{"id":58144,"date":"2015-01-16T10:00:16","date_gmt":"2015-01-16T10:00:16","guid":{"rendered":"https:\/\/www.chronobiology.com\/how-chronobiology-is-affecting-cancer-treatment\/"},"modified":"2024-07-18T14:40:40","modified_gmt":"2024-07-18T21:40:40","slug":"comment-la-chronobiologie-affecte-le-traitement-du-cancer","status":"publish","type":"post","link":"https:\/\/dev.chronobiology.com\/fr\/comment-la-chronobiologie-affecte-le-traitement-du-cancer\/","title":{"rendered":"Comment la chronobiologie affecte le traitement du cancer"},"content":{"rendered":"

Les scientifiques commencent tout juste \u00e0 comprendre la relation du cerveau humain avec le temps. Nous savons depuis des d\u00e9cennies que le corps fonctionne selon des rythmes circadiens, avec des cycles qui se r\u00e9p\u00e8tent toutes les 24 heures. En r\u00e9alit\u00e9, notre corps fonctionne selon plusieurs horloges diff\u00e9rentes, la croissance cellulaire, la lib\u00e9ration d’hormones et d’autres activit\u00e9s quotidiennes \u00e9tant r\u00e9gl\u00e9es sur un cycle bas\u00e9 sur le sommeil, les niveaux de lumi\u00e8re et d’obscurit\u00e9 et bien d’autres choses encore. La chronobiologie<\/a> \u00e9tudie nos horloges internes et la mani\u00e8re dont elles sont affect\u00e9es par ce que nous consommons et quand nous le consommons. Il est donc naturel que de nombreux chronobiologistes esp\u00e8rent faire une perc\u00e9e dans la lutte contre le cancer. Certains l’ont peut-\u00eatre d\u00e9j\u00e0 fait.<\/p>\n

\n

Chronobiologie et cancer<\/h2>\n

\"How<\/a>Les chronobiologistes du monde entier tentent de mieux comprendre les horloges internes<\/a> du corps humain et beaucoup esp\u00e8rent que cette compr\u00e9hension pourrait \u00eatre la cl\u00e9 d’un meilleur traitement du cancer. Ces horloges internes contr\u00f4lent la croissance cellulaire, de sorte que toute modification de leur fonction peut entra\u00eener une croissance incontr\u00f4l\u00e9e et une r\u00e9duction de l’apoptose, ou mort cellulaire programm\u00e9e, qui sont toutes deux des causes fondamentales du cancer.<\/p>\n

Lesrythmes circadiens<\/a> influencent le fonctionnement des m\u00e9dicaments, y compris les th\u00e9rapies modernes contre le cancer. Les chimioth\u00e9rapies modernes ciblent des parties cruciales du m\u00e9tabolisme des cellules canc\u00e9reuses. Ainsi, l’administration des th\u00e9rapies \u00e0 des moments o\u00f9 elles sont le plus efficaces permet d’am\u00e9liorer les r\u00e9sultats du traitement. La compr\u00e9hension de ces moments optimaux est l’un des principaux objectifs des chronobiologistes.<\/p>\n

La m\u00e9thode des rythmes : Administrer les m\u00e9dicaments anticanc\u00e9reux au moment o\u00f9 ils sont le plus efficaces<\/h2>\n

La connaissance de la chronobiologie et des rythmes circadiens peut permettre d’am\u00e9liorer les traitements anticanc\u00e9reux<\/a> pour plusieurs raisons. Tout d’abord, le fait de cibler certaines parties du m\u00e9tabolisme des cellules canc\u00e9reuses au cours de la phase la plus sensible du cycle cellulaire permet de r\u00e9duire plus rapidement la taille des tumeurs et d’obtenir une r\u00e9mission. Deuxi\u00e8mement, de nombreux m\u00e9dicaments et chimioth\u00e9rapies anticanc\u00e9reux doivent \u00eatre m\u00e9tabolis\u00e9s ou activ\u00e9s avant d’\u00eatre efficaces. L’administration de doses de ces th\u00e9rapies au moment o\u00f9 elles seront activ\u00e9es \u00e0 la bonne vitesse augmentera la quantit\u00e9 de m\u00e9dicament disponible. Enfin, les chimioth\u00e9rapies fonctionnent mieux en pr\u00e9sence de certaines hormones. Les niveaux hormonaux varient en fonction des rythmes circadiens, de sorte que les m\u00e9dicaments sont plus efficaces lorsque les doses sont administr\u00e9es \u00e0 un moment qui co\u00efncide avec des niveaux hormonaux b\u00e9n\u00e9fiques.<\/p>\n

R\u00e9duction de la toxicit\u00e9 gr\u00e2ce \u00e0 la chronobiologie<\/h2>\n

\"Chronobiology,<\/a>Un autre avantage possible de l’utilisation de la chronobiologie dans la planification de la chimioth\u00e9rapie est que les patients seraient moins susceptibles de recevoir des doses toxiques<\/a> du m\u00e9dicament. De nombreux patients sont contraints d’arr\u00eater d’utiliser un m\u00e9dicament particulier en raison de ses effets toxiques sur leur organisme, m\u00eame s’il est efficace. En r\u00e9duisant la toxicit\u00e9 des m\u00e9dicaments anticanc\u00e9reux, on r\u00e9duit les effets secondaires d\u00e9sagr\u00e9ables et on augmente les chances que le m\u00e9dicament s’attaque au cancer.<\/p>\n

La chronobiologie permet de r\u00e9duire la toxicit\u00e9 associ\u00e9e \u00e0 la chimioth\u00e9rapie de plusieurs mani\u00e8res. Lorsque les m\u00e9dicaments sont administr\u00e9s \u00e0 des moments plus efficaces, une quantit\u00e9 moindre de m\u00e9dicament est n\u00e9cessaire. Il y a des moments de la journ\u00e9e o\u00f9 les m\u00e9dicaments sont mieux tol\u00e9r\u00e9s par l’organisme, en raison des niveaux d’hormones du patient ou de la vitesse \u00e0 laquelle il m\u00e9tabolise le m\u00e9dicament et excr\u00e8te les m\u00e9tabolites nocifs. La chimioth\u00e9rapie s’accompagnant d’effets secondaires n\u00e9gatifs li\u00e9s \u00e0 la toxicit\u00e9 des m\u00e9dicaments, tout ce qui permettrait de r\u00e9duire la toxicit\u00e9 sans compromettre le traitement constituerait une avanc\u00e9e consid\u00e9rable dans la lutte contre le cancer.<\/p>\n

Chronobiologie et traitement du cancer en pratique<\/h2>\n

\"Chronobiology,<\/a>De nouvelles \u00e9tudes r\u00e9v\u00e8lent les avantages de l’utilisation de la chronobiologie pour cibler la chimioth\u00e9rapie. Par exemple, il a \u00e9t\u00e9 prouv\u00e9 que les m\u00e9dicaments anticanc\u00e9reux tels que le m\u00e9thotrexate et le 5-fluorouracile, connus sous le nom d’antim\u00e9tabolites, agissent mieux et produisent moins d’effets secondaires lorsqu’ils sont administr\u00e9s le soir ou la nuit<\/a>. Cela s’explique par le fait que ces m\u00e9dicaments interf\u00e8rent avec la synth\u00e8se de l’ADN. Comme les cellules humaines normales ralentissent la synth\u00e8se de l’ADN tard dans la nuit, ce qui n’est pas le cas des cellules canc\u00e9reuses, l’administration d’antim\u00e9tabolites \u00e0 ce moment-l\u00e0 att\u00e9nue leur effet sur les cellules saines et r\u00e9duit donc les effets secondaires.<\/p>\n

Les antim\u00e9tabolites ne sont pas les seuls m\u00e9dicaments de chimioth\u00e9rapie qui se r\u00e9v\u00e8lent plus efficaces \u00e0 diff\u00e9rents moments de la journ\u00e9e. Des \u00e9tudes men\u00e9es sur des animaux de laboratoire ont montr\u00e9 que 30 m\u00e9dicaments anticanc\u00e9reux courants sont plus efficaces et moins toxiques lorsqu’ils sont administr\u00e9s \u00e0 des heures qui correspondent \u00e0 l’horloge interne de l’organisme.<\/p>\n

La chronobiologie est une science nouvelle et \u00e9volutive qui fait l’objet de nombreuses \u00e9tudes en cours. La fa\u00e7on dont la chronobiologie peut \u00eatre utilis\u00e9e \u00e0 terme pour aider \u00e0 traiter le cancer est peut-\u00eatre l’aspect le plus passionnant de cette science, et c’est quelque chose que nous suivrons de pr\u00e8s.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Les scientifiques commencent tout juste \u00e0 comprendre la relation du cerveau humain avec le temps. Nous savons depuis des d\u00e9cennies que le corps fonctionne selon des rythmes circadiens, avec des cycles qui se r\u00e9p\u00e8tent toutes les 24 heures. En r\u00e9alit\u00e9, notre corps fonctionne selon plusieurs horloges diff\u00e9rentes, la croissance cellulaire, la lib\u00e9ration d’hormones et d’autres […]<\/p>\n","protected":false},"author":11,"featured_media":23008,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","footnotes":""},"categories":[174,241,242],"tags":[],"class_list":{"0":"post-58144","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-le-rythme-circadien","8":"category-recherche-sur-le-cancer","9":"category-sante-des-cellules","10":"entry"},"acf":[],"yoast_head":"\nComment la chronobiologie affecte le traitement du cancer – Chronobiology.com<\/title>\n<meta name=\"description\" content=\"Chronobiology studies our internal clocks and how they are affected by what we consume and when we consume it. 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