{"id":58168,"date":"2015-03-04T22:20:12","date_gmt":"2015-03-04T22:20:12","guid":{"rendered":"https:\/\/www.chronobiology.com\/skin-and-circadian-rhythm-the-internal-clocks-of-skin-cells\/"},"modified":"2024-07-18T14:41:10","modified_gmt":"2024-07-18T21:41:10","slug":"la-peau-et-le-rythme-circadien-les-horloges-internes-des-cellules-de-la-peau","status":"publish","type":"post","link":"https:\/\/dev.chronobiology.com\/fr\/la-peau-et-le-rythme-circadien-les-horloges-internes-des-cellules-de-la-peau\/","title":{"rendered":"La peau et le rythme circadien : Les horloges internes des cellules de la peau"},"content":{"rendered":"

Lesrythmes circadiens<\/a>, ou horloges biologiques internes de 24 heures, font l’objet de nombreuses recherches en cours. Les scientifiques commencent \u00e0 peine \u00e0 d\u00e9couvrir les effets des cycles de lumi\u00e8re et d’obscurit\u00e9 sur le corps humain, qui constituent un nouveau domaine de la biologie appel\u00e9 chronobiologie<\/a>. Les derni\u00e8res recherches montrent que ces horloges internes contr\u00f4lent non seulement nos humeurs, nos niveaux d’\u00e9nergie et nos hormones, mais aussi la sant\u00e9 de notre peau.<\/p>\n

Les horloges internes des cellules de la peau<\/h2>\n

De nombreuses fonctions des rythmes circadiens sont contr\u00f4l\u00e9es par le noyau suprachiasmatique du cerveau. Cependant, de nombreux types de cellules poss\u00e8dent leur propre horloge interne. Ces horloges cr\u00e9ent des vagues d’activit\u00e9 en fonction de l’heure de la journ\u00e9e. Les cellules de la peau poss\u00e8dent \u00e9galement ces horloges<\/a>. Les cellules souches de l’\u00e9piderme se reproduisent principalement la nuit, cr\u00e9ant de nouvelles cellules cutan\u00e9es qui remplacent les cellules \u00e2g\u00e9es et r\u00e9duisent l’apparence du vieillissement. En outre, la r\u00e9paration de l’ADN se produit principalement \u00e0 des heures pr\u00e9cises de la journ\u00e9e, ce qui est important car il s’agit de la premi\u00e8re ligne de d\u00e9fense de l’organisme contre les dommages caus\u00e9s par les UV et le cancer de la peau.<\/p>\n

Comme les cellules de la peau<\/a> sont engag\u00e9es dans diff\u00e9rentes activit\u00e9s \u00e0 diff\u00e9rents moments de la journ\u00e9e, elles sont \u00e9galement plus sensibles aux dommages \u00e0 certains moments. Comprendre le rythme circadien des cellules de la peau peut \u00eatre un moyen important de pr\u00e9venir le vieillissement pr\u00e9matur\u00e9 et le cancer de la peau.<\/p>\n

Les g\u00e8nes CLOCK et votre peau<\/h2>\n

\"Skin<\/a>Les derni\u00e8res recherches<\/a> indiquent que les g\u00e8nes CLOCK, pr\u00e9c\u00e9demment identifi\u00e9s dans d’autres types de cellules, sont probablement les g\u00e8nes qui affectent l’horloge interne des cellules de la peau. L’\u00e9piderme joue un r\u00f4le important dans la sant\u00e9. Il s\u00e9pare nos organes vitaux des influences n\u00e9fastes de l’environnement ext\u00e9rieur, notamment les rayons UV, les produits chimiques, l’oxydation et le stress m\u00e9canique. Les g\u00e8nes CLOCK des cellules de l’\u00e9piderme semblent anticiper les p\u00e9riodes de plus grand stress et programmer les r\u00e9parations.<\/p>\n

Il semble que la r\u00e9paration de l’ADN dans les cellules de la peau ait lieu l’apr\u00e8s-midi et le soir. Ce sont les moments o\u00f9 la peau est le plus susceptible d’\u00eatre expos\u00e9e aux rayons UV directs. Ce ph\u00e9nom\u00e8ne est suivi, tard dans la nuit, par la prolif\u00e9ration des cellules souches \u00e9pidermiques. On pense que la prolif\u00e9ration se produit la nuit parce que c’est le moment o\u00f9 ces processus d\u00e9licats risquent le moins d’\u00eatre interrompus ou perturb\u00e9s. Il en r\u00e9sulte que les dommages caus\u00e9s \u00e0 l’ADN le matin et la nuit, en particulier les dommages caus\u00e9s par les UV, sont moins susceptibles d’\u00eatre r\u00e9par\u00e9s \u00e0 temps, tandis que les personnes qui veillent tard et qui exposent leur peau \u00e0 la lumi\u00e8re et \u00e0 des produits chimiques tels que l’alcool et le tabac peuvent souffrir d’un vieillissement pr\u00e9matur\u00e9.<\/p>\n

Effets des rythmes circadiens sur la peau<\/h2>\n

Avant la d\u00e9couverte des g\u00e8nes CLOCK, les scientifiques avaient d\u00e9j\u00e0 observ\u00e9 que l’\u00e9tat de la peau varie de mani\u00e8re pr\u00e9visible sur un cycle de 24 heures. Par exemple, les femmes jugent r\u00e9guli\u00e8rement leur peau plus attrayante le matin que le soir, ce qui, nous le savons aujourd’hui, est probablement d\u00fb \u00e0 la prolif\u00e9ration de nouvelles cellules cutan\u00e9es pendant la nuit. En outre, il a \u00e9t\u00e9 prouv\u00e9 que les cr\u00e8mes anti-\u00e2ge sont plus efficaces lorsqu’elles sont utilis\u00e9es avant le coucher.<\/p>\n

Par ailleurs, la peau semble plus sensible \u00e0 l’inflammation \u00e0 certains moments de la journ\u00e9e. Les sympt\u00f4mes de la dermatite atopique sont plus marqu\u00e9s la nuit, et c’est aussi \u00e0 ce moment-l\u00e0 que le psoriasis est le plus s\u00e9v\u00e8re. Les personnes qui passent des tests d’allergie et des tests cutan\u00e9s de d\u00e9pistage de la tuberculose sont moins susceptibles d’obtenir un r\u00e9sultat positif lorsque le test est effectu\u00e9 le matin plut\u00f4t que l’apr\u00e8s-midi ou le soir.<\/p>\n

Le choix du moment est-il la cl\u00e9 de la pr\u00e9vention ?<\/h2>\n

\"Skin<\/a>Bien que l’\u00e9tude du rythme circadien de la peau n’en soit qu’\u00e0 ses d\u00e9buts, il est possible que ces connaissances puissent \u00eatre utilis\u00e9es pour mieux pr\u00e9venir et traiter les affections cutan\u00e9es. Par exemple, les m\u00e9dicaments contre le psoriasis et la dermatite peuvent \u00eatre plus efficaces lorsqu’ils sont administr\u00e9s la nuit, car c’est le moment o\u00f9 les pouss\u00e9es se produisent. Si les personnes doivent sortir au milieu des rayons UV non bloqu\u00e9s, elles peuvent pr\u00e9voir de le faire l’apr\u00e8s-midi ou en d\u00e9but de soir\u00e9e<\/a>. Les traitements contre le cancer de la peau, tels que la chimioth\u00e9rapie, peuvent \u00eatre plus efficaces s’ils sont planifi\u00e9s de mani\u00e8re \u00e0 co\u00efncider avec les moments les plus efficaces du cycle cellulaire de la peau.<\/p>\n

La chronobiologie est un domaine \u00e9mergent qui s’av\u00e8re de plus en plus important pour la sant\u00e9 humaine. La compr\u00e9hension des g\u00e8nes CLOCK et de leurs effets sur les cellules de la peau pourrait \u00eatre un moyen important de pr\u00e9venir le cancer de la peau, le vieillissement pr\u00e9matur\u00e9 et une vari\u00e9t\u00e9 de troubles cutan\u00e9s.<\/p>\n","protected":false},"excerpt":{"rendered":"

Lesrythmes circadiens, ou horloges biologiques internes de 24 heures, font l’objet de nombreuses recherches en cours. Les scientifiques commencent \u00e0 peine \u00e0 d\u00e9couvrir les effets des cycles de lumi\u00e8re et d’obscurit\u00e9 sur le corps humain, qui constituent un nouveau domaine de la biologie appel\u00e9 chronobiologie. Les derni\u00e8res recherches montrent que ces horloges internes contr\u00f4lent non […]<\/p>\n","protected":false},"author":15,"featured_media":23180,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","footnotes":""},"categories":[254,241,242],"tags":[],"class_list":{"0":"post-58168","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-peau","8":"category-recherche-sur-le-cancer","9":"category-sante-des-cellules","10":"entry"},"acf":[],"yoast_head":"\nLa peau et le rythme circadien : Les horloges internes des cellules de la peau – Chronobiology.com<\/title>\n<meta name=\"description\" content=\"Scientists are only beginning to discover the effects of light and dark cycles on the human body, which comprise a new field of biology called chronobiology. 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