{"id":63989,"date":"2024-09-04T04:07:56","date_gmt":"2024-09-04T11:07:56","guid":{"rendered":"https:\/\/www.chronobiology.com\/vedci-testuji-novy-lek-urceny-ke-zmirneni-srdecniho-selhani-a-spankove-apnoe\/"},"modified":"2024-09-04T04:07:56","modified_gmt":"2024-09-04T11:07:56","slug":"vedci-testuji-novy-lek-urceny-ke-zmirneni-srdecniho-selhani-a-spankove-apnoe","status":"publish","type":"post","link":"https:\/\/dev.chronobiology.com\/cs\/vedci-testuji-novy-lek-urceny-ke-zmirneni-srdecniho-selhani-a-spankove-apnoe\/","title":{"rendered":"V\u011bdci testuj\u00ed nov\u00fd l\u00e9k ur\u010den\u00fd ke zm\u00edrn\u011bn\u00ed srde\u010dn\u00edho selh\u00e1n\u00ed a sp\u00e1nkov\u00e9 apnoe"},"content":{"rendered":"

Srde\u010dn\u00ed selh\u00e1n\u00ed<\/a> je b\u011b\u017en\u00fd stav.
\nV Evrop\u011b trp\u00ed srde\u010dn\u00ed nedostate\u010dnost\u00ed v\u00edce ne\u017e 10 milion\u016f lid\u00ed.
\nZ r\u016fzn\u00fdch d\u016fvod\u016f ji\u017e srdce nedok\u00e1\u017ee produkovat dostate\u010dn\u011b vysok\u00fd srde\u010dn\u00ed v\u00fddej, aby z\u00e1sobilo t\u011blo dostate\u010dn\u00fdm mno\u017estv\u00edm kysl\u00edku a umo\u017enilo norm\u00e1ln\u00ed metabolismus.
\nTo m\u016f\u017ee b\u00fdt zp\u016fsobeno sn\u00ed\u017een\u00fdm \u010derpac\u00edm v\u00fdkonem (systolick\u00e9 srde\u010dn\u00ed selh\u00e1n\u00ed) nebo naru\u0161enou schopnost\u00ed srde\u010dn\u00edho svalu relaxovat (diastolick\u00e9 srde\u010dn\u00ed selh\u00e1n\u00ed).
\nNov\u00fd l\u00e9k v\u0161ak \u00fadajn\u011b slibn\u011b zm\u00edr\u0148uje srde\u010dn\u00ed selh\u00e1n\u00ed, kter\u00e9 je spojeno se sp\u00e1nkovou apnoe a zkr\u00e1cen\u00edm d\u00e9lky \u017eivota<\/a>. <\/p>\n

Nov\u00fd l\u00e9k je pr\u00fd \u00fa\u010dinn\u00fd p\u0159i srde\u010dn\u00edm selh\u00e1n\u00ed a sp\u00e1nkov\u00e9 apnoe<\/h2>\n

Tento l\u00e9k, zn\u00e1m\u00fd jako AF-130, byl testov\u00e1n na zv\u00ed\u0159ec\u00edm modelu na Waipapa Taumata Rau na univerzit\u011b v Aucklandu, kde v\u011bdci zjistili, \u017ee zlep\u0161uje schopnost srdce pumpovat, ale co je stejn\u011b d\u016fle\u017eit\u00e9, zabra\u0148uje sp\u00e1nkov\u00e9 apnoe,<\/a> kter\u00e1 zkracuje d\u00e9lku \u017eivota.
\nLid\u00e9 trp\u00edc\u00ed sp\u00e1nkovou apnoe p\u0159est\u00e1vaj\u00ed b\u011bhem sp\u00e1nku d\u00fdchat.
\nD\u00fdchac\u00ed cesty posti\u017een\u00fdch jsou natolik z\u00fa\u017een\u00e9, \u017ee d\u00fdch\u00e1n\u00ed je nejen v\u00fdrazn\u011b obt\u00ed\u017en\u011bj\u0161\u00ed, ale zcela se zastav\u00ed.
\nNov\u00fd l\u00e9k je prosp\u011b\u0161n\u00fd nejen p\u0159i srde\u010dn\u00edm selh\u00e1n\u00ed, ale m\u016f\u017ee tak\u00e9 zm\u00edrnit apnoe, na kterou v sou\u010dasn\u00e9 dob\u011b neexistuje jin\u00fd l\u00e9k ne\u017e CPAP (d\u00fdchac\u00ed p\u0159\u00edstroj), kter\u00fd je \u0161patn\u011b sn\u00e1\u0161en.
\nKdy\u017e \u010dlov\u011bk utrp\u00ed srde\u010dn\u00ed infarkt<\/a> a n\u00e1sledn\u00e9 srde\u010dn\u00ed selh\u00e1n\u00ed, mozek reaguje aktivac\u00ed sympatick\u00e9ho syst\u00e9mu, reakc\u00ed „bojuj nebo ute\u010d“, aby stimuloval srdce k pumpov\u00e1n\u00ed krve.
\nMozek v\u0161ak tuto aktivaci nervov\u00e9ho syst\u00e9mu udr\u017euje i v dob\u011b, kdy ji\u017e nen\u00ed pot\u0159eba, a to spolu s n\u00e1slednou sp\u00e1nkovou apnoe p\u0159isp\u00edv\u00e1 ke zkr\u00e1cen\u00ed d\u00e9lky \u017eivota pacienta.
\nV\u011bt\u0161ina pacient\u016f um\u00edr\u00e1 do p\u011bti let od stanoven\u00ed diagn\u00f3zy srde\u010dn\u00edho selh\u00e1n\u00ed.
\nTato studie odhalila prvn\u00ed l\u00e9k, kter\u00fd tlum\u00ed nervovou aktivitu z mozku do srdce, a t\u00edm zvr\u00e1t\u00ed postupn\u00fd \u00fapadek srdce p\u0159i srde\u010dn\u00edm selh\u00e1n\u00ed, vysv\u011btluj\u00ed v\u011bdci.
\n\u010c\u00e1st mozku, kter\u00e1 vys\u00edl\u00e1 nervov\u00e9 impulsy do srdce, tak\u00e9 \u0159\u00edd\u00ed d\u00fdch\u00e1n\u00ed, tak\u017ee tento l\u00e9k pln\u00ed dvoj\u00ed funkci: sni\u017euje reakci „bojuj nebo ute\u010d“ a z\u00e1rove\u0148 stimuluje d\u00fdch\u00e1n\u00ed, aby zastavil sp\u00e1nkovou apnoe.
\nTyto v\u00fdsledky maj\u00ed re\u00e1ln\u00fd potenci\u00e1l zlep\u0161it pohodu a d\u00e9lku \u017eivota lid\u00ed s onemocn\u011bn\u00edm srdce.
\nDal\u0161\u00edm vzru\u0161uj\u00edc\u00edm faktorem pro v\u011bdce, kte\u0159\u00ed sv\u00e9 v\u00fdsledky publikovali v \u010dasopise Nature Communications<\/a>, je, \u017ee l\u00e9k bude brzy schv\u00e1len FDA, i kdy\u017e pro jin\u00fd zdravotn\u00ed probl\u00e9m, co\u017e otev\u00edr\u00e1 cestu pro studie na lidech v pr\u016fb\u011bhu p\u0159\u00ed\u0161t\u00edho roku nebo dvou. <\/p>\n

\n

Jak souvis\u00ed sp\u00e1nkov\u00e9 n\u00e1vyky a srde\u010dn\u00ed selh\u00e1n\u00ed<\/h2>\n

Klidn\u00fd sp\u00e1nek<\/a> hraje d\u016fle\u017eitou roli tak\u00e9 pro srdce.
\nV\u00fdzkumy toti\u017e ukazuj\u00ed, \u017ee probl\u00e9my se sp\u00e1nkem<\/a> mohou hr\u00e1t roli p\u0159i vzniku srde\u010dn\u00edch onemocn\u011bn\u00ed, ale zdrav\u00e9 sp\u00e1nkov\u00e9 n\u00e1vyky jsou spojeny s ni\u017e\u0161\u00edm rizikem srde\u010dn\u00edho selh\u00e1n\u00ed.
\nTato observa\u010dn\u00ed studie<\/a> zkoumala vztah mezi zdrav\u00fdmi sp\u00e1nkov\u00fdmi n\u00e1vyky a srde\u010dn\u00edm selh\u00e1n\u00edm a zahrnovala \u00fadaje od 408 802 \u00fa\u010dastn\u00edk\u016f britsk\u00e9 biobanky ve v\u011bku 37 a\u017e 73 let v dob\u011b za\u0159azen\u00ed do studie (2006-2010).
\nV\u00fdskyt srde\u010dn\u00edho selh\u00e1n\u00ed byl zaznamen\u00e1n a\u017e do 1. dubna 2019.
\nV\u011bdci zaznamenali 5 221 p\u0159\u00edpad\u016f srde\u010dn\u00edho selh\u00e1n\u00ed b\u011bhem pr\u016fm\u011brn\u00e9 doby sledov\u00e1n\u00ed 10 let.
\nV\u00fdzkumn\u00edci analyzovali kvalitu sp\u00e1nku i celkov\u00e9 sp\u00e1nkov\u00e9 vzorce.
\nM\u011b\u0159en\u00ed kvality sp\u00e1nku zahrnovalo d\u00e9lku sp\u00e1nku, nespavost<\/a> a chr\u00e1p\u00e1n\u00ed a dal\u0161\u00ed charakteristiky souvisej\u00edc\u00ed se sp\u00e1nkem, jako nap\u0159\u00edklad: zda \u00fa\u010dastn\u00edk byl rann\u00ed pt\u00e1\u010de nebo no\u010dn\u00ed sova a zda byl b\u011bhem dne unaven\u00fd (pravd\u011bpodobn\u011b necht\u011bn\u011b k\u00fdvl nebo b\u011bhem dne usnul). <\/div>\n

Sn\u00ed\u017een\u00ed rizika srde\u010dn\u00edho selh\u00e1n\u00ed o 42 procent<\/h3>\n

Sk\u00f3re zdrav\u00e9ho sp\u00e1nku, kter\u00e9 v\u011bdci vytvo\u0159ili, vych\u00e1zelo z hodnocen\u00ed t\u011bchto p\u011bti sp\u00e1nkov\u00fdch vzorc\u016f.
\nSp\u00e1nkov\u00e9 chov\u00e1n\u00ed bylo zaznamen\u00e1v\u00e1no pomoc\u00ed dotazn\u00edk\u016f na dotykov\u00e9 obrazovce. D\u00e9lka sp\u00e1nku<\/a> byla rozd\u011blena do t\u0159\u00ed skupin: kr\u00e1tk\u00fd sp\u00e1nek<\/a> neboli m\u00e9n\u011b ne\u017e 7 hodin denn\u011b; 7 a\u017e 8 hodin denn\u011b, 9 hodin a v\u00edce denn\u011b.
\nPo zohledn\u011bn\u00ed cukrovky, vysok\u00e9ho krevn\u00edho tlaku, u\u017e\u00edv\u00e1n\u00ed l\u00e9k\u016f, genetick\u00fdch variac\u00ed a dal\u0161\u00edch kovari\u00e1t se u dosp\u011bl\u00fdch s nejzdrav\u011bj\u0161\u00edm sp\u00e1nkov\u00fdm re\u017eimem (\u010dasn\u00e9 vst\u00e1v\u00e1n\u00ed, 7-8 hodin sp\u00e1nku denn\u011b a bez \u010dast\u00e9 nespavosti, chr\u00e1p\u00e1n\u00ed nebo nadm\u011brn\u00e9 denn\u00ed ospalosti) sn\u00ed\u017eilo riziko srde\u010dn\u00edho selh\u00e1n\u00ed o 42 % ve srovn\u00e1n\u00ed s t\u011bmi, kte\u0159\u00ed m\u011bli nezdrav\u00fd sp\u00e1nkov\u00fd re\u017eim.
\nZjistili tak\u00e9, \u017ee riziko srde\u010dn\u00edho selh\u00e1n\u00ed bylo o 8 % ni\u017e\u0161\u00ed u lid\u00ed, kte\u0159\u00ed brzy vst\u00e1vaj\u00ed, o 12 % ni\u017e\u0161\u00ed u lid\u00ed, kte\u0159\u00ed spali 7-8 hodin denn\u011b, o 17 % ni\u017e\u0161\u00ed u t\u011bch, kte\u0159\u00ed netrp\u011bli \u010dastou nespavost\u00ed, a o 34 % ni\u017e\u0161\u00ed u t\u011bch, kte\u0159\u00ed nepoci\u0165ovali denn\u00ed ospalost.
\nV\u00fdsledky ukazuj\u00ed, \u017ee sp\u00e1nek a srde\u010dn\u00ed onemocn\u011bn\u00ed<\/a> spolu souvisej\u00ed, a zd\u016fraz\u0148uj\u00ed v\u00fdznam zlep\u0161en\u00ed celkov\u00e9ho sp\u00e1nkov\u00e9ho re\u017eimu pro prevenci srde\u010dn\u00edho selh\u00e1n\u00ed. <\/p>\n","protected":false},"excerpt":{"rendered":"

Srde\u010dn\u00ed selh\u00e1n\u00ed je b\u011b\u017en\u00fd stav. V Evrop\u011b trp\u00ed srde\u010dn\u00ed nedostate\u010dnost\u00ed v\u00edce ne\u017e 10 milion\u016f lid\u00ed. Z r\u016fzn\u00fdch d\u016fvod\u016f ji\u017e srdce nedok\u00e1\u017ee produkovat dostate\u010dn\u011b vysok\u00fd srde\u010dn\u00ed v\u00fddej, aby z\u00e1sobilo t\u011blo dostate\u010dn\u00fdm mno\u017estv\u00edm kysl\u00edku a umo\u017enilo norm\u00e1ln\u00ed metabolismus. To m\u016f\u017ee b\u00fdt zp\u016fsobeno sn\u00ed\u017een\u00fdm \u010derpac\u00edm v\u00fdkonem (systolick\u00e9 srde\u010dn\u00ed selh\u00e1n\u00ed) nebo naru\u0161enou schopnost\u00ed srde\u010dn\u00edho svalu relaxovat (diastolick\u00e9 srde\u010dn\u00ed selh\u00e1n\u00ed). […]<\/p>\n","protected":false},"author":11,"featured_media":54161,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","footnotes":""},"categories":[371,365],"tags":[],"class_list":{"0":"post-63989","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-spanek","8":"category-zdravi-srdce","9":"entry"},"acf":[],"yoast_head":"\nV\u011bdci testuj\u00ed nov\u00fd l\u00e9k ur\u010den\u00fd ke zm\u00edrn\u011bn\u00ed srde\u010dn\u00edho selh\u00e1n\u00ed a sp\u00e1nkov\u00e9 apnoe – Chronobiology.com<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/dev.chronobiology.com\/cs\/vedci-testuji-novy-lek-urceny-ke-zmirneni-srdecniho-selhani-a-spankove-apnoe\/\" \/>\n<meta property=\"og:locale\" content=\"cs_CZ\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"V\u011bdci testuj\u00ed nov\u00fd l\u00e9k ur\u010den\u00fd ke zm\u00edrn\u011bn\u00ed srde\u010dn\u00edho selh\u00e1n\u00ed a sp\u00e1nkov\u00e9 apnoe\" \/>\n<meta property=\"og:description\" content=\"Srde\u010dn\u00ed selh\u00e1n\u00ed je b\u011b\u017en\u00fd stav. V Evrop\u011b trp\u00ed srde\u010dn\u00ed nedostate\u010dnost\u00ed v\u00edce ne\u017e 10 milion\u016f lid\u00ed. Z r\u016fzn\u00fdch d\u016fvod\u016f ji\u017e srdce nedok\u00e1\u017ee produkovat dostate\u010dn\u011b vysok\u00fd srde\u010dn\u00ed v\u00fddej, aby z\u00e1sobilo t\u011blo dostate\u010dn\u00fdm mno\u017estv\u00edm kysl\u00edku a umo\u017enilo norm\u00e1ln\u00ed metabolismus. To m\u016f\u017ee b\u00fdt zp\u016fsobeno sn\u00ed\u017een\u00fdm \u010derpac\u00edm v\u00fdkonem (systolick\u00e9 srde\u010dn\u00ed selh\u00e1n\u00ed) nebo naru\u0161enou schopnost\u00ed srde\u010dn\u00edho svalu relaxovat (diastolick\u00e9 srde\u010dn\u00ed selh\u00e1n\u00ed). 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