{"id":62050,"date":"2017-03-08T13:13:27","date_gmt":"2017-03-08T21:13:27","guid":{"rendered":"https:\/\/www.chronobiology.com\/fighting-cancer-place-24-hour-rhythms\/"},"modified":"2024-07-21T22:15:20","modified_gmt":"2024-07-22T05:15:20","slug":"la-lucha-contra-el-c-ncer-el-lugar-de-los-ritmos-de-24-horas","status":"publish","type":"post","link":"https:\/\/dev.chronobiology.com\/es\/la-lucha-contra-el-c-ncer-el-lugar-de-los-ritmos-de-24-horas\/","title":{"rendered":"La lucha contra el c\u00e1ncer: El lugar de los ritmos de 24 horas"},"content":{"rendered":"<p>Los cient\u00edficos buscan constantemente tratamientos nuevos e innovadores contra el c\u00e1ncer. Investigaciones recientes sugieren que mejorar los relojes circadianos puede ralentizar el crecimiento tumoral y ayudar en el tratamiento del c\u00e1ncer.<\/p>\n<p>La alteraci\u00f3n del ritmo circadiano es una consecuencia com\u00fan de la vida moderna. A menudo, las personas no pueden dormir lo suficiente debido a sus apretadas agendas de trabajo y otras obligaciones. Adem\u00e1s, los viajes y otras actividades comunes nos dejan a muchos con jet lag y agotados. Se ha descubierto que esto tiene una serie de efectos f\u00edsicos y psicol\u00f3gicos negativos, pero los recientes v\u00ednculos entre la alteraci\u00f3n del ritmo circadiano y el c\u00e1ncer sugieren que las consecuencias pueden ser incluso mortales.<\/p>\n<h2>Alteraci\u00f3n del ritmo circadiano y c\u00e1ncer<\/h2>\n<p><a href=\"https:\/\/www.chronobiology.com\/wp-content\/uploads\/2017\/02\/fighting-cancer-the-place-of-24-hour-rhythms.jpg\"><img decoding=\"async\" class=\"alignright size-medium wp-image-19470\" src=\"https:\/\/www.chronobiology.com\/wp-content\/uploads\/2017\/02\/fighting-cancer-the-place-of-24-hour-rhythms-300x200.jpg\" alt=\"Fighting Cancer: The Place of 24-Hour Rhythms\" width=\"300\" height=\"200\" srcset=\"https:\/\/dev.chronobiology.com\/wp-content\/uploads\/2017\/02\/fighting-cancer-the-place-of-24-hour-rhythms-300x200.jpg 300w, https:\/\/dev.chronobiology.com\/wp-content\/uploads\/2017\/02\/fighting-cancer-the-place-of-24-hour-rhythms-768x512.jpg 768w, https:\/\/dev.chronobiology.com\/wp-content\/uploads\/2017\/02\/fighting-cancer-the-place-of-24-hour-rhythms.jpg 800w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/a>La alteraci\u00f3n del ritmo circadiano se ha relacionado con diversos tipos de c\u00e1ncer, como <a href=\"https:\/\/www.chronobiology.com\/research-shines-light-on-links-between-disrupted-circadian-rhythms-and-breast-cancer\/\" target=\"_blank\" rel=\"noopener\">el de mama<\/a>, el de colon y el melanoma. Se cree que los niveles irregulares de melatonina son la causa de esta relaci\u00f3n. <a href=\"https:\/\/www.chronobiology.com\/melatonin-chronobiology\/\" target=\"_blank\" rel=\"noopener\">La melatonina<\/a> es una parte integral del ciclo celular, que indica a las c\u00e9lulas cu\u00e1ndo deben realizar procesos cr\u00edticos de reparaci\u00f3n del ADN para poder reproducirse de forma segura. Cuando los niveles de melatonina son bajos en los momentos equivocados, las c\u00e9lulas no llevan a cabo los procesos de reparaci\u00f3n y reconstrucci\u00f3n tan bien. Se cree que \u00e9sta es una de las causas fundamentales de una de las enfermedades m\u00e1s mortales del mundo: El c\u00e1ncer.<\/p>\n<p>\u00bfPuede ayudar al tratamiento del c\u00e1ncer ayudar a las c\u00e9lulas tumorales a regular su ritmo circadiano intr\u00ednseco? Un grupo de investigadores ha estudiado esta cuesti\u00f3n y ha hallado respuestas sorprendentes.<\/p>\n<h2>Un nuevo estudio revela que los relojes circadianos son esenciales en el tratamiento del c\u00e1ncer<\/h2>\n<p>Los genes del reloj, que regulan el ritmo circadiano, est\u00e1n suprimidos en muchos de los c\u00e1nceres m\u00e1s comunes. Los investigadores tomaron c\u00e9lulas de melanoma e indujeron un ritmo circadiano sano utilizando dexametasona, forskolina o choque t\u00e9rmico. Las c\u00e9lulas de melanoma que respondieron a este tratamiento adoptando un ritmo circadiano saludable mostraron <a href=\"http:\/\/bmcbiol.biomedcentral.com\/articles\/10.1186\/s12915-017-0349-7\" target=\"_blank\" rel=\"noopener\">un crecimiento mucho menor tras el tratamiento<\/a>. En otras palabras, inducir a los genes del reloj a adoptar de nuevo su ritmo nativo puede ser una forma potencial de ralentizar o detener el crecimiento tumoral.<\/p>\n<p>Las c\u00e9lulas del melanoma no son las \u00fanicas c\u00e9lulas cancerosas que responden a este tratamiento. Ciertos genotipos de c\u00e1ncer de colon tambi\u00e9n detienen o ralentizan su crecimiento cuando se induce un ritmo circadiano saludable. Sin embargo, este tratamiento no funciona cuando el gen del reloj BMAL1 ha sido \u00abeliminado\u00bb. Las implicaciones son claras: un ritmo circadiano que funcione puede ser crucial para las c\u00e9lulas sanas, pero parece tener un efecto negativo en la proliferaci\u00f3n de las c\u00e9lulas cancerosas.<\/p>\n<h2>Cronobiolog\u00eda: \u00bfEl pr\u00f3ximo gran tratamiento contra el c\u00e1ncer?<\/h2>\n<p>Muchos tratamientos contra el c\u00e1ncer son muy invasivos o simplemente inc\u00f3modos. La cirug\u00eda para extirpar el c\u00e1ncer puede requerir una larga recuperaci\u00f3n; la quimioterapia puede afectar a las c\u00e9lulas sanas y, por tanto, dejar a las personas fatigadas y enfermas. Sin embargo, restablecer un ritmo circadiano saludable s\u00f3lo tiene efectos positivos en el tratamiento del c\u00e1ncer.<\/p>\n<p>Aunque esta investigaci\u00f3n se centra en el ritmo circadiano intr\u00ednseco de las c\u00e9lulas cancerosas, <a href=\"https:\/\/www.chronobiology.com\/circadian-clock-genes-may-influence-cancer-growth\/\" target=\"_blank\" rel=\"noopener\">si le preocupa la prevenci\u00f3n del c\u00e1ncer, mantener un ritmo circadiano saludable es clave<\/a>. Un ritmo circadiano funcional puede ayudarle a sentirse m\u00e1s sano tanto hoy como a lo largo de su vida.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Los cient\u00edficos buscan constantemente tratamientos nuevos e innovadores contra el c\u00e1ncer. Investigaciones recientes sugieren que mejorar los relojes circadianos puede ralentizar el crecimiento tumoral y ayudar en el tratamiento del c\u00e1ncer. La alteraci\u00f3n del ritmo circadiano es una consecuencia com\u00fan de la vida moderna. A menudo, las personas no pueden dormir lo suficiente debido a [&hellip;]<\/p>\n","protected":false},"author":15,"featured_media":25459,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","footnotes":""},"categories":[173,200,215],"tags":[],"class_list":{"0":"post-62050","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-el-ritmo-circadiano","8":"category-investigacion-sobre-el-cancer","9":"category-melatonina-es","10":"entry"},"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.4 (Yoast SEO v23.4) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Fighting Cancer: The Place of 24-Hour Rhythms<\/title>\n<meta name=\"description\" content=\"Scientists are constantly searching for new and innovative treatments for cancer. 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