{"id":54512,"date":"2023-08-08T07:20:28","date_gmt":"2023-08-08T14:20:28","guid":{"rendered":"https:\/\/www.chronobiology.com\/melatonin-chronobiologie\/exogenni-poruchy-spanku\/"},"modified":"2023-08-08T07:20:30","modified_gmt":"2023-08-08T14:20:30","slug":"exogenni-poruchy-spanku","status":"publish","type":"page","link":"https:\/\/dev.chronobiology.com\/cs\/melatonin-chronobiologie\/exogenni-poruchy-spanku\/","title":{"rendered":"Exogenn\u00ed poruchy sp\u00e1nku"},"content":{"rendered":"

[vc_row full_width=“stretch_row“ el_class=“banner-top“ css=“.vc_custom_1479393416057{background-image: url(https:\/\/www.chronobiology.com\/wp-content\/uploads\/2016\/11\/melatonin_sleep_disturbances.jpg?id=11711) !important;}“][vc_column][vc_custom_heading source=“post_title“ font_container=“tag:h1|text_align:center“ use_theme_fonts=“yes“][\/vc_column][\/vc_row][vc_row el_class=“melatoninfacts“][vc_column][vc_column_text]<\/p>\n

Exogenn\u00ed poruchy sp\u00e1nku<\/h2>\n

Poruchy sp\u00e1nku mohou m\u00edt mnoho r\u016fzn\u00fdch p\u0159\u00ed\u010din. Rozli\u0161uj\u00ed se poruchy sp\u00e1nku, kter\u00e9 vznikaj\u00ed v d\u016fsledku endogenn\u00ed poruchy, nebo ty, kter\u00e9 jsou vyvol\u00e1ny vn\u011bj\u0161\u00edmi nebo exogenn\u00edmi faktory. Ty lze rozd\u011blit na n\u00e1sleduj\u00edc\u00ed:[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_tta_accordion color=“turquoise“ c_icon=“chevron“ c_position=“right“ active_section=“99″ no_fill=“true“ collapsible_all=“true“][vc_tta_section title=“Jetlag a pr\u00e1ce na sm\u011bny“ tab_id=“1479159301199-fd863768-f6afa61f-d34d“][vc_row_inner css=“.vc_custom_1479393829403{background-image: url(https:\/\/www.chronobiology.com\/wp-content\/uploads\/2016\/11\/disturb_1.jpg?id=11714) !important;}“][vc_column_inner][vc_column_text]Jetlag se projevuje, pokud v kr\u00e1tk\u00e9m \u010dasov\u00e9m \u00faseku projdete v\u00edce \u010dasov\u00fdmi p\u00e1smy a p\u0159irozen\u00e9 vnit\u0159n\u00ed hodiny ji\u017e nejsou v souladu se skute\u010dn\u00fdm denn\u00edm \u010dasem. To zp\u016fsobuje zmatek v hormon\u00e1ln\u00ed rovnov\u00e1ze, kter\u00e1 je z\u00e1kladem norm\u00e1ln\u00edho a typick\u00e9ho denn\u00edho rytmu. Jetlag je t\u00edm z\u00e1va\u017en\u011bj\u0161\u00ed, \u010d\u00edm v\u00edce \u010dasov\u00fdch p\u00e1sem se p\u0159ekra\u010duje, proto\u017ee p\u0159izp\u016fsoben\u00ed vnit\u0159n\u00edho rytmu m\u016f\u017ee prob\u00edhat jen pomalu. Mezi typick\u00e9 p\u0159\u00edznaky pat\u0159\u00ed no\u010dn\u00ed nespavost a ospalost b\u011bhem dne, celkov\u00e1 nepohoda a dal\u0161\u00ed somatick\u00e9 p\u0159\u00edznaky, jako jsou pot\u00ed\u017ee se soust\u0159ed\u011bn\u00edm a kardiovaskul\u00e1rn\u00ed probl\u00e9my. Jsou mo\u017en\u00e9 dopady na zdrav\u00ed: denn\u00ed ospalost, probl\u00e9my s us\u00edn\u00e1n\u00edm a udr\u017een\u00edm sp\u00e1nku v noci, omezen\u00e1 fyzick\u00e1 zdatnost, sn\u00ed\u017een\u00e9 kognitivn\u00ed schopnosti, v\u00fdkyvy n\u00e1lad a gastrointestin\u00e1ln\u00ed a psychosomatick\u00e9 probl\u00e9my. M\u016f\u017ee b\u00fdt tak\u00e9 zhor\u0161ena reak\u010dn\u00ed doba. V nejhor\u0161\u00edch p\u0159\u00edpadech se mohou objevit kardiovaskul\u00e1rn\u00ed onemocn\u011bn\u00ed, cukrovka a rakovina.<\/p>\n

V tomto p\u0159\u00edpad\u011b je melatonin \u00fa\u010dinn\u00fd p\u0159i regulaci posunu rytmu sp\u00e1nek-bd\u011bn\u00ed, jak k nim doch\u00e1z\u00ed, zejm\u00e9na p\u0159i letu p\u0159es v\u00edce \u010dasov\u00fdch p\u00e1sem. \u010cetn\u00e9 studie prok\u00e1zaly, \u017ee melatonin m\u016f\u017ee urychlit p\u0159izp\u016fsoben\u00ed se nov\u00e9mu \u010dasov\u00e9mu p\u00e1smu. Melatonin se rovn\u011b\u017e osv\u011bd\u010dil p\u0159i zm\u00edr\u0148ov\u00e1n\u00ed dal\u0161\u00edch p\u0159\u00edznak\u016f jetlagu. Melatonin je tak\u00e9 vhodn\u00fd pro pracovn\u00edky na sm\u011bny, kte\u0159\u00ed \u010dasto trp\u00ed poruchami sp\u00e1nku, proto\u017ee tito lid\u00e9 – podobn\u011b jako lid\u00e9 se syndromem jetlag – jsou vystaveni \u010dast\u00fdm zm\u011bn\u00e1m denn\u00edho rytmu. Je d\u016fle\u017eit\u00e9 db\u00e1t na p\u0159esn\u00e9 na\u010dasov\u00e1n\u00ed p\u0159\u00edjmu, aby byl posun f\u00e1z\u00ed zp\u016fsoben\u00fd melatoninem \u00fa\u010dinn\u00fd. P\u0159\u00edkladem takov\u00e9ho ide\u00e1ln\u00edho \u010dasu m\u016f\u017ee b\u00fdt nap\u0159\u00edklad doba mezi 21. a 22. hodinou nov\u00e9ho \u010dasov\u00e9ho p\u00e1sma u osob s jetlagem a jedna hodina p\u0159ed novou f\u00e1z\u00ed odpo\u010dinku u pracovn\u00edk\u016f na sm\u011bny. Tento typ chronoterapie lze podpo\u0159it sv\u011btelnou terapi\u00ed, p\u0159i n\u00ed\u017e se na kr\u00e1tkou dobu aplikuje siln\u00e9 sv\u011btlo p\u0159\u00edmo na o\u010di. P\u0159i jetlagu se prov\u00e1d\u00ed r\u00e1no v nov\u00e9m \u010dasov\u00e9m p\u00e1smu a bezprost\u0159edn\u011b p\u0159ed aktivn\u00ed f\u00e1z\u00ed u pracovn\u00edk\u016f na sm\u011bny.<\/p>\n

Farmakologicky navozen\u00e9 poruchy sp\u00e1nku<\/h2>\n

Uvol\u0148ov\u00e1n\u00ed melatoninu m\u016f\u017ee negativn\u011b ovlivnit tak\u00e9 \u0159ada l\u00e9k\u016f a\/nebo stimulant\u016f. Bylo prok\u00e1z\u00e1no, \u017ee n\u011bkter\u00e9 l\u00e9ky na span\u00ed, jako jsou benzodiazepiny, a tak\u00e9 srde\u010dn\u00ed p\u0159\u00edpravky, jako jsou beta-blok\u00e1tory, potla\u010duj\u00ed tvorbu melatoninu. Nadm\u011brn\u00e1 konzumace alkoholu a\/nebo kofeinu z k\u00e1vy nebo \u010dern\u00e9ho \u010daje m\u016f\u017ee m\u00edt rovn\u011b\u017e negativn\u00ed vliv na uvol\u0148ov\u00e1n\u00ed melatoninu a v\u00e9st k naru\u0161en\u00ed sp\u00e1nku nebo nezdrav\u00e9mu sp\u00e1nku. P\u0159i snaze podpo\u0159it endogenn\u00ed produkci melatoninu u\u017e\u00edv\u00e1n\u00edm p\u0159edb\u011b\u017en\u00fdch l\u00e1tek, jako je tryptofan a\/nebo 5HTP, je d\u016fle\u017eit\u00e9 si uv\u011bdomit, \u017ee star\u0161\u00ed lid\u00e9 ji\u017e nejsou schopni syntetizovat melatonin z v\u00fd\u0161e uveden\u00fdch l\u00e1tek. V\u00fdsledkem ve\u010dern\u00edho pod\u00e1n\u00ed t\u011bchto p\u0159\u00edpravk\u016f je pak zv\u00fd\u0161en\u00e1 hladina serotoninu, kter\u00e1 vede sp\u00ed\u0161e k bd\u011blosti ne\u017e ke zv\u00fd\u0161en\u00e9 hladin\u011b melatoninu, p\u0159i\u010dem\u017e kone\u010dn\u00fdm v\u00fdsledkem je farmakologicky navozen\u00e9 naru\u0161en\u00ed sp\u00e1nku.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_tta_section][\/vc_tta_accordion][vc_tta_accordion color=“turquoise“ c_icon=“chevron“ c_position=“right“ active_section=“99″ no_fill=“true“ collapsible_all=“true“][vc_tta_section title=“Endogenn\u00ed poruchy sp\u00e1nku“ tab_id=“1481055229702-eb1cfb13-afda“][vc_row_inner css=“.vc_custom_1479393849506{background-image: url(https:\/\/www.chronobiology.com\/wp-content\/uploads\/2016\/11\/disturb_2.jpg?id=11713) !important;}“][vc_column_inner][vc_column_text]P\u0159i endogenn\u00edch poruch\u00e1ch sp\u00e1nku je mno\u017estv\u00ed produkovan\u00e9ho melatoninu bu\u010f sn\u00ed\u017eeno, nebo se melatonin uvol\u0148uje v nespr\u00e1vnou dobu, p\u0159esto\u017ee je \u010dlov\u011bk v norm\u00e1ln\u00edm denn\u00edm\/no\u010dn\u00edm rytmu.<\/p>\n

Syndrom opo\u017ed\u011bn\u00e9ho n\u00e1stupu sp\u00e1nku<\/h3>\n

P\u0159i syndromu opo\u017ed\u011bn\u00e9ho n\u00e1stupu sp\u00e1nku je p\u0159\u00edtomna porucha sp\u00e1nku, kter\u00e1 je zp\u016fsobena posunut\u00fdm rytmem melatoninu. Obvykle se objevuje u dosp\u00edvaj\u00edc\u00edch a mlad\u00fdch dosp\u011bl\u00fdch, kte\u0159\u00ed pat\u0159\u00ed k chronotypu „no\u010dn\u00ed sovy“. Z noci si d\u011blaj\u00ed den a z\u016fst\u00e1vaj\u00ed vzh\u016fru a\u017e do \u010dasn\u00fdch rann\u00edch hodin a pak sp\u00ed a\u017e do odpoledne. Posti\u017een\u00ed uv\u00e1d\u011bj\u00ed chronickou nespavost.<\/p>\n

Syndrom opo\u017ed\u011bn\u00e9ho n\u00e1stupu sp\u00e1nku t\u011bchto sov se nejsn\u00e1ze l\u00e9\u010d\u00ed pomoc\u00ed rann\u00ed sv\u011bteln\u00e9 terapie. Doporu\u010duje se prov\u00e1d\u011bt sv\u011btelnou terapii brzy r\u00e1no, aby se rytmus sp\u00e1nku a bd\u011bn\u00ed posunul dop\u0159edu. Podobn\u00fdch \u00fa\u010dink\u016f lze dos\u00e1hnout u\u017e\u00edv\u00e1n\u00edm melatoninu v prvn\u00edch ve\u010dern\u00edch hodin\u00e1ch, a\u0165 u\u017e se jedn\u00e1 o melatonin rychle se uvol\u0148uj\u00edc\u00ed nebo pulzuj\u00edc\u00ed. Mo\u017en\u00e1 je tak\u00e9 kombinace obou terapi\u00ed.<\/p>\n

Poruchy sp\u00e1nku a bd\u011bn\u00ed u nevidom\u00fdch (syndrom Non-24)<\/h3>\n

Non-24 je z\u00e1va\u017en\u00e1, z\u00e1va\u017en\u00e1 a chronick\u00e1 porucha rytmu den\/noc, kter\u00e1 je zvl\u00e1\u0161t\u011b \u010dast\u00e1 u nevidom\u00fdch. Lid\u00e9 se syndromem non-24 nejsou schopni p\u0159izp\u016fsobit nebo synchronizovat sv\u00e9 vnit\u0159n\u00ed hodiny 24hodinov\u00e9mu denn\u00edmu rytmu. Tito lid\u00e9 \u017eij\u00ed ve sv\u00e9m vlastn\u00edm rytmu, kter\u00fd trv\u00e1 mezi 24 a p\u016fl a 25 hodinami. To vede k tomu, \u017ee ka\u017ed\u00fd den us\u00ednaj\u00ed a vst\u00e1vaj\u00ed o 30-60 minut pozd\u011bji. Podle toho se posouvaj\u00ed i v\u0161echny ostatn\u00ed rytmy t\u011bla, jako je t\u011blesn\u00e1 teplota, uvol\u0148ov\u00e1n\u00ed hormon\u016f nebo v\u00fd\u0161ka aktivity.<\/p>\n

C\u00edlem chronobiologicky spr\u00e1vn\u00e9 terapie je synchronizovat vnit\u0159n\u00ed hodiny posti\u017een\u00fdch lid\u00ed s 24hodinov\u00fdm denn\u00edm rytmem. Pokud je to nutn\u00e9, lze toho dos\u00e1hnout r\u00e1no pomoc\u00ed sv\u011bteln\u00e9 terapie a tak\u00e9 pomoc\u00ed l\u00e1tek, kter\u00e9 potla\u010duj\u00ed denn\u00ed ospalost. To v\u0161ak funguje pouze u t\u011bch, kte\u0159\u00ed jsou je\u0161t\u011b schopni minim\u00e1ln\u011b vn\u00edmat sv\u011btlo a tmu. U v\u0161ech ostatn\u00edch pacient\u016f by m\u011blo no\u010dn\u00ed pod\u00e1v\u00e1n\u00ed melatoninu nebo podobn\u011b p\u016fsob\u00edc\u00edch l\u00e1tek podpo\u0159it sp\u00e1nek a slou\u017eit jako \u010dasom\u00edra, podle kter\u00e9 se vnit\u0159n\u00ed hodiny \u0159\u00edd\u00ed.<\/p>\n

K \u00faprav\u011b endogenn\u00edho rytmu nevidom\u00fdch na rytmus norm\u00e1ln\u00edho dne a noci lze pou\u017e\u00edt r\u016fzn\u00e9 l\u00e1tky: Na jedn\u00e9 stran\u011b je mo\u017en\u00e9 pou\u017e\u00edt melatonin jako hormon, kter\u00fd ve\u010der ud\u00e1v\u00e1 \u010das. Po\u017eit\u00edm melatoninu, a\u0165 u\u017e se jedn\u00e1 o rychle se uvol\u0148uj\u00edc\u00ed nebo pulzuj\u00edc\u00ed prepar\u00e1t, je t\u011blu signalizov\u00e1no, \u017ee je nyn\u00ed noc. V posledn\u00ed dob\u011b jsou k dispozici tak\u00e9 n\u011bkter\u00e9 l\u00e1tky podobn\u00e9 melatoninu, nap\u0159\u00edklad Tasimelteon (Hetlioz\u00ae), kter\u00fd je rovn\u011b\u017e t\u0159eba u\u017e\u00edvat ve\u010der a p\u016fsob\u00ed p\u0159es melatoninov\u00e9 receptory v mozku na nastaven\u00ed vnit\u0159n\u00edch hodin podle rytmu den\/noc.<\/p>\n

Poruchy sp\u00e1nku ve st\u00e1\u0159\u00ed a ve zvl\u00e1\u0161tn\u00edch \u017eivotn\u00edch situac\u00edch<\/h3>\n

P\u0159esto\u017ee u lid\u00ed zat\u00edm nebyl prok\u00e1z\u00e1n \u00fa\u010dinek prodlu\u017euj\u00edc\u00ed \u017eivot, je jist\u00e9, \u017ee melatonin m\u00e1 pozitivn\u00ed vliv na kvalitu \u017eivota, zejm\u00e9na u star\u0161\u00edch lid\u00ed. Zd\u00e1 se, \u017ee tento hormon je \u00fa\u010dinn\u00fd p\u0159i l\u00e9\u010db\u011b nejr\u016fzn\u011bj\u0161\u00edch proces\u016f, kter\u00e9 souvisej\u00ed se st\u00e1rnut\u00edm, jako jsou poruchy rytmu sp\u00e1nku a bd\u011bn\u00ed, sn\u00ed\u017een\u00ed krevn\u00edho tlaku a p\u0159i n\u00e1prav\u011b nedostatk\u016f imunitn\u00edho syst\u00e9mu. P\u0159edpokl\u00e1d\u00e1 se tak\u00e9, \u017ee hormon pom\u00e1h\u00e1 odd\u00e1lit molekul\u00e1rn\u00ed destrukci, \u00fabytek bun\u011bk a po\u0161kozen\u00ed organismu, co\u017e jsou faktory, kter\u00e9 p\u0159isp\u00edvaj\u00ed ke st\u00e1rnut\u00ed.<\/p>\n

V d\u016fsledku s v\u011bkem souvisej\u00edc\u00edho poklesu no\u010dn\u00ed hladiny melatoninu trp\u00ed star\u0161\u00ed lid\u00e9 \u010dasto poruchami sp\u00e1nku. V sou\u010dasn\u00e9 dob\u011b se p\u0159edpokl\u00e1d\u00e1, \u017ee ka\u017ed\u00fd druh\u00fd \u010dlov\u011bk star\u0161\u00ed 65 let trp\u00ed poruchami sp\u00e1nku. V tomto p\u0159\u00edpad\u011b se osv\u011bd\u010dila l\u00e9\u010dba melatoninem. Studie prok\u00e1zaly, \u017ee u\u017e\u00edv\u00e1n\u00ed melatoninu zaji\u0161\u0165uje nejen zlep\u0161en\u00ed kvality sp\u00e1nku, ale tak\u00e9 sn\u00ed\u017een\u00ed depres\u00ed a obav. Pozitivn\u00ed \u00fa\u010dinek tohoto hormonu lze p\u0159ipsat jeho schopnosti normalizovat cirkadi\u00e1nn\u00ed rytmus. Takto zregenerovan\u00fd rytmus pak m\u016f\u017ee pozitivn\u011b ovlivnit v\u0161echny ostatn\u00ed fyziologick\u00e9 procesy a m\u016f\u017ee v\u00fdrazn\u011b zv\u00fd\u0161it kvalitu \u017eivota a p\u0159\u00edpadn\u011b b\u00fdt faktorem prodlu\u017euj\u00edc\u00edm d\u00e9lku \u017eivota.<\/p>\n

Zvl\u00e1\u0161tn\u00ed skupinou pacient\u016f jsou \u017eeny proch\u00e1zej\u00edc\u00ed menopauzou. Tuto \u017eivotn\u00ed etapu prov\u00e1zej\u00ed hluboce zako\u0159en\u011bn\u00e9 hormon\u00e1ln\u00ed zm\u011bny, kter\u00e9 vedou nejen k probl\u00e9m\u016fm se sp\u00e1nkem, ale mohou vyvolat i dal\u0161\u00ed p\u0159\u00edznaky. Rozsah, v jak\u00e9m se sekrece melatoninu touto ud\u00e1lost\u00ed m\u011bn\u00ed, je st\u00e1le p\u0159edm\u011btem r\u016fzn\u00fdch zkoum\u00e1n\u00ed. Nicm\u00e9n\u011b studie s \u017eenami v perimenopauze dok\u00e1zaly, \u017ee \u010dinnost hypof\u00fdzy i funkce \u0161t\u00edtn\u00e9 \u017el\u00e1zy se mohou zlep\u0161it po\u017eit\u00edm melatoninu. V\u011bt\u0161ina \u017een l\u00e9\u010den\u00fdch melatoninem nav\u00edc uv\u00e1d\u011bla celkov\u00e9 zlep\u0161en\u00ed n\u00e1lady a v\u00fdrazn\u00e9 zm\u00edrn\u011bn\u00ed deprese. Tuto tezi podporuje skute\u010dnost, \u017ee vysok\u00e1 koncentrace melatoninu ve st\u00e1\u0159\u00ed – jak prok\u00e1zaly v\u0161echny p\u0159edchoz\u00ed studie – zlep\u0161uje celkovou pohodu a m\u016f\u017ee v\u00e9st ke zm\u00edrn\u011bn\u00ed nemoc\u00ed spojen\u00fdch s v\u011bkem. Tento \u00fa\u010dinek odr\u00e1\u017e\u00ed \u00fa\u010dinek melatoninu jako regul\u00e1toru sp\u00e1nku i jako siln\u00e9ho antioxidantu. U v\u0161ech lid\u00ed, v\u010detn\u011b \u017een v menopauze, bylo mo\u017en\u00e9 prok\u00e1zat, \u017ee klidn\u00fd sp\u00e1nek v\u00fdrazn\u011b zlep\u0161uje celkovou pohodu n\u00e1sleduj\u00edc\u00edho dne.<\/p>\n

Poruchy sp\u00e1nku p\u0159i zimn\u00ed depresi<\/h3>\n

Takzvan\u00e1 zimn\u00ed deprese, zn\u00e1m\u00e1 tak\u00e9 jako sez\u00f3nn\u00ed afektivn\u00ed porucha (SAD), se zab\u00fdv\u00e1 zvl\u00e1\u0161tn\u00ed formou deprese, kter\u00e1 se nejv\u00edce vyskytuje na podzim a v zimn\u00edch m\u011bs\u00edc\u00edch. Hlavn\u00edmi p\u0159\u00edznaky jsou potla\u010den\u00e1 n\u00e1lada, sn\u00ed\u017een\u00ed hladiny energie a boj\u00e1cnost, d\u00e1le prodlou\u017een\u00ed doby sp\u00e1nku, zv\u00fd\u0161en\u00e1 chu\u0165 na sladk\u00e9 (la\u010dn\u00e1 chu\u0165 na sacharidy) a p\u0159ib\u00fdv\u00e1n\u00ed na v\u00e1ze. Na druhou stranu deprese, kter\u00e1 nen\u00ed sez\u00f3nn\u011b charakterizov\u00e1na, je doprov\u00e1zena sp\u00ed\u0161e ztr\u00e1tou chuti k j\u00eddlu, \u00fabytkem hmotnosti a zkr\u00e1cen\u00edm sp\u00e1nku. Vzhledem k tomu, \u017ee tento typ deprese se \u010dast\u011bji vyskytuje v oblastech, kter\u00e9 maj\u00ed dlouh\u00e9 zimy s dlouh\u00fdmi nocemi (nap\u0159\u00edklad pol\u00e1rn\u00ed oblasti), p\u0159edpokl\u00e1d\u00e1 se, \u017ee tito lid\u00e9 trp\u00ed poruchou produkce melatoninu. Tito lid\u00e9 \u010dasto uvol\u0148uj\u00ed melatonin \u010dast\u011bji a po del\u0161\u00ed dobu.<\/p>\n

Zaj\u00edmav\u00e9 je, \u017ee pozitivn\u00ed \u00fa\u010dinek exogenn\u00edho melatoninu se p\u0159esto poda\u0159ilo prok\u00e1zat. Ji\u017e mal\u00e1 podve\u010dern\u00ed d\u00e1vka melatoninu v rychle se uvol\u0148uj\u00edc\u00ed l\u00e9kov\u00e9 form\u011b m\u016f\u017ee p\u0159isp\u011bt ke zlep\u0161en\u00ed synchronizace vnit\u0159n\u00edch hodin a biologick\u00e9ho denn\u00edho rytmu se sv\u011bteln\u00fdmi podm\u00ednkami p\u0159\u00edtomn\u00fdmi v zimn\u00edm obdob\u00ed, co\u017e v\u00fdrazn\u011b zlep\u0161uje emo\u010dn\u00ed stav. Krom\u011b toho se jako l\u00e9\u010debn\u00e1 metoda osv\u011bd\u010dila tak\u00e9 sv\u011bteln\u00e1 terapie. P\u0159i rann\u00ed aplikaci nejen\u017ee sni\u017euje rann\u00ed hladinu melatoninu, ale pozitivn\u011b ovliv\u0148uje cel\u00fd rytmus.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_tta_section][\/vc_tta_accordion][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

[vc_row full_width=“stretch_row“ el_class=“banner-top“ css=“.vc_custom_1479393416057{background-image: url(https:\/\/www.chronobiology.com\/wp-content\/uploads\/2016\/11\/melatonin_sleep_disturbances.jpg?id=11711) !important;}“][vc_column][vc_custom_heading source=“post_title“ font_container=“tag:h1|text_align:center“ use_theme_fonts=“yes“][\/vc_column][\/vc_row][vc_row el_class=“melatoninfacts“][vc_column][vc_column_text] Exogenn\u00ed poruchy sp\u00e1nku Poruchy sp\u00e1nku mohou m\u00edt mnoho r\u016fzn\u00fdch p\u0159\u00ed\u010din. Rozli\u0161uj\u00ed se poruchy sp\u00e1nku, kter\u00e9 vznikaj\u00ed v d\u016fsledku endogenn\u00ed poruchy, nebo ty, kter\u00e9 jsou vyvol\u00e1ny vn\u011bj\u0161\u00edmi nebo exogenn\u00edmi faktory. Ty lze rozd\u011blit na n\u00e1sleduj\u00edc\u00ed:[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_tta_accordion color=“turquoise“ c_icon=“chevron“ c_position=“right“ active_section=“99″ no_fill=“true“ collapsible_all=“true“][vc_tta_section title=“Jetlag a pr\u00e1ce na sm\u011bny“ […]<\/p>\n","protected":false},"author":15,"featured_media":48560,"parent":54509,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"full-width-content","footnotes":""},"categories":[373,371],"class_list":{"0":"post-54512","1":"page","2":"type-page","3":"status-publish","4":"has-post-thumbnail","6":"category-melatonin-cs","7":"category-spanek","8":"entry"},"acf":[],"yoast_head":"\nExogenn\u00ed poruchy sp\u00e1nku – Chronobiology.com<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/dev.chronobiology.com\/cs\/melatonin-chronobiologie\/exogenni-poruchy-spanku\/\" \/>\n<meta property=\"og:locale\" content=\"cs_CZ\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Exogenn\u00ed poruchy sp\u00e1nku\" \/>\n<meta property=\"og:description\" content=\"[vc_row full_width=“stretch_row“ el_class=“banner-top“ css=“.vc_custom_1479393416057{background-image: url(https:\/\/www.chronobiology.com\/wp-content\/uploads\/2016\/11\/melatonin_sleep_disturbances.jpg?id=11711) !important;}“][vc_column][vc_custom_heading source=“post_title“ font_container=“tag:h1|text_align:center“ use_theme_fonts=“yes“][\/vc_column][\/vc_row][vc_row el_class=“melatoninfacts“][vc_column][vc_column_text] Exogenn\u00ed poruchy sp\u00e1nku Poruchy sp\u00e1nku mohou m\u00edt mnoho r\u016fzn\u00fdch p\u0159\u00ed\u010din. 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