{"id":61658,"date":"2016-04-13T11:38:44","date_gmt":"2016-04-13T18:38:44","guid":{"rendered":"https:\/\/www.chronobiology.com\/disrupting-the-circadian-rhythm-of-cancer-potential-for-new-treatment-2\/"},"modified":"2024-07-19T12:57:13","modified_gmt":"2024-07-19T19:57:13","slug":"alterar-el-ritmo-circadiano-del-c-ncer-potencial-para-un-nuevo-tratamiento","status":"publish","type":"post","link":"https:\/\/dev.chronobiology.com\/es\/alterar-el-ritmo-circadiano-del-c-ncer-potencial-para-un-nuevo-tratamiento\/","title":{"rendered":"Alterar el ritmo circadiano del c\u00e1ncer: Potencial para un nuevo tratamiento"},"content":{"rendered":"

Comprender y atacar el ritmo circadiano<\/a> de las c\u00e9lulas cancerosas puede ser la forma m\u00e1s eficaz de tratar c\u00e1nceres como la leucemia mieloide aguda, seg\u00fan un nuevo estudio.<\/p>\n

Tratar c\u00e1nceres como la leucemia mieloide aguda es uno de los mayores retos de la medicina moderna. Dado que las c\u00e9lulas cancerosas son c\u00e9lulas humanas, muchas terapias dirigidas a las c\u00e9lulas cancerosas tambi\u00e9n pueden afectar a las sanas. Con el fin de desarrollar mejores tratamientos con menos efectos secundarios, los investigadores han estado estudiando qu\u00e9 hace diferentes a las c\u00e9lulas cancerosas. Una diferencia clave entre las c\u00e9lulas sanas y las cancerosas radica en su ritmo circadiano, que puede ofrecer nuevas v\u00edas de tratamiento.<\/p>\n

\u00bfQu\u00e9 es la leucemia mieloide aguda?<\/h2>\n

La leucemiamieloide<\/a> aguda es un tipo de c\u00e1ncer de m\u00e9dula \u00f3sea que afecta a las c\u00e9lulas sangu\u00edneas y sus precursores. Puede afectar a los gl\u00f3bulos rojos, los gl\u00f3bulos blancos, las plaquetas o cualquier combinaci\u00f3n de \u00e9stos. Dado que las c\u00e9lulas sangu\u00edneas son fundamentales para casi todas las funciones corporales, este tipo de c\u00e1ncer puede presentarse con una amplia variedad de s\u00edntomas como fatiga, fiebre y facilidad para la aparici\u00f3n de hematomas. Este tipo de leucemia tambi\u00e9n tiene un alto riesgo de met\u00e1stasis, o diseminaci\u00f3n, porque las c\u00e9lulas sangu\u00edneas acceden a todo el organismo.<\/p>\n

El ritmo circadiano del c\u00e1ncer<\/h2>\n

Se ha demostrado que la alteraci\u00f3n del ritmo interno de una c\u00e9lula es una de las principales causas del c\u00e1ncer, pero tambi\u00e9n puede ser el tratamiento del c\u00e1ncer. Cuando las personas no duermen lo suficiente o lo hacen a horas intempestivas, son m\u00e1s propensas a desarrollar mutaciones que conducen al c\u00e1ncer. Las mutaciones en los genes CLOCK y otros genes relacionados con el ritmo circadiano<\/a> parecen especialmente importantes en el paso de una c\u00e9lula sana a anormal o maligna.<\/p>\n

Un nuevo estudio sugiere que las c\u00e9lulas de la leucemia mieloide aguda tienen un ritmo circadiano muy diferente al de las c\u00e9lulas sanas. Las c\u00e9lulas cancerosas suelen crecer de forma incontrolada, sin los controles y equilibrios que controlan el crecimiento en las c\u00e9lulas sanas. Las c\u00e9lulas leuc\u00e9micas parecen depender especialmente de dos genes, BMAL1 y C<\/a>LOCK. Mientras que el CLOCK es un gen necesario para los precursores de las c\u00e9lulas sangu\u00edneas sanas, el BMAL1 no lo es. Atacar el gen BMAL1 podr\u00eda destruir las c\u00e9lulas de la leucemia mieloide aguda sin afectar a las c\u00e9lulas sanas.<\/p>\n

Adem\u00e1s, las c\u00e9lulas leuc\u00e9micas parecen estar activas en momentos del d\u00eda en los que las c\u00e9lulas normales no lo est\u00e1n. Dirigir las terapias a estos momentos, lo que se conoce como cronofarmacolog\u00eda, conduce a un tratamiento m\u00e1s eficaz de este c\u00e1ncer con escasos efectos sobre otras c\u00e9lulas del organismo.<\/p>\n

Cronofarmacolog\u00eda y tratamiento del c\u00e1ncer<\/h2>\n

\"Disrupting<\/a>La cronofarmacolog\u00eda<\/a>, o programaci\u00f3n de los tratamientos para el momento en que ser\u00e1n m\u00e1s eficaces, es una de las \u00e1reas m\u00e1s candentes de la investigaci\u00f3n m\u00e9dica. Hasta hace poco, los cient\u00edficos y los m\u00e9dicos carec\u00edan de conocimientos s\u00f3lidos sobre las bases bioqu\u00edmicas del ritmo circadiano. La \u00faltima d\u00e9cada ha tra\u00eddo miles de nuevos estudios sobre los ritmos naturales de distintas c\u00e9lulas y sistemas org\u00e1nicos, as\u00ed como nuevas formas de medir la actividad celular. El c\u00e1ncer parece ser especialmente sensible a un tratamiento cuidadosamente programado<\/a>, ya que los ritmos innatos de las c\u00e9lulas cancerosas son casi siempre diferentes de los de los tejidos sanos. La informaci\u00f3n sobre el funcionamiento interno de las c\u00e9lulas cancerosas est\u00e1 aportando nuevos enfoques al tratamiento.<\/p>\n

El c\u00e1ncer es una enfermedad profundamente interrelacionada con los relojes internos del organismo. Debido a esta relaci\u00f3n, la cronofarmacolog\u00eda resulta especialmente prometedora en el tratamiento de diversos tipos de c\u00e1ncer. Sin embargo, la cronolog\u00eda parece desempe\u00f1ar un papel importante en muchos problemas de salud. Comprender la relaci\u00f3n entre los ritmos innatos y las enfermedades ayudar\u00e1 a m\u00e9dicos y cient\u00edficos a tratar a los pacientes con mayor eficacia y menos efectos secundarios.<\/p>\n","protected":false},"excerpt":{"rendered":"

Comprender y atacar el ritmo circadiano de las c\u00e9lulas cancerosas puede ser la forma m\u00e1s eficaz de tratar c\u00e1nceres como la leucemia mieloide aguda, seg\u00fan un nuevo estudio. Tratar c\u00e1nceres como la leucemia mieloide aguda es uno de los mayores retos de la medicina moderna. Dado que las c\u00e9lulas cancerosas son c\u00e9lulas humanas, muchas terapias […]<\/p>\n","protected":false},"author":15,"featured_media":24343,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","footnotes":""},"categories":[173,200],"tags":[],"class_list":{"0":"post-61658","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-el-ritmo-circadiano","8":"category-investigacion-sobre-el-cancer","9":"entry"},"acf":[],"yoast_head":"\nAlterar el ritmo circadiano del c\u00e1ncer: Potencial para un nuevo tratamiento – Chronobiology.com<\/title>\n<meta name=\"description\" content=\"Understanding and attacking the circadian rhythm of cancer cells may 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