{"id":62283,"date":"2017-10-02T13:17:00","date_gmt":"2017-10-02T20:17:00","guid":{"rendered":"https:\/\/www.chronobiology.com\/circadian-rhythm-discoveries-win-nobel-prize\/"},"modified":"2024-07-21T22:18:17","modified_gmt":"2024-07-22T05:18:17","slug":"los-descubrimientos-sobre-el-ritmo-circadiano-ganan-el-nobel","status":"publish","type":"post","link":"https:\/\/dev.chronobiology.com\/es\/los-descubrimientos-sobre-el-ritmo-circadiano-ganan-el-nobel\/","title":{"rendered":"Los descubrimientos sobre el ritmo circadiano ganan el Nobel"},"content":{"rendered":"

La comunidad de la cronobiolog\u00eda recibi\u00f3 el lunes uno de los mayores reconocimientos al concederse el Premio Nobel de Fisiolog\u00eda o Medicina a tres estadounidenses por sus descubrimientos sobre c\u00f3mo los relojes internos y los ritmos biol\u00f3gicos rigen la vida humana.<\/p>\n

Jeffrey C. Hall, Michael Rosbash y Michael W. Young se llevaron a casa el premio \u00abpor sus descubrimientos de los mecanismos moleculares que controlan el ritmo circadiano\u00bb, dijo la Fundaci\u00f3n Nobel. El trabajo del tr\u00edo explica c\u00f3mo las plantas, los animales y los seres humanos adaptan sus ritmos biol\u00f3gicos en sincron\u00eda con las rotaciones de la Tierra.<\/p>\n

Identificados los genes del reloj interno<\/h2>\n

Seg\u00fan el resumen del descubrimiento, la Asamblea Nobel del Karolinska Institutet:<\/p>\n

\u00abUtilizando moscas de la fruta como organismo modelo, los galardonados con el Nobel de este a\u00f1o aislaron un gen que controla el ritmo biol\u00f3gico diario normal. Demostraron que este gen codifica una prote\u00edna que se acumula en la c\u00e9lula durante la noche y se degrada durante el d\u00eda. Posteriormente, identificaron otros componentes prote\u00ednicos de esta maquinaria, exponiendo el mecanismo que rige el mecanismo de relojer\u00eda autosostenido dentro de la c\u00e9lula. Ahora reconocemos que los relojes biol\u00f3gicos funcionan seg\u00fan los mismos principios en las c\u00e9lulas de otros organismos pluricelulares, incluidos los humanos.<\/p>\n

\u00abCon una precisi\u00f3n exquisita, nuestro reloj interno adapta nuestra fisiolog\u00eda a las fases dr\u00e1sticamente diferentes del d\u00eda. El reloj regula funciones cr\u00edticas como el comportamiento, los niveles hormonales, el sue\u00f1o, la temperatura corporal y el metabolismo.\u00bb<\/p>\n

Or\u00edgenes en el siglo XVIII<\/h2>\n

\"Circadian<\/a>Cuando el astr\u00f3nomo Jacques d’Ortous de Mairan estudi\u00f3 las plantas de mimosa en el sigloXVIII<\/sup>, descubri\u00f3 que las hojas de la planta se abren hacia el sol durante el d\u00eda y se cierran al anochecer, descubriendo as\u00ed que las plantas tienen su propio reloj biol\u00f3gico. Esto le llev\u00f3 a descubrir que los humanos y los animales tambi\u00e9n tienen un reloj biol\u00f3gico y fluctuaciones fisiol\u00f3gicas diarias. Esta adaptaci\u00f3n diaria se conoce como ritmo circadiano.<\/p>\n

El reloj interno controla diversas funciones corporales<\/h2>\n

Los galardonados con el Nobel de este a\u00f1o trataron de averiguar c\u00f3mo funciona realmente este reloj interno. Hall y Rosbash aislaron previamente el gen period en 1984, tras lo cual descubrieron que la prote\u00edna PER (codificada por period) se acumulaba durante la noche y se degradaba durante el d\u00eda, demostrando que los niveles de prote\u00edna PER oscilan a lo largo de un ciclo de 24 horas en sincron\u00eda con el ritmo circadiano. A continuaci\u00f3n, Young descubri\u00f3 un segundo gen reloj llamado timeless que codificaba la prote\u00edna TIM, necesaria para un ritmo circadiano normal. Como resultado, Young demostr\u00f3 que cuando TIM se un\u00eda a PER, las prote\u00ednas entraban en el n\u00facleo celular y bloqueaban el gen del periodo. Este bucle de retroalimentaci\u00f3n arroj\u00f3 luz sobre c\u00f3mo se produc\u00eda la oscilaci\u00f3n proteica celular. A continuaci\u00f3n, Young identific\u00f3 el gen del doble periodo (DBT) que retrasaba la acumulaci\u00f3n de la prote\u00edna PER.<\/p>\n

Gracias a estos descubrimientos, se enteraron de que todos los organismos pluricelulares -incluidos los humanos- utilizan mecanismos similares para controlar los ritmos circadianos. Durante las distintas fases del d\u00eda, el organismo se prepara para distintos procesos. Por ejemplo, el cortisol se libera a las 6 de la ma\u00f1ana, a las 9 de la ma\u00f1ana el estado de alerta es elevado y la mejor coordinaci\u00f3n se alcanza a mediod\u00eda, hacia las 3 de la tarde, cuando se producen los tiempos de reacci\u00f3n m\u00e1s r\u00e1pidos. La temperatura corporal m\u00e1s alta se alcanza alrededor de las 18.00 horas, la presi\u00f3n arterial m\u00e1s alta del cuerpo se produce por la noche, seguida de la secreci\u00f3n de melatonina alrededor de las 22.00 horas. El sue\u00f1o m\u00e1s profundo del ciclo se produce despu\u00e9s de medianoche, seguido de la temperatura corporal m\u00e1s baja alrededor de las 3.00 horas y, a continuaci\u00f3n, el ciclo vuelve a empezar.<\/p>\n","protected":false},"excerpt":{"rendered":"

La comunidad de la cronobiolog\u00eda recibi\u00f3 el lunes uno de los mayores reconocimientos al concederse el Premio Nobel de Fisiolog\u00eda o Medicina a tres estadounidenses por sus descubrimientos sobre c\u00f3mo los relojes internos y los ritmos biol\u00f3gicos rigen la vida humana. Jeffrey C. Hall, Michael Rosbash y Michael W. Young se llevaron a casa el […]<\/p>\n","protected":false},"author":11,"featured_media":25859,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","footnotes":""},"categories":[173,214],"tags":[],"class_list":{"0":"post-62283","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-el-ritmo-circadiano","8":"category-sueno","9":"entry"},"acf":[],"yoast_head":"\nLos descubrimientos sobre el ritmo circadiano ganan el Nobel – Chronobiology.com<\/title>\n<meta name=\"description\" content=\"The Nobel Prize in physiology or medicine was awarded to three Americans for their discovery on how internal clocks & biological rhythms govern human life.\" 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