{"id":61654,"date":"2016-04-08T11:40:55","date_gmt":"2016-04-08T18:40:55","guid":{"rendered":"https:\/\/www.chronobiology.com\/the-genetic-link-between-sleep-deprivation-and-metabolic-disorders-translin-2\/"},"modified":"2024-07-19T12:57:10","modified_gmt":"2024-07-19T19:57:10","slug":"el-v-nculo-gen-tico-entre-la-falta-de-sue-o-y-los-trastornos-metab-licos-translin","status":"publish","type":"post","link":"https:\/\/dev.chronobiology.com\/es\/el-v-nculo-gen-tico-entre-la-falta-de-sue-o-y-los-trastornos-metab-licos-translin\/","title":{"rendered":"El v\u00ednculo gen\u00e9tico entre la falta de sue\u00f1o y los trastornos metab\u00f3licos: Translin"},"content":{"rendered":"

Un nuevo estudio ha identificado el gen que podr\u00eda ser el eslab\u00f3n perdido entre la falta de sue\u00f1o y los trastornos metab\u00f3licos.<\/p>\n

Los cient\u00edficos saben desde hace tiempo que existe una relaci\u00f3n entre la falta de sue\u00f1o y trastornos del sistema me<\/a> tab\u00f3lico como la obesidad y la diabetes de tipo 2. Los estudios indican que algunas personas son m\u00e1s susceptibles a los efectos endocrinos de la falta de sue\u00f1o. Dado que las personas de determinadas familias son m\u00e1s propensas a sufrir los efectos metab\u00f3licos de la falta de sue\u00f1o, los investigadores sospecharon que exist\u00eda un componente gen\u00e9tico. Un gen recientemente descubierto, llamado translina, es el probable culpable.<\/p>\n

Sue\u00f1o y metabolismo<\/h2>\n

Existe una relaci\u00f3n clara entre el sue\u00f1o y el metabolismo. La falta de sue\u00f1o hace que el metabolismo funcione m\u00e1s despacio, que el metabolismo de la glucosa sea m\u00e1s lento<\/a>, que el crecimiento celular sea m\u00e1s lento y que las personas se muevan m\u00e1s despacio debido a la fatiga. Los trastornos metab\u00f3licos tambi\u00e9n pueden afectar a los h\u00e1bitos de sue\u00f1o, ya que tanto la fatiga como el insomnio suelen presentarse como s\u00edntomas iniciales de enfermedades como la diabetes y el hipotiroidismo. El metabolismo y los h\u00e1bitos de sue\u00f1o est\u00e1n claramente relacionados, pero \u00bfc\u00f3mo?<\/p>\n

La mosca de la fruta y el sue\u00f1o<\/h2>\n

Aunque las moscas de la fruta son muy diferentes de los humanos, a menudo se utilizan como objeto de investigaci\u00f3n gen\u00e9tica y molecular<\/a>. Hay varias razones para ello. Su genoma -y, por tanto, su desarrollo- es similar al nuestro, aunque con el tiempo nos convirtamos en organismos muy diferentes. Adem\u00e1s, las moscas de la fruta tienen un tiempo de generaci\u00f3n corto, por lo que los investigadores pueden rastrear los efectos de los cambios gen\u00e9ticos a lo largo de generaciones en tan s\u00f3lo unas semanas. Las moscas de la fruta tambi\u00e9n tienen h\u00e1bitos de sue\u00f1o similares a los nuestros, por lo que han sido objeto de un estudio pionero sobre los trastornos del sue\u00f1o y los h\u00e1bitos alimentarios.<\/p>\n

Cuando las moscas de la fruta perciben que necesitan comida, el gen translin<\/a> crea prote\u00ednas que les ayudan a mantenerse despiertas para poder buscar alimento. En las moscas de la fruta con una mutaci\u00f3n de la translina, esta vigilia y el hambre persisten incluso cuando las moscas est\u00e1n bien alimentadas. La translina es un gen muy conservado, lo que significa que animales m\u00e1s complejos, como los humanos, tambi\u00e9n lo tienen.<\/p>\n

\u00bfEl huevo o la gallina?<\/h2>\n

\"The<\/a>Los investigadores sospechan desde hace tiempo que la falta de sue\u00f1o provoca trastornos alimentarios y metab\u00f3licos. Numerosas investigaciones respaldan esta hip\u00f3tesis. Aunque esto puede seguir siendo cierto, el nuevo estudio sobre la mosca de la fruta sugiere que existe un tercer factor gen\u00e9tico que causa tanto el insomnio como el comer en exceso. Esto es importante porque nuestra capacidad para tratar las mutaciones gen\u00e9ticas crece d\u00eda a d\u00eda. Adem\u00e1s, es posible que los investigadores puedan identificar las prote\u00ednas producidas por la translina y crear un f\u00e1rmaco que contrarreste sus efectos. Una cosa est\u00e1 clara: tanto los humanos como las moscas de la fruta a veces buscan un tentempi\u00e9 en lugar de dormir<\/a>, lo que provoca aumento de peso y privaci\u00f3n de sue\u00f1o.<\/p>\n

Los trastornos del sue\u00f1o pueden afectar a casi todos los aspectos de nuestra vida, desde nuestros niveles de energ\u00eda hasta nuestra salud mental<\/a> e incluso el riesgo cardiovascular. Los trastornos metab\u00f3licos pueden tener un impacto de similar alcance en la salud y el bienestar. Este gen aporta nuevos conocimientos sobre ambos tipos de enfermedades, lo que esperamos que permita a las personas recibir el tratamiento que necesitan para llevar una vida feliz, sana y bien descansada.<\/p>\n","protected":false},"excerpt":{"rendered":"

Un nuevo estudio ha identificado el gen que podr\u00eda ser el eslab\u00f3n perdido entre la falta de sue\u00f1o y los trastornos metab\u00f3licos. Los cient\u00edficos saben desde hace tiempo que existe una relaci\u00f3n entre la falta de sue\u00f1o y trastornos del sistema me tab\u00f3lico como la obesidad y la diabetes de tipo 2. Los estudios indican […]<\/p>\n","protected":false},"author":15,"featured_media":24315,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","footnotes":""},"categories":[173,212,214],"tags":[],"class_list":{"0":"post-61654","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-el-ritmo-circadiano","8":"category-metabolismo-es","9":"category-sueno","10":"entry"},"acf":[],"yoast_head":"\nEl v\u00ednculo gen\u00e9tico entre la falta de sue\u00f1o y los trastornos metab\u00f3licos: Translin – Chronobiology.com<\/title>\n<meta name=\"description\" content=\"A new study has identified the gene that may be the missing link between sleep deprivation 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