{"id":61185,"date":"2015-01-16T10:00:16","date_gmt":"2015-01-16T10:00:16","guid":{"rendered":"https:\/\/www.chronobiology.com\/how-chronobiology-is-affecting-cancer-treatment\/"},"modified":"2024-07-19T12:51:12","modified_gmt":"2024-07-19T19:51:12","slug":"c-mo-afecta-la-cronobiolog-a-al-tratamiento-del-c-ncer","status":"publish","type":"post","link":"https:\/\/dev.chronobiology.com\/es\/c-mo-afecta-la-cronobiolog-a-al-tratamiento-del-c-ncer\/","title":{"rendered":"C\u00f3mo afecta la cronobiolog\u00eda al tratamiento del c\u00e1ncer"},"content":{"rendered":"

Los cient\u00edficos est\u00e1n empezando a comprender la relaci\u00f3n del cerebro humano con el tiempo. Sabemos desde hace d\u00e9cadas que el cuerpo funciona con ritmos circadianos, con ciclos que se repiten cada 24 horas. En realidad, nuestro cuerpo funciona con varios relojes diferentes: el crecimiento celular, la liberaci\u00f3n de hormonas y otras actividades cotidianas est\u00e1n conectadas a un ciclo basado en el sue\u00f1o, los niveles de luz y oscuridad y otros factores. La cronobiolog\u00eda<\/a> estudia nuestros relojes internos y c\u00f3mo se ven afectados por lo que consumimos y cu\u00e1ndo lo hacemos. As\u00ed que, naturalmente, muchos cronobi\u00f3logos esperan descubrir un gran avance en la forma de combatir el c\u00e1ncer. Puede que algunos ya lo hayan hecho.<\/p>\n

\n

Cronobiolog\u00eda y c\u00e1ncer<\/h2>\n

\"How<\/a>Cronobi\u00f3logos de todo el mundo intentan comprender mejor los relojes internos<\/a> del cuerpo humano y muchos esperan que esa comprensi\u00f3n pueda ser la clave para un mejor tratamiento del c\u00e1ncer. Estos relojes internos controlan el crecimiento celular, por lo que cualquier cambio en su funcionamiento puede provocar un crecimiento descontrolado y una reducci\u00f3n de la apoptosis, o muerte celular programada, dos causas fundamentales del c\u00e1ncer.<\/p>\n

Losritmos circadianos<\/a> afectan al funcionamiento de los medicamentos, incluidas las modernas terapias contra el c\u00e1ncer. Las quimioterapias modernas se dirigen a partes cruciales del metabolismo de las c\u00e9lulas cancerosas. As\u00ed pues, administrar las terapias en los momentos en que ser\u00e1n m\u00e1s eficaces mejorar\u00e1 los resultados del tratamiento. Uno de los principales objetivos de los cronobi\u00f3logos es comprender cu\u00e1les son esos momentos \u00f3ptimos.<\/p>\n

El m\u00e9todo del ritmo: Administrar los f\u00e1rmacos contra el c\u00e1ncer cuando mejor funcionan<\/h2>\n

Existen varias razones por las que el conocimiento de la cronobiolog\u00eda y los ritmos circadianos puede mejorar el tratamiento del c\u00e1ncer.<\/a> En primer lugar, si se act\u00faa sobre partes del metabolismo de la c\u00e9lula cancerosa durante la secci\u00f3n m\u00e1s sensible del ciclo celular, el tumor se reduce y remite m\u00e1s r\u00e1pidamente. En segundo lugar, muchos f\u00e1rmacos y quimioterapias contra el c\u00e1ncer deben metabolizarse o activarse antes de ser eficaces. Administrar dosis de estas terapias cuando se activar\u00e1n a la velocidad correcta aumentar\u00e1 la cantidad de f\u00e1rmaco disponible. Por \u00faltimo, las quimioterapias funcionan mejor en presencia de determinadas hormonas. Los niveles hormonales var\u00edan seg\u00fan los ritmos circadianos, por lo que los medicamentos son m\u00e1s eficaces cuando las dosis coinciden con los niveles hormonales beneficiosos.<\/p>\n

Reducir la toxicidad con la cronobiolog\u00eda<\/h2>\n

\"Chronobiology,<\/a>Otro posible beneficio del uso de la cronobiolog\u00eda en la planificaci\u00f3n de la quimioterapia es que las personas tendr\u00edan menos probabilidades de recibir dosis t\u00f3xicas<\/a> del f\u00e1rmaco. Muchos pacientes se ven obligados a dejar de utilizar un determinado f\u00e1rmaco debido a los efectos t\u00f3xicos que tiene en su organismo, aunque est\u00e9 funcionando. Disminuir la toxicidad de los f\u00e1rmacos contra el c\u00e1ncer significar\u00e1 menos efectos secundarios desagradables con los que lidiar y una mayor probabilidad de que el f\u00e1rmaco ataque al c\u00e1ncer.<\/p>\n

La cronobiolog\u00eda reduce la toxicidad asociada a la quimioterapia de varias maneras. Cuando los f\u00e1rmacos se administran en momentos m\u00e1s eficaces, se necesita menos cantidad. Hay momentos del d\u00eda en que los f\u00e1rmacos son mejor tolerados por el organismo, debido a los niveles hormonales del paciente o a su velocidad para metabolizar el f\u00e1rmaco y excretar los metabolitos nocivos. Dado que la quimioterapia conlleva efectos secundarios negativos relacionados con la toxicidad de los f\u00e1rmacos, cualquier cosa que reduzca la toxicidad sin comprometer el tratamiento ser\u00eda un gran avance en la lucha contra el c\u00e1ncer.<\/p>\n

La cronobiolog\u00eda y el tratamiento del c\u00e1ncer en la pr\u00e1ctica<\/h2>\n

\"Chronobiology,<\/a>Nuevos estudios est\u00e1n revelando las ventajas de utilizar la cronobiolog\u00eda para tratar la quimioterapia. Por ejemplo, se ha demostrado que f\u00e1rmacos contra el c\u00e1ncer como el metotrexato y el 5-fluorouracilo, conocidos como antimetabolitos, funcionan mejor y producen menos efectos secundarios cuando se administran por la tarde o por la noche<\/a>. Esto se debe a que estos f\u00e1rmacos interfieren en la s\u00edntesis del ADN. Dado que las c\u00e9lulas humanas normales ralentizan la s\u00edntesis de ADN a \u00faltima hora de la noche, y las c\u00e9lulas cancerosas no, la administraci\u00f3n de f\u00e1rmacos antimetabolitos a esta hora disminuir\u00e1 su efecto sobre las c\u00e9lulas sanas y, por tanto, los efectos secundarios.<\/p>\n

Los antimetabolitos no son los \u00fanicos f\u00e1rmacos de quimioterapia que han demostrado ser m\u00e1s eficaces a distintas horas del d\u00eda. Estudios realizados en animales de laboratorio han demostrado que 30 f\u00e1rmacos comunes contra el c\u00e1ncer aumentan su eficacia y reducen su toxicidad cuando se controla el horario para que coincida con el reloj interno del cuerpo.<\/p>\n

La cronobiolog\u00eda es una ciencia nueva y en evoluci\u00f3n, objeto de numerosos estudios en curso. El uso de la cronobiolog\u00eda en el tratamiento del c\u00e1ncer puede ser el aspecto m\u00e1s apasionante de esta ciencia y algo que seguiremos de cerca.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Los cient\u00edficos est\u00e1n empezando a comprender la relaci\u00f3n del cerebro humano con el tiempo. Sabemos desde hace d\u00e9cadas que el cuerpo funciona con ritmos circadianos, con ciclos que se repiten cada 24 horas. En realidad, nuestro cuerpo funciona con varios relojes diferentes: el crecimiento celular, la liberaci\u00f3n de hormonas y otras actividades cotidianas est\u00e1n conectadas […]<\/p>\n","protected":false},"author":11,"featured_media":23011,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","footnotes":""},"categories":[173,200,201],"tags":[],"class_list":{"0":"post-61185","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-el-ritmo-circadiano","8":"category-investigacion-sobre-el-cancer","9":"category-salud-celular","10":"entry"},"acf":[],"yoast_head":"\nC\u00f3mo afecta la cronobiolog\u00eda al tratamiento del c\u00e1ncer – Chronobiology.com<\/title>\n<meta name=\"description\" content=\"Chronobiology studies our internal clocks and how they are affected by what we consume and when we consume it. 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