{"id":63636,"date":"2024-09-02T23:43:31","date_gmt":"2024-09-03T06:43:31","guid":{"rendered":"https:\/\/www.chronobiology.com\/?p=63636"},"modified":"2024-09-04T02:50:11","modified_gmt":"2024-09-04T09:50:11","slug":"kdy-je-nejlepsi-denni-doba-pro-lecbu-rakoviny","status":"publish","type":"post","link":"https:\/\/dev.chronobiology.com\/cs\/kdy-je-nejlepsi-denni-doba-pro-lecbu-rakoviny\/","title":{"rendered":"Kdy je nejlep\u0161\u00ed denn\u00ed doba pro l\u00e9\u010dbu rakoviny?"},"content":{"rendered":"<p>\u00da\u010dinnost l\u00e9k\u016f z\u00e1vis\u00ed na r\u016fzn\u00fdch faktorech, v\u010detn\u011b <a href=\"https:\/\/www.chronobiology.com\/scientists-strive-to-determine-the-best-time-of-day-to-take-medication\/\" target=\"_blank\" rel=\"noopener\">denn\u00ed doby,<\/a> kdy jsou pod\u00e1v\u00e1ny. A pro\u010d? Proto\u017ee na\u0161e t\u011blo nefunguje v\u017edy \u00fapln\u011b stejn\u011b. M\u00edsto toho se \u0159\u00edd\u00ed cyklem sv\u00fdch vnit\u0159n\u00edch hodin, tzv. cirkadi\u00e1nn\u00edm rytmem. Proto\u017ee je v\u0161ak tento rytmus u ka\u017ed\u00e9ho \u010dlov\u011bka jin\u00fd a z\u00e1vis\u00ed na \u0159ad\u011b r\u016fzn\u00fdch faktor\u016f, je obt\u00ed\u017en\u00e9 p\u0159izp\u016fsobit pod\u00e1v\u00e1n\u00ed l\u00e9k\u016f individu\u00e1ln\u00edm t\u011blesn\u00fdm hodin\u00e1m pacienta.<br \/>\nV\u011bdci z Charit\u00e9 &#8211; Universit\u00e4tsmedizin Berlin nyn\u00ed vyvinuli metodu, kter\u00e1 umo\u017e\u0148uje ur\u010dit optim\u00e1ln\u00ed na\u010dasov\u00e1n\u00ed <a href=\"https:\/\/www.chronobiology.com\/how-chronobiology-is-affecting-cancer-treatment\/\" target=\"_blank\" rel=\"noopener\">l\u00e9\u010dby rakoviny na<\/a> z\u00e1klad\u011b specifick\u00fdch bun\u011b\u010dn\u00fdch lini\u00ed rakoviny prsu.<br \/>\nSv\u016fj p\u0159\u00edstup popsali v \u010dasopise <a href=\"https:\/\/www.nature.com\/articles\/s41467-024-51611-3\" target=\"_blank\" rel=\"noopener\"><em>Nature Communications<\/em><\/a><em>.<\/em> Lidsk\u00e9 vnit\u0159n\u00ed hodiny ur\u010duj\u00ed rytmus mnoha r\u016fzn\u00fdch t\u011blesn\u00fdch funkc\u00ed a metabolick\u00fdch proces\u016f, jako je sp\u00e1nek a tr\u00e1ven\u00ed.<br \/>\nNejsou to v\u0161ak jen org\u00e1ny, kter\u00e9 jsou v\u00edce \u010di m\u00e9n\u011b aktivn\u00ed v z\u00e1vislosti na denn\u00ed dob\u011b.<\/p>\n<p>Tak\u00e9 jednotliv\u00e9 bu\u0148ky se \u0159\u00edd\u00ed cyklem, kter\u00fd ur\u010duj\u00ed lidsk\u00e9 t\u011blesn\u00e9 hodiny, tak\u017ee v r\u016fzn\u00fdch denn\u00edch dob\u00e1ch reaguj\u00ed na vn\u011bj\u0161\u00ed vlivy odli\u0161n\u011b. To m\u00e1 velk\u00fd v\u00fdznam pro chemoterapii p\u0159i l\u00e9\u010db\u011b rakoviny.<br \/>\nP\u0159edchoz\u00ed studie uk\u00e1zaly, \u017ee <a href=\"https:\/\/www.chronobiology.com\/chronobiology-and-chemotherapy-drug-timing-improves-treatment-effectiveness\/\" target=\"_blank\" rel=\"noopener\">chemoterapie<\/a> je nej\u00fa\u010dinn\u011bj\u0161\u00ed, kdy\u017e se n\u00e1dorov\u00e9 bu\u0148ky d\u011bl\u00ed. Tento poznatek se v\u0161ak dosud v klinick\u00e9 l\u00e9\u010db\u011b t\u00e9m\u011b\u0159 nevyu\u017e\u00edval. Mezioborov\u00fd t\u00fdm na Charit\u00e9 veden\u00fd Dr. Adri\u00e1nem Enriquem Granadou z Charit\u00e9 Comprehensive Cancer Center (CCCC) se rozhodl tuto mezeru odstranit. T\u00fdm se rozhodl naj\u00edt optim\u00e1ln\u00ed \u010das pro pod\u00e1v\u00e1n\u00ed l\u00e9k\u016f na z\u00e1klad\u011b individu\u00e1ln\u00edch cirkadi\u00e1nn\u00edch rytm\u016f n\u00e1dor\u016f.<\/p>\n<h2>P\u0159\u00edklad trojit\u011b negativn\u00edho karcinomu prsu<\/h2>\n<p><a href=\"https:\/\/www.chronobiology.com\/wp-content\/uploads\/2024\/08\/can.jpg\"><img decoding=\"async\" class=\"wp-image-63575 size-medium alignright\" title=\"m\u016f\u017ee\" src=\"https:\/\/www.chronobiology.com\/wp-content\/uploads\/2024\/08\/can-300x180.jpg\" alt=\"m\u016f\u017ee\" width=\"300\" height=\"180\" srcset=\"https:\/\/dev.chronobiology.com\/wp-content\/uploads\/2024\/08\/can-300x180.jpg 300w, https:\/\/dev.chronobiology.com\/wp-content\/uploads\/2024\/08\/can-768x461.jpg 768w, https:\/\/dev.chronobiology.com\/wp-content\/uploads\/2024\/08\/can.jpg 800w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/a>&#8222;Kultivovali jsme bu\u0148ky pacientek s trojit\u011b negativn\u00edm <a href=\"https:\/\/www.chronobiology.com\/being-a-night-owl-increases-breast-cancer-risk\/\" target=\"_blank\" rel=\"noopener\">karcinomem<\/a> prsu, abychom zjistili, jak reaguj\u00ed na l\u00e9ky pod\u00e1van\u00e9 v r\u016fzn\u00fdch denn\u00edch dob\u00e1ch,&#8220; vysv\u011btluje Carolin Ector, v\u00fdzkumn\u00e1 pracovnice Granadova t\u00fdmu. Trojit\u011b negativn\u00ed rakovina prsu je velmi agresivn\u00ed forma rakoviny prsu, na kterou existuje jen m\u00e1lo \u00fa\u010dinn\u00fdch l\u00e9k\u016f. &#8222;Pomoc\u00ed \u017eiv\u00e9ho zobrazov\u00e1n\u00ed, metody pro nep\u0159etr\u017eit\u00e9 sledov\u00e1n\u00ed \u017eiv\u00fdch bun\u011bk, a komplexn\u00edch technik anal\u00fdzy dat mohli v\u011bdci podrobn\u011b pozorovat a vyhodnocovat cirkadi\u00e1nn\u00ed rytmy, r\u016fstov\u00e9 cykly a reakce t\u011bchto rakovinn\u00fdch bun\u011bk na l\u00e9ky. T\u00edmto zp\u016fsobem v\u011bdci identifikovali konkr\u00e9tn\u00ed denn\u00ed doby, kdy rakovinn\u00e9 bu\u0148ky nejl\u00e9pe reaguj\u00ed na l\u00e9\u010dbu l\u00e9ky.<\/p>\n<p>Bylo nap\u0159\u00edklad zji\u0161t\u011bno, \u017ee chemoterapeutikum 5-fluorouracil (5-FU) je proti ur\u010dit\u00e9 linii rakovinn\u00fdch bun\u011bk nej\u00fa\u010dinn\u011bj\u0161\u00ed mezi osmou a des\u00e1tou hodinou dopoledne. Jak studie tak\u00e9 ukazuje, rozhoduj\u00edc\u00ed jsou ur\u010dit\u00e9 bun\u011b\u010dn\u00e9 a genetick\u00e9 faktory. V\u011bdc\u016fm se dokonce poda\u0159ilo ur\u010dit, kter\u00e9 geny jsou rozhoduj\u00edc\u00ed pro cirkadi\u00e1nn\u00ed \u00fa\u010dinek ur\u010dit\u00fdch l\u00e9\u010div. &#8222;\u0158\u00edk\u00e1me jim &#8218;j\u00e1drov\u00e9 hodinov\u00e9 geny&#8216;. Podle Granady maj\u00ed v\u00fdznamn\u00fd vliv na to, jak dob\u0159e rakovinn\u00e9 bu\u0148ky reaguj\u00ed na l\u00e9\u010dbu pod\u00e1vanou v r\u016fzn\u00fdch denn\u00edch dob\u00e1ch.<\/p>\n<h2>Profily ukazuj\u00ed, jak typy rakovinn\u00fdch bun\u011bk reaguj\u00ed na l\u00e9ky<\/h2>\n<p>Tento p\u0159\u00edstup lze pou\u017e\u00edt k vytvo\u0159en\u00ed podrobn\u00fdch profil\u016f, kter\u00e9 ukazuj\u00ed, jak r\u016fzn\u00e9 typy n\u00e1dorov\u00fdch bun\u011bk reaguj\u00ed na r\u016fzn\u00e9 <a href=\"https:\/\/www.chronobiology.com\/circadian-rhythms-can-influence-the-effectiveness-of-medication\/\" target=\"_blank\" rel=\"noopener\">l\u00e9ky<\/a> v r\u016fzn\u00fdch obdob\u00edch. Podle v\u011bdc\u016f to m\u016f\u017ee pomoci ur\u010dit nej\u00fa\u010dinn\u011bj\u0161\u00ed kombinace l\u00e9k\u016f. Celkov\u011b tyto v\u00fdsledky nazna\u010duj\u00ed, \u017ee personalizovan\u00e9 l\u00e9\u010debn\u00e9 pl\u00e1ny zalo\u017een\u00e9 na individu\u00e1ln\u00edch cirkadi\u00e1nn\u00edch rytmech by mohly v\u00fdrazn\u011b zlep\u0161it \u00fa\u010dinnost l\u00e9\u010dby rakoviny.<br \/>\nKrom\u011b toho by se mohly sn\u00ed\u017eit i ne\u017e\u00e1douc\u00ed vedlej\u0161\u00ed \u00fa\u010dinky.<\/p>\n<p>Aby mohly b\u00fdt tyto poznatky brzy za\u010dlen\u011bny do klinick\u00e9 praxe, je t\u0159eba v\u00fdsledky ov\u011b\u0159it ve studi\u00edch s v\u011bt\u0161\u00edmi skupinami pacient\u016f. V\u011bdci tak\u00e9 pl\u00e1nuj\u00ed prozkoumat molekul\u00e1rn\u00ed mechanismy, kter\u00e9 stoj\u00ed za cirkadi\u00e1nn\u00edmi vlivy na citlivost na l\u00e9ky, aby bylo mo\u017en\u00e9 d\u00e1le optimalizovat dobu l\u00e9\u010dby a identifikovat nov\u00e9 terapeutick\u00e9 c\u00edle.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u00da\u010dinnost l\u00e9k\u016f z\u00e1vis\u00ed na r\u016fzn\u00fdch faktorech, v\u010detn\u011b denn\u00ed doby, kdy jsou pod\u00e1v\u00e1ny. A pro\u010d? Proto\u017ee na\u0161e t\u011blo nefunguje v\u017edy \u00fapln\u011b stejn\u011b. M\u00edsto toho se \u0159\u00edd\u00ed cyklem sv\u00fdch vnit\u0159n\u00edch hodin, tzv. cirkadi\u00e1nn\u00edm rytmem. Proto\u017ee je v\u0161ak tento rytmus u ka\u017ed\u00e9ho \u010dlov\u011bka jin\u00fd a z\u00e1vis\u00ed na \u0159ad\u011b r\u016fzn\u00fdch faktor\u016f, je obt\u00ed\u017en\u00e9 p\u0159izp\u016fsobit pod\u00e1v\u00e1n\u00ed l\u00e9k\u016f individu\u00e1ln\u00edm t\u011blesn\u00fdm hodin\u00e1m [&hellip;]<\/p>\n","protected":false},"author":11,"featured_media":63612,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","footnotes":""},"categories":[358],"tags":[],"class_list":{"0":"post-63636","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-zdravi-bunek","8":"entry"},"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.4 (Yoast SEO v23.4) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Kdy je nejlep\u0161\u00ed denn\u00ed doba pro l\u00e9\u010dbu rakoviny? &#8211; Chronobiology.com<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/dev.chronobiology.com\/cs\/kdy-je-nejlepsi-denni-doba-pro-lecbu-rakoviny\/\" \/>\n<meta property=\"og:locale\" content=\"cs_CZ\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Kdy je nejlep\u0161\u00ed denn\u00ed doba pro l\u00e9\u010dbu rakoviny?\" \/>\n<meta property=\"og:description\" content=\"\u00da\u010dinnost l\u00e9k\u016f z\u00e1vis\u00ed na r\u016fzn\u00fdch faktorech, v\u010detn\u011b denn\u00ed doby, kdy jsou pod\u00e1v\u00e1ny. 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