{"id":61951,"date":"2016-12-21T11:31:00","date_gmt":"2016-12-21T19:31:00","guid":{"rendered":"https:\/\/www.chronobiology.com\/new-findings-show-the-liver-has-a-clear-rhythm\/"},"modified":"2024-07-21T22:14:14","modified_gmt":"2024-07-22T05:14:14","slug":"nuevos-hallazgos-demuestran-que-el-h-gado-tiene-un-ritmo-claro","status":"publish","type":"post","link":"https:\/\/dev.chronobiology.com\/es\/nuevos-hallazgos-demuestran-que-el-h-gado-tiene-un-ritmo-claro\/","title":{"rendered":"Nuevos hallazgos demuestran que el h\u00edgado tiene un ritmo claro"},"content":{"rendered":"

Se ha estudiado y escrito mucho sobre el ritmo circadiano. Nuevas investigaciones sugieren que el h\u00edgado desempe\u00f1a un papel fundamental en el mantenimiento de los relojes internos.<\/p>\n

El h\u00edgado es uno de los \u00f3rganos m\u00e1s importantes del cuerpo. Este \u00f3rgano mantiene el az\u00facar en sangre a un nivel seguro, crea muchas de las prote\u00ednas necesarias para actividades que van desde la coagulaci\u00f3n a la digesti\u00f3n e incluso desempe\u00f1a un papel vital en la limpieza de metabolitos y toxinas del torrente sangu\u00edneo. El h\u00edgado tambi\u00e9n produce bilis, que desempe\u00f1a una doble funci\u00f3n al ayudarnos a digerir las grasas y eliminar la bilirrubina del organismo. Nuevas investigaciones sugieren que el humilde h\u00edgado tambi\u00e9n desempe\u00f1a un papel importante en los relojes internos, con c\u00e9lulas que mantienen un ritmo circadiano independiente del resto del cuerpo.<\/p>\n

AMPK y CKII: prote\u00ednas clave en el ritmo circadiano<\/h2>\n

En muchos sentidos, nuestros cuerpos funcionan como m\u00e1quinas con una variedad de prote\u00ednas que act\u00faan como mecanismos de sincronizaci\u00f3n e incluso como engranajes. La AMPK es una de estas<\/a> prote\u00ednas, que detecta cu\u00e1ndo las c\u00e9lulas tienen poca energ\u00eda y \u00abenciende\u00bb el metabolismo seg\u00fan sea necesario. La CK2 es otra prote\u00edna reguladora multifuncional<\/a> que ayuda a las c\u00e9lulas a decidir si dividirse y cu\u00e1ndo, e incluso cu\u00e1ndo morir.<\/p>\n

Como puede imaginarse, estas prote\u00ednas son especialmente importantes en las c\u00e9lulas hep\u00e1ticas. El h\u00edgado desempe\u00f1a un papel inmenso en la regulaci\u00f3n del metabolismo y el crecimiento celular en el cuerpo humano. Adem\u00e1s, nuevas investigaciones indican que estas prote\u00ednas tambi\u00e9n ayudan al h\u00edgado a funcionar y mantener un ritmo circadiano que est\u00e1 conectado al ciclo sue\u00f1o-vigilia<\/a> del resto del cuerpo y que, sin embargo, es independiente de \u00e9ste.<\/p>\n

El ritmo diario de las c\u00e9lulas hep\u00e1ticas<\/h2>\n

\"New<\/a>Los investigadores midieron los niveles de distintas prote\u00ednas, como la AMPK y la CKII, en el h\u00edgado de ratones sometidos a un estricto r\u00e9gimen de ayuno y alimentaci\u00f3n o a una alimentaci\u00f3n normal. Comprobaron que los niveles de estas y otras prote\u00ednas en el h\u00edgado cambiaban seg\u00fan la hora del<\/a> d\u00eda, lo que demuestra una clara relaci\u00f3n con el principal reloj interno del cuerpo, fijado por el n\u00facleo supraquiasm\u00e1tico<\/a> del hipot\u00e1lamo. Adem\u00e1s, las c\u00e9lulas hep\u00e1ticas de ratones sometidos a un programa espec\u00edfico de alimentaci\u00f3n y ayuno mostraban un reloj interno ligeramente distinto, que respond\u00eda tanto a las se\u00f1ales del cerebro como a las de la ingesta de alimentos del animal.<\/p>\n

Esta investigaci\u00f3n sugiere que el ritmo circadiano del h\u00edgado se mantiene no s\u00f3lo por el reloj central del organismo, sino por su propio mecanismo interno. Aunque actualmente se desconoce el funcionamiento de este \u00abreloj digestivo\u00bb, puede ser importante para entender enfermedades como la diabetes, en las que la funci\u00f3n hep\u00e1tica suele estar alterada o desregulada.<\/p>\n

Biolog\u00eda circadiana y salud<\/h2>\n

A pesar de lo insignificante que pueda parecer a primera vista el ritmo circadiano de un solo \u00f3rgano, estos descubrimientos podr\u00edan tener pronto importantes repercusiones en la salud humana. La CKII, una de las prote\u00ednas que se ha demostrado que est\u00e1 regulada en parte por el ritmo circadiano del h\u00edgado, se ha visto implicada en algunos tipos de c\u00e1ncer<\/a>, as\u00ed como en enfermedades metab\u00f3licas como la diabetes de tipo 2. Comprender c\u00f3mo controlar los niveles de esta prote\u00edna puede permitirnos tratar m\u00e1s eficazmente esta amplia variedad de enfermedades humanas en el futuro. Adem\u00e1s, las investigaciones sobre cronobiolog\u00eda que arrojen luz sobre los relojes internos de \u00f3rganos como \u00e9ste podr\u00edan conducir a formas m\u00e1s eficaces de tratar los trastornos del ritmo circadiano que afectan a millones de personas.<\/p>\n

El h\u00edgado es uno de los \u00f3rganos m\u00e1s importantes del cuerpo humano, ya que interviene en casi todos los aspectos de nuestra salud y, a menudo, tambi\u00e9n en las enfermedades. Comprender mejor c\u00f3mo el h\u00edgado afecta y se ve afectado por nuestros relojes internos es el primer paso hacia nuevas terapias que curen enfermedades y salven vidas.<\/p>\n","protected":false},"excerpt":{"rendered":"

Se ha estudiado y escrito mucho sobre el ritmo circadiano. Nuevas investigaciones sugieren que el h\u00edgado desempe\u00f1a un papel fundamental en el mantenimiento de los relojes internos. El h\u00edgado es uno de los \u00f3rganos m\u00e1s importantes del cuerpo. Este \u00f3rgano mantiene el az\u00facar en sangre a un nivel seguro, crea muchas de las prote\u00ednas necesarias […]<\/p>\n","protected":false},"author":15,"featured_media":25191,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","footnotes":""},"categories":[173,200],"tags":[],"class_list":{"0":"post-61951","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-el-ritmo-circadiano","8":"category-investigacion-sobre-el-cancer","9":"entry"},"acf":[],"yoast_head":"\nNew Findings Show the Liver has a Clear Rhythm<\/title>\n<meta name=\"description\" content=\"A lot has been studied and written about circadian rhythm. 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New research suggests that your liver plays an intricate role in maintaining your internal clocks.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/dev.chronobiology.com\/es\/nuevos-hallazgos-demuestran-que-el-h-gado-tiene-un-ritmo-claro\/\" \/>\n<meta property=\"og:site_name\" content=\"Chronobiology.com\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/chronobiology\" \/>\n<meta property=\"article:published_time\" content=\"2016-12-21T19:31:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-07-22T05:14:14+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/dev.chronobiology.com\/wp-content\/uploads\/2016\/12\/new-findings-show-the-liver-has-a-clear-rhythm-2.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1800\" \/>\n\t<meta property=\"og:image:height\" content=\"679\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Edwin Urbina\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@chronobionews\" \/>\n<meta name=\"twitter:site\" content=\"@chronobionews\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"Edwin Urbina\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/dev.chronobiology.com\/es\/nuevos-hallazgos-demuestran-que-el-h-gado-tiene-un-ritmo-claro\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/dev.chronobiology.com\/es\/nuevos-hallazgos-demuestran-que-el-h-gado-tiene-un-ritmo-claro\/\"},\"author\":{\"name\":\"Edwin Urbina\",\"@id\":\"https:\/\/dev.chronobiology.com\/es\/#\/schema\/person\/bbdffa2f15784a87635cc2a178677bf9\"},\"headline\":\"Nuevos hallazgos demuestran que el h\u00edgado tiene un ritmo claro\",\"datePublished\":\"2016-12-21T19:31:00+00:00\",\"dateModified\":\"2024-07-22T05:14:14+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/dev.chronobiology.com\/es\/nuevos-hallazgos-demuestran-que-el-h-gado-tiene-un-ritmo-claro\/\"},\"wordCount\":732,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/dev.chronobiology.com\/es\/#organization\"},\"image\":{\"@id\":\"https:\/\/dev.chronobiology.com\/es\/nuevos-hallazgos-demuestran-que-el-h-gado-tiene-un-ritmo-claro\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/dev.chronobiology.com\/wp-content\/uploads\/2016\/12\/new-findings-show-the-liver-has-a-clear-rhythm-2.jpg\",\"articleSection\":[\"El ritmo circadiano\",\"Investigaci\u00f3n sobre el c\u00e1ncer\"],\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/dev.chronobiology.com\/es\/nuevos-hallazgos-demuestran-que-el-h-gado-tiene-un-ritmo-claro\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/dev.chronobiology.com\/es\/nuevos-hallazgos-demuestran-que-el-h-gado-tiene-un-ritmo-claro\/\",\"url\":\"https:\/\/dev.chronobiology.com\/es\/nuevos-hallazgos-demuestran-que-el-h-gado-tiene-un-ritmo-claro\/\",\"name\":\"New Findings Show the Liver has a Clear Rhythm\",\"isPartOf\":{\"@id\":\"https:\/\/dev.chronobiology.com\/es\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/dev.chronobiology.com\/es\/nuevos-hallazgos-demuestran-que-el-h-gado-tiene-un-ritmo-claro\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/dev.chronobiology.com\/es\/nuevos-hallazgos-demuestran-que-el-h-gado-tiene-un-ritmo-claro\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/dev.chronobiology.com\/wp-content\/uploads\/2016\/12\/new-findings-show-the-liver-has-a-clear-rhythm-2.jpg\",\"datePublished\":\"2016-12-21T19:31:00+00:00\",\"dateModified\":\"2024-07-22T05:14:14+00:00\",\"description\":\"A lot has been studied and written about circadian rhythm. 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