{"id":61262,"date":"2015-03-04T22:20:12","date_gmt":"2015-03-04T22:20:12","guid":{"rendered":"https:\/\/www.chronobiology.com\/skin-and-circadian-rhythm-the-internal-clocks-of-skin-cells\/"},"modified":"2024-07-19T12:51:41","modified_gmt":"2024-07-19T19:51:41","slug":"la-piel-y-el-ritmo-circadiano-los-relojes-internos-de-las-c-lulas-cut-neas","status":"publish","type":"post","link":"https:\/\/dev.chronobiology.com\/es\/la-piel-y-el-ritmo-circadiano-los-relojes-internos-de-las-c-lulas-cut-neas\/","title":{"rendered":"La piel y el ritmo circadiano: Los relojes internos de las c\u00e9lulas cut\u00e1neas"},"content":{"rendered":"

Los ritmos circadianos<\/a>, o relojes biol\u00f3gicos internos de 24 horas, son objeto de numerosos ensayos de investigaci\u00f3n en la actualidad. Los cient\u00edficos est\u00e1n empezando a descubrir los efectos de los ciclos de luz y oscuridad en el cuerpo humano, que constituyen un nuevo campo de la biolog\u00eda llamado cronobiolog\u00eda<\/a>. Las \u00faltimas investigaciones demuestran que estos relojes internos no s\u00f3lo controlan nuestro estado de \u00e1nimo, nuestros niveles de energ\u00eda y nuestras hormonas, sino tambi\u00e9n la salud de nuestra piel.<\/p>\n

Los relojes internos de las c\u00e9lulas cut\u00e1neas<\/h2>\n

Muchas funciones de los ritmos circadianos est\u00e1n controladas por el n\u00facleo supraquiasm\u00e1tico del cerebro. Sin embargo, muchos tipos de c\u00e9lulas diferentes tienen sus propios relojes internos. Estos relojes crean ondas de actividad en funci\u00f3n de la hora del d\u00eda. Las c\u00e9lulas de la piel tambi\u00e9n tienen estos<\/a> relojes. Las c\u00e9lulas madre de la epidermis se reproducen principalmente por la noche, creando nuevas c\u00e9lulas cut\u00e1neas que sustituyen a las envejecidas y reducen el aspecto del envejecimiento. Adem\u00e1s, la reparaci\u00f3n del ADN se produce principalmente durante determinadas horas del d\u00eda, lo cual es importante porque se trata de la primera l\u00ednea de defensa del organismo contra los da\u00f1os causados por los rayos UV y el c\u00e1ncer de piel.<\/p>\n

Dado que las c\u00e9lulas de la piel<\/a> realizan diferentes actividades durante las distintas horas del d\u00eda, tambi\u00e9n son m\u00e1s sensibles a los da\u00f1os en determinados momentos. Comprender el ritmo circadiano de las c\u00e9lulas cut\u00e1neas puede ser una forma importante de prevenir el envejecimiento prematuro y el c\u00e1ncer de piel.<\/p>\n

Los genes CLOCK y la piel<\/h2>\n

\"Skin<\/a>Las \u00faltimas investigaciones<\/a> indican que los genes CLOCK, previamente identificados en otros tipos de c\u00e9lulas, son los que probablemente afectan a los relojes internos de las c\u00e9lulas de la piel. La epidermis desempe\u00f1a un papel importante en la salud. Separa nuestros \u00f3rganos vitales de las influencias nocivas del entorno exterior, como los rayos UV, los productos qu\u00edmicos, la oxidaci\u00f3n y el estr\u00e9s mec\u00e1nico. Los genes CLOCK de las c\u00e9lulas epid\u00e9rmicas parecen anticipar los momentos de mayor estr\u00e9s y programar las reparaciones.<\/p>\n

Parece que la reparaci\u00f3n del ADN en las c\u00e9lulas de la piel se produce por la tarde y por la noche. Estas son las horas en las que la piel est\u00e1 m\u00e1s expuesta a los rayos UV directos. A \u00faltima hora de la noche se produce la proliferaci\u00f3n de c\u00e9lulas madre epid\u00e9rmicas. Se cree que la proliferaci\u00f3n se produce por la noche porque es el momento en que estos delicados procesos tienen menos probabilidades de ser interrumpidos o perturbados. El resultado es que los da\u00f1os en el ADN que se producen por la ma\u00f1ana y por la noche, especialmente los causados por los rayos UV, tienen menos probabilidades de repararse a tiempo, mientras que las personas que trasnochan exponiendo su piel a la luz y a sustancias qu\u00edmicas como el alcohol y el tabaco pueden sufrir un envejecimiento prematuro.<\/p>\n

Efectos de los ritmos circadianos en la piel<\/h2>\n

Antes de que se descubrieran los genes CLOCK, los cient\u00edficos ya hab\u00edan observado que el estado de la piel var\u00eda de forma predecible a lo largo de un ciclo de 24 horas. Por ejemplo, las mujeres suelen considerar que su piel es m\u00e1s atractiva por la ma\u00f1ana que por la tarde, lo que ahora sabemos que se debe probablemente a la proliferaci\u00f3n de nuevas c\u00e9lulas cut\u00e1neas por la noche. Adem\u00e1s, se ha demostrado que las cremas antienvejecimiento son m\u00e1s eficaces cuando se utilizan antes de acostarse.<\/p>\n

Adem\u00e1s, la piel parece ser m\u00e1s sensible a la inflamaci\u00f3n en determinados momentos del d\u00eda. Los s\u00edntomas de la dermatitis at\u00f3pica empeoran por la noche, que es tambi\u00e9n cuando la psoriasis es m\u00e1s grave. Las personas que se someten a pruebas de alergia y pruebas cut\u00e1neas de la tuberculosis tienen menos probabilidades de dar positivo cuando la prueba se realiza por la ma\u00f1ana en lugar de por la tarde o por la noche.<\/p>\n

\u00bfEs el momento oportuno la clave de la prevenci\u00f3n?<\/h2>\n

\"Skin<\/a>Aunque el estudio del ritmo circadiano de la piel se encuentra todav\u00eda en sus fases iniciales, es posible que estos conocimientos puedan utilizarse para prevenir y tratar mejor los trastornos cut\u00e1neos. Por ejemplo, los medicamentos para la psoriasis y la dermatitis pueden ser m\u00e1s eficaces si se administran por la noche, ya que es el momento en que se producen los brotes. Si hay que exponerse a los rayos UV, puede hacerse por la tarde o a primera hora de la noche<\/a>. Los tratamientos contra el c\u00e1ncer de piel, como la quimioterapia, pueden ser m\u00e1s eficaces si se planifican para que coincidan con los momentos m\u00e1s eficaces del ciclo celular cut\u00e1neo.<\/p>\n

La cronobiolog\u00eda es un campo emergente que est\u00e1 demostrando ser cada vez m\u00e1s importante en la salud humana. Comprender los genes CLOCK y sus efectos en las c\u00e9lulas de la piel puede ser una forma importante de prevenir el c\u00e1ncer de piel, el envejecimiento prematuro y diversos trastornos cut\u00e1neos.<\/p>\n","protected":false},"excerpt":{"rendered":"

Los ritmos circadianos, o relojes biol\u00f3gicos internos de 24 horas, son objeto de numerosos ensayos de investigaci\u00f3n en la actualidad. Los cient\u00edficos est\u00e1n empezando a descubrir los efectos de los ciclos de luz y oscuridad en el cuerpo humano, que constituyen un nuevo campo de la biolog\u00eda llamado cronobiolog\u00eda. Las \u00faltimas investigaciones demuestran que estos […]<\/p>\n","protected":false},"author":15,"featured_media":23183,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","footnotes":""},"categories":[200,213,201],"tags":[],"class_list":{"0":"post-61262","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-investigacion-sobre-el-cancer","8":"category-piel","9":"category-salud-celular","10":"entry"},"acf":[],"yoast_head":"\nLa piel y el ritmo circadiano: Los relojes internos de las c\u00e9lulas cut\u00e1neas – Chronobiology.com<\/title>\n<meta name=\"description\" content=\"Scientists are only beginning to discover the effects of light and dark cycles on the human body, which comprise a new field of biology called chronobiology. 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