{"id":54515,"date":"2023-08-08T07:38:07","date_gmt":"2023-08-08T14:38:07","guid":{"rendered":"https:\/\/www.chronobiology.com\/melatonin-chronobiologie\/indikace\/"},"modified":"2023-08-08T07:38:09","modified_gmt":"2023-08-08T14:38:09","slug":"indikace","status":"publish","type":"page","link":"https:\/\/dev.chronobiology.com\/cs\/melatonin-chronobiologie\/indikace\/","title":{"rendered":"Indikace"},"content":{"rendered":"

[vc_row full_width=“stretch_row“ el_class=“banner-top“][vc_column][vc_custom_heading source=“post_title“ font_container=“tag:h1|text_align:center“ use_theme_fonts=“yes“][\/vc_column][\/vc_row][vc_row el_class=“melatoninfacts2″][vc_column][vc_column_text]<\/p>\n

Indikace<\/h2>\n

Nov\u00fd v\u00fdzkum v oblasti cirkadi\u00e1nn\u00ed biologie prok\u00e1zal, \u017ee zdrav\u00fd cirkadi\u00e1nn\u00ed rytmus, a zejm\u00e9na zdrav\u00e1 hladina melatoninu, m\u00e1 pozitivn\u00ed vliv na zdrav\u00ed. B\u011bhem posledn\u00edch 20 let bylo v mnoha klinick\u00fdch studi\u00edch testov\u00e1no a prok\u00e1z\u00e1no terapeutick\u00e9 vyu\u017eit\u00ed melatoninu v r\u016fzn\u00fdch oblastech medic\u00edny a to, \u017ee u\u017e\u00edv\u00e1n\u00ed tohoto hormonu m\u016f\u017ee b\u00fdt \u00fa\u010dinnou l\u00e9\u010dbou r\u016fzn\u00fdch onemocn\u011bn\u00ed. V budoucnu bude prov\u00e1d\u011bno je\u0161t\u011b v\u00edce v\u00fdzkum\u016f o nejr\u016fzn\u011bj\u0161\u00edch mo\u017enostech vyu\u017eit\u00ed melatoninu, zejm\u00e9na ve spojen\u00ed s jin\u00fdmi tradi\u010dn\u00edmi l\u00e9\u010debn\u00fdmi postupy, a to bu\u010f za \u00fa\u010delem zv\u00fd\u0161en\u00ed jejich terapeutick\u00e9 \u00fa\u010dinnosti, nebo sn\u00ed\u017een\u00ed jejich toxicity. Melatonin tak m\u016f\u017ee b\u00fdt vyu\u017e\u00edv\u00e1n bu\u010f jako \u00fa\u010dinn\u00e1 l\u00e1tka, nebo jako ukazatel \u010dasu, kter\u00fd pom\u00e1h\u00e1 \u0159\u00eddit cirkadi\u00e1nn\u00ed rytmus.[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_tta_accordion color=“turquoise“ c_icon=“chevron“ c_position=“right“ active_section=“99″ no_fill=“true“ collapsible_all=“true“][vc_tta_section title=“Tr\u00e1vic\u00ed syst\u00e9m“ tab_id=“1479159301199-fd863768-f6af00cc-ae91″][vc_row_inner css=“.vc_custom_1479392036356{background-image: url(https:\/\/www.chronobiology.com\/wp-content\/uploads\/2016\/11\/indications_1.jpg?id=11701) !important;}“][vc_column_inner][vc_column_text]Enterochromafinn\u00ed bu\u0148ky (neuroendokrinn\u00ed bu\u0148ky, kter\u00e9 se nach\u00e1zej\u00ed v epitelov\u00e9 tk\u00e1ni st\u0159evn\u00edho traktu) tr\u00e1vic\u00edho syst\u00e9mu produkuj\u00ed 400kr\u00e1t v\u00edce melatoninu ne\u017e epif\u00fdza. V\u011bt\u0161ina zde vyprodukovan\u00e9ho melatoninu se v\u0161ak neuvol\u0148uje do krve, ale vyu\u017e\u00edv\u00e1 se p\u0159edev\u0161\u00edm p\u0159\u00edmo na m\u00edst\u011b.<\/p>\n

P\u0159esto\u017ee p\u0159esn\u00e1 funkce melatoninu v tr\u00e1vic\u00ed soustav\u011b nen\u00ed dosud zn\u00e1ma, m\u00e1 tento hormon d\u00edky sv\u00fdm antioxida\u010dn\u00edm vlastnostem ochrannou funkci proti vzniku v\u0159ed\u016f v \u017ealude\u010dn\u00ed sliznici. Zda hraj\u00ed roli mechanismy \u00fa\u010dinku p\u0159en\u00e1\u0161en\u00e9 receptory, se v sou\u010dasn\u00e9 dob\u011b st\u00e1le d\u016fkladn\u011b zkoum\u00e1.<\/p>\n

Gastroezofage\u00e1ln\u00ed refluxn\u00ed choroba<\/h3>\n

Mnoho hormon\u016f, kter\u00e9 souvisej\u00ed s j\u00eddeln\u00edm chov\u00e1n\u00edm a tr\u00e1ven\u00edm, jako jsou ghrelin, inzulin a leptin, se pravideln\u011b uvol\u0148uj\u00ed ve velmi specifick\u00fdch \u010dasech cyklicky po dobu 24 hodin. Pokud nen\u00ed po del\u0161\u00ed dobu k dispozici sv\u011btlo, tyto hormon\u00e1ln\u00ed cykly se p\u0159eru\u0161\u00ed. M\u00edsto cyklick\u00e9ho uvol\u0148ov\u00e1n\u00ed hormon\u016f, nap\u0159\u00edklad kdy\u017e je \u010dlov\u011bk vzh\u016fru a mus\u00ed j\u00edst, se nyn\u00ed hormony uvol\u0148uj\u00ed n\u00e1hodn\u011b. Proto\u017ee tyto hormony mohou b\u00fdt bez p\u0159\u00edtomnosti potravy v tr\u00e1vic\u00edm traktu \u0161kodliv\u00e9, proto\u017ee zp\u016fsobuj\u00ed dodate\u010dnou produkci \u017ealude\u010dn\u00ed kyseliny. Z toho lze vyvodit, \u017ee to m\u016f\u017ee b\u00fdt hlavn\u00ed p\u0159\u00ed\u010dinou mnoha onemocn\u011bn\u00ed za\u017e\u00edvac\u00edho traktu a poruch p\u0159\u00edjmu potravy.<\/p>\n

Nedostate\u010dn\u00e1 hormon\u00e1ln\u00ed regulace spolu s m\u011bn\u00edc\u00edmi se cykly autonomn\u00edch \u010dinnost\u00ed m\u016f\u017ee v\u00e9st k poruch\u00e1m tr\u00e1ven\u00ed. V p\u0159\u00edpad\u011b gastroezofage\u00e1ln\u00ed refluxn\u00ed choroby, kdy se nespr\u00e1vn\u011b zv\u00fd\u0161en\u00e9 mno\u017estv\u00ed \u017ealude\u010dn\u00ed kyseliny tla\u010d\u00ed do j\u00edcnu, m\u016f\u017ee melatonin skute\u010dn\u011b sn\u00ed\u017eit po\u0161kozen\u00ed oxidovan\u00e9 DNA sliznice. Krom\u011b toho m\u016f\u017ee hormon slou\u017eit jako ochrana \u017ealude\u010dn\u00ed sliznice p\u0159ed zdrav\u00ed ohro\u017euj\u00edc\u00edmi l\u00e1tkami, jako jsou salicyl\u00e1ty (obsa\u017een\u00e9 v potravin\u00e1ch a l\u00e9c\u00edch proti bolesti), a\/nebo vrtuln\u00edkov\u00fdmi bakteriemi.<\/p>\n

Syndrom dr\u00e1\u017ediv\u00e9ho tra\u010dn\u00edku<\/h3>\n

Syndrom dr\u00e1\u017ediv\u00e9ho tra\u010dn\u00edku (IBS) je charakterizov\u00e1n nevysv\u011btlitelnou bolest\u00ed \u017ealudku, plynatost\u00ed spojenou se zm\u011bnami ve vyprazd\u0148ov\u00e1n\u00ed, jako je z\u00e1cpa nebo pr\u016fjem, a celkov\u00fdm nepohodl\u00edm. V tomto p\u0159\u00edpad\u011b m\u016f\u017ee melatonin pomoci prost\u0159ednictv\u00edm regulace motility a citlivosti tr\u00e1vic\u00edho traktu. R\u016fzn\u00e9 studie prok\u00e1zaly, \u017ee melatonin m\u00e1 pozitivn\u00ed \u00fa\u010dinek p\u0159i l\u00e9\u010db\u011b syndromu dr\u00e1\u017ediv\u00e9ho tra\u010dn\u00edku mimo jin\u00e9 t\u00edm, \u017ee sni\u017euje bolesti \u017ealudku a kone\u010dn\u00edku a sni\u017euje souvisej\u00edc\u00ed poruchy sp\u00e1nku. Nov\u00e9 studie nav\u00edc prok\u00e1zaly, \u017ee by tento hormon mohl hr\u00e1t d\u016fle\u017eitou roli tak\u00e9 se zdrav\u00edm st\u0159evn\u00ed fl\u00f3ry a jej\u00edm cirkadi\u00e1nn\u00edm rytmem. Tr\u00e1vic\u00ed bakterie maj\u00ed sv\u016fj vlastn\u00ed cirkadi\u00e1nn\u00ed rytmus, kter\u00fd ovliv\u0148uje i na\u0161i funk\u010dnost. St\u00e1le v\u00edce studi\u00ed nazna\u010duje, \u017ee tito mikrobi jsou pro lidsk\u00e9 zdrav\u00ed nesm\u00edrn\u011b d\u016fle\u017eit\u00ed a \u017ee i mal\u00e1 nerovnov\u00e1ha m\u016f\u017ee zp\u016fsobit poruchu. Pr\u00e1v\u011b tento rytmus tr\u00e1vic\u00edch bakteri\u00ed je pomoc\u00ed melatoninu synchronizov\u00e1n s cirkadi\u00e1nn\u00edmi procesy na\u0161eho t\u011bla.<\/p>\n

Z\u00e1n\u011btliv\u00e1 st\u0159evn\u00ed onemocn\u011bn\u00ed<\/h3>\n

Pat\u0159\u00ed sem \u0159ada chronick\u00fdch z\u00e1n\u011btliv\u00fdch onemocn\u011bn\u00ed, jako je ulcer\u00f3zn\u00ed kolitida (chronick\u00fd z\u00e1n\u011bt tlust\u00e9ho st\u0159eva) a Crohnova choroba. R\u016fzn\u00e9 studie prok\u00e1zaly, \u017ee melatonin je d\u016fle\u017eit\u00fdm regul\u00e1torem z\u00e1n\u011btu i pohyblivosti tr\u00e1vic\u00edho traktu, co\u017e poukazuje na skute\u010dnost, \u017ee dopl\u0148kov\u00fd melatonin m\u016f\u017ee m\u00edt pozitivn\u00ed vliv na z\u00e1n\u011bt tlust\u00e9ho st\u0159eva.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_tta_section][\/vc_tta_accordion][vc_tta_accordion color=“turquoise“ c_icon=“chevron“ c_position=“right“ active_section=“99″ no_fill=“true“ collapsible_all=“true“][vc_tta_section title=“Kardiovaskul\u00e1rn\u00ed onemocn\u011bn\u00ed“ tab_id=“1481054223339-720930fd-7ae7″][vc_row_inner css=“.vc_custom_1479392221643{background-image: url(https:\/\/www.chronobiology.com\/wp-content\/uploads\/2016\/11\/indications_2.jpg?id=11702) !important;}“][vc_column_inner][vc_column_text]D\u00edky sv\u00e9mu antioxida\u010dn\u00edmu \u00fa\u010dinku proti \u0161kodliv\u00fdm usazenin\u00e1m cholesterolu m\u016f\u017ee melatonin chr\u00e1nit srdce i c\u00e9vy. Tento hormon sni\u017euje ostatn\u00ed stresov\u00e9 hormony, sni\u017euje krevn\u00ed tlak a dosahuje pozitivn\u00edho vlivu na kardiovaskul\u00e1rn\u00ed syst\u00e9m. Melatonin m\u016f\u017ee b\u00fdt u\u017eite\u010dn\u00fd p\u0159i sni\u017eov\u00e1n\u00ed srde\u010dn\u00ed hypertrofie a sni\u017eovat \u010detnost srde\u010dn\u00edch infarkt\u016f. Hormon p\u016fsob\u00ed tak\u00e9 jako odp\u016frce voln\u00fdch radik\u00e1l\u016f, kter\u00e9 napadaj\u00ed srde\u010dn\u00ed sval. Vzhledem k tomu, \u017ee melatonin m\u00e1 protiz\u00e1n\u011btliv\u00e9 vlastnosti, m\u016f\u017ee b\u00fdt \u00fa\u010dinn\u011b vyu\u017e\u00edv\u00e1n tak\u00e9 p\u0159i l\u00e9\u010db\u011b arterioskler\u00f3zy. N\u011bkolik invitro studi\u00ed prok\u00e1zalo, \u017ee melatonin \u00fa\u010dinn\u011b inhibuje oxidaci LDL, kter\u00e1 je jednou z hlavn\u00edch p\u0159\u00ed\u010din vzniku arterioskler\u00f3zy.<\/p>\n

Vysok\u00fd krevn\u00ed tlak<\/h3>\n

Vysok\u00fd krevn\u00ed tlak pat\u0159\u00ed k onemocn\u011bn\u00edm roz\u0161\u00ed\u0159en\u00fdm v z\u00e1padn\u00edch pr\u016fmyslov\u00fdch zem\u00edch. P\u0159i hypertenzi se zvy\u0161uje tlak v c\u00e9v\u00e1ch, aby bylo zaji\u0161t\u011bno, \u017ee omezen\u00fdmi c\u00e9vami m\u016f\u017ee st\u00e1le proudit dostate\u010dn\u00e9 mno\u017estv\u00ed krve. Tento vysok\u00fd tlak v\u0161ak podporuje dal\u0161\u00ed omezen\u00ed c\u00e9v a\/nebo odtr\u017een\u00ed st\u00e1vaj\u00edc\u00edch krevn\u00edch sra\u017eenin, co\u017e m\u016f\u017ee v\u00e9st k mrtvici, srde\u010dn\u00edmu infarktu a dal\u0161\u00edm onemocn\u011bn\u00edm c\u00e9v. Melatonin se uk\u00e1zal jako u\u017eite\u010dn\u00fd p\u0159i regulaci krevn\u00edho tlaku. Studie dok\u00e1zaly, \u017ee peror\u00e1ln\u00ed u\u017e\u00edv\u00e1n\u00ed melatoninu m\u016f\u017ee sn\u00ed\u017eit vysok\u00fd krevn\u00ed tlak i reaktivitu c\u00e9v. Je to d\u016fsledek toho, \u017ee melatonin m\u00e1 uvol\u0148uj\u00edc\u00ed \u00fa\u010dinek na c\u00e9vy a p\u016fsob\u00ed jako siln\u00fd lapa\u010d radik\u00e1l\u016f, proto\u017ee voln\u00e9 radik\u00e1ly maj\u00ed negativn\u00ed vliv na krevn\u00ed tlak. Nicm\u00e9n\u011b p\u0159esn\u00e9 mechanismy p\u016fsoben\u00ed melatoninu s ohledem na krevn\u00ed tlak nejsou dodnes zn\u00e1my.<\/p>\n

Srde\u010dn\u00ed infarkt a mrtvice<\/h3>\n

Srde\u010dn\u00ed infarkt i mozkov\u00e1 mrtvice se t\u00fdkaj\u00ed akutn\u00edho uz\u00e1v\u011bru c\u00e9vy, tak\u017ee tk\u00e1n\u011b, kter\u00e9 jsou touto c\u00e9vou z\u00e1sobov\u00e1ny, jsou zbaveny kysl\u00edku a po\u0161kozeny. Hlavn\u00edm c\u00edlem l\u00e9\u010dby je co nejrychleji obnovit z\u00e1sobov\u00e1n\u00ed krv\u00ed a kysl\u00edkem. Jakmile se obnov\u00ed \u017eivotod\u00e1rn\u00e9 z\u00e1sobov\u00e1n\u00ed kysl\u00edkem, je ji\u017e po\u0161kozen\u00e1 tk\u00e1\u0148 n\u00e1chyln\u00e1 k dal\u0161\u00edmu oxida\u010dn\u00edmu po\u0161kozen\u00ed v d\u016fsledku z\u00e1plavy p\u0159ich\u00e1zej\u00edc\u00edho kysl\u00edku. P\u0159esn\u011bji \u0159e\u010deno, tato sekund\u00e1rn\u00ed po\u0161kozen\u00ed lze sn\u00ed\u017eit nebo jim dokonce zcela zabr\u00e1nit sou\u010dasn\u00fdm pod\u00e1v\u00e1n\u00edm vy\u0161\u0161\u00ed d\u00e1vky melatoninu. P\u0159edb\u011b\u017en\u00e9 studie ukazuj\u00ed, \u017ee melatonin m\u016f\u017ee v t\u011bchto situac\u00edch v\u00fdznamn\u011b sn\u00ed\u017eit rozsah po\u0161kozen\u00ed bun\u011bk.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_tta_section][\/vc_tta_accordion][vc_tta_accordion color=“turquoise“ c_icon=“chevron“ c_position=“right“ active_section=“99″ no_fill=“true“ collapsible_all=“true“][vc_tta_section title=“Diabetes“ tab_id=“1481054247663-4337e241-bd12″][vc_row_inner css=“.vc_custom_1479392377806{background-image: url(https:\/\/www.chronobiology.com\/wp-content\/uploads\/2016\/11\/indications_3.jpg?id=11703) !important;}“][vc_column_inner][vc_column_text]Cukrovka je roz\u0161\u00ed\u0159en\u00e9 onemocn\u011bn\u00ed, kter\u00e9 se t\u00fdk\u00e1 zejm\u00e9na star\u0161\u00edch lid\u00ed. V\u011bdci p\u0159edpokl\u00e1daj\u00ed, \u017ee mutace v genu pro melatoninov\u00fd receptor MT2 naru\u0161uje spojen\u00ed mezi vnit\u0159n\u00edmi hodinami a uvol\u0148ov\u00e1n\u00edm inzulinu. To m\u016f\u017ee v\u00e9st k abnorm\u00e1ln\u00edm hodnot\u00e1m cukru v krvi a nakonec k cukrovce. Asi t\u0159etina lid\u00ed m\u00e1 pon\u011bkud pozm\u011bn\u011bnou verzi tohoto melatoninov\u00e9ho receptoru, kter\u00fd se nach\u00e1z\u00ed na bun\u011b\u010dn\u00fdch membr\u00e1n\u00e1ch beta bun\u011bk ve slinivce b\u0159i\u0161n\u00ed. Beta bu\u0148ky ve slinivce b\u0159i\u0161n\u00ed jsou zodpov\u011bdn\u00e9 za uvol\u0148ov\u00e1n\u00ed inzul\u00ednu. Pokud se melatonin nav\u00e1\u017ee na receptory t\u011bchto bun\u011bk, uvol\u0148ov\u00e1n\u00ed se zpomal\u00ed. M\u00edrn\u011b mutovan\u00e1 verze beta bun\u011bk v\u0161ak na melatonin reaguje zv\u00fd\u0161en\u00edm po\u010dtu receptor\u016f. T\u00edm se zes\u00edl\u00ed \u00fa\u010dinek, kter\u00fd melatonin na bu\u0148ky m\u00e1, co\u017e zp\u016fsobuje hypoglyk\u00e9mii a dal\u0161\u00ed p\u0159eddiabetick\u00e9 stavy. Kdy\u017e lid\u00e9 s touto genovou variantou pracuj\u00ed a jed\u00ed v noci, kdy je jejich hladina melatoninu vysok\u00e1, pak maj\u00ed vy\u0161\u0161\u00ed hladinu cukru v krvi, kter\u00e1 zvy\u0161uje riziko vzniku cukrovky a dal\u0161\u00edch endokrinn\u00edch onemocn\u011bn\u00ed.<\/p>\n

R\u016fzn\u00e9 studie prok\u00e1zaly, \u017ee melatonin m\u016f\u017ee ovliv\u0148ovat sekreci inzulinu a homeost\u00e1zu gluk\u00f3zy. Pokusy na bu\u0148k\u00e1ch vedly ke zji\u0161t\u011bn\u00ed, \u017ee tento hormon potla\u010duje uvol\u0148ov\u00e1n\u00ed inzulinu v beta bu\u0148k\u00e1ch slinivky b\u0159i\u0161n\u00ed. Krysy, kter\u00e9 m\u011bly sklon k diabetu 2. typu, byly u\u017e\u00edv\u00e1n\u00edm melatoninu chr\u00e1n\u011bny p\u0159ed hyperlipidemi\u00ed a hyperglyk\u00e9mi\u00ed. U my\u0161\u00ed do\u0161lo ke zlep\u0161en\u00ed inzulinov\u00e9 rezistence i metabolismu gluk\u00f3zy. V n\u00e1hodn\u00e9 dvojit\u011b zaslepen\u00e9 studii s 22 \u017eenami po menopauze bylo zji\u0161t\u011bno, \u017ee melatonin zlep\u0161uje gluk\u00f3zovou toleranci a citlivost na inzulin u star\u0161\u00edch \u017een. Jin\u00e1 studie zjistila, \u017ee melatonin je \u00fa\u010dinn\u00fdm antioxidantem, kter\u00fd zlep\u0161uje \u00fa\u010dinnost peror\u00e1ln\u00edch antidiabetik. Uv\u011bdom\u00edme-li si, \u017ee no\u010dn\u00ed hladina melatoninu je zvl\u00e1\u0161t\u011b u star\u0161\u00edch lid\u00ed n\u00edzk\u00e1, pak je jasn\u00e9, pro\u010d pr\u00e1v\u011b tato skupina lid\u00ed m\u00e1 zv\u00fd\u0161en\u00e9 riziko cukrovky, proto\u017ee melatonin ji\u017e nen\u00ed schopen spr\u00e1vn\u011b \u0159\u00eddit no\u010dn\u00ed uvol\u0148ov\u00e1n\u00ed inzulinu.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_tta_section][\/vc_tta_accordion][vc_tta_accordion color=“turquoise“ c_icon=“chevron“ c_position=“right“ active_section=“99″ no_fill=“true“ collapsible_all=“true“][vc_tta_section title=“Fibromyalgie“ tab_id=“1481321243325-21232dbc-d1b5″][vc_row_inner css=“.vc_custom_1479392377806{background-image: url(https:\/\/www.chronobiology.com\/wp-content\/uploads\/2016\/11\/indications_3.jpg?id=11703) !important;}“][vc_column_inner][vc_column_text]Fibromyalgie je chronick\u00e9 bolestiv\u00e9 onemocn\u011bn\u00ed, kter\u00e9 postihuje p\u0159ibli\u017en\u011b \u010dty\u0159i procenta populace. Nov\u00e1 studie zjistila, \u017ee k tomuto onemocn\u011bn\u00ed m\u016f\u017ee p\u0159isp\u00edvat n\u00edzk\u00e1 hladina melatoninu.<\/p>\n

Slovo „fibromyalgie“ poch\u00e1z\u00ed ze t\u0159\u00ed r\u016fzn\u00fdch slov: latinsk\u00e9ho slova „fibra“, co\u017e znamen\u00e1 vl\u00e1knit\u00e1 tk\u00e1\u0148, \u0159eck\u00e9ho slova „myos“, co\u017e znamen\u00e1 sval, a „algos“, co\u017e znamen\u00e1 bolest. Ve skute\u010dnosti jsou hlavn\u00edmi p\u0159\u00edznaky tohoto onemocn\u011bn\u00ed bolesti sval\u016f, \u0161lach a vaz\u016f. Bolest sval\u016f v\u0161ak nen\u00ed jedin\u00fdm p\u0159\u00edznakem. U lid\u00ed posti\u017een\u00fdch touto nemoc\u00ed \u010dasto doch\u00e1z\u00ed tak\u00e9 ke zm\u011bn\u00e1m, kter\u00e9 zp\u016fsobuj\u00ed, \u017ee nervov\u00fd syst\u00e9m nad\u00e1le p\u0159en\u00e1\u0161\u00ed a zpracov\u00e1v\u00e1 bolest, i kdy\u017e podn\u011bty nejsou p\u0159\u00edtomny. Mezi dal\u0161\u00ed p\u0159\u00edznaky pat\u0159\u00ed \u00fanava, deprese a nespavost.<\/p>\n

Existuje v\u00edce studi\u00ed regraduj\u00edc\u00edch melatonin a bolest. Melatonin je nejen hormon, kter\u00fd pom\u00e1h\u00e1 \u0159\u00eddit n\u00e1\u0161 vrozen\u00fd cirkadi\u00e1nn\u00ed rytmus neboli biologick\u00e9 24hodinov\u00e9 hodiny, ale slou\u017e\u00ed tak\u00e9 jako regul\u00e1tor bolesti. Hormon p\u016fsob\u00ed nep\u0159\u00edmo na opioidn\u00ed receptory, co\u017e jsou stejn\u00e9 receptory, na kter\u00e9 se zam\u011b\u0159uj\u00ed l\u00e9ky proti bolesti. I kdy\u017e se dlouho p\u0159edpokl\u00e1dalo, \u017ee nespavost a \u00fanavu spojenou s nemoc\u00ed lze p\u0159i\u010d\u00edst neust\u00e1l\u00e9mu pro\u017e\u00edv\u00e1n\u00ed bolesti, nyn\u00ed se p\u0159edpokl\u00e1d\u00e1, \u017ee nedostatek melatoninu k n\u00ed p\u0159isp\u00edv\u00e1 tak\u00e9 n\u00e1sleduj\u00edc\u00edmi dv\u011bma zp\u016fsoby: Jeho vliv na cirkadi\u00e1nn\u00ed rytmus, nap\u0159\u00edklad na sp\u00e1nkov\u00e9 chov\u00e1n\u00ed, a jeho vliv na bolest prost\u0159ednictv\u00edm opioidn\u00edch receptor\u016f. Ned\u00e1vno proveden\u00e1 skupina experiment\u016f toti\u017e zjistila, \u017ee u\u017e\u00edv\u00e1n\u00ed dopl\u0148k\u016f stravy s melatoninem m\u016f\u017ee v\u00fdrazn\u011b zlep\u0161it \u0159adu p\u0159\u00edznak\u016f FMS.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_tta_section][\/vc_tta_accordion][vc_tta_accordion color=“turquoise“ c_icon=“chevron“ c_position=“right“ active_section=“99″ no_fill=“true“ collapsible_all=“true“][vc_tta_section title=“Neuropsychiatrick\u00e9 poruchy“ tab_id=“1481054287060-61d9c82c-ade3″][vc_row_inner css=“.vc_custom_1479392649001{background-image: url(https:\/\/www.chronobiology.com\/wp-content\/uploads\/2016\/11\/indications_4.jpg?id=11704) !important;}“][vc_column_inner][vc_column_text]<\/p>\n

Alzheimerova choroba<\/h3>\n

Alzheimerova choroba je progresivn\u00ed neurodegenerativn\u00ed onemocn\u011bn\u00ed, kter\u00e9 zp\u016fsobuje ztr\u00e1tu pam\u011bti a zm\u011bny v my\u0161len\u00ed a chov\u00e1n\u00ed, kter\u00e9 se postupem \u010dasu zhor\u0161uj\u00ed. Pacienti s Alzheimerovou chorobou maj\u00ed ve srovn\u00e1n\u00ed s kontroln\u00edmi skupinami mnohem ni\u017e\u0161\u00ed hladinu melatoninu, co\u017e vede k domn\u011bnce, \u017ee by tento hormon mohl hr\u00e1t pozitivn\u00ed roli p\u0159i l\u00e9\u010db\u011b tohoto onemocn\u011bn\u00ed.<\/p>\n

N\u011bkolik klinick\u00fdch studi\u00ed se zam\u011b\u0159ilo na u\u017e\u00edv\u00e1n\u00ed melatoninu a na to, jak lze jeho prost\u0159ednictv\u00edm zm\u00edrnit n\u011bkter\u00e9 p\u0159\u00edznaky Alzheimerovy choroby, v\u010detn\u011b poruch sp\u00e1nku a kognitivn\u00edch funkc\u00ed. SCN (suprachiasmatick\u00e9 j\u00e1dro), j\u00e1drov\u00e1 oblast v hypotalamu, ur\u010duje cirkadi\u00e1nn\u00ed rytmus p\u0159edev\u0161\u00edm prost\u0159ednictv\u00edm stimulace produkce melatoninu a prost\u0159ednictv\u00edm melatoninu je tak\u00e9 kontraregulov\u00e1na. Pokud SCN u pacient\u016f s Alzheimerovou chorobou reaguje na sv\u011btlo jen neochotn\u011b, m\u016f\u017ee b\u00fdt u\u017eite\u010dn\u00e9 p\u0159\u00edm\u00e9 pod\u00e1v\u00e1n\u00ed dopl\u0148k\u016f melatoninu. Ve studii proveden\u00e9 v roce 2012 byl melatonin u\u017e\u00edv\u00e1n v souvislosti s fyzick\u00fdm pohybem. Tato l\u00e9\u010dba sn\u00ed\u017eila kognitivn\u00ed po\u0161kozen\u00ed a oxida\u010dn\u00ed stres v mozku, co\u017e jsou faktory, kter\u00e9 p\u0159isp\u00edvaj\u00ed ke vzniku Alzheimerovy choroby.<\/p>\n

Dal\u0161\u00ed terapie, kter\u00e1 kombinuje jasn\u00e9 sv\u011btlo r\u00e1no s peror\u00e1ln\u00edm pod\u00e1v\u00e1n\u00edm melatoninu ve\u010der, se ukazuje jako prosp\u011b\u0161n\u00e1 pro zlep\u0161en\u00ed doby bd\u011bn\u00ed a aktivity pacient\u016f s Alzheimerovou chorobou, kte\u0159\u00ed jsou um\u00edst\u011bni ve zdravotnick\u00fdch za\u0159\u00edzen\u00edch. N\u011bkolik v\u011bdc\u016f tak\u00e9 uvedlo, \u017ee hudebn\u00ed terapie zvy\u0161uje vylu\u010dov\u00e1n\u00ed melatoninu, co\u017e je tak\u00e9 terapie pou\u017e\u00edvan\u00e1 u pacient\u016f s Alzheimerovou chorobou.<\/p>\n

Parkinsonova choroba<\/h3>\n

Parkinsonova choroba je roz\u0161\u00ed\u0159en\u00e9 neurodegenerativn\u00ed onemocn\u011bn\u00ed, kter\u00e9 nelze vyl\u00e9\u010dit. Parkinsonova choroba je zp\u016fsobena degenerac\u00ed ur\u010dit\u00fdch neuron\u016f v mozku, kter\u00e9 ztr\u00e1cej\u00ed schopnost produkovat dopamin, neurotransmiter, kter\u00fd podporuje kognitivn\u00ed funkce, kontrolu emoc\u00ed, koordinaci pohyb\u016f a \u0159adu dal\u0161\u00edch d\u016fle\u017eit\u00fdch funkc\u00ed. P\u0159\u00edznaky za\u010d\u00ednaj\u00ed pomalu, roky p\u0159edt\u00edm, ne\u017e se projev\u00ed motorick\u00e9 p\u0159\u00edznaky, kter\u00e9 vedou ke stanoven\u00ed diagn\u00f3zy, a obvykle zahrnuj\u00ed probl\u00e9my se sp\u00e1nkem a ztr\u00e1tu \u010dichu (anosmii). A\u010dkoli je Parkinsonova choroba spojov\u00e1na p\u0159edev\u0161\u00edm s blok\u00e1dou dopaminu mozku, zd\u00e1 se, \u017ee svou roli hraje tak\u00e9 melatonin. To by mohlo vysv\u011btlovat, pro\u010d jdou poruchy sp\u00e1nku ruku v ruce s t\u00edmto onemocn\u011bn\u00edm. V pr\u016fb\u011bhu progrese Parkinsonovy choroby doch\u00e1z\u00ed k poklesu melatoninov\u00fdch receptor\u016f v mozku. V\u010dasn\u00e9 pod\u00e1v\u00e1n\u00ed melatoninu m\u016f\u017ee osob\u00e1m trp\u00edc\u00edm Parkinsonovou chorobou pomoci dob\u0159e sp\u00e1t a tak\u00e9 ochr\u00e1nit jejich mozek p\u0159ed dal\u0161\u00edmi degenerativn\u00edmi zm\u011bnami. \u010cetn\u00e9 studie nazna\u010duj\u00ed, \u017ee stabilizace sp\u00e1nkov\u00fdch cykl\u016f prost\u0159ednictv\u00edm p\u0159\u00edjmu melatoninu by m\u011bla b\u00fdt standardn\u00ed sou\u010d\u00e1st\u00ed l\u00e9\u010dby tohoto onemocn\u011bn\u00ed.<\/p>\n

Lid\u00e9 s Parkinsonovou chorobou, kte\u0159\u00ed melatonin u\u017e\u00edvaj\u00ed, vykazuj\u00ed m\u00e9n\u011b a slab\u0161\u00ed p\u0159\u00edznaky ne\u017e ti, kte\u0159\u00ed jej neu\u017e\u00edvaj\u00ed. Dlouhou dobu se to p\u0159isuzovalo l\u00e9\u010debn\u00e9 povaze dostate\u010dn\u00e9ho sp\u00e1nku, ale nyn\u00ed v\u00edme, \u017ee melatonin je nejen hormonem navozuj\u00edc\u00edm sp\u00e1nek, ale tak\u00e9 neuroprotektivn\u00ed l\u00e1tkou, kter\u00e1 m\u016f\u017ee zastavit nebo sn\u00ed\u017eit po\u0161kozen\u00ed a tak\u00e9 podpo\u0159it regeneraci nervov\u00fdch bun\u011bk v mozku a kostn\u00ed d\u0159eni. A\u010dkoli se tato skute\u010dnost zat\u00edm intenzivn\u011b nezkoum\u00e1, p\u0159edpokl\u00e1d\u00e1 se, \u017ee neuroprotektivn\u00ed vlastnosti melatoninu mohou zpomalit postup Parkinsonovy nemoci, zejm\u00e9na zpomalen\u00edm neurologick\u00fdch po\u0161kozen\u00ed, kter\u00e1 zp\u016fsobuj\u00ed postupnou ztr\u00e1tu nervosvalov\u00fdch funkc\u00ed.<\/p>\n

Epilepsie<\/h3>\n

Epilepsie je porucha elektricky veden\u00fdch nervov\u00fdch bun\u011bk v mozku, kter\u00e1 u posti\u017een\u00fdch osob zp\u016fsobuje z\u00e1chvaty a\/nebo do\u010dasnou ztr\u00e1tu v\u011bdom\u00ed. Jin\u00e9 formy epilepsie a z\u00e1chvat\u016f jsou zp\u016fsobeny oxida\u010dn\u00edm stresem a voln\u00fdmi radik\u00e1ly. Nov\u00e1 studie zjistila, \u017ee existuje souvislost mezi naru\u0161en\u00edm sp\u00e1nku a epilepsi\u00ed, co\u017e op\u011bt poukazuje na skute\u010dnost, \u017ee cirkadi\u00e1nn\u00ed rytmus m\u00e1 vliv na v\u00fdskyt z\u00e1chvat\u016f. Ji\u017e p\u0159ed lety v\u011bdci zjistili, \u017ee tyto z\u00e1chvaty se \u010dasto \u0159\u00edd\u00ed 24hodinov\u00fdm rytmem. To znamen\u00e1, \u017ee se objevuj\u00ed ka\u017ed\u00fd den p\u0159ibli\u017en\u011b ve stejnou dobu. V\u011bdci se domn\u00edvaj\u00ed, \u017ee to lze \u010d\u00e1ste\u010dn\u011b p\u0159i\u010d\u00edst cirkadi\u00e1nn\u00edmu rytmu na\u0161eho mozku.<\/p>\n

R\u016fzn\u00e9 studie mezi d\u011btmi uk\u00e1zaly, \u017ee pod\u00e1v\u00e1n\u00ed melatoninu dok\u00e1zalo sn\u00ed\u017eit z\u00e1va\u017enost epileptick\u00fdch z\u00e1chvat\u016f. D\u00edky sv\u00fdm antioxida\u010dn\u00edm vlastnostem v centr\u00e1ln\u00edm nervov\u00e9m syst\u00e9mu je tento hormon schopen p\u016fsobit jako neuroprotector proti oxida\u010dn\u00edmu stresu, kter\u00fd je u pacient\u016f s epilepsi\u00ed patrn\u00fd. D\u00e1le bylo mo\u017en\u00e9 dokumentovat specifick\u00e9 melatoninov\u00e9 receptory v mozkov\u00e9 k\u016f\u0159e a to, \u017ee stimulace t\u011bchto receptor\u016f melatoninem potla\u010duje za\u010d\u00e1tek z\u00e1chvat\u016f. Zd\u00e1 se tak, \u017ee melatonin m\u00e1 prost\u0159ednictv\u00edm r\u016fzn\u00fdch mechanism\u016f \u00fa\u010dinku pozitivn\u00ed vliv na \u0159adu r\u016fzn\u00fdch typ\u016f epilepsie.<\/p>\n

Porucha pozornosti \/ hyperaktivita<\/h3>\n

Naru\u0161en\u00ed sp\u00e1nku je velmi \u010dast\u00e9 u d\u011bt\u00ed, kter\u00e9 trp\u00ed poruchou pozornosti\/hyperaktivitou (ADHD). Sou\u010dasn\u00e1 studie zkoum\u00e1 dlouhodobou konzumaci melatoninu a jeho \u00fa\u010dinnost p\u0159i pomoci d\u011btem s ADHD. Podle vyj\u00e1d\u0159en\u00ed rodi\u010d\u016f do\u0161lo u 88 % l\u00e9\u010den\u00fdch d\u011bt\u00ed ke zlep\u0161en\u00ed poruch sp\u00e1nku. Krom\u011b toho 71 procent z nich uvedlo zlep\u0161en\u00ed chov\u00e1n\u00ed a 61 procent zlep\u0161en\u00ed n\u00e1lady.<\/p>\n

Schizofrenie<\/h3>\n

Schizofrenie je dal\u0161\u00ed neuro-psychiatrickou poruchou, u n\u00ed\u017e bylo zji\u0161t\u011bno, \u017ee je doprov\u00e1zena naru\u0161en\u00edm cirkadi\u00e1nn\u00edho rytmu a sn\u00ed\u017een\u00edm hladiny melatoninu. Vzhledem k t\u011bmto anom\u00e1li\u00edm se p\u0159edpokl\u00e1d\u00e1, \u017ee by melatonin mohl pomoci p\u0159i l\u00e9\u010db\u011b tohoto onemocn\u011bn\u00ed. Bylo tak\u00e9 zji\u0161t\u011bno, \u017ee tento hormon zvy\u0161uje \u00fa\u010dinnost antipsychotick\u00fdch l\u00e9k\u016f a m\u016f\u017ee sni\u017eovat jejich vedlej\u0161\u00ed \u00fa\u010dinky. Ve studii s pacienty trp\u00edc\u00edmi schizofreni\u00ed byl melatonin pou\u017eit spole\u010dn\u011b s obl\u00edben\u00fdmi antipsychotiky. Dal\u0161\u00ed skupina pacient\u016f, kter\u00e1 se \u00fa\u010dastnila stejn\u00e9 studie, dost\u00e1vala tak\u00e9 toto antipsychotikum, ale m\u00edsto melatoninu dost\u00e1vala pouze doprovodn\u00e9 placebo. U \u00fa\u010dastn\u00edk\u016f, kte\u0159\u00ed dost\u00e1vali melatonin, se projevilo m\u00e9n\u011b vedlej\u0161\u00edch \u00fa\u010dink\u016f, jako je p\u0159ib\u00fdv\u00e1n\u00ed na v\u00e1ze, a tak\u00e9 ni\u017e\u0161\u00ed hodnota PANSS, kter\u00e1 m\u011b\u0159\u00ed z\u00e1va\u017enost schizofrenn\u00edch p\u0159\u00edznak\u016f.<\/p>\n

Deprese<\/h3>\n

Deprese je nemoc, kterou je t\u0159eba br\u00e1t v\u00e1\u017en\u011b a kter\u00e1 je doprov\u00e1zena p\u0159\u00edznaky, jako je nedostatek energie, beznad\u011bj, negativn\u00ed my\u0161lenky, poruchy sp\u00e1nku a v nejhor\u0161\u00edch p\u0159\u00edpadech my\u0161lenky na sebevra\u017edu. Mezi fyzick\u00e9 p\u0159\u00edznaky pat\u0159\u00ed denn\u00ed ospalost, nespavost, bolesti sval\u016f, gastrointestin\u00e1ln\u00ed pot\u00ed\u017ee, bolesti hlavy a dal\u0161\u00ed nespecifick\u00e9 smyslov\u00e9 poruchy. U lid\u00ed trp\u00edc\u00edch depres\u00ed se t\u00e9m\u011b\u0159 v\u017edy projevuje funk\u010dn\u00ed porucha serotoninov\u00e9ho syst\u00e9mu. Serotonin je jedn\u00edm z nejd\u016fle\u017eit\u011bj\u0161\u00edch neurotransmiter\u016f\/posilova\u010d\u016f v lidsk\u00e9m t\u011ble a \u010dasto je tak\u00e9 ozna\u010dov\u00e1n jako hormon \u0161t\u011bst\u00ed, proto\u017ee hladina serotoninu v\u00fdrazn\u011b ovliv\u0148uje na\u0161i emo\u010dn\u00ed pohodu. Nedostatek serotoninu, zejm\u00e9na v mozku, umo\u017e\u0148uje zhor\u0161en\u00ed na\u0161\u00ed n\u00e1lady a zaji\u0161\u0165uje \u0161patn\u00fd stav mysli. Skute\u010dnost, \u017ee serotonin je ve\u010der vyu\u017e\u00edv\u00e1n k produkci no\u010dn\u00edho hormonu melatoninu, vysv\u011btluje, pro\u010d m\u016f\u017ee nedostatek serotoninu v\u00e9st tak\u00e9 ke \u0161patn\u00e9mu sp\u00e1nku.<\/p>\n

Existuj\u00ed studie, kter\u00e9 dokazuj\u00ed, \u017ee melatonin m\u016f\u017ee p\u0159inejmen\u0161\u00edm zlep\u0161it n\u011bkter\u00e9 p\u0159\u00edznaky deprese, zejm\u00e9na ty, kter\u00e9 souvisej\u00ed s poruchami sp\u00e1nku. V\u00fdsledkem je, \u017ee pacienti s t\u011b\u017ekou depres\u00ed byli l\u00e9\u010deni melatoninem. Melatonin byl \u00fa\u010dinn\u00fd p\u0159i zlep\u0161ov\u00e1n\u00ed kvality sp\u00e1nku posti\u017een\u00fdch osob. Pozitivn\u00ed v\u00fdsledky lze nav\u00edc pozorovat u pacient\u016f, kte\u0159\u00ed trp\u00ed sez\u00f3nn\u00ed depres\u00ed. Jin\u00e1 studie uv\u00e1d\u00ed ni\u017e\u0161\u00ed m\u00edru deprese u pacient\u016f se zimn\u00ed depres\u00ed, kte\u0159\u00ed byli l\u00e9\u010deni n\u00edzkou d\u00e1vkou melatoninu v odpoledn\u00edch hodin\u00e1ch. I mal\u00e9 d\u00e1vky melatoninu mohou zlep\u0161it synchronizaci vnit\u0159n\u00edch hodin a biologick\u00e9ho denn\u00edho rytmu se zm\u011bn\u011bn\u00fdm pom\u011brem sv\u011btla b\u011bhem zimy, co\u017e umo\u017e\u0148uje v\u00fdrazn\u00e9 zlep\u0161en\u00ed n\u00e1lady.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_tta_section][\/vc_tta_accordion][vc_tta_accordion color=“turquoise“ c_icon=“chevron“ c_position=“right“ active_section=“99″ no_fill=“true“ collapsible_all=“true“][vc_tta_section title=“Rakovina“ tab_id=“1481054316572-f240aafe-4074″][vc_row_inner css=“.vc_custom_1479393247359{background-image: url(https:\/\/www.chronobiology.com\/wp-content\/uploads\/2016\/11\/indications_5.jpg?id=11708) !important;}“][vc_column_inner][vc_column_text]Melatonin se ji\u017e des\u00edtky let pou\u017e\u00edv\u00e1 k l\u00e9\u010db\u011b nespavosti a jin\u00fdch poruch sp\u00e1nku, ale m\u016f\u017ee b\u00fdt cenn\u00fd i p\u0159i l\u00e9\u010db\u011b rakoviny. Rakovina se v mnoha ohledech zab\u00fdv\u00e1 spr\u00e1vn\u00fdm na\u010dasov\u00e1n\u00edm. Norm\u00e1ln\u00ed bu\u0148ky rostou a um\u00edraj\u00ed d\u00edky extr\u00e9mn\u011b regulovan\u00fdm proces\u016fm, kter\u00e9 jsou p\u0159edur\u010deny na\u0161imi hodinov\u00fdmi geny. Pokud tyto geny vykazuj\u00ed n\u011bjak\u00e9 mutace nebo jinak nefunguj\u00ed spr\u00e1vn\u011b, mohou bu\u0148ky za\u010d\u00edt nekontrolovateln\u011b r\u016fst a zab\u00edjet ostatn\u00ed zdrav\u00e9 bu\u0148ky v okol\u00ed.<\/p>\n

Nov\u00e9 v\u00fdzkumy nazna\u010duj\u00ed, \u017ee melatonin podvazuje r\u016fst n\u00e1dor\u016f a z\u00e1rove\u0148 zm\u00edr\u0148uje vedlej\u0161\u00ed \u00fa\u010dinky jin\u00fdch zp\u016fsob\u016f l\u00e9\u010dby rakoviny. Abychom byli konkr\u00e9tn\u011bj\u0161\u00ed, lid\u00e9, kte\u0159\u00ed v noci nemohou sp\u00e1t, vykazuj\u00ed vy\u0161\u0161\u00ed riziko vzniku rakoviny, a proto Sv\u011btov\u00e1 zdravotnick\u00e1 organizace klasifikovala pr\u00e1ci na sm\u011bny jako karcinogenn\u00ed (podporuj\u00edc\u00ed vznik rakoviny).<\/p>\n

A\u010dkoli je souvislost mezi naru\u0161en\u00fdm cirkadi\u00e1nn\u00edm rytmem a rakovinou jasn\u00e1, mechanismus zv\u00fd\u0161en\u00e9ho rizika vzniku rakoviny nebyl a\u017e dosud objasn\u011bn. Nov\u00e1 metaanal\u00fdza chronobiologick\u00fdch studi\u00ed nazna\u010duje, \u017ee melatonin \u00fato\u010d\u00ed na rakovinu v jej\u00edch z\u00e1kladech t\u00edm, \u017ee p\u0159eru\u0161uje biochemick\u00e9 procesy, kter\u00e9 n\u00e1dory vyu\u017e\u00edvaj\u00ed k r\u016fstu. Melatonin dok\u00e1\u017ee zabr\u00e1nit rakovinn\u00fdm bu\u0148k\u00e1m v mno\u017een\u00ed t\u00edm, \u017ee zp\u016fsobuje apopt\u00f3zu (programovanou bun\u011b\u010dnou smrt) a p\u0159eru\u0161uje p\u0159\u00edvod krve do n\u00e1dor\u016f. Je tak\u00e9 zn\u00e1mo, \u017ee tento hormon p\u016fsob\u00ed jako antioxida\u010dn\u00ed l\u00e1tka, kter\u00e1 zlep\u0161uje imunitn\u00ed syst\u00e9m, co\u017e rovn\u011b\u017e br\u00e1n\u00ed rozvoji rakoviny. A kone\u010dn\u011b p\u0159\u00edli\u0161 m\u00e1lo melatoninu m\u016f\u017ee v\u00e9st k vysok\u00e9 hladin\u011b cytokin\u016f (p\u0159irozen\u00e1 molekula, kter\u00e1 je spojov\u00e1na s rakovinou).<\/p>\n

P\u0159i pod\u00e1v\u00e1n\u00ed melatoninu laboratorn\u00edm zv\u00ed\u0159at\u016fm, kter\u00e1 trp\u011bla n\u00e1dory, se pak r\u016fst n\u00e1doru v\u00fdrazn\u011b zpomalil. Studie tak\u00e9 ukazuj\u00ed, \u017ee lid\u0161t\u00ed pacienti s rakovinou sn\u00e1\u0161ej\u00ed p\u0159i u\u017e\u00edv\u00e1n\u00ed dopl\u0148ku stravy s melatoninem snadn\u011bji dal\u0161\u00ed l\u00e9\u010dbu. V bl\u00edzk\u00e9 budoucnosti by se tento z\u00e1zra\u010dn\u00fd hormon mohl st\u00e1t sou\u010d\u00e1st\u00ed standardn\u00ed l\u00e9\u010dby rakoviny.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_tta_section][\/vc_tta_accordion][vc_tta_accordion color=“turquoise“ c_icon=“chevron“ c_position=“right“ active_section=“99″ no_fill=“true“ collapsible_all=“true“][vc_tta_section title=“Bolesti hlavy“ tab_id=“1481054421918-d560abc5-f17a“][vc_row_inner css=“.vc_custom_1481067315830{background-image: url(https:\/\/www.chronobiology.com\/wp-content\/uploads\/2016\/11\/indications-4.jpg?id=18360) !important;}“][vc_column_inner][vc_column_text]Melatonin by tak\u00e9 mohl b\u00fdt u\u017eite\u010dn\u00fd proti r\u016fzn\u00fdm typ\u016fm bolest\u00ed hlavy a migr\u00e9ny. Mezi vlastnosti melatoninu, kter\u00e9 pom\u00e1haj\u00ed v boji proti bolestem hlavy, pat\u0159\u00ed tyto: p\u016fsob\u00ed protiz\u00e1n\u011btliv\u011b, potla\u010duje nadm\u011brn\u00e9 uvol\u0148ov\u00e1n\u00ed dopaminu, stabilizuje membr\u00e1ny a zvy\u0161uje hladinu GABA (nejd\u016fle\u017eit\u011bj\u0161\u00edho inhibi\u010dn\u00edho neurotransmiteru v mozku). Krom\u011b toho p\u016fsob\u00ed jako ochrana proti voln\u00fdm radik\u00e1l\u016fm.<\/p>\n

Podle studi\u00ed m\u016f\u017ee hormon dokonce p\u0159edch\u00e1zet migr\u00e9n\u00e1m. P\u0159esn\u00fd mechanismus nen\u00ed v sou\u010dasn\u00e9 dob\u011b zn\u00e1m, ale existuje mnoho souvislost\u00ed mezi cirkadi\u00e1nn\u00edm rytmem a t\u00edmto typem bolesti hlavy. V\u011bt\u0161ina lid\u00ed, kte\u0159\u00ed trp\u00ed migr\u00e9nami, je dost\u00e1v\u00e1 ka\u017ed\u00fd den t\u00e9m\u011b\u0159 ve stejnou dobu, co\u017e vede k z\u00e1v\u011bru, \u017ee cirkadi\u00e1nn\u00ed slo\u017eky hraj\u00ed ur\u010ditou roli. Krom\u011b toho m\u016f\u017ee b\u00fdt jednou z hlavn\u00edch p\u0159\u00ed\u010din tohoto typu bolesti hlavy tak\u00e9 gen, kter\u00fd je spojen s poruchami cirkadi\u00e1nn\u00edho rytmu. Je mo\u017en\u00e9, \u017ee u\u017e\u00edv\u00e1n\u00ed melatoninu m\u016f\u017ee zab\u00edt dv\u011b mouchy jednou ranou, proto\u017ee potla\u010duje migr\u00e9ny a z\u00e1rove\u0148 podporuje zdrav\u00fd cyklus sp\u00e1nku a bd\u011bn\u00ed. Zlep\u0161en\u00ed by melatonin mohl dos\u00e1hnout tak\u00e9 p\u0159i l\u00e9\u010db\u011b clusterov\u00fdch bolest\u00ed hlavy a idiopatick\u00fdch bodav\u00fdch bolest\u00ed hlavy. Klastrov\u00e9 bolesti hlavy se vyzna\u010duj\u00ed siln\u00fdmi jednostrann\u00fdmi bolestmi hlavy. Jako doprovodn\u00e9 p\u0159\u00edznaky jsou zn\u00e1my slz\u00edc\u00ed o\u010di nebo tekouc\u00ed nos. Nedostate\u010dn\u00e1 sekrece melatoninu m\u016f\u017ee v\u00e9st k v\u00fdskytu z\u00e1chvat\u016f bolesti v noci nebo i b\u011bhem dne. \u010cetnost bolest\u00ed hlavy by se u n\u011bkter\u00fdch pacient\u016f mohla pomoc\u00ed melatoninu v\u00fdrazn\u011b sn\u00ed\u017eit. Melatonin se u idiopatick\u00fdch bodav\u00fdch bolest\u00ed hlavy (spont\u00e1nn\u011b se vyskytuj\u00edc\u00ed bodav\u00e1 bolest trvaj\u00edc\u00ed n\u011bkolik sekund) uk\u00e1zal jako \u00fa\u010dinn\u011bj\u0161\u00ed ne\u017e jin\u00e9 l\u00e9ky proti bolesti a vykazoval tak\u00e9 m\u00e9n\u011b vedlej\u0161\u00edch \u00fa\u010dink\u016f.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_tta_section][\/vc_tta_accordion][vc_tta_accordion color=“turquoise“ c_icon=“chevron“ c_position=“right“ active_section=“99″ no_fill=“true“ collapsible_all=“true“][vc_tta_section title=“O\u010di“ tab_id=“1481054457945-508ecd0b-50c9″][vc_row_inner css=“.vc_custom_1481067398768{background-image: url(https:\/\/www.chronobiology.com\/wp-content\/uploads\/2016\/11\/indications-2.jpg?id=18358) !important;}“][vc_column_inner][vc_column_text]Melatonin se netvo\u0159\u00ed pouze v epif\u00fdze, ale tak\u00e9 v s\u00edtnici. Tento hormon, jeho\u017e mno\u017estv\u00ed se u star\u0161\u00edch lid\u00ed sni\u017euje, se pod\u00edl\u00ed na kontrole pigmentace o\u010d\u00ed. Pom\u00e1h\u00e1 mimo jin\u00e9 regulovat mno\u017estv\u00ed sv\u011btla, kter\u00e9 dopad\u00e1 na fotoreceptory oka. Pigmentov\u00fd epitel s\u00edtnice (vn\u011bj\u0161\u00ed vrstva s\u00edtnice) je tak\u00e9 nez\u00e1visle chr\u00e1n\u011bn p\u0159ed oxida\u010dn\u00edm po\u0161kozen\u00edm.<\/p>\n

Makul\u00e1rn\u00ed degenerace<\/h3>\n

Toto o\u010dn\u00ed onemocn\u011bn\u00ed, kter\u00e9 ni\u010d\u00ed nejd\u016fle\u017eit\u011bj\u0161\u00ed, centr\u00e1ln\u00ed \u010d\u00e1st s\u00edtnice, pat\u0159\u00ed mezi nej\u010dast\u011bj\u0161\u00ed p\u0159\u00ed\u010diny slepoty u dosp\u011bl\u00fdch. Podle studi\u00ed m\u016f\u017ee u\u017e\u00edv\u00e1n\u00ed melatoninu zpomalit progresi onemocn\u011bn\u00ed a chr\u00e1nit s\u00edtnici. Zda melatonin p\u016fsob\u00ed pouze jako zachycova\u010d radik\u00e1l\u016f, nebo zda existuj\u00ed i vlivy p\u0159en\u00e1\u0161en\u00e9 receptory, je v sou\u010dasn\u00e9 dob\u011b st\u00e1le p\u0159edm\u011btem v\u00fdzkumu.<\/p>\n

Glaukom<\/h3>\n

Glaukomem oka se rozum\u00ed \u0159ada r\u016fzn\u00fdch o\u010dn\u00edch onemocn\u011bn\u00ed, kter\u00e1 mohou v\u00e9st ke ztr\u00e1t\u011b optick\u00fdch nervov\u00fdch vl\u00e1ken. Hlavn\u00ed p\u0159\u00ed\u010dinou tohoto onemocn\u011bn\u00ed je zv\u00fd\u0161en\u00fd tlak v o\u010dn\u00ed komo\u0159e, kter\u00fd \u010dasto souvis\u00ed s n\u00edzk\u00fdm tlakem v c\u00e9v\u00e1ch z\u00e1sobuj\u00edc\u00edch s\u00edtnici. Pokud je onemocn\u011bn\u00ed pokro\u010dil\u00e9, m\u016f\u017ee v\u00e9st k erozi zornice, p\u0159i n\u00ed\u017e jsou nejprve po\u0161kozeny vn\u011bj\u0161\u00ed nervy s\u00edtnice a postupn\u011b n\u00e1sleduj\u00ed nervy vnit\u0159n\u00ed. V\u00fdsledkem je v\u00fdpadek zorn\u00e9ho pole – od okraje sm\u011brem dovnit\u0159 -, kter\u00fd m\u016f\u017ee nakonec zp\u016fsobit \u00faplnou slepotu. V\u00fdzkum uk\u00e1zal, \u017ee oxida\u010dn\u00ed stres u glaukomu m\u016f\u017ee tak\u00e9 zp\u016fsobit ztr\u00e1tu fotoreceptor\u016f. V tomto p\u0159\u00edpad\u011b m\u016f\u017ee b\u00fdt \u00fa\u010dinn\u00fd melatonin, kter\u00fd sni\u017euje tlak v oku a nav\u00edc chr\u00e1n\u00ed fotoreceptory p\u0159ed voln\u00fdmi radik\u00e1ly.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_tta_section][\/vc_tta_accordion][vc_tta_accordion color=“turquoise“ c_icon=“chevron“ c_position=“right“ active_section=“99″ no_fill=“true“ collapsible_all=“true“][vc_tta_section title=“Plodnost a t\u011bhotenstv\u00ed“ tab_id=“1481054489011-c3c7f4d0-5362″][vc_row_inner css=“.vc_custom_1481067422458{background-image: url(https:\/\/www.chronobiology.com\/wp-content\/uploads\/2016\/11\/indications-3.jpg?id=18359) !important;}“][vc_column_inner][vc_column_text]Ned\u00e1vno publikovan\u00e1 studie Texask\u00e9 univerzity nazna\u010duje, \u017ee pro optim\u00e1ln\u00ed plodnost je nezbytn\u00e1 zdrav\u00e1 hladina melatoninu. Stejn\u011b jako ostatn\u00ed bu\u0148ky v t\u011ble jsou i vaj\u00ed\u010dka n\u00e1chyln\u00e1 k p\u016fsoben\u00ed voln\u00fdch radik\u00e1l\u016f, kter\u00e9 mohou zp\u016fsobit po\u0161kozen\u00ed DNA. V tomto p\u0159\u00edpad\u011b p\u016fsob\u00ed melatonin ve vaje\u010dn\u00edc\u00edch jako antioxidant t\u00edm, \u017ee odstra\u0148uje voln\u00e9 radik\u00e1ly a zabra\u0148uje po\u0161kozen\u00ed bun\u011bk. Dal\u0161\u00ed chronobiologick\u00e1 studie publikovan\u00e1 v \u010dasopise Journal of Medicine and Life zjistila, \u017ee melatonin m\u00e1 zna\u010dn\u00fd v\u00fdznam pro v\u00fdvoj embrya a plodu. Hladina melatoninu se v pr\u016fb\u011bhu t\u011bhotenstv\u00ed zvy\u0161uje konstantn\u00ed rychlost\u00ed. Vzhledem k tomu, \u017ee se tento hormon p\u0159en\u00e1\u0161\u00ed placentou v nezm\u011bn\u011bn\u00e9 podob\u011b, lze jej detekovat jak v plodov\u00e9 vod\u011b, tak ve vyv\u00edjej\u00edc\u00edm se plodu. Plod m\u00e1 receptory pro melatonin v mozku ji\u017e dlouho p\u0159edt\u00edm, ne\u017e se pln\u011b zformuje.<\/p>\n

Melatonin od matky m\u00e1 pro plod r\u016fzn\u00e9 funkce. Na jedn\u00e9 stran\u011b p\u0159ed\u00e1v\u00e1 mozku plodu informace o cyklech sv\u011btla a tmy, co\u017e d\u00edt\u011bti pom\u00e1h\u00e1 vybudovat si vlastn\u00ed cirkadi\u00e1nn\u00ed rytmus. Na druh\u00e9 stran\u011b se p\u0159edpokl\u00e1d\u00e1, \u017ee melatonin hraje d\u016fle\u017eitou roli tak\u00e9 p\u0159i aktivaci ur\u010dit\u00fdch gen\u016f, kter\u00e9 jsou d\u016fle\u017eit\u00e9 pro spr\u00e1vn\u00fd v\u00fdvoj od po\u010det\u00ed a\u017e po narozen\u00ed. Z tohoto d\u016fvodu mnoho r\u016fzn\u00fdch v\u011bdc\u016f doporu\u010duje pod\u00e1v\u00e1n\u00ed melatoninu t\u011bhotn\u00fdm \u017een\u00e1m, zejm\u00e9na p\u0159i p\u0159\u00edtomnosti poruch sp\u00e1nku, proto\u017ee byly prok\u00e1z\u00e1ny pouze pozitivn\u00ed \u00fa\u010dinky pro d\u00edt\u011b.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_tta_section][\/vc_tta_accordion][vc_tta_accordion color=“turquoise“ c_icon=“chevron“ c_position=“right“ active_section=“99″ no_fill=“true“ collapsible_all=“true“][vc_tta_section title=“Sp\u00e1nek“ tab_id=“1481054511245-6cd0663b-bbaf“][vc_row_inner css=“.vc_custom_1479393081118{background-image: url(https:\/\/www.chronobiology.com\/wp-content\/uploads\/2016\/11\/indications_9.jpg?id=11706) !important;}“][vc_column_inner][vc_column_text]Nejd\u016fkladn\u011bji prozkouman\u00fdm a zdokumentovan\u00fdm \u00fa\u010dinkem melatoninu je jeho vliv na rytmus sp\u00e1nku a bd\u011bn\u00ed. Melatonin je vhodn\u00fd jak pro us\u00edn\u00e1n\u00ed, tak pro udr\u017een\u00ed sp\u00e1nku. Tento hormon se osv\u011bd\u010dil p\u0159i \u0159ad\u011b poruch sp\u00e1nku, jako je nap\u0159\u00edklad jetlag, pr\u00e1ce na sm\u011bny, syndrom opo\u017ed\u011bn\u00e9ho n\u00e1stupu sp\u00e1nku nebo u star\u0161\u00edch lid\u00ed s probl\u00e9my se sp\u00e1nkem. Jeho prost\u0159ednictv\u00edm lze v\u00fdrazn\u011b zlep\u0161it efektivitu sp\u00e1nku a celkovou dobu sp\u00e1nku.<\/p>\n

Poruchy sp\u00e1nku a jejich d\u016fsledky<\/h3>\n

Chronick\u00e9 poruchy sp\u00e1nku, kter\u00e9 se vyskytuj\u00ed v pr\u016fm\u011bru ve t\u0159ech ze sedmi noc\u00ed, zvy\u0161uj\u00ed mo\u017enost vzniku infarktu, mrtvice, cukrovky, c\u00e9vn\u00edch onemocn\u011bn\u00ed a problematick\u00e9 obezity.<\/p>\n

T\u00fdm z Pensylv\u00e1nsk\u00e9 univerzity poprv\u00e9 analyzoval shrom\u00e1\u017ed\u011bn\u00e9 \u00fadaje od v\u00edce ne\u017e 130 000 lid\u00ed (pr\u016fm\u011brn\u00fd v\u011bk 46 let) a dok\u00e1zal vyvodit n\u00e1sleduj\u00edc\u00ed z\u00e1v\u011bry: Minim\u00e1ln\u00ed poruchy p\u0159i us\u00edn\u00e1n\u00ed nebo b\u011bhem sp\u00e1nku, ale tak\u00e9 p\u0159i p\u0159\u00edli\u0161 dlouh\u00e9m sp\u00e1nku mohou m\u00edt obrovsk\u00fd v\u00fdznam. Riziko obezity se zvy\u0161uje o 35 procent, cukrovky o 54 procent a kardiovaskul\u00e1rn\u00edch onemocn\u011bn\u00ed o 98 procent. Zdvojn\u00e1sobuje se tak\u00e9 riziko mrtvice.<\/p>\n

V\u011bdci z Harvard Medical School se zam\u011b\u0159uj\u00ed na 90 a\u017e 120 minut ka\u017edou noc, kter\u00e9 zdrav\u00fdm lidem dod\u00e1vaj\u00ed hlubok\u00fd sp\u00e1nek. Oslovili 784 lid\u00ed s norm\u00e1ln\u00edm krevn\u00edm tlakem, kte\u0159\u00ed souhlasili s t\u00edm, \u017ee budou doma sledovat f\u00e1ze sv\u00e9ho sp\u00e1nku pomoc\u00ed mal\u00e9ho p\u0159\u00edstroje. Experiment prob\u00edhal po dobu 42 m\u011bs\u00edc\u016f.<\/p>\n

Hlubok\u00fd sp\u00e1nek obecn\u011b tvo\u0159\u00ed asi 25 procent no\u010dn\u00edho sp\u00e1nku. V t\u00e9to f\u00e1zi doch\u00e1z\u00ed k oslaben\u00ed mozkov\u00e9 aktivity, sn\u00ed\u017een\u00ed srde\u010dn\u00ed frekvence a uvol\u0148ov\u00e1n\u00ed stresov\u00fdch hormon\u016f. Hodnoty krevn\u00edho tlaku jsou v t\u00e9to dob\u011b zpravidla o 10 bod\u016f ni\u017e\u0161\u00ed ne\u017e norm\u00e1ln\u011b. No\u010dn\u00ed sn\u00ed\u017een\u00ed tlaku je vn\u00edm\u00e1no mimo\u0159\u00e1dn\u011b pozitivn\u011b. Stav, kdy tlak z\u016fst\u00e1v\u00e1 zv\u00fd\u0161en\u00fd, je v\u0161ak pova\u017eov\u00e1n za rizikov\u00fd faktor srde\u010dn\u00edch onemocn\u011bn\u00ed.<\/p>\n

V\u00fdsledkem bylo, \u017ee mu\u017ei, u nich\u017e se projevila krat\u0161\u00ed regenera\u010dn\u00ed f\u00e1ze, reagovali zv\u00fd\u0161en\u00fdm krevn\u00edm tlakem nebezpe\u010dn\u00fdch rozm\u011br\u016f (n\u011bkolik ze sledovan\u00fdch dos\u00e1hlo pouze \u010dty\u0159 procent, tedy 15 minut pot\u0159ebn\u00e9ho hlubok\u00e9ho sp\u00e1nku). Zpravidla se u v\u011bt\u0161iny z nich projevil p\u0159eru\u0161ovan\u00fd a zkr\u00e1cen\u00fd sp\u00e1nek. T\u00e9to skupin\u011b by m\u011bla prosp\u011bt suplementace melatoninem.<\/p>\n

Dopl\u0148ky melatoninu<\/h3>\n

Nejstar\u0161\u00ed studie v oblasti chronobiologie uk\u00e1zaly, \u017ee melatoninov\u00e9 dopl\u0148ky mohou pomoci p\u0159i l\u00e9\u010db\u011b cirkadi\u00e1nn\u00edch poruch sp\u00e1nku a tak\u00e9 p\u0159i \u0159e\u0161en\u00ed \u0159ady probl\u00e9m\u016f souvisej\u00edc\u00edch se sp\u00e1nkem. Ne v\u0161echny melatoninov\u00e9 dopl\u0148ky jsou v\u0161ak stejn\u00e9. Zp\u016fsob, jak\u00fdm se melatonin v t\u011bchto dopl\u0148c\u00edch uvol\u0148uje, m\u016f\u017ee m\u00edt neuv\u011b\u0159iteln\u00fd vliv na fyziologick\u00e9 hodnoty a \u00fa\u010dinky tohoto hormonu.<\/p>\n

N\u011bkte\u0159\u00ed lid\u00e9 jsou toho n\u00e1zoru, \u017ee melatonin nefunguje tak dramaticky, jak o\u010dek\u00e1vali. \u010casto se pak myln\u011b domn\u00edvaj\u00ed, \u017ee melatonin nen\u00ed p\u0159i l\u00e9\u010db\u011b probl\u00e9m\u016f se sp\u00e1nkem u\u017eite\u010dn\u00fd, ale ve skute\u010dnosti si mo\u017en\u00e1 jen vybrali \u0161patn\u00fd druh melatoninov\u00e9ho dopl\u0148ku. Nav\u00edc lze m\u00edt za to, \u017ee melatonin nefunguje jako klasick\u00e9 hypnotikum, ale sp\u00ed\u0161e jako regul\u00e1tor rytmu sp\u00e1nek-bd\u011bn\u00ed. Z tohoto d\u016fvodu lze \u00fa\u010dinek vyhodnotit a\u017e nejd\u0159\u00edve r\u00e1no, kdy si m\u016f\u017eete polo\u017eit ot\u00e1zku, jak jste fit a zda byl sp\u00e1nek klidn\u00fd, jak dlouho v\u00e1m trvalo usnout a jak \u010dasto jste se budili.<\/p>\n

Pomal\u00e9 nebo rychl\u00e9 uvol\u0148ov\u00e1n\u00ed<\/h4>\n

Nejb\u011b\u017en\u011bj\u0161\u00ed typ melatoninov\u00fdch dopl\u0148k\u016f m\u00e1 bu\u010f rychl\u00e9, nebo pomal\u00e9 uvol\u0148ov\u00e1n\u00ed hormonu. Rychl\u00e9 uvol\u0148ov\u00e1n\u00ed melatoninu vede k rychl\u00e9mu vzestupu hladiny melatoninu, kter\u00e1 za\u010dne po jedn\u00e9 a\u017e dvou hodin\u00e1ch op\u011bt klesat. Lid\u00e9, kte\u0159\u00ed u\u017e\u00edvaj\u00ed tento typ dopl\u0148ku stravy, zjist\u00ed, \u017ee jsou rychle ospal\u00ed, ale maj\u00ed pot\u00ed\u017ee s no\u010dn\u00edm sp\u00e1nkem nebo jednodu\u0161e nemaj\u00ed kvalitn\u00ed sp\u00e1nek. Naproti tomu pomalu se uvol\u0148uj\u00edc\u00ed melatonin pot\u0159ebuje hodiny, ne\u017e navod\u00ed sp\u00e1nek, a nepolevuje a\u017e do \u010dasn\u00fdch rann\u00edch hodin. Lid\u00e9, kte\u0159\u00ed si vybrali p\u0159\u00edpravky umo\u017e\u0148uj\u00edc\u00ed pomal\u00e9 uvol\u0148ov\u00e1n\u00ed melatoninu, mohou m\u00edt probl\u00e9my s us\u00edn\u00e1n\u00edm kv\u016fli po\u010d\u00e1te\u010dn\u00ed n\u00edzk\u00e9 hladin\u011b melatoninu a n\u00e1sledn\u011b s probouzen\u00edm, proto\u017ee r\u00e1no je hladina melatoninu st\u00e1le nep\u0159irozen\u011b vysok\u00e1.<\/p>\n

Dob\u0159e na\u010dasovan\u00e9 uvol\u0148ov\u00e1n\u00ed melatoninu (chronobiologicky spr\u00e1vn\u011b kombinovan\u00fd melatonin nebo pulzuj\u00edc\u00ed melatonin) nab\u00edz\u00ed lep\u0161\u00ed mo\u017enost udr\u017een\u00ed p\u0159irozen\u00e9ho cirkadi\u00e1nn\u00edho rytmu.<\/p>\n

Dob\u0159e na\u010dasovan\u00e9 uvol\u0148ov\u00e1n\u00ed (chronobiologick\u00fd spr\u00e1vn\u011b kombinovan\u00fd melatonin nebo pulzuj\u00edc\u00ed melatonin):<\/h4>\n

\u010casov\u011b \u0159\u00edzen\u00e9 uvol\u0148ov\u00e1n\u00ed melatoninu je dopln\u011bk stravy, kter\u00fd je sestaven tak, aby se hormon uvol\u0148oval p\u0159esn\u011b v mno\u017estv\u00ed, kter\u00e9 napodobuje zdravou, p\u0159irozenou hladinu melatoninu. Uvol\u0148uje se postupn\u011b, tak\u017ee hladina melatoninu po u\u017eit\u00ed dopl\u0148ku rychle stoup\u00e1 a pot\u00e9 z\u016fst\u00e1v\u00e1 na t\u00e9to vysok\u00e9 \u00farovni po dobu n\u011bkolika hodin. K r\u00e1nu pak hladina op\u011bt rychle kles\u00e1, aby umo\u017enila probuzen\u00ed. T\u00edm se napodobuj\u00ed zdrav\u00e9, norm\u00e1ln\u00ed cykly cirkadi\u00e1nn\u00edho rytmu, kter\u00e9 jsou spojeny s klidn\u00fdm sp\u00e1nkem.<\/p>\n

V\u00fdzkum v oblasti chronobiologie uk\u00e1zal, \u017ee udr\u017eov\u00e1n\u00ed melatoninov\u00e9ho cyklu je d\u016fle\u017eit\u00e9 nejen pro klidn\u00fd sp\u00e1nek, ale tak\u00e9 pro celkovou pohodu. Z tohoto d\u016fvodu st\u00e1le v\u00edce odborn\u00edk\u016f na zdrav\u00ed doporu\u010duje jako ide\u00e1ln\u00ed dopln\u011bk stravy dob\u0159e na\u010dasovan\u00e9 uvol\u0148ov\u00e1n\u00ed melatoninu. Tento typ dopl\u0148ku se mnohem v\u00edce bl\u00ed\u017e\u00ed p\u0159irozen\u00e9mu melatoninu p\u0159\u00edtomn\u00e9mu ve zdrav\u00e9m mozku. Zaji\u0161t\u011bn\u00ed zdrav\u00e9ho cirkadi\u00e1nn\u00edho rytmu je pro zdrav\u00ed d\u016fle\u017eit\u00e9, a proto je dob\u0159e na\u010dasovan\u00fd dopln\u011bk stravy s melatoninem zpravidla tou nejlep\u0161\u00ed volbou. P\u0159i poruch\u00e1ch cirkadi\u00e1nn\u00edho rytmu, jako je nap\u0159\u00edklad jetlag, pr\u00e1ce na sm\u011bny nebo syndrom opo\u017ed\u011bn\u00e9ho n\u00e1stupu sp\u00e1nku, se sice melatonin produkuje v dostate\u010dn\u00e9m mno\u017estv\u00ed, ale v nespr\u00e1vnou dobu. V takov\u00e9m p\u0159\u00edpad\u011b p\u0159ich\u00e1z\u00ed v \u00favahu pou\u017eit\u00ed jak dob\u0159e na\u010dasovan\u00e9ho p\u0159\u00edpravku s melatoninem, tak p\u0159\u00edpravku s rychle se uvol\u0148uj\u00edc\u00edm melatoninem, aby se p\u0159eprogramoval p\u0159irozen\u00fd cirkadi\u00e1nn\u00ed rytmus na po\u017eadovan\u00fd no\u010dn\u00ed rytmus. Tento typ l\u00e9\u010dby se naz\u00fdv\u00e1 chronoterapie, proto\u017ee nenahrazuje melatonin, ale sp\u00ed\u0161e reguluje jeho endogenn\u00ed uvol\u0148ov\u00e1n\u00ed.<\/p>\n

Pokud je p\u0159\u00ed\u010dinou poruch sp\u00e1nku v\u00edce \u010di m\u00e9n\u011b v\u00fdrazn\u00fd nedostatek melatoninu, je t\u0159eba melatonin doplnit, nap\u0159\u00edklad pomoc\u00ed hormon\u00e1ln\u00ed substitu\u010dn\u00ed terapie. K tomu je t\u0159eba pou\u017e\u00edt chronobiologicky optimalizovan\u00fd farmaceutick\u00fd p\u0159\u00edpravek, kter\u00fd uvol\u0148uje melatonin po dobu \u0161esti hodin. V tomto p\u0159\u00edpad\u011b by m\u011bla b\u00fdt pou\u017eita v\u00fd\u0161e popsan\u00e1 pulzn\u00ed forma.<\/p>\n

\"melatonin-chronobiology\"<\/a>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_tta_section][\/vc_tta_accordion][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

[vc_row full_width=“stretch_row“ el_class=“banner-top“][vc_column][vc_custom_heading source=“post_title“ font_container=“tag:h1|text_align:center“ use_theme_fonts=“yes“][\/vc_column][\/vc_row][vc_row el_class=“melatoninfacts2″][vc_column][vc_column_text] Indikace Nov\u00fd v\u00fdzkum v oblasti cirkadi\u00e1nn\u00ed biologie prok\u00e1zal, \u017ee zdrav\u00fd cirkadi\u00e1nn\u00ed rytmus, a zejm\u00e9na zdrav\u00e1 hladina melatoninu, m\u00e1 pozitivn\u00ed vliv na zdrav\u00ed. B\u011bhem posledn\u00edch 20 let bylo v mnoha klinick\u00fdch studi\u00edch testov\u00e1no a prok\u00e1z\u00e1no terapeutick\u00e9 vyu\u017eit\u00ed melatoninu v r\u016fzn\u00fdch oblastech medic\u00edny a to, \u017ee u\u017e\u00edv\u00e1n\u00ed tohoto hormonu m\u016f\u017ee […]<\/p>\n","protected":false},"author":15,"featured_media":48532,"parent":54509,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"full-width-content","footnotes":""},"categories":[373,371],"class_list":{"0":"post-54515","1":"page","2":"type-page","3":"status-publish","4":"has-post-thumbnail","6":"category-melatonin-cs","7":"category-spanek","8":"entry"},"acf":[],"yoast_head":"\nIndikace – Chronobiology.com<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/dev.chronobiology.com\/cs\/melatonin-chronobiologie\/indikace\/\" \/>\n<meta property=\"og:locale\" content=\"cs_CZ\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Indikace\" \/>\n<meta property=\"og:description\" content=\"[vc_row full_width=“stretch_row“ el_class=“banner-top“][vc_column][vc_custom_heading source=“post_title“ font_container=“tag:h1|text_align:center“ use_theme_fonts=“yes“][\/vc_column][\/vc_row][vc_row el_class=“melatoninfacts2″][vc_column][vc_column_text] Indikace Nov\u00fd v\u00fdzkum v oblasti cirkadi\u00e1nn\u00ed biologie prok\u00e1zal, \u017ee zdrav\u00fd cirkadi\u00e1nn\u00ed rytmus, a zejm\u00e9na zdrav\u00e1 hladina melatoninu, m\u00e1 pozitivn\u00ed vliv na zdrav\u00ed. 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