{"id":63629,"date":"2024-09-02T00:26:48","date_gmt":"2024-09-02T07:26:48","guid":{"rendered":"https:\/\/www.chronobiology.com\/?p=63629"},"modified":"2024-09-04T02:51:06","modified_gmt":"2024-09-04T09:51:06","slug":"hvornaar-er-det-bedste-tidspunkt-paa-dagen-for-kraeftbehandling","status":"publish","type":"post","link":"https:\/\/dev.chronobiology.com\/da\/hvornaar-er-det-bedste-tidspunkt-paa-dagen-for-kraeftbehandling\/","title":{"rendered":"Hvorn\u00e5r er det bedste tidspunkt p\u00e5 dagen for kr\u00e6ftbehandling?"},"content":{"rendered":"

Hvor effektiv medicin er, afh\u00e6nger af forskellige faktorer, herunder tidspunktet p\u00e5 dagen<\/a>, hvor den indgives. Og hvorfor er det s\u00e5dan? Fordi vores krop ikke altid fungerer p\u00e5 pr\u00e6cis samme m\u00e5de.
\nI stedet f\u00f8lger den cyklussen i sit indre ur, den s\u00e5kaldte cirkadiske rytme. Men da denne rytme er forskellig fra person til person og afh\u00e6nger af en r\u00e6kke forskellige faktorer, er det sv\u00e6rt at tilpasse medicinindtagelsen til patientens individuelle kropsur. Forskere ved Charit\u00e9 – Universit\u00e4tsmedizin Berlin har nu udviklet en metode til at bestemme den optimale timing af kr\u00e6ftbehandling<\/a> baseret p\u00e5 specifikke brystkr\u00e6ftcellelinjer. De beskriver deres tilgang i tidsskriftet Nature Communications<\/em><\/a>.<\/em> Menneskets indre ur bestemmer rytmen for mange forskellige kropsfunktioner og metaboliske processer, s\u00e5som s\u00f8vn og ford\u00f8jelse. Men det er ikke kun organerne, der er mere eller mindre aktive afh\u00e6ngigt af tidspunktet p\u00e5 dagen.<\/p>\n

De enkelte celler f\u00f8lger ogs\u00e5 en cyklus, der er bestemt af det menneskelige kropsur, s\u00e5 de reagerer forskelligt p\u00e5 ydre p\u00e5virkninger p\u00e5 forskellige tidspunkter af d\u00f8gnet. Det har stor betydning for kemoterapi i behandlingen af kr\u00e6ft. Tidligere unders\u00f8gelser har vist, at kemoterapi<\/a> er mest effektiv, n\u00e5r tumorcellerne deler sig. Denne opdagelse er dog n\u00e6ppe blevet brugt i klinisk behandling til dato. Et tv\u00e6rfagligt team p\u00e5 Charit\u00e9 under ledelse af Dr. Adri\u00e1n Enrique Granada fra Charit\u00e9 Comprehensive Cancer Center (CCCC) satte sig for at lukke dette hul. Holdet satte sig for at finde det optimale tidspunkt at give medicin p\u00e5 ud fra tumorernes individuelle d\u00f8gnrytmer.<\/p>\n

Eksempel p\u00e5 triple negativ brystkr\u00e6ft<\/h2>\n

\"kan\"<\/a>“Vi dyrkede celler fra patienter med triple-negativ brystkr\u00e6ft<\/a> for at se, hvordan de reagerede p\u00e5 l\u00e6gemidlerne, der blev givet p\u00e5 forskellige tidspunkter af dagen”, forklarer Carolin Ector, der er forskningsassistent i Granadas team. Triple-negativ brystkr\u00e6ft er en meget aggressiv form for brystkr\u00e6ft, som der kun findes f\u00e5 effektive behandlinger for. “Ved hj\u00e6lp af live imaging, en metode til kontinuerlig overv\u00e5gning af levende celler, og komplekse dataanalyseteknikker var forskerne i stand til at observere og evaluere disse kr\u00e6ftcellers d\u00f8gnrytmer, v\u00e6kstcyklusser og l\u00e6gemiddelrespons i detaljer.
\nP\u00e5 den m\u00e5de identificerede forskerne specifikke tidspunkter p\u00e5 dagen, hvor kr\u00e6ftcellerne reagerer bedst p\u00e5 l\u00e6gemiddelbehandlinger.<\/p>\n

For eksempel fandt man ud af, at det kemoterapeutiske middel 5-fluorouracil (5-FU) er mest effektivt mod en bestemt kr\u00e6ftcellelinje mellem klokken otte og ti om morgenen. Som unders\u00f8gelsen ogs\u00e5 viser, er visse cellul\u00e6re og genetiske faktorer afg\u00f8rende. Forskerne var endda i stand til at bestemme, hvilke gener der er afg\u00f8rende for den d\u00f8gnrytmiske effekt af visse l\u00e6gemidler. “Vi kalder dem ‘core clock genes’. If\u00f8lge Granada har de en betydelig indflydelse p\u00e5, hvor godt kr\u00e6ftceller reagerer p\u00e5 behandlinger, der gives p\u00e5 forskellige tidspunkter af d\u00f8gnet.<\/p>\n

Profiler viser, hvordan kr\u00e6ftcelletyper reagerer p\u00e5 medicin<\/h2>\n

Denne tilgang kan bruges til at skabe detaljerede profiler, der viser, hvordan forskellige typer kr\u00e6ftceller reagerer p\u00e5 forskellige l\u00e6gemidler<\/a> p\u00e5 forskellige tidspunkter. If\u00f8lge forskerne kan dette hj\u00e6lpe med at bestemme de mest effektive l\u00e6gemiddelkombinationer. Samlet set tyder disse resultater p\u00e5, at personlige behandlingsplaner baseret p\u00e5 individuelle d\u00f8gnrytmer kan forbedre effektiviteten af kr\u00e6ftbehandlingen betydeligt. Desuden kan u\u00f8nskede bivirkninger ogs\u00e5 reduceres.<\/p>\n

For at disse resultater snart kan indarbejdes i klinisk praksis, skal de valideres i studier med st\u00f8rre patientgrupper. Forskerne planl\u00e6gger ogs\u00e5 at unders\u00f8ge de molekyl\u00e6re mekanismer bag d\u00f8gnets indflydelse p\u00e5 l\u00e6gemiddelf\u00f8lsomheden for yderligere at kunne optimere behandlingstider og identificere nye terapeutiske m\u00e5l.<\/p>\n","protected":false},"excerpt":{"rendered":"

Hvor effektiv medicin er, afh\u00e6nger af forskellige faktorer, herunder tidspunktet p\u00e5 dagen, hvor den indgives. Og hvorfor er det s\u00e5dan? Fordi vores krop ikke altid fungerer p\u00e5 pr\u00e6cis samme m\u00e5de. I stedet f\u00f8lger den cyklussen i sit indre ur, den s\u00e5kaldte cirkadiske rytme. Men da denne rytme er forskellig fra person til person og afh\u00e6nger […]<\/p>\n","protected":false},"author":11,"featured_media":63613,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","footnotes":""},"categories":[390],"tags":[],"class_list":{"0":"post-63629","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-cellulaer-sundhed","8":"entry"},"acf":[],"yoast_head":"\nHvorn\u00e5r er det bedste tidspunkt p\u00e5 dagen for kr\u00e6ftbehandling? – Chronobiology.com<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/dev.chronobiology.com\/da\/hvornaar-er-det-bedste-tidspunkt-paa-dagen-for-kraeftbehandling\/\" \/>\n<meta property=\"og:locale\" content=\"da_DK\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Hvorn\u00e5r er det bedste tidspunkt p\u00e5 dagen for kr\u00e6ftbehandling?\" \/>\n<meta property=\"og:description\" content=\"Hvor effektiv medicin er, afh\u00e6nger af forskellige faktorer, herunder tidspunktet p\u00e5 dagen, hvor den indgives. Og hvorfor er det s\u00e5dan? Fordi vores krop ikke altid fungerer p\u00e5 pr\u00e6cis samme m\u00e5de. I stedet f\u00f8lger den cyklussen i sit indre ur, den s\u00e5kaldte cirkadiske rytme. 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Og hvorfor er det s\u00e5dan? Fordi vores krop ikke altid fungerer p\u00e5 pr\u00e6cis samme m\u00e5de. I stedet f\u00f8lger den cyklussen i sit indre ur, den s\u00e5kaldte cirkadiske rytme. 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