plus on l’\u00e9tudie, plus son impact s’av\u00e8re important.<\/p>\n

De nombreux processus fondamentaux de l’organisme sont ancr\u00e9s dans le rythme circadien, tels que la production d’\u0153strog\u00e8nes, l’interaction m\u00e9latonine\/s\u00e9rotonine, la production de cortisol et m\u00eame la lib\u00e9ration de cytokines, substances du syst\u00e8me immunitaire qui d\u00e9clenchent l’inflammation. Pour les personnes souffrant de maladies inflammatoires, l’\u00e9tude de la biologie circadienne n’est pas seulement intrigante : elle est imp\u00e9rative.<\/p>\n

Les rythmes circadiens peuvent guider le traitement pour une efficacit\u00e9 optimale<\/h2>\n

La polyarthrite rhumato\u00efde est l’une des maladies inflammatoires les plus courantes, qui a fait l’objet d’\u00e9tudes approfondies \u00e0 la lumi\u00e8re de la biologie circadienne. Cette forme d’arthrite est particuli\u00e8rement pr\u00e9judiciable car, en tant que maladie auto-immune, elle pousse l’organisme \u00e0 s’attaquer lui-m\u00eame. Pour la plupart des malades, la douleur est g\u00e9n\u00e9ralement plus forte le matin<\/a>, ce qui sugg\u00e8re un lien avec le rythme circadien.<\/p>\n

\"Circadian<\/a>Selon le chercheur Andrew Coogan<\/a>, qui a dirig\u00e9 une \u00e9quipe dans le cadre d’une \u00e9tude intensive sur les implications de la chronoth\u00e9rapie et de la polyarthrite rhumato\u00efde, le fait que la maladie suive un sch\u00e9ma circadien signifie que la th\u00e9rapie peut \u00eatre optimis\u00e9e en \u00e9tant propos\u00e9e au bon moment. \u00c9tant donn\u00e9 que les d\u00e9clencheurs de l’arthrite se produisent la nuit, l’\u00e9quipe a v\u00e9rifi\u00e9 si l’adaptation des m\u00e9dicaments pour qu’ils soient administr\u00e9s \u00e0 ces moments-l\u00e0 s’av\u00e9rait b\u00e9n\u00e9fique.<\/p>\n

Les r\u00e9sultats ont \u00e9t\u00e9 concluants.<\/p>\n

Selon Coogan :<\/p>\n

\n

\u00ab\u00a0La douleur, la d\u00e9pression et les troubles du sommeil semblent \u00eatre li\u00e9s dans la polyarthrite rhumato\u00efde. Comprendre l’impact de la chronoth\u00e9rapie sur tous ces domaines nous permettra de tirer des conclusions cliniquement pertinentes et d’am\u00e9liorer les soins aux patients. Le pipeline de m\u00e9dicaments est pauvre, mais nous pouvons faire quelque chose de simple en changeant simplement le moment o\u00f9 le patient prend ses m\u00e9dicaments\u00a0\u00bb.<\/p>\n<\/blockquote>\n

Il a \u00e9galement d\u00e9clar\u00e9 :<\/p>\n

\n

\u00ab\u00a0Il est surprenant que la chronoth\u00e9rapie ne soit pas mentionn\u00e9e dans les lignes directrices officielles relatives \u00e0 la conduite des essais de m\u00e9dicaments contre la polyarthrite rhumato\u00efde, mais nous esp\u00e9rons que nos recherches auront une influence sur ce point.<\/p>\n<\/blockquote>\n

La chronoth\u00e9rapie ne remplace pas le m\u00e9dicament proprement dit. En revanche, on insiste sur le moment o\u00f9<\/i> le m\u00e9dicament est pris. Les r\u00e9sultats prouvent qu’il s’agit d’une composante essentielle de tout r\u00e9gime de r\u00e9tablissement et qu’elle doit \u00eatre \u00e9tudi\u00e9e de mani\u00e8re plus approfondie.<\/p>\n

La perturbation des rythmes circadiens ouvre la voie aux probl\u00e8mes<\/h2>\n

La compr\u00e9hension de la biologie circadienne est non seulement essentielle pour le traitement de l’arthrite, mais aussi pour la pr\u00e9vention. Selon une \u00e9tude men\u00e9e par Robin M. Voigt, Ph.D.<\/a>, du Rush Medical College, lorsqu’il est associ\u00e9 \u00e0 d’autres choix mena\u00e7ant la sant\u00e9, un syst\u00e8me circadien perturb\u00e9 peut augmenter consid\u00e9rablement les risques de contracter des maladies inflammatoires.<\/p>\n

Selon Voigt :<\/p>\n

\n

\u00ab\u00a0Nous pensons que la perturbation chronique du rythme circadien favorise\/exacerbe les maladies \u00e0 m\u00e9diation inflammatoire, au moins en partie, en raison de changements dans le microbiote intestinal.\u00a0\u00bb<\/p>\n<\/blockquote>\n

\"Circadian<\/a>L’une des fa\u00e7ons dont les rythmes circadiens d\u00e9salign\u00e9s peuvent s’av\u00e9rer nocifs est qu’ils favorisent l’inflammation lorsqu’ils sont associ\u00e9s \u00e0 un r\u00e9gime riche en graisses et en sucres. Les maladies dont le nom se termine par \u00ab\u00a0-itis\u00a0\u00bb sont des maladies inflammatoires telles que l’arthrite, la conjonctivite, la dermatite et l’h\u00e9patite. De nombreuses maladies inflammatoires prennent naissance dans l’intestin, et des habitudes de sommeil non r\u00e9gul\u00e9es cr\u00e9ent une temp\u00eate parfaite \u00e0 l’int\u00e9rieur de l’intestin, qui n’attend que l’ajout de sucre et de graisses pour d\u00e9clencher l’inflammation qui touche tant de personnes aujourd’hui.<\/p>\n

Ce n’est que r\u00e9cemment que les scientifiques ont commenc\u00e9 \u00e0 comprendre que le moment o\u00f9<\/i> certaines fonctions sont ex\u00e9cut\u00e9es est tout aussi important que la nature de ces <\/i>fonctions. La d\u00e9couverte que la perturbation des rythmes circadiens<\/a>, les sch\u00e9mas naturels jour\/nuit qui durent environ 24 heures, peut ouvrir la voie \u00e0 toute une s\u00e9rie de maladies est une information vitale qui est encore quelque peu nouvelle pour le public.<\/p>\n

\u00c9tant donn\u00e9 que les maladies li\u00e9es \u00e0 l’inflammation commencent dans le tube digestif, la mesure dans laquelle les rythmes circadiens affectent le microbiote intestinal est un domaine qui n\u00e9cessite davantage d’\u00e9tudes. Il suffit de dire que le fait de suivre des horaires normaux, avec la lumi\u00e8re du soleil pour se r\u00e9veiller et l’obscurit\u00e9 pour s’endormir, est un pas dans la bonne direction.<\/p>\n

Pour certaines personnes, cela signifie qu’il est temps d’arr\u00eater les \u00e9missions de vari\u00e9t\u00e9s de fin de soir\u00e9e et les marathons de jeux vid\u00e9o qui durent toute la nuit. Dans certains cas, la d\u00e9cision difficile de changer d’emploi afin d’\u00e9liminer le travail de nuit peut \u00eatre la meilleure d\u00e9cision \u00e0 prendre pour am\u00e9liorer votre sant\u00e9 future.<\/p>\n

Quel que soit le degr\u00e9 d’\u00e9volution de la soci\u00e9t\u00e9 moderne, il semble que certaines choses ne changent jamais. Les recherches modernes confirment la sagesse des anciens : Une bonne nuit de sommeil et une journ\u00e9e de travail bien remplie sont deux b\u00e9n\u00e9dictions qui ne peuvent \u00eatre remplac\u00e9es.<\/p>\n","protected":false},"excerpt":{"rendered":"

Dans le monde moderne de la m\u00e9decine, la tentation est grande de se tourner vers les id\u00e9es d\u00e9su\u00e8tes et souvent ridiculis\u00e9es du pass\u00e9 et de supposer que la science a d\u00e9sormais tout compris. Cet \u00e9tat d’esprit n’est pas seulement \u00e9go\u00efste, il peut \u00eatre carr\u00e9ment dangereux. Les nouvelles informations qui surgissent constamment mettent en lumi\u00e8re des […]<\/p>\n","protected":false},"author":15,"featured_media":23400,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","footnotes":""},"categories":[250,240,255],"tags":[],"class_list":{"0":"post-58200","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-flore-intestinale","8":"category-os-et-articulations","9":"category-sommeil","10":"entry"},"acf":[],"yoast_head":"\nLa connexion circadienne : Le cha\u00eenon manquant dans le traitement et la pr\u00e9vention de l'arthrite – Chronobiology.com<\/title>\n<meta name=\"description\" content=\"Many fundamental body processes are rooted in the circadian rhythm such as estrogen production, melatonin\/serotonin interaction, cortisol production, and even the release of cytokines, which are immune system-based substances that trigger inflammation. 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