{"id":61386,"date":"2015-07-10T19:20:49","date_gmt":"2015-07-10T19:20:49","guid":{"rendered":"https:\/\/www.chronobiology.com\/autism-and-circadian-sleep-disorders-go-hand-in-hand\/"},"modified":"2024-07-19T12:53:12","modified_gmt":"2024-07-19T19:53:12","slug":"el-autismo-y-los-trastornos-circadianos-del-sue-o-van-de-la-mano","status":"publish","type":"post","link":"https:\/\/dev.chronobiology.com\/es\/el-autismo-y-los-trastornos-circadianos-del-sue-o-van-de-la-mano\/","title":{"rendered":"El autismo y los trastornos circadianos del sue\u00f1o van de la mano"},"content":{"rendered":"

Los trastornos del espectro autista afectan a un porcentaje grande y creciente de ni\u00f1os en el mundo occidental. Uno de los principales problemas de salud asociados al autismo son los trastornos circadianos del sue\u00f1o.<\/p>\n

Autismo y trastornos circadianos del sue\u00f1o<\/h2>\n

Alrededor del 60 al 80 por ciento de los<\/a> ni\u00f1os con espectro autista padecen un trastorno<\/a> circadiano del sue\u00f1o. Algunos tienen problemas para conciliar el sue\u00f1o, mientras que otros tienen problemas para permanecer dormidos. Esto puede causar inmensos problemas a las familias, ya que estos ni\u00f1os necesitan ser supervisados constantemente mientras est\u00e1n despiertos. Los ni\u00f1os sufren f\u00edsica y conductualmente por la falta de sue\u00f1o, mientras que a los padres les resulta m\u00e1s dif\u00edcil afrontar los retos \u00fanicos de un ni\u00f1o con necesidades especiales mientras est\u00e1 privado de sue\u00f1o.<\/p>\n

S\u00edntesis de melatonina en personas con trastorno del espectro autista<\/h2>\n

\"Autism<\/a>La melatonina<\/a> es una hormona importante asociada con el sue\u00f1o, producida en la gl\u00e1ndula pineal en respuesta a la oscuridad. Desde hace tiempo se ha observado un bajo nivel de melatonina en personas con autismo. Los investigadores en cronobiolog\u00eda<\/a> descubrieron que una mutaci\u00f3n gen\u00e9tica, en el gen ASMT, es com\u00fan en las personas con autismo.<\/p>\n

Este gen codifica la s\u00edntesis de melatonina, lo que explica las tasas m\u00e1s elevadas de melatonina baja<\/a> en esta poblaci\u00f3n. Dado que se cree que la melatonina no s\u00f3lo afecta al sue\u00f1o, sino tambi\u00e9n a varios aspectos del comportamiento humano, se trata de un avance significativo en la lucha por identificar y tratar las causas del trastorno del espectro autista.<\/p>\n

Una nueva base gen\u00e9tica de los trastornos del sue\u00f1o en el autismo<\/h2>\n

Una nueva investigaci\u00f3n<\/a> sugiere que existen otras bases gen\u00e9ticas firmes para los trastornos del sue\u00f1o en ni\u00f1os con trastorno del espectro autista. Los investigadores secuenciaron genes asociados al ritmo circadiano en ni\u00f1os y adultos autistas. Descubrieron que 15 de estos genes cr\u00edticos presentaban mutaciones, y que siete de estas mutaciones marcaban una diferencia fundamental en las prote\u00ednas relacionadas con los ciclos del sue\u00f1o.<\/p>\n

En total, el grupo de personas con autismo presentaba el doble de mutaciones que las personas que no pertenecen al espectro. Esto ocurr\u00eda incluso entre los autistas que no padec\u00edan trastornos del sue\u00f1o. Estas mutaciones podr\u00edan ser la causa no s\u00f3lo de los trastornos del sue\u00f1o, sino del propio autismo.<\/p>\n

Curiosamente, muchos de los padres de ni\u00f1os con espectro autista presentaban estas mismas mutaciones a pesar de no padecer autismo. Los investigadores sospechan desde hace tiempo que los trastornos del espectro autista tienen una base gen\u00e9tica; \u00e9sta puede ser una pista importante.<\/p>\n

Una nueva v\u00eda para la investigaci\u00f3n en cronobiolog\u00eda<\/h2>\n

Los investigadores en cronobiolog\u00eda llevan mucho tiempo buscando una base biol\u00f3gica para los trastornos del sue\u00f1o en individuos autistas, por lo que \u00e9sta es una noticia emocionante. Aunque se desconoce la relaci\u00f3n exacta entre estos genes y otros s\u00edntomas del trastorno del espectro autista, esto abre nuevas v\u00edas de investigaci\u00f3n. Los efectos de estas mutaciones gen\u00e9ticas pueden ir mucho m\u00e1s all\u00e1 de los trastornos del sue\u00f1o.<\/p>\n

Tratamientos futuros para los trastornos circadianos del sue\u00f1o en personas con autismo<\/h2>\n

\"AutismDada la importancia de la melatonina para conciliar y mantener el sue\u00f1o, la administraci\u00f3n de suplementos de melatonina puede ser la respuesta a muchos de los problemas de sue\u00f1o relacionados con el autismo. Investigadores en el campo de la cronobiolog\u00eda descubrieron que dosis bajas de melatonina ayudaban a resolver muchos trastornos del sue\u00f1o en ni\u00f1os con autismo. No se observaron efectos secundarios, pero el sue\u00f1o mejor\u00f3 significativamente. Se observ\u00f3 que ni\u00f1os de tan s\u00f3lo cuatro a\u00f1os se beneficiaban del tratamiento con melatonina.<\/p>\n

Aunque los investigadores est\u00e1n lejos de descubrir una cura para el autismo, estos descubrimientos ofrecen esperanza a las personas con autismo y a los seres queridos que los cuidan. Adem\u00e1s, la relaci\u00f3n entre el autismo y estas mutaciones gen\u00e9ticas reci\u00e9n descubiertas dar\u00e1 a los investigadores de la biolog\u00eda circadiana una nueva \u00e1rea que examinar para comprender mejor este trastorno neurol\u00f3gico com\u00fan.<\/p>\n","protected":false},"excerpt":{"rendered":"

Los trastornos del espectro autista afectan a un porcentaje grande y creciente de ni\u00f1os en el mundo occidental. Uno de los principales problemas de salud asociados al autismo son los trastornos circadianos del sue\u00f1o. Autismo y trastornos circadianos del sue\u00f1o Alrededor del 60 al 80 por ciento de los ni\u00f1os con espectro autista padecen un […]<\/p>\n","protected":false},"author":15,"featured_media":23603,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","footnotes":""},"categories":[215,214],"tags":[],"class_list":{"0":"post-61386","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-melatonina-es","8":"category-sueno","9":"entry"},"acf":[],"yoast_head":"\nEl autismo y los trastornos circadianos del sue\u00f1o van de la mano – Chronobiology.com<\/title>\n<meta name=\"description\" content=\"Autism spectrum disorders affect a large and growing percentage of children in the Western world. 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