{"id":61478,"date":"2015-10-02T17:51:23","date_gmt":"2015-10-02T17:51:23","guid":{"rendered":"https:\/\/www.chronobiology.com\/new-study-backs-chronopharmacology-in-cancer-treatment-2\/"},"modified":"2024-07-19T12:54:21","modified_gmt":"2024-07-19T19:54:21","slug":"un-nuevo-estudio-respalda-la-cronofarmacolog-a-en-el-tratamiento-del-c-ncer","status":"publish","type":"post","link":"https:\/\/dev.chronobiology.com\/es\/un-nuevo-estudio-respalda-la-cronofarmacolog-a-en-el-tratamiento-del-c-ncer\/","title":{"rendered":"Un nuevo estudio respalda la cronofarmacolog\u00eda en el tratamiento del c\u00e1ncer"},"content":{"rendered":"<p>La sincronizaci\u00f3n lo es todo, y m\u00e1s en la biolog\u00eda circadiana. El cuerpo humano funciona como un reloj cuando goza de buena salud, pero estos intrincados ritmos pueden verse alterados por la enfermedad. En algunas enfermedades, la identificaci\u00f3n de estos relojes internos alterados puede ser clave para un tratamiento nuevo y m\u00e1s eficaz. El c\u00e1ncer es una de las muchas enfermedades en las que las nuevas investigaciones sobre biolog\u00eda circadiana pueden salvar vidas.<\/p>\n<h2>El c\u00e1ncer y el ritmo circadiano<\/h2>\n<p><a href=\"https:\/\/www.chronobiology.com\/wp-content\/uploads\/2015\/09\/new-study-backs-chronopharmacology-in-cancer-treatment-3.jpg\"><img decoding=\"async\" class=\"alignright size-medium wp-image-6904\" src=\"https:\/\/www.chronobiology.com\/wp-content\/uploads\/2015\/09\/new-study-backs-chronopharmacology-in-cancer-treatment-3-300x225.jpg\" alt=\"cancer cells\" width=\"300\" height=\"225\" srcset=\"https:\/\/www.chronobiology.com\/wp-content\/uploads\/2015\/09\/new-study-backs-chronopharmacology-in-cancer-treatment-3-300x225.jpg 300w, https:\/\/www.chronobiology.com\/wp-content\/uploads\/2015\/09\/new-study-backs-chronopharmacology-in-cancer-treatment-3.jpg 750w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/a>En muchos sentidos, el c\u00e1ncer es una cuesti\u00f3n de sincronizaci\u00f3n. Las c\u00e9lulas normales crecen y mueren de una forma muy regimentada, determinada por los genes del reloj. Cuando estos genes mutan o no funcionan con normalidad, las c\u00e9lulas pueden empezar a crecer de forma incontrolada, matando a las c\u00e9lulas sanas que las rodean. <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20042409\" target=\"_blank\" rel=\"noopener\">La mayor\u00eda de los c\u00e1nceres surgen de una de las diversas mutaciones conocidas de los genes reguladores del ciclo celular.<\/a> Este conocimiento moderno de c\u00f3mo se produce el c\u00e1ncer y c\u00f3mo se comportan las c\u00e9lulas cancerosas ha dado lugar a tratamientos nuevos e innovadores que pueden combatir el c\u00e1ncer con menos efectos secundarios.<\/p>\n<h2>El oncog\u00e9n Myc: La codificaci\u00f3n del c\u00e1ncer<\/h2>\n<p>Muchos c\u00e1nceres se han relacionado con el <a href=\"http:\/\/www.nature.com\/onc\/journal\/v22\/n56\/full\/1207261a.html\" target=\"_blank\" rel=\"noopener\">oncog\u00e9n<\/a> Myc, un gen muy implicado en la regulaci\u00f3n del ciclo celular. Hasta el 70 por ciento de los c\u00e1nceres implican una mutaci\u00f3n en este gen. Cuando este gen est\u00e1 sano, garantiza que crezcan y maduren las c\u00e9lulas justas en los distintos \u00f3rganos. No se producen c\u00e9lulas nuevas a menos que sea necesario, y las c\u00e9lulas da\u00f1adas se reciclan. Este proceso es crucial para mantener los tejidos sanos y funcionales. Sin embargo, cuando el gen Myc est\u00e1 mutado, ya no detiene el crecimiento celular cuando es necesario. El resultado es que las c\u00e9lulas cancerosas pueden crecer sin control y extenderse a otras partes del cuerpo.<\/p>\n<h2>Detener los relojes internos<\/h2>\n<p><a href=\"http:\/\/www.sciencedaily.com\/releases\/2015\/09\/150917135002.htm\" target=\"_blank\" rel=\"noopener\">Un nuevo estudio en cronobiolog\u00eda<\/a> ha descubierto que Myc tambi\u00e9n desempe\u00f1a un papel en el ritmo circadiano y que \u00e9ste se resiente en las c\u00e9lulas que sufren cambios cancerosos. Las prote\u00ednas fabricadas por el gen Myc se unen a ciertos segmentos de ADN responsables del ritmo circadiano y otros relojes internos. El resultado es la sobreproducci\u00f3n de prote\u00ednas y un cambio en la sincronizaci\u00f3n del ciclo celular. Todas las partes del <a href=\"https:\/\/www.chronobiology.com\/health-benefits-of-chronopharmacology\/metabolism\/\" target=\"_blank\" rel=\"noopener\">metabolismo<\/a> se ven afectadas por estos cambios en el ritmo <a href=\"https:\/\/www.chronobiology.com\/about-chronobiology\/#CircadianRhythm\" target=\"_blank\" rel=\"noopener\">circadiano<\/a>, o ritmo biol\u00f3gico de 24 horas de nuestro cuerpo, incluidos el crecimiento y la diferenciaci\u00f3n.<\/p>\n<h2>Aplicar los nuevos conocimientos a nuevos tratamientos<\/h2>\n<p><img decoding=\"async\" class=\"alignright size-medium wp-image-6891\" src=\"https:\/\/www.chronobiology.com\/wp-content\/uploads\/2015\/09\/new-study-backs-chronopharmacology-in-cancer-treatment-200x300.jpg\" alt=\"New Study Backs Chronopharmacology in Cancer Treatment, chronobiology, cancer treatment\" width=\"200\" height=\"300\" srcset=\"https:\/\/www.chronobiology.com\/wp-content\/uploads\/2015\/09\/new-study-backs-chronopharmacology-in-cancer-treatment-200x300.jpg 200w, https:\/\/www.chronobiology.com\/wp-content\/uploads\/2015\/09\/new-study-backs-chronopharmacology-in-cancer-treatment.jpg 533w\" sizes=\"(max-width: 200px) 100vw, 200px\" \/>\u00bfC\u00f3mo pueden aplicarse estos conocimientos a los tratamientos contra el c\u00e1ncer? <a href=\"https:\/\/www.chronobiology.com\/practice-of-chronobiology\/chronopharmacology\/\" target=\"_blank\" rel=\"noopener\">La cronofarmacolog\u00eda<\/a>, es decir, el estudio de c\u00f3mo programar las terapias para que produzcan el m\u00e1ximo beneficio y el m\u00ednimo perjuicio, es especialmente importante en los tratamientos contra el c\u00e1ncer. Los investigadores han descubierto que algunos tratamientos son m\u00e1s eficaces o tienen menos efectos secundarios a determinadas horas del d\u00eda. Saber que las c\u00e9lulas cancerosas funcionan con un reloj alterado es una informaci\u00f3n valiosa a la hora de planificar el momento de la quimioterapia. Muchos de los f\u00e1rmacos quimioterap\u00e9uticos m\u00e1s nuevos y prometedores atacan a las c\u00e9lulas en un momento espec\u00edfico de su ciclo celular y deben programarse para que las c\u00e9lulas cancerosas se encuentren en esta fase mientras que las sanas no.<\/p>\n<p>Las nuevas investigaciones sobre biolog\u00eda circadiana se utilizan cada d\u00eda para mejorar la salud y tratar enfermedades. Nuestros relojes internos son uno de los factores m\u00e1s importantes de nuestra salud y bienestar diarios, por lo que es importante mantenerlos en buen estado de funcionamiento.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>La sincronizaci\u00f3n lo es todo, y m\u00e1s en la biolog\u00eda circadiana. El cuerpo humano funciona como un reloj cuando goza de buena salud, pero estos intrincados ritmos pueden verse alterados por la enfermedad. En algunas enfermedades, la identificaci\u00f3n de estos relojes internos alterados puede ser clave para un tratamiento nuevo y m\u00e1s eficaz. El c\u00e1ncer [&hellip;]<\/p>\n","protected":false},"author":11,"featured_media":23867,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","footnotes":""},"categories":[200,201],"tags":[],"class_list":{"0":"post-61478","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-investigacion-sobre-el-cancer","8":"category-salud-celular","9":"entry"},"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.4 (Yoast SEO v23.4) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Un nuevo estudio respalda la cronofarmacolog\u00eda en el tratamiento del c\u00e1ncer &#8211; Chronobiology.com<\/title>\n<meta name=\"description\" content=\"In some illnesses, identifying altered internal clocks can be a key to new and more effective treatment. 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