{"id":58194,"date":"2015-04-29T22:17:38","date_gmt":"2015-04-29T22:17:38","guid":{"rendered":"https:\/\/www.chronobiology.com\/research-shines-light-on-links-between-disrupted-circadian-rhythms-and-breast-cancer\/"},"modified":"2024-07-18T14:41:42","modified_gmt":"2024-07-18T21:41:42","slug":"la-recherche-met-en-lumi-re-les-liens-entre-la-perturbation-des-rythmes-circadiens-et-le-cancer-du-sein","status":"publish","type":"post","link":"https:\/\/dev.chronobiology.com\/fr\/la-recherche-met-en-lumi-re-les-liens-entre-la-perturbation-des-rythmes-circadiens-et-le-cancer-du-sein\/","title":{"rendered":"La recherche met en lumi\u00e8re les liens entre la perturbation des rythmes circadiens et le cancer du sein"},"content":{"rendered":"

Bien que les chercheurs ne sachent toujours pas pourquoi des rythmes circadiens<\/a> mal align\u00e9s peuvent constituer une telle menace pour le bien-\u00eatre \u00e0 long terme des personnes dont les cycles veille-sommeil sont perturb\u00e9s de mani\u00e8re prolong\u00e9e ou r\u00e9currente, la science ne cesse de montrer qu’il s’agit d’un facteur important dans un certain nombre de maladies. Chez les femmes, la perturbation des rythmes circadiens peut m\u00eame entra\u00eener un risque accru de cancer du sein<\/a>.<\/p>\n

Alors que les scientifiques cherchent encore \u00e0 \u00e9lucider toutes les questions sur la mani\u00e8re dont les rythmes circadiens affectent les cellules canc\u00e9reuses, de nouvelles \u00e9tudes \u00e9clairent le sujet comme jamais auparavant.<\/p>\n

Lumi\u00e8re artificielle et m\u00e9latonine<\/h2>\n

L’un des principaux responsables de ce dilemme est la lumi\u00e8re artificielle. Bien que les scientifiques ne comprennent pas encore tout sur l’interaction entre la lumi\u00e8re et la m\u00e9latonine<\/a>, leurs connaissances progressent. Selon Russell Foster, Ph.D.<\/a>, de l’Imperial College School of Medicine de Londres, \u00ab\u00a0ce n’est pas la vision qui est en cause, mais plut\u00f4t la m\u00e9latonine :<\/p>\n

\n

\"Circadian<\/a>\u00ab\u00a0Ce n’est pas la vision, mais plut\u00f4t un autre syst\u00e8me de phototransduction dans la r\u00e9tine qui provoque la suppression de la m\u00e9latonine en r\u00e9ponse \u00e0 la lumi\u00e8re.\u00a0\u00bb<\/p>\n<\/blockquote>\n

Les scientifiques ont d\u00e9couvert qu’une lumi\u00e8re vive r\u00e9guli\u00e8re la nuit<\/a> peut supprimer la production de m\u00e9latonine. La m\u00e9latonine inhibe non seulement la croissance du cancer, mais des \u00e9tudes sugg\u00e8rent qu’elle augmente \u00e9galement la production d’\u0153strog\u00e8nes tout en limitant la r\u00e9ceptivit\u00e9 aux \u0153strog\u00e8nes. Sa suppression peut d\u00e9s\u00e9quilibrer l’organisme sur le plan hormonal.<\/p>\n

Les m\u00e9decins savent qu’un d\u00e9s\u00e9quilibre hormonal peut facilement faire pencher la balance du c\u00f4t\u00e9 du cancer du sein. Comprendre les m\u00e9canismes par lesquels ces hormones se d\u00e9s\u00e9quilibrent est imp\u00e9ratif pour tout programme de pr\u00e9vention, et ces nouvelles informations peuvent fournir aux femmes des conseils pratiques. En s’en tenant aux heures normales de la journ\u00e9e et en \u00e9vitant les carri\u00e8res qui exigent de passer de longues heures sous des lumi\u00e8res artificielles alors que le corps r\u00e9clame du sommeil, les femmes ont beaucoup plus de chances d’\u00e9viter le cancer du sein.<\/p>\n

Comment nous savons que la lumi\u00e8re artificielle est coupable<\/h2>\n

L’une des preuves que la lumi\u00e8re artificielle est coupable d’avoir introduit le d\u00e9s\u00e9quilibre circadien est que les femmes aveugles ont un avantage marqu\u00e9 lorsqu’il s’agit d’\u00e9viter le cancer du sein<\/a>. Selon le pr\u00e9sident de la conf\u00e9rence du NIH et \u00e9pid\u00e9miologiste du cancer Richard Stevens, Ph :<\/p>\n

\n

\u00ab\u00a0On a d’abord pens\u00e9 que les femmes aveugles pouvaient avoir un risque plus \u00e9lev\u00e9 de d\u00e9velopper un cancer du sein, parce que certaines \u00e9tudes ont rapport\u00e9 qu’elles avaient des r\u00e8gles plus pr\u00e9coces et un \u00e2ge de procr\u00e9ation plus tardif, deux facteurs qui ont \u00e9t\u00e9 consid\u00e9r\u00e9s comme augmentant le risque de cancer du sein chez les femmes, alors qu’on a constat\u00e9 que ces femmes avaient un risque plus faible de d\u00e9velopper la maladie.<\/p>\n<\/blockquote>\n

\"Circadian<\/a>Stevens et ses coll\u00e8gues ont r\u00e9cemment annonc\u00e9 leurs conclusions qui prouvent que plus une femme est malvoyante, moins elle a de chances de se voir diagnostiquer un cancer. Cette recherche, associ\u00e9e \u00e0 la d\u00e9couverte que les femmes qui travaillent souvent de nuit ont une incidence consid\u00e9rablement plus \u00e9lev\u00e9e de cancer du sein, sugg\u00e8re aux scientifiques que la suppression de la m\u00e9latonine r\u00e9sulte de l’exposition \u00e0 la lumi\u00e8re artificielle au milieu de la nuit.<\/p>\n

Alors que les femmes qui travaillent comme h\u00f4tesses de l’air sont g\u00e9n\u00e9ralement confront\u00e9es \u00e0 une incidence plus \u00e9lev\u00e9e du cancer du sein que les autres travailleuses de premi\u00e8re \u00e9quipe, les personnes aveugles et malvoyantes b\u00e9n\u00e9ficient d’une diminution de 15 % de l’incidence du cancer. Bien que les raisons de ce ph\u00e9nom\u00e8ne ne soient pas enti\u00e8rement comprises, un rythme circadien d\u00e9salign\u00e9 caus\u00e9 par l’incidence de la lumi\u00e8re aux mauvais moments a un impact, et les scientifiques s’efforcent de mieux comprendre les liens.<\/p>\n

Pour les femmes qui souhaitent pr\u00e9venir le cancer du sein, le choix le plus \u00e9vident est de s’en tenir \u00e0 la lumi\u00e8re du jour et d’\u00e9viter les lumi\u00e8res vives au milieu de la nuit. Bien que de nombreuses femmes puissent penser qu’elles sont hors de danger parce qu’elles ne travaillent pas de nuit, elles devraient \u00e9galement veiller \u00e0 ne pas rester debout trop tard \u00e0 consulter leur t\u00e9l\u00e9phone ou \u00e0 regarder la t\u00e9l\u00e9vision, car les lumi\u00e8res artificielles de toutes sortes peuvent supprimer la m\u00e9latonine qui prot\u00e8ge leur corps et maintient leurs niveaux d’hormones stables.<\/p>\n

\u00c0 mesure que l’on s’attache \u00e0 comprendre la chronobiologie<\/a> et la mani\u00e8re dont le corps humain est affect\u00e9 par les rythmes circadiens, il est probable que de nombreuses autres maladies qui ont perturb\u00e9 les individus pendant des d\u00e9cennies s’av\u00e8rent avoir un lien avec la biologie circadienne. Cela montre que les anciens avaient raison lorsqu’ils disaient : \u00ab\u00a0Il y a une saison pour tout, et un temps pour chaque chose sous le ciel\u00a0\u00bb.<\/p>\n

Il y a m\u00eame un temps pour se r\u00e9veiller et un temps pour dormir.<\/p>\n","protected":false},"excerpt":{"rendered":"

Bien que les chercheurs ne sachent toujours pas pourquoi des rythmes circadiens mal align\u00e9s peuvent constituer une telle menace pour le bien-\u00eatre \u00e0 long terme des personnes dont les cycles veille-sommeil sont perturb\u00e9s de mani\u00e8re prolong\u00e9e ou r\u00e9currente, la science ne cesse de montrer qu’il s’agit d’un facteur important dans un certain nombre de maladies. […]<\/p>\n","protected":false},"author":15,"featured_media":23356,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","footnotes":""},"categories":[256,241,258,255,257],"tags":[],"class_list":{"0":"post-58194","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-melatonine","8":"category-recherche-sur-le-cancer","9":"category-sante-de-la-femme","10":"category-sommeil","11":"category-travail-poste","12":"entry"},"acf":[],"yoast_head":"\nLa recherche met en lumi\u00e8re les liens entre la perturbation des rythmes circadiens et le cancer du sein – Chronobiology.com<\/title>\n<meta name=\"description\" content=\"Although researchers are still in the dark about why misaligned circadian rhythms can pose such a threat to the long term well-being of individuals who experience prolonged or recurring disrupted sleep\/wake cycles, science is continually showing that it is an important factor in a number of maladies. 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