{"id":61718,"date":"2016-06-08T12:29:31","date_gmt":"2016-06-08T19:29:31","guid":{"rendered":"https:\/\/www.chronobiology.com\/circadian-rhythm-strength-may-controlled-key-protein-2\/"},"modified":"2024-07-19T12:58:21","modified_gmt":"2024-07-19T19:58:21","slug":"la-fuerza-del-ritmo-circadiano-podr-a-estar-controlada-por-esta-prote-na-clave","status":"publish","type":"post","link":"https:\/\/dev.chronobiology.com\/es\/la-fuerza-del-ritmo-circadiano-podr-a-estar-controlada-por-esta-prote-na-clave\/","title":{"rendered":"La fuerza del ritmo circadiano podr\u00eda estar controlada por esta prote\u00edna clave"},"content":{"rendered":"

Si bajas el volumen lo suficiente, no puedes o\u00edr la radio. Una nueva investigaci\u00f3n ha descubierto que la fuerza del ritmo circadiano tambi\u00e9n tiene un \u00abcontrol de volumen\u00bb: la prote\u00edna REV-ERB\u03b1.<\/p>\n

La mayor parte de la investigaci\u00f3n sobre el ritmo circadiano<\/a> trata de qu\u00e9 ocurre, cu\u00e1ndo y por qu\u00e9. Sin embargo, la fuerza de una se\u00f1al molecular tambi\u00e9n es importante. Si una se\u00f1al es demasiado d\u00e9bil, no tendr\u00e1 ning\u00fan efecto. Si es demasiado fuerte, podr\u00eda interferir con otras funciones. En biolog\u00eda molecular, como en Ricitos de Oro, s\u00f3lo \u00ablo justo\u00bb es suficiente. Los investigadores han descubierto que una prote\u00edna llamada REV-ERB\u03b1, ya conocida por su importancia en el ritmo circadiano, puede ser el factor que controla la fuerza del ritmo circadiano, manteni\u00e9ndolo en el rango de amplitud donde es m\u00e1s eficaz.<\/p>\n

\u00bfQu\u00e9 es REV-ERB\u03b1?<\/h2>\n

Al igual que muchas prote\u00ednas del cuerpo humano, REV-ERB\u03b1 parece desempe\u00f1ar diversas funciones. Es una parte integral de los receptores de la hormona tiroidea<\/a>, importante en la regulaci\u00f3n del metabolismo del cart\u00edlago<\/a> y tambi\u00e9n desempe\u00f1a un papel importante en el ritmo circadiano. Su papel en<\/a> el ritmo circadiano ha sido objeto de muchas investigaciones debido al inusual m\u00e9todo de acci\u00f3n de esta prote\u00edna. Durante el momento del d\u00eda en que ciertos genes circadianos no deber\u00edan expresarse, REV-ERB\u03b1 se une al ADN de estos genes para detener f\u00edsicamente la transcripci\u00f3n.<\/p>\n

El control del \u00abvolumen\u00bb de la fuerza del ritmo circadiano<\/h2>\n

Al igual que muchas prote\u00ednas relacionadas con el ritmo circadiano, REV-ERB\u03b1 se expresa de forma r\u00edtmica. Alcanza su m\u00e1ximo durante el d\u00eda y sus niveles m\u00e1s bajos por la noche. Los investigadores decidieron desactivar la enzima que degrada REV-ERB\u03b1, manteniendo sus niveles altos por la noche. La sincronizaci\u00f3n del ritmo circadiano no cambi\u00f3, pero se alteraron las fluctuaciones de la expresi\u00f3n g\u00e9nica. Los genes que normalmente se expresan en niveles variables a lo largo de un ciclo de 24 horas se expresaron en niveles altos independientemente de la hora. En otras palabras, el ritmo circadiano segu\u00eda siendo el mismo, pero su volumen era constante y \u00abalto\u00bb en lugar de aumentar y disminuir de forma r\u00edtmica.<\/p>\n

Los investigadores creen que REV-ERB\u03b1 puede ser el bot\u00f3n maestro del volumen que gobierna la fuerza del ritmo circadiano. El autor principal, Ronald Evans, que tambi\u00e9n es director del Laboratorio de Expresi\u00f3n G\u00e9nica del Salk, coment\u00f3,<\/p>\n

\n

\u00abTanto si se trata de la Novena Sinfon\u00eda de Beethoven en el equipo de m\u00fasica como de la sinfon\u00eda de genes en nuestro cuerpo, ambas requieren volumen para ser escuchadas. Nuestro trabajo reciente describe c\u00f3mo REV-ERB\u03b1 act\u00faa como un conductor molecular que permite subir o bajar el volumen o la actividad de miles de genes.\u00bb<\/p>\n<\/blockquote>\n

La amplitud lo es todo<\/h2>\n

Esta es la primera vez que los cient\u00edficos han sido capaces de afectar experimentalmente a la fuerza del ritmo circadiano, pero parece ser un factor muy importante. Los ratones de este estudio de cronobiolog\u00eda a los que se alter\u00f3 gen\u00e9ticamente para que carecieran de REV-ERB\u03b1 desarrollaron diversos problemas de salud graves, como la enfermedad del h\u00edgado graso. Un exceso de esta prote\u00edna tambi\u00e9n podr\u00eda tener graves efectos sobre la salud. Habr\u00e1 que seguir investigando en este campo, pero hay dos cosas claras: la amplitud, o volumen, de nuestros ritmos circadianos parece ser extremadamente importante para la salud, y esta amplitud est\u00e1 controlada, al menos en parte, por la prote\u00edna REV-ERB\u03b1.<\/p>\n

El ritmo circadiano es parte integrante de la salud de todos los organismos, por lo que tiene sentido que est\u00e9 estrechamente controlado en todos los sentidos. Esta investigaci\u00f3n abre las puertas a nuevas investigaciones sobre c\u00f3mo la fuerza del ritmo circadiano puede ser un factor que afecte tanto a los relojes internos como a la salud de todo el organismo.<\/p>\n","protected":false},"excerpt":{"rendered":"

Si bajas el volumen lo suficiente, no puedes o\u00edr la radio. Una nueva investigaci\u00f3n ha descubierto que la fuerza del ritmo circadiano tambi\u00e9n tiene un \u00abcontrol de volumen\u00bb: la prote\u00edna REV-ERB\u03b1. La mayor parte de la investigaci\u00f3n sobre el ritmo circadiano trata de qu\u00e9 ocurre, cu\u00e1ndo y por qu\u00e9. Sin embargo, la fuerza de una […]<\/p>\n","protected":false},"author":15,"featured_media":24519,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","footnotes":""},"categories":[173],"tags":[],"class_list":{"0":"post-61718","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-el-ritmo-circadiano","8":"entry"},"acf":[],"yoast_head":"\nCircadian Rhythm Strength May be Controlled by This Key Protein<\/title>\n<meta name=\"description\" content=\"If you turn the volume low enough, you cannot hear the radio. 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