{"id":61366,"date":"2015-06-19T19:09:37","date_gmt":"2015-06-19T19:09:37","guid":{"rendered":"https:\/\/www.chronobiology.com\/new-research-supports-idea-that-a-disrupted-circadian-rhythm-is-linked-to-cancer\/"},"modified":"2024-07-19T12:52:56","modified_gmt":"2024-07-19T19:52:56","slug":"una-nueva-investigaci-n-apoya-la-idea-de-que-un-ritmo-circadiano-alterado-est-relacionado-con-el-c-ncer","status":"publish","type":"post","link":"https:\/\/dev.chronobiology.com\/es\/una-nueva-investigaci-n-apoya-la-idea-de-que-un-ritmo-circadiano-alterado-est-relacionado-con-el-c-ncer\/","title":{"rendered":"Una nueva investigaci\u00f3n apoya la idea de que un ritmo circadiano alterado est\u00e1 relacionado con el c\u00e1ncer"},"content":{"rendered":"

La relaci\u00f3n entre el c\u00e1ncer y un ritmo circadiano alterado<\/a> ha sido aceptada por los cient\u00edficos m\u00e9dicos durante a\u00f1os. Un nuevo estudio en cronobiolog\u00eda<\/a> publicado recientemente confirma esta conexi\u00f3n al tiempo que ofrece nuevos conocimientos sobre los procesos celulares que vinculan ambos problemas de salud.<\/p>\n

C\u00e1ncer y ADN<\/h2>\n

El c\u00e1ncer es intr\u00ednsecamente una enfermedad del ADN. Nuestro c\u00f3digo gen\u00e9tico controla la proliferaci\u00f3n y el crecimiento celular. Las mutaciones en este c\u00f3digo permiten el crecimiento incontrolado y la p\u00e9rdida de la funci\u00f3n normal en c\u00e9lulas anormales. Cuando los cient\u00edficos descubrieron que los genes del RELOJ y otros genes relacionados con el ritmo circadiano<\/a> ayudan a programar el crecimiento y la reproducci\u00f3n celular, sospecharon inmediatamente que exist\u00eda una relaci\u00f3n con el c\u00e1ncer. Desde entonces, este v\u00ednculo se ha confirmado en varios estudios. Sin embargo, no se sab\u00eda lo suficiente sobre la relaci\u00f3n entre el c\u00e1ncer y el ritmo circadiano como para utilizar estos nuevos conocimientos en el tratamiento del c\u00e1ncer. Esto est\u00e1 cambiando a medida que nuevos estudios exploran c\u00f3mo la cronobiolog\u00eda est\u00e1 relacionada con el c\u00e1ncer y otras enfermedades mortales.<\/p>\n

PASD1: \u00bfLa prote\u00edna detr\u00e1s del c\u00e1ncer?<\/h2>\n

Cuando los genes se \u00abactivan\u00bb, producen prote\u00ednas. Un gen mutado crear\u00e1 prote\u00ednas anormales. En algunos casos, esta prote\u00edna anormal puede contribuir a algunos de los comportamientos que hacen que una c\u00e9lula sea cancerosa, incluido el crecimiento incontrolado.<\/p>\n

\"New<\/a>Los investigadores de la UC Santa Cruz identificaron esta prote\u00edna y determinaron su relaci\u00f3n con las c\u00e9lulas cancer<\/a>osas. La PASD1 se encuentra en c\u00e9lulas que se dividir\u00e1n y crecer\u00e1n r\u00e1pidamente, incluidas las c\u00e9lulas germinales, las c\u00e9lulas madre y las c\u00e9lulas cancerosas. Aunque no se encuentra en todas las c\u00e9lulas cancerosas, s\u00ed est\u00e1 vinculada a muchos c\u00e1nceres comunes, como el melanoma y el c\u00e1ncer de mama. PASD1 parece silenciar el ritmo circadiano en las c\u00e9lulas que tienen esta prote\u00edna, lo que permite un crecimiento constante en lugar de programado. Esto permite que los tumores y otros crecimientos cancerosos crezcan mucho m\u00e1s r\u00e1pido que las c\u00e9lulas normales.<\/p>\n

Nuevos enfoques para el tratamiento del c\u00e1ncer<\/h2>\n

Este nuevo descubrimiento ofrece una nueva v\u00eda para el tratamiento del<\/a> c\u00e1ncer en tumores que expresan la prote\u00edna PASD1. Mediante el uso de medicamentos que interfer\u00edan en la producci\u00f3n de la prote\u00edna PASD1, los investigadores pudieron volver a activar el ritmo circadiano. Esto ralentiz\u00f3 enormemente el crecimiento del tumor. Aunque este tratamiento no es una cura completa para el c\u00e1ncer, puede ayudar a ralentizar el crecimiento tumoral cuando se utiliza junto con otros tratamientos contra el c\u00e1ncer. Los investigadores de este estudio se\u00f1alan que vivir fuera del ciclo diario natural no es saludable, tanto si se es un ser humano como una simple c\u00e9lula. Estos relojes internos son esenciales para una buena salud y funcionamiento.<\/p>\n

Los investigadores de la UC Santa Cruz esperan seguir estudiando las prote\u00ednas que se producen en las c\u00e9lulas cancerosas y explorar c\u00f3mo afectan estas prote\u00ednas al ritmo circadiano de dichas c\u00e9lulas. Muchos de los tratamientos modernos m\u00e1s eficaces contra el c\u00e1ncer se basan en atacar la expresi\u00f3n del ADN de las c\u00e9lulas cancerosas. Comprender la relaci\u00f3n entre el c\u00e1ncer y el ritmo circadiano permitir\u00e1 nuevos tratamientos que detengan el crecimiento del c\u00e1ncer y restauren la salud.<\/p>\n","protected":false},"excerpt":{"rendered":"

La relaci\u00f3n entre el c\u00e1ncer y un ritmo circadiano alterado ha sido aceptada por los cient\u00edficos m\u00e9dicos durante a\u00f1os. Un nuevo estudio en cronobiolog\u00eda publicado recientemente confirma esta conexi\u00f3n al tiempo que ofrece nuevos conocimientos sobre los procesos celulares que vinculan ambos problemas de salud. C\u00e1ncer y ADN El c\u00e1ncer es intr\u00ednsecamente una enfermedad del […]<\/p>\n","protected":false},"author":15,"featured_media":23559,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","footnotes":""},"categories":[200,201],"tags":[],"class_list":{"0":"post-61366","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-investigacion-sobre-el-cancer","8":"category-salud-celular","9":"entry"},"acf":[],"yoast_head":"\nUna nueva investigaci\u00f3n apoya la idea de que un ritmo circadiano alterado est\u00e1 relacionado con el c\u00e1ncer – Chronobiology.com<\/title>\n<meta name=\"description\" content=\"The link between cancer and a disrupted circadian rhythm has been accepted by medical scientists for years. 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