{"id":61885,"date":"2016-09-30T10:07:37","date_gmt":"2016-09-30T17:07:37","guid":{"rendered":"https:\/\/www.chronobiology.com\/new-research-cancer-genes-dictate-circadian-rhythm\/"},"modified":"2024-07-21T22:13:37","modified_gmt":"2024-07-22T05:13:37","slug":"nuevas-investigaciones-sobre-el-c-ncer-y-los-genes-que-dictan-el-ritmo-circadiano","status":"publish","type":"post","link":"https:\/\/dev.chronobiology.com\/es\/nuevas-investigaciones-sobre-el-c-ncer-y-los-genes-que-dictan-el-ritmo-circadiano\/","title":{"rendered":"Nuevas investigaciones sobre el c\u00e1ncer y los genes que dictan el ritmo circadiano"},"content":{"rendered":"<p>Nuevas investigaciones est\u00e1n arrojando nueva informaci\u00f3n sobre los genes que dictan el ritmo circadiano, informaci\u00f3n que podr\u00eda utilizarse para tratar e incluso curar el c\u00e1ncer en el futuro.<\/p>\n<p>El c\u00e1ncer es una de las enfermedades m\u00e1s temidas que puede padecer una persona. La lucha contra el c\u00e1ncer es siempre una lucha por la vida, y muchos de los tratamientos pueden ser tan debilitantes como la enfermedad. Sin embargo, conocer los genes que dictan el ritmo circadiano puede ayudarnos a tratar el c\u00e1ncer de forma m\u00e1s eficaz y con menos efectos secundarios.<\/p>\n<h2>Tratamiento del c\u00e1ncer de mama con los genes que dictan el ritmo circadiano<\/h2>\n<p>En el tratamiento del c\u00e1ncer de mama, los receptores lo son todo. Uno de los primeros pasos tras el diagn\u00f3stico de c\u00e1ncer de mama es genotipar el c\u00e1ncer, averiguando qu\u00e9 receptores y genes tiene. Este conocimiento es crucial porque estos receptores son esenciales para que el c\u00e1ncer crezca y haga met\u00e1stasis, lo que los convierte en un punto d\u00e9bil desde el que podemos atacar al enemigo. El c\u00e1ncer de mama que carece de receptor de estr\u00f3genos es uno de los tipos m\u00e1s dif\u00edciles de tratar porque carece de este tal\u00f3n de Aquiles. Sin embargo, un gen del reloj circadiano llamado ARNTL2 puede ser una futura v\u00eda de tratamiento.<\/p>\n<p>Como muchos genes reloj, el ARNTL2 es una parte esencial del crecimiento y el metabolismo, lo que lo hace imprescindible para que el c\u00e1ncer haga met\u00e1stasis. Las personas que padecen c\u00e1ncer con altos niveles de actividad de ARNTL2 tienen <a href=\"http:\/\/journals.plos.org\/plosgenetics\/article?id=10.1371\/journal.pgen.1006267\" target=\"_blank\" rel=\"noopener\">m\u00e1s probabilidades de que sus c\u00e1nceres hagan met\u00e1stasis<\/a> y, en \u00faltima instancia, de morir a causa de la enfermedad. El hecho de que un gen del ritmo circadiano est\u00e9 implicado en el crecimiento y la met\u00e1stasis del c\u00e1ncer puede explicar por qu\u00e9 las personas que trabajan en horarios extra\u00f1os, especialmente las mujeres, tienen <a href=\"https:\/\/www.chronobiology.com\/research-shines-light-on-links-between-disrupted-circadian-rhythms-and-breast-cancer\/\" target=\"_blank\" rel=\"noopener\">m\u00e1s probabilidades de desarrollar c\u00e1ncer<\/a>.<\/p>\n<h2>Ayudar a los enfermos de c\u00e1ncer a respirar mejor<\/h2>\n<p>El c\u00e1ncer de mama no es el \u00fanico tumor maligno relacionado con los genes del ritmo circadiano. El c\u00e1ncer de pulm\u00f3n parece depender de un conjunto diferente de genes que tambi\u00e9n funcionan como relojes internos, Per2 y BMAL1. Cuando las personas <a href=\"http:\/\/www.cell.com\/cell-metabolism\/pdfExtended\/S1550-4131(16)30312-6\" target=\"_blank\" rel=\"noopener\">pierden la funci\u00f3n de estos genes en las mutaciones<\/a>, tienen m\u00e1s probabilidades de desarrollar c\u00e1ncer de pulm\u00f3n y tambi\u00e9n m\u00e1s probabilidades de tener met\u00e1stasis. La p\u00e9rdida de estos genes, que forman parte de los \u00abpuntos de control\u00bb que regulan el crecimiento y el desarrollo, conduce a un crecimiento descontrolado y, finalmente, al c\u00e1ncer.<\/p>\n<h2>La relaci\u00f3n entre el trabajo por turnos y el c\u00e1ncer<\/h2>\n<p>El c\u00e1ncer de pr\u00f3stata es otra enfermedad que asola a muchas personas. Al igual que el c\u00e1ncer de mama, el de pr\u00f3stata puede tratarse a menudo atacando los receptores que gobiernan su crecimiento. En el caso del c\u00e1ncer de pr\u00f3stata, intervienen multitud de hormonas y receptores diferentes. La melatonina parece <a href=\"http:\/\/erc.endocrinology-journals.org\/content\/early\/2016\/09\/22\/ERC-16-0366.abstract\" target=\"_blank\" rel=\"noopener\">suprimir varios de estos genes reloj<\/a>, suprimiendo su activaci\u00f3n y suprimiendo as\u00ed el crecimiento del c\u00e1ncer de pr\u00f3stata. Esta puede ser la raz\u00f3n por la que los hombres que <a href=\"https:\/\/www.chronobiology.com\/does-sleep-duration-matter-when-it-comes-to-prostate-cancer\/\" target=\"_blank\" rel=\"noopener\">trabajan por turnos tienen m\u00e1s probabilidades de desarrollar este c\u00e1ncer<\/a> y tambi\u00e9n m\u00e1s probabilidades de morir a causa de \u00e9l. Ya se est\u00e1n desarrollando medicamentos para suprimir estos receptores y evitar as\u00ed que estos tumores crezcan, hagan met\u00e1stasis y, en \u00faltima instancia, se cobren m\u00e1s vidas.<\/p>\n<p>Comprender el ritmo circadiano humano puede producir informaci\u00f3n que nos permita dormir m\u00e1s f\u00e1cilmente. Pero este conocimiento tambi\u00e9n puede ayudarnos a tratar m\u00e1s eficazmente el c\u00e1ncer y a devolver la salud a las personas que m\u00e1s la necesitan. Los genes que dictan el ritmo circadiano son tambi\u00e9n genes que controlan multitud de procesos en el organismo, por lo que comprenderlos puede tener un enorme impacto en la salud humana.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Nuevas investigaciones est\u00e1n arrojando nueva informaci\u00f3n sobre los genes que dictan el ritmo circadiano, informaci\u00f3n que podr\u00eda utilizarse para tratar e incluso curar el c\u00e1ncer en el futuro. El c\u00e1ncer es una de las enfermedades m\u00e1s temidas que puede padecer una persona. La lucha contra el c\u00e1ncer es siempre una lucha por la vida, y [&hellip;]<\/p>\n","protected":false},"author":15,"featured_media":24743,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","footnotes":""},"categories":[173,200,215,216],"tags":[],"class_list":{"0":"post-61885","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-el-ritmo-circadiano","8":"category-investigacion-sobre-el-cancer","9":"category-melatonina-es","10":"category-trabajo-por-turnos","11":"entry"},"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.4 (Yoast SEO v23.4) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>The 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